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Fusion gene ID: 26184 |
FusionGeneSummary for PCDH10_CHMP1A |
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Fusion gene information | Fusion gene name: PCDH10_CHMP1A | Fusion gene ID: 26184 | Hgene | Tgene | Gene symbol | PCDH10 | CHMP1A | Gene ID | 57575 | 5119 |
Gene name | protocadherin 10 | charged multivesicular body protein 1A | |
Synonyms | OL-PCDH|PCDH19 | CHMP1|PCH8|PCOLN3|PRSM1|VPS46-1|VPS46A | |
Cytomap | 4q28.3 | 16q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protocadherin-10 | charged multivesicular body protein 1acharged multivesicular body protein 1/chromatin modifying protein 1chromatin modifying protein 1Aprocollagen (type III) N-endopeptidaseprotease, metallo, 1, 33kDvacuolar protein sorting-associated protein 46-1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9P2E7 | Q9HD42 | |
Ensembl transtripts involved in fusion gene | ENST00000264360, | ENST00000397901, ENST00000253475, ENST00000535997, ENST00000550102, ENST00000547614, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 15 X 8 X 9=1080 |
# samples | 3 | 20 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(20/1080*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PCDH10 [Title/Abstract] AND CHMP1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CHMP1A | GO:0007076 | mitotic chromosome condensation | 11559747 |
Tgene | CHMP1A | GO:0016192 | vesicle-mediated transport | 11559748 |
Tgene | CHMP1A | GO:0016458 | gene silencing | 11559747 |
Tgene | CHMP1A | GO:0045892 | negative regulation of transcription, DNA-templated | 11559747 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG008253 | PCDH10 | chr4 | 134071750 | - | CHMP1A | chr16 | 89712392 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000264360 | ENST00000397901 | PCDH10 | chr4 | 134071750 | - | CHMP1A | chr16 | 89712392 | - |
5CDS-3UTR | ENST00000264360 | ENST00000253475 | PCDH10 | chr4 | 134071750 | - | CHMP1A | chr16 | 89712392 | - |
5CDS-3UTR | ENST00000264360 | ENST00000535997 | PCDH10 | chr4 | 134071750 | - | CHMP1A | chr16 | 89712392 | - |
5CDS-3UTR | ENST00000264360 | ENST00000550102 | PCDH10 | chr4 | 134071750 | - | CHMP1A | chr16 | 89712392 | - |
5CDS-intron | ENST00000264360 | ENST00000547614 | PCDH10 | chr4 | 134071750 | - | CHMP1A | chr16 | 89712392 | - |
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FusionProtFeatures for PCDH10_CHMP1A |
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Hgene | Tgene |
PCDH10 | CHMP1A |
Potential calcium-dependent cell-adhesion protein. | Probable peripherally associated component of theendosomal sorting required for transport complex III (ESCRT-III)which is involved in multivesicular bodies (MVBs) formation andsorting of endosomal cargo proteins into MVBs. MVBs containintraluminal vesicles (ILVs) that are generated by invaginationand scission from the limiting membrane of the endosome and mostlyare delivered to lysosomes enabling degradation of membraneproteins, such as stimulated growth factor receptors, lysosomalenzymes and lipids. The MVB pathway appears to require thesequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membranebefore the ILV is released. The ESCRT machinery also functions intopologically equivalent membrane fission events, such as theterminal stages of cytokinesis and the budding of envelopedviruses (HIV-1 and other lentiviruses). ESCRT-III proteins arebelieved to mediate the necessary vesicle extrusion and/ormembrane fission activities, possibly in conjunction with the AAAATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4Aand/or VPS4B to the midbody of dividing cells. May also beinvolved in chromosome condensation. Targets the Polycomb group(PcG) protein BMI1/PCGF4 to regions of condensed chromatin. Mayplay a role in stable cell cycle progression and in PcG genesilencing. {ECO:0000269|PubMed:11559747,ECO:0000269|PubMed:11559748, ECO:0000269|PubMed:19129479,ECO:0000269|PubMed:23045692}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PCDH10_CHMP1A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PCDH10_CHMP1A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCDH10_CHMP1A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCDH10_CHMP1A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PCDH10 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | PCDH10 | C0004352 | Autistic Disorder | 1 | CTD_human |