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Fusion gene ID: 26082 |
FusionGeneSummary for PAX7_FOXO1 |
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Fusion gene information | Fusion gene name: PAX7_FOXO1 | Fusion gene ID: 26082 | Hgene | Tgene | Gene symbol | PAX7 | FOXO1 | Gene ID | 5081 | 2308 |
Gene name | paired box 7 | forkhead box O1 | |
Synonyms | HUP1|PAX7B|RMS2 | FKH1|FKHR|FOXO1A | |
Cytomap | 1p36.13 | 13q14.11 | |
Type of gene | protein-coding | protein-coding | |
Description | paired box protein Pax-7PAX7 transcriptional factorpaired box homeotic gene 7paired domain gene 7 | forkhead box protein O1forkhead box protein O1Aforkhead, Drosophila, homolog of, in rhabdomyosarcoma | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | P23759 | Q12778 | |
Ensembl transtripts involved in fusion gene | ENST00000375375, ENST00000420770, ENST00000400661, | ENST00000379561, ENST00000473775, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 8 X 6 X 4=192 |
# samples | 2 | 12 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(12/192*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PAX7 [Title/Abstract] AND FOXO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FOXO1 | GO:0009267 | cellular response to starvation | 20543840 |
Tgene | FOXO1 | GO:0032873 | negative regulation of stress-activated MAPK cascade | 19696738 |
Tgene | FOXO1 | GO:0043066 | negative regulation of apoptotic process | 10871843 |
Tgene | FOXO1 | GO:0045893 | positive regulation of transcription, DNA-templated | 7862145|10871843|12228231 |
Tgene | FOXO1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10871843|12228231 |
Tgene | FOXO1 | GO:0071455 | cellular response to hyperoxia | 20543840 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | HQ824715 | PAX7 | chr1 | 19029790 | + | FOXO1 | chr13 | 41135000 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000375375 | ENST00000379561 | PAX7 | chr1 | 19029790 | + | FOXO1 | chr13 | 41135000 | - |
5CDS-5UTR | ENST00000375375 | ENST00000473775 | PAX7 | chr1 | 19029790 | + | FOXO1 | chr13 | 41135000 | - |
In-frame | ENST00000420770 | ENST00000379561 | PAX7 | chr1 | 19029790 | + | FOXO1 | chr13 | 41135000 | - |
5CDS-5UTR | ENST00000420770 | ENST00000473775 | PAX7 | chr1 | 19029790 | + | FOXO1 | chr13 | 41135000 | - |
In-frame | ENST00000400661 | ENST00000379561 | PAX7 | chr1 | 19029790 | + | FOXO1 | chr13 | 41135000 | - |
5CDS-5UTR | ENST00000400661 | ENST00000473775 | PAX7 | chr1 | 19029790 | + | FOXO1 | chr13 | 41135000 | - |
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FusionProtFeatures for PAX7_FOXO1 |
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Hgene | Tgene |
PAX7 | FOXO1 |
Transcription factor playing a role in myogenesisthrough regulation of muscle precursor cells proliferation.{ECO:0000250|UniProtKB:P47239}. | Transcription factor that is the main target of insulinsignaling and regulates metabolic homeostasis in response tooxidative stress. Binds to the insulin response element (IRE) withconsensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator ofredox balance and osteoblast numbers and controls bone mass.Orchestrates the endocrine function of the skeleton in regulatingglucose metabolism. Acts synergistically with ATF4 to suppressosteocalcin/BGLAP activity, increasing glucose levels andtriggering glucose intolerance and insulin insensitivity. Alsosuppresses the transcriptional activity of RUNX2, an upstreamactivator of osteocalcin/BGLAP. In hepatocytes, promotesgluconeogenesis by acting together with PPARGC1A and CEBPA toactivate the expression of genes such as IGFBP1, G6PC and PCK1.Important regulator of cell death acting downstream of