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Fusion gene ID: 26139 |
FusionGeneSummary for PBXIP1_MAN2B2 |
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Fusion gene information | Fusion gene name: PBXIP1_MAN2B2 | Fusion gene ID: 26139 | Hgene | Tgene | Gene symbol | PBXIP1 | MAN2B2 | Gene ID | 57326 | 23324 |
Gene name | PBX homeobox interacting protein 1 | mannosidase alpha class 2B member 2 | |
Synonyms | HPIP | - | |
Cytomap | 1q21.3 | 4p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | pre-B-cell leukemia transcription factor-interacting protein 1hematopoietic PBX-interacting proteinpre-B-cell leukemia homeobox interacting protein 1 | epididymis-specific alpha-mannosidasecore-specific lysosomal alpha-1,6-Mannosidase | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96AQ6 | Q9Y2E5 | |
Ensembl transtripts involved in fusion gene | ENST00000368465, ENST00000368463, ENST00000539880, ENST00000542459, ENST00000368460, ENST00000498553, | ENST00000285599, ENST00000504248, ENST00000504960, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: PBXIP1 [Title/Abstract] AND MAN2B2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF922845 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000368465 | ENST00000285599 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000368465 | ENST00000504248 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3UTR | ENST00000368465 | ENST00000504960 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000368463 | ENST00000285599 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000368463 | ENST00000504248 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3UTR | ENST00000368463 | ENST00000504960 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000539880 | ENST00000285599 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000539880 | ENST00000504248 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3UTR | ENST00000539880 | ENST00000504960 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000542459 | ENST00000285599 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000542459 | ENST00000504248 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3UTR | ENST00000542459 | ENST00000504960 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000368460 | ENST00000285599 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000368460 | ENST00000504248 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3UTR | ENST00000368460 | ENST00000504960 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000498553 | ENST00000285599 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3CDS | ENST00000498553 | ENST00000504248 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
intron-3UTR | ENST00000498553 | ENST00000504960 | PBXIP1 | chr1 | 154918751 | - | MAN2B2 | chr4 | 6610905 | + |
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FusionProtFeatures for PBXIP1_MAN2B2 |
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Hgene | Tgene |
PBXIP1 | MAN2B2 |
Regulator of pre-B-cell leukemia transcription factors(BPXs) function. Inhibits the binding of PBX1-HOX complex to DNAand blocks the transcriptional activity of E2A-PBX1. Tethersestrogen receptor-alpha (ESR1) to microtubules and allows them toinfluence estrogen receptors-alpha signaling.{ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403,ECO:0000269|PubMed:17043237}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PBXIP1_MAN2B2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PBXIP1_MAN2B2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PBXIP1_MAN2B2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PBXIP1_MAN2B2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |