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Fusion gene ID: 26140 |
FusionGeneSummary for PCAT4_SPTAN1 |
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Fusion gene information | Fusion gene name: PCAT4_SPTAN1 | Fusion gene ID: 26140 | Hgene | Tgene | Gene symbol | PCAT4 | SPTAN1 | Gene ID | 118425 | 6709 |
Gene name | prostate cancer associated transcript 4 | spectrin alpha, non-erythrocytic 1 | |
Synonyms | GDEP|PCA4|PCAN1 | EIEE5|NEAS|SPTA2 | |
Cytomap | 4q21.21 | 9q34.11 | |
Type of gene | ncRNA | protein-coding | |
Description | gene differentially expressed in prostateprostate cancer associated transcript 4 (non-protein coding)prostate cancer gene 1 | spectrin alpha chain, non-erythrocytic 1alpha-II spectrinalpha-fodrinfodrin alpha chainspectrin, non-erythroid alpha chainspectrin, non-erythroid alpha subunit | |
Modification date | 20180517 | 20180529 | |
UniProtAcc | Q13813 | ||
Ensembl transtripts involved in fusion gene | ENST00000504263, | ENST00000358161, ENST00000372739, ENST00000372731, ENST00000475367, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 13 X 14 X 6=1092 |
# samples | 1 | 15 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(15/1092*10)=-2.86393845042397 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PCAT4 [Title/Abstract] AND SPTAN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG055063 | PCAT4 | chr4 | 80748689 | - | SPTAN1 | chr9 | 131395756 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000504263 | ENST00000358161 | PCAT4 | chr4 | 80748689 | - | SPTAN1 | chr9 | 131395756 | - |
3UTR-3UTR | ENST00000504263 | ENST00000372739 | PCAT4 | chr4 | 80748689 | - | SPTAN1 | chr9 | 131395756 | - |
3UTR-3UTR | ENST00000504263 | ENST00000372731 | PCAT4 | chr4 | 80748689 | - | SPTAN1 | chr9 | 131395756 | - |
3UTR-intron | ENST00000504263 | ENST00000475367 | PCAT4 | chr4 | 80748689 | - | SPTAN1 | chr9 | 131395756 | - |
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FusionProtFeatures for PCAT4_SPTAN1 |
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Hgene | Tgene |
PCAT4 | SPTAN1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PCAT4_SPTAN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PCAT4_SPTAN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PCAT4_SPTAN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PCAT4_SPTAN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SPTAN1 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |