FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 26103

FusionGeneSummary for PBLD_PBLD

check button Fusion gene summary
Fusion gene informationFusion gene name: PBLD_PBLD
Fusion gene ID: 26103
HgeneTgene
Gene symbol

PBLD

PBLD

Gene ID

64081

64081

Gene namephenazine biosynthesis like protein domain containingphenazine biosynthesis like protein domain containing
SynonymsHEL-S-306|MAWBP|MAWDBPHEL-S-306|MAWBP|MAWDBP
Cytomap

10q21.3

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionphenazine biosynthesis-like domain-containing proteinMAWD-binding proteinepididymis secretory protein Li 306phenazine biosynthesis-like domain-containing proteinMAWD-binding proteinepididymis secretory protein Li 306
Modification date2018051920180519
UniProtAcc

P30039

P30039

Ensembl transtripts involved in fusion geneENST00000336578, ENST00000358769, 
ENST00000309049, ENST00000432941, 
ENST00000495025, 		ENST00000336578, 
ENST00000358769, ENST00000309049, 
ENST00000432941, ENST00000495025, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: PBLD [Title/Abstract] AND PBLD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1L32610PBLDchr10

70091828

-PBLDchr10

70091940

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000336578ENST00000336578PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000336578ENST00000358769PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000336578ENST00000309049PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000336578ENST00000432941PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000336578ENST00000495025PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000358769ENST00000336578PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000358769ENST00000358769PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000358769ENST00000309049PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000358769ENST00000432941PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000358769ENST00000495025PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000309049ENST00000336578PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000309049ENST00000358769PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000309049ENST00000309049PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000309049ENST00000432941PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000309049ENST00000495025PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000432941ENST00000336578PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000432941ENST00000358769PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000432941ENST00000309049PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000432941ENST00000432941PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000432941ENST00000495025PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000495025ENST00000336578PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000495025ENST00000358769PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000495025ENST00000309049PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000495025ENST00000432941PBLDchr10

70091828

-PBLDchr10

70091940

+
intron-intronENST00000495025ENST00000495025PBLDchr10

70091828

-PBLDchr10

70091940

+

Top

FusionProtFeatures for PBLD_PBLD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PBLD

P30039

PBLD

P30039


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PBLD_PBLD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PBLD_PBLD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PBLD_PBLD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PBLD_PBLD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePBLDC0032927Precancerous Conditions1CTD_human
TgenePBLDC0032927Precancerous Conditions1CTD_human