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Fusion gene ID: 26067 |
FusionGeneSummary for PAWR_PTPRR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PAWR_PTPRR | Fusion gene ID: 26067 | Hgene | Tgene | Gene symbol | PAWR | PTPRR | Gene ID | 5074 | 5801 |
| Gene name | pro-apoptotic WT1 regulator | protein tyrosine phosphatase, receptor type R | |
| Synonyms | PAR4|Par-4 | EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ | |
| Cytomap | 12q21.2 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PRKC apoptosis WT1 regulator proteinPRKC, apoptosis, WT1, regulatorWT1-interacting proteinprostate apoptosis response protein 4prostate apoptosis response protein PAR-4prostate apoptosis response-4transcriptional repressor PAR4 | receptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96IZ0 | Q15256 | |
| Ensembl transtripts involved in fusion gene | ENST00000328827, ENST00000547571, | ENST00000283228, ENST00000440835, ENST00000537619, ENST00000378778, ENST00000342084, ENST00000549308, | |
| Fusion gene scores | * DoF score | 4 X 1 X 3=12 | 33 X 13 X 10=4290 |
| # samples | 4 | 31 | |
| ** MAII score | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(31/4290*10)=-3.79063752711267 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PAWR [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-B6-A408-01A | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000328827 | ENST00000283228 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| In-frame | ENST00000328827 | ENST00000440835 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| 5CDS-intron | ENST00000328827 | ENST00000537619 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| 5CDS-intron | ENST00000328827 | ENST00000378778 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| 5CDS-intron | ENST00000328827 | ENST00000342084 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| 5CDS-intron | ENST00000328827 | ENST00000549308 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| 5UTR-3CDS | ENST00000547571 | ENST00000283228 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| 5UTR-3CDS | ENST00000547571 | ENST00000440835 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| 5UTR-intron | ENST00000547571 | ENST00000537619 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| 5UTR-intron | ENST00000547571 | ENST00000378778 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| 5UTR-intron | ENST00000547571 | ENST00000342084 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
| 5UTR-intron | ENST00000547571 | ENST00000549308 | PAWR | chr12 | 80083509 | - | PTPRR | chr12 | 71092129 | - |
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FusionProtFeatures for PAWR_PTPRR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PAWR | PTPRR |
| Pro-apoptopic protein capable of selectively inducingapoptosis in cancer cells, sensitizing the cells to diverseapoptotic stimuli and causing regression of tumors in animalmodels. Induces apoptosis in certain cancer cells by activation ofthe Fas prodeath pathway and coparallel inhibition of NF-kappa-Btranscriptional activity. Inhibits the transcriptional activationand augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction withWT1. Seems also to be a transcriptional repressor by itself. Maybe directly involved in regulating the amyloid precursor protein(APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}. | Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PAWR | chr12:80083509 | chr12:71092129 | ENST00000328827 | - | 2 | 7 | 49_120 | 172 | 341 | Compositional bias | Note=Ala-rich |
| Hgene | PAWR | chr12:80083509 | chr12:71092129 | ENST00000328827 | - | 2 | 7 | 145_161 | 172 | 341 | Motif | Nuclear localization signal |
| Hgene | PAWR | chr12:80083509 | chr12:71092129 | ENST00000328827 | - | 2 | 7 | 68_72 | 172 | 341 | Motif | B30.2/SPRY domain-binding motif |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000342084 | - | 5 | 13 | 393_647 | 286 | 546 | Domain | Tyrosine-protein phosphatase |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000378778 | - | 3 | 11 | 393_647 | 192 | 452 | Domain | Tyrosine-protein phosphatase |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000440835 | - | 2 | 10 | 393_647 | 153 | 413 | Domain | Tyrosine-protein phosphatase |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000549308 | - | 3 | 11 | 393_647 | 153 | 413 | Domain | Tyrosine-protein phosphatase |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000283228 | - | 6 | 14 | 588_594 | 398 | 658 | Region | Substrate binding |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000342084 | - | 5 | 13 | 588_594 | 286 | 546 | Region | Substrate binding |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000378778 | - | 3 | 11 | 588_594 | 192 | 452 | Region | Substrate binding |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000440835 | - | 2 | 10 | 588_594 | 153 | 413 | Region | Substrate binding |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000549308 | - | 3 | 11 | 588_594 | 153 | 413 | Region | Substrate binding |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000378778 | - | 3 | 11 | 249_657 | 192 | 452 | Topological domain | Cytoplasmic |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000440835 | - | 2 | 10 | 249_657 | 153 | 413 | Topological domain | Cytoplasmic |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000549308 | - | 3 | 11 | 249_657 | 153 | 413 | Topological domain | Cytoplasmic |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000378778 | - | 3 | 11 | 228_248 | 192 | 452 | Transmembrane | Helical |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000440835 | - | 2 | 10 | 228_248 | 153 | 413 | Transmembrane | Helical |
| Tgene | >PTPRR | chr12:80083509 | chr12:71092129 | ENST00000549308 | - | 3 | 11 | 228_248 | 153 | 413 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PAWR | chr12:80083509 | chr12:71092129 | ENST00000328827 | - | 2 | 7 | 186_206 | 172 | 341 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PAWR | chr12:80083509 | chr12:71092129 | ENST00000328827 | - | 2 | 7 | 145_203 | 172 | 341 | Region | Note=Selective for apoptosis induction in cancer cells (SAC) |
| Hgene | >PAWR | chr12:80083509 | chr12:71092129 | ENST00000328827 | - | 2 | 7 | 300_340 | 172 | 341 | Region | Note=Leucine-zipper |
| Tgene | PTPRR | chr12:80083509 | chr12:71092129 | ENST00000283228 | - | 6 | 14 | 393_647 | 398 | 658 | Domain | Tyrosine-protein phosphatase |
| Tgene | PTPRR | chr12:80083509 | chr12:71092129 | ENST00000283228 | - | 6 | 14 | 22_227 | 398 | 658 | Topological domain | Extracellular |
| Tgene | PTPRR | chr12:80083509 | chr12:71092129 | ENST00000283228 | - | 6 | 14 | 249_657 | 398 | 658 | Topological domain | Cytoplasmic |
| Tgene | PTPRR | chr12:80083509 | chr12:71092129 | ENST00000342084 | - | 5 | 13 | 22_227 | 286 | 546 | Topological domain | Extracellular |
| Tgene | PTPRR | chr12:80083509 | chr12:71092129 | ENST00000342084 | - | 5 | 13 | 249_657 | 286 | 546 | Topological domain | Cytoplasmic |
| Tgene | PTPRR | chr12:80083509 | chr12:71092129 | ENST00000378778 | - | 3 | 11 | 22_227 | 192 | 452 | Topological domain | Extracellular |
| Tgene | PTPRR | chr12:80083509 | chr12:71092129 | ENST00000440835 | - | 2 | 10 | 22_227 | 153 | 413 | Topological domain | Extracellular |
| Tgene | PTPRR | chr12:80083509 | chr12:71092129 | ENST00000549308 | - | 3 | 11 | 22_227 | 153 | 413 | Topological domain | Extracellular |
| Tgene | PTPRR | chr12:80083509 | chr12:71092129 | ENST00000283228 | - | 6 | 14 | 228_248 | 398 | 658 | Transmembrane | Helical |
| Tgene | PTPRR | chr12:80083509 | chr12:71092129 | ENST00000342084 | - | 5 | 13 | 228_248 | 286 | 546 | Transmembrane | Helical |
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FusionGeneSequence for PAWR_PTPRR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PTPRR_ENST00000283228_chr12_71092129_-_432aa MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVN CAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAEEIPMNFVD PKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKE KNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVV >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PTPRR_ENST00000440835_chr12_71092129_-_432aa MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVN CAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAEEIPMNFVD PKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKE KNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PTPRR_ENST00000283228_chr12_71092129_-_1296nt ATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTGGAGGAGTGGAAGGCGAAACGCGAGAAGATG CGCGCCAAGCAGAACCCCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGGGGCTCTGGGCACC CCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCACCTGCCGTCCCCGGTCCCGGGGGCGTGAAC TGCGCGGTCGGCTCCGCCATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTCTGCCTCGGCTGCA CCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCGGGCCCCAGTGCCAGGAAAGGCAAGGGGCAG ATCGAGAAGAGGAAGCTGCGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGGAAATACCAATGAACTTTGTGGAT CCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCA AAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAG GGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAA AAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTAAATGAATGTGAT AACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAG ACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTC CACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCA CTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTGCACCATGCTCTGTGCCTG >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PTPRR_ENST00000440835_chr12_71092129_-_1296nt ATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTGGAGGAGTGGAAGGCGAAACGCGAGAAGATG CGCGCCAAGCAGAACCCCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGGGGCTCTGGGCACC CCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCACCTGCCGTCCCCGGTCCCGGGGGCGTGAAC TGCGCGGTCGGCTCCGCCATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTCTGCCTCGGCTGCA CCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCGGGCCCCAGTGCCAGGAAAGGCAAGGGGCAG ATCGAGAAGAGGAAGCTGCGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGGAAATACCAATGAACTTTGTGGAT CCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCA AAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAG GGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAA AAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTAAATGAATGTGAT AACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAG ACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTC CACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCA CTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTGCACCATGCTCTGTGCCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PTPRR_ENST00000283228_chr12_71092129_-_2771nt TTTTCCGCTCGTGCTTCGGCGCCGCTCGGCTCCCTTCCCGCCCCTGGCTCCCTCCCTCCCTCCCTCCCTCCTTCTTCTCCCTCCCTCCTG TCCTGGGATTGCCTGGAGCTCCGCACCGCGAGTTTGCCGCGGCACTTTCCGCGCGGCGGAAGAGCGCGCGCCAGCTTCGGCACACCTGGG AGCCGGATCCCAGCCCTACGCCTCGTCCCCTACAAGCTCCTCCAAGCCCCGCCGGCTGCTGTGGGAGCGGCGGCCGTCCCTCTCCTGGAG GTCGTCTCCTGGCATCCTCGGGGCCGCAGGAAGGAAGAGGAGGCAGCGGCCGGAGCCCTGGTGGGCGGCCTGAGGTGAGAGCCCGACCGG CCCCTTTGGGAATATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTGGAGGAGTGGAAGGCGAA ACGCGAGAAGATGCGCGCCAAGCAGAACCCCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGG GGCTCTGGGCACCCCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCACCTGCCGTCCCCGGTCC CGGGGGCGTGAACTGCGCGGTCGGCTCCGCCATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTC TGCCTCGGCTGCACCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCGGGCCCCAGTGCCAGGAA AGGCAAGGGGCAGATCGAGAAGAGGAAGCTGCGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGGAAATACCAAT GAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCCCTCAGCAGAGT GTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTT CATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATTGTTATGATCAC AAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGT AAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGGTACACCTCATG GCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGG GCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGG AGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTGCACCA TGCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAGACTGTCCAGTGAGTCATTGAAGACTTGTCAGACCATCAATCTCTTGGGGTGAT TAATCAAATTACCCACCCAAGGCTTCTAGAAGGAGCTTCCTGCAATGGAAGGAAGGAGAAGCTCTGAAGCCCATGTATGGCATGGATTGT GGAAGACTGGGCAACATATTTAAGATTTCCAGCTCCTTGTGTATATGAATGCATTTGTAAGCATCCCCCAAATTATTCTGAAGGTTTTTT GATGATGGAGGTATGATAGGTTTATCACACAGCCTAAGGCAGATTTTGTTTTGTCTGTACTGACTCTATCTGCCACACAGAATGTATGTA TGTAATATTCAGTAATAAATGTCATCAGGTGATGACTGGATGAGCTGCTGAAGACATTCGTATTATGTGTTAGATGCTTTAATGTTTGCA AAATCTGTCTTGTGAATGGACTGTCAGCTGTTAAACTGTTCCTGTTTTGAAGTGCTATTACCTTTCTCAGTTACCAGAATCTTGCTGCTA AAGTTGCAAGTGATTGATAATGGATTTTTAACAGAGAAGTCTTTGTTTTTGAAAAACAAAAATCAAAAACAGTAACTATTTTATATGGAA ATGTGTCTTGATAATATTACCTATTAAATGTGTATTTATAGTCCCTCCTATCAAACAATTACAGAGCACAATGATTGTCATTGGGTATAT ATGTATTTACTCTCTATTATTGGGCATAAAGGTGGCTTCTGCTCCAGAACTCTATCCACTGTATTTCCACATCGTGAGTCATTTTACTTT AAAAGGGAAAAACAAATTTGTAGCAACTCTGAAGTATCAAGAGTTTTAACTACTTGTCTCTCTTTTGCTAAGAAGGGATTTTTGAATATG CTATCTACCTGGAATCTCTCTCTCAACAAAAGGTATATGCCTTCAGGAATGATATAATCTGTCCCATTTTCGAGGCTCCTTATAAGGACA TTTCCATGTATGTCCTTACATTTCTGAAAGCTTTCAATCTTCAAGAGACAAAAAAAATTAAAATAACTACCCTCAGCAAACACTAGCTGT >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PTPRR_ENST00000440835_chr12_71092129_-_2780nt TTTTCCGCTCGTGCTTCGGCGCCGCTCGGCTCCCTTCCCGCCCCTGGCTCCCTCCCTCCCTCCCTCCCTCCTTCTTCTCCCTCCCTCCTG TCCTGGGATTGCCTGGAGCTCCGCACCGCGAGTTTGCCGCGGCACTTTCCGCGCGGCGGAAGAGCGCGCGCCAGCTTCGGCACACCTGGG AGCCGGATCCCAGCCCTACGCCTCGTCCCCTACAAGCTCCTCCAAGCCCCGCCGGCTGCTGTGGGAGCGGCGGCCGTCCCTCTCCTGGAG GTCGTCTCCTGGCATCCTCGGGGCCGCAGGAAGGAAGAGGAGGCAGCGGCCGGAGCCCTGGTGGGCGGCCTGAGGTGAGAGCCCGACCGG CCCCTTTGGGAATATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTGGAGGAGTGGAAGGCGAA ACGCGAGAAGATGCGCGCCAAGCAGAACCCCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGG GGCTCTGGGCACCCCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCACCTGCCGTCCCCGGTCC CGGGGGCGTGAACTGCGCGGTCGGCTCCGCCATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTC TGCCTCGGCTGCACCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCGGGCCCCAGTGCCAGGAA AGGCAAGGGGCAGATCGAGAAGAGGAAGCTGCGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGGAAATACCAAT GAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCCCTCAGCAGAGT GTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTT CATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATTGTTATGATCAC AAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGT AAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGGTACACCTCATG GCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGG GCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGG AGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTGCACCA TGCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAGACTGTCCAGTGAGTCATTGAAGACTTGTCAGACCATCAATCTCTTGGGGTGAT TAATCAAATTACCCACCCAAGGCTTCTAGAAGGAGCTTCCTGCAATGGAAGGAAGGAGAAGCTCTGAAGCCCATGTATGGCATGGATTGT GGAAGACTGGGCAACATATTTAAGATTTCCAGCTCCTTGTGTATATGAATGCATTTGTAAGCATCCCCCAAATTATTCTGAAGGTTTTTT GATGATGGAGGTATGATAGGTTTATCACACAGCCTAAGGCAGATTTTGTTTTGTCTGTACTGACTCTATCTGCCACACAGAATGTATGTA TGTAATATTCAGTAATAAATGTCATCAGGTGATGACTGGATGAGCTGCTGAAGACATTCGTATTATGTGTTAGATGCTTTAATGTTTGCA AAATCTGTCTTGTGAATGGACTGTCAGCTGTTAAACTGTTCCTGTTTTGAAGTGCTATTACCTTTCTCAGTTACCAGAATCTTGCTGCTA AAGTTGCAAGTGATTGATAATGGATTTTTAACAGAGAAGTCTTTGTTTTTGAAAAACAAAAATCAAAAACAGTAACTATTTTATATGGAA ATGTGTCTTGATAATATTACCTATTAAATGTGTATTTATAGTCCCTCCTATCAAACAATTACAGAGCACAATGATTGTCATTGGGTATAT ATGTATTTACTCTCTATTATTGGGCATAAAGGTGGCTTCTGCTCCAGAACTCTATCCACTGTATTTCCACATCGTGAGTCATTTTACTTT AAAAGGGAAAAACAAATTTGTAGCAACTCTGAAGTATCAAGAGTTTTAACTACTTGTCTCTCTTTTGCTAAGAAGGGATTTTTGAATATG CTATCTACCTGGAATCTCTCTCTCAACAAAAGGTATATGCCTTCAGGAATGATATAATCTGTCCCATTTTCGAGGCTCCTTATAAGGACA TTTCCATGTATGTCCTTACATTTCTGAAAGCTTTCAATCTTCAAGAGACAAAAAAAATTAAAATAACTACCCTCAGCAAACACTAGCTGT |
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FusionGenePPI for PAWR_PTPRR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PAWR | THAP1, SLC5A7, SLC5A1, AATF, DAPK3, PRKCZ, WT1, HSPA5, FBXO25, SPSB1, SPSB2, SPSB4, SQSTM1, DRD2, PAN2, APEH, CAND1, CARS, FAM129B, H3F3A, IDE, JMJD6, ATP6V1C1, SHMT1, PPM1G, SHMT2, SNX2, SNX6, STAT1, VPS29, FBXO45, CCDC8, EED, LUZP4, DDX39A, CEP290, CEP128, MYH9, HMG20A, IKBIP, SCOC, SLC25A41, G3BP1, HDAC6 | PTPRR | MAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PAWR_PTPRR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAWR_PTPRR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PAWR | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | PAWR | C0041696 | Unipolar Depression | 2 | PSYGENET |
| Hgene | PAWR | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
| Hgene | PAWR | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | PAWR | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | PAWR | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Hgene | PAWR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | PAWR | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | PAWR | C0525045 | Mood Disorders | 1 | PSYGENET |
| Hgene | PAWR | C0600427 | Cocaine Dependence | 1 | PSYGENET |
| Tgene | PTPRR | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | PTPRR | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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