CDK1,PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediatesinsulin action on adipose tissue. Regulates the expression ofadipogenic genes such as PPARG during preadipocyte differentiationand, adipocyte size and adipose tissue-specific gene expression inresponse to excessive calorie intake. Regulates thetranscriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell deathinduction in response to starvation or oxidative stress in atranscription-independent manner. Mediates the function of MLIP incardiomyocytes hypertrophy and cardiac remodeling (By similarity).{ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0,ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231,ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677,ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179,ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PAX7 | chr1:19029790 | chr13:41135000 | ENST00000375375 | + | 7 | 8 | 217_276 | 385 | 521 | DNA binding | Homeobox |
Hgene | PAX7 | chr1:19029790 | chr13:41135000 | ENST00000400661 | + | 7 | 8 | 217_276 | 383 | 519 | DNA binding | Homeobox |
Hgene | PAX7 | chr1:19029790 | chr13:41135000 | ENST00000420770 | + | 7 | 9 | 217_276 | 385 | 506 | DNA binding | Homeobox |
Hgene | PAX7 | chr1:19029790 | chr13:41135000 | ENST00000375375 | + | 7 | 8 | 34_163 | 385 | 521 | Domain | Paired |
Hgene | PAX7 | chr1:19029790 | chr13:41135000 | ENST00000400661 | + | 7 | 8 | 34_163 | 383 | 519 | Domain | Paired |
Hgene | PAX7 | chr1:19029790 | chr13:41135000 | ENST00000420770 | + | 7 | 9 | 34_163 | 385 | 506 | Domain | Paired |
Tgene | >FOXO1 | chr1:19029790 | chr13:41135000 | ENST00000379561 | - | 0 | 3 | 211_218 | 210 | 1440 | Region | Note=DNA-binding |
Tgene | >FOXO1 | chr1:19029790 | chr13:41135000 | ENST00000379561 | - | 0 | 3 | 234_237 | 210 | 1440 | Region | Note=DNA-binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PAX7 | chr1:19029790 | chr13:41135000 | ENST00000375375 | + | 7 | 8 | 479_491 | 385 | 521 | Motif | OAR |
Hgene | >PAX7 | chr1:19029790 | chr13:41135000 | ENST00000400661 | + | 7 | 8 | 479_491 | 383 | 519 | Motif | OAR |
Hgene | >PAX7 | chr1:19029790 | chr13:41135000 | ENST00000420770 | + | 7 | 9 | 479_491 | 385 | 506 | Motif | OAR |
Tgene | FOXO1 | chr1:19029790 | chr13:41135000 | ENST00000379561 | - | 0 | 3 | 120_130 | 210 | 1440 | Compositional bias | Note=Poly-Pro |
Tgene | FOXO1 | chr1:19029790 | chr13:41135000 | ENST00000379561 | - | 0 | 3 | 152_155 | 210 | 1440 | Compositional bias | Note=Poly-Ser |
Tgene | FOXO1 | chr1:19029790 | chr13:41135000 | ENST00000379561 | - | 0 | 3 | 91_102 | 210 | 1440 | Compositional bias | Note=Poly-Ala |
Tgene | FOXO1 | chr1:19029790 | chr13:41135000 | ENST00000379561 | - | 0 | 3 | 159_235 | 210 | 1440 | DNA binding | Fork-head |
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FusionGeneSequence for PAX7_FOXO1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PAX7_FOXO1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PAX7 | WDR5, ASH2L, TRIM27, MYOD1, NEDD4, CSNK2A1 | FOXO1 | AR, SMAD3, SMAD4, CREBBP, YWHAG, YWHAZ, TSC2, ESR1, CEBPB, HOXA5, HNF4A, RFWD2, PARP1, HOXA11, LRPPRC, SKP2, PML, SIRT1, AKT1, SIRT2, ATG7, STUB1, NLK, MDM2, RARA, FSHR, IRF3, FHL2, EP300, MST1, YWHAQ, NCOA1, PIK3R3, TENC1, XPO1, CCNB1, CDKN1A, GSK3B, FOXO1, FOXO4, RECQL, FOXO3B, CUX1, DLX5, HOXD13, SATB1, SATB2, SMARCA4, SETD7, MORF4L2, SNX17, RB1, DNAJC9, FOXO6, PRKACA, CRY1, PITX1, SIRT7, ATM |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PAX7_FOXO1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAX7_FOXO1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FOXO1 | C0022578 | Keratoconus | 1 | CTD_human |
Tgene | FOXO1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |