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Fusion gene ID: 26066 |
FusionGeneSummary for PAWR_PPP1R12A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PAWR_PPP1R12A | Fusion gene ID: 26066 | Hgene | Tgene | Gene symbol | PAWR | PPP1R12A | Gene ID | 5074 | 4659 |
| Gene name | pro-apoptotic WT1 regulator | protein phosphatase 1 regulatory subunit 12A | |
| Synonyms | PAR4|Par-4 | M130|MBS|MYPT1 | |
| Cytomap | 12q21.2 | 12q21.2-q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PRKC apoptosis WT1 regulator proteinPRKC, apoptosis, WT1, regulatorWT1-interacting proteinprostate apoptosis response protein 4prostate apoptosis response protein PAR-4prostate apoptosis response-4transcriptional repressor PAR4 | protein phosphatase 1 regulatory subunit 12Amyosin binding subunitmyosin phosphatase, target subunit 1myosin phosphatase-targeting subunit 1protein phosphatase 1, regulatory (inhibitor) subunit 12Aprotein phosphatase myosin-binding subunit | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96IZ0 | O14974 | |
| Ensembl transtripts involved in fusion gene | ENST00000328827, ENST00000547571, | ENST00000261207, ENST00000450142, ENST00000437004, ENST00000546369, ENST00000550107, | |
| Fusion gene scores | * DoF score | 4 X 1 X 3=12 | 5 X 4 X 4=80 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PAWR [Title/Abstract] AND PPP1R12A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PPP1R12A | GO:0030155 | regulation of cell adhesion | 20354225 |
| Tgene | PPP1R12A | GO:0035507 | regulation of myosin-light-chain-phosphatase activity | 20354225 |
| Tgene | PPP1R12A | GO:0043086 | negative regulation of catalytic activity | 19245366 |
| Tgene | PPP1R12A | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19245366 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-JY-A938-01A | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000328827 | ENST00000261207 | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
| In-frame | ENST00000328827 | ENST00000450142 | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
| In-frame | ENST00000328827 | ENST00000437004 | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
| 5CDS-5UTR | ENST00000328827 | ENST00000546369 | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
| 5CDS-5UTR | ENST00000328827 | ENST00000550107 | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
| 5UTR-3CDS | ENST00000547571 | ENST00000261207 | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
| 5UTR-3CDS | ENST00000547571 | ENST00000450142 | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
| 5UTR-3CDS | ENST00000547571 | ENST00000437004 | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
| 5UTR-5UTR | ENST00000547571 | ENST00000546369 | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
| 5UTR-5UTR | ENST00000547571 | ENST00000550107 | PAWR | chr12 | 80083509 | - | PPP1R12A | chr12 | 80266718 | - |
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FusionProtFeatures for PAWR_PPP1R12A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PAWR | PPP1R12A |
| Pro-apoptopic protein capable of selectively inducingapoptosis in cancer cells, sensitizing the cells to diverseapoptotic stimuli and causing regression of tumors in animalmodels. Induces apoptosis in certain cancer cells by activation ofthe Fas prodeath pathway and coparallel inhibition of NF-kappa-Btranscriptional activity. Inhibits the transcriptional activationand augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction withWT1. Seems also to be a transcriptional repressor by itself. Maybe directly involved in regulating the amyloid precursor protein(APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}. | Key regulator of protein phosphatase 1C (PPP1C).Mediates binding to myosin. As part of the PPP1C complex, involvedin dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.{ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366,ECO:0000269|PubMed:20354225}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PAWR | chr12:80083509 | chr12:80266718 | ENST00000328827 | - | 2 | 7 | 49_120 | 172 | 341 | Compositional bias | Note=Ala-rich |
| Hgene | PAWR | chr12:80083509 | chr12:80266718 | ENST00000328827 | - | 2 | 7 | 145_161 | 172 | 341 | Motif | Nuclear localization signal |
| Hgene | PAWR | chr12:80083509 | chr12:80266718 | ENST00000328827 | - | 2 | 7 | 68_72 | 172 | 341 | Motif | B30.2/SPRY domain-binding motif |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 519_660 | 79 | 1031 | Compositional bias | Note=Ser/Thr-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 721_753 | 79 | 1031 | Compositional bias | Note=Glu/Lys-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 773_795 | 79 | 1031 | Compositional bias | Note=Ser-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 519_660 | 79 | 996 | Compositional bias | Note=Ser/Thr-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 721_753 | 79 | 996 | Compositional bias | Note=Glu/Lys-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 773_795 | 79 | 996 | Compositional bias | Note=Ser-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 519_660 | 79 | 1031 | Compositional bias | Note=Ser/Thr-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 721_753 | 79 | 1031 | Compositional bias | Note=Glu/Lys-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 773_795 | 79 | 1031 | Compositional bias | Note=Ser-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 519_660 | -8 | 944 | Compositional bias | Note=Ser/Thr-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 721_753 | -8 | 944 | Compositional bias | Note=Glu/Lys-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 773_795 | -8 | 944 | Compositional bias | Note=Ser-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 519_660 | 79 | 975 | Compositional bias | Note=Ser/Thr-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 721_753 | 79 | 975 | Compositional bias | Note=Glu/Lys-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 773_795 | 79 | 975 | Compositional bias | Note=Ser-rich |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 35_38 | -8 | 944 | Motif | Note=KVKF motif |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 105_134 | 79 | 1031 | Repeat | Note=ANK 3 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 138_164 | 79 | 1031 | Repeat | Note=ANK 4 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 198_227 | 79 | 1031 | Repeat | Note=ANK 5 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 231_260 | 79 | 1031 | Repeat | Note=ANK 6 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 105_134 | 79 | 996 | Repeat | Note=ANK 3 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 138_164 | 79 | 996 | Repeat | Note=ANK 4 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 198_227 | 79 | 996 | Repeat | Note=ANK 5 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 231_260 | 79 | 996 | Repeat | Note=ANK 6 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 105_134 | 79 | 1031 | Repeat | Note=ANK 3 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 138_164 | 79 | 1031 | Repeat | Note=ANK 4 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 198_227 | 79 | 1031 | Repeat | Note=ANK 5 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 231_260 | 79 | 1031 | Repeat | Note=ANK 6 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 105_134 | -8 | 944 | Repeat | Note=ANK 3 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 138_164 | -8 | 944 | Repeat | Note=ANK 4 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 198_227 | -8 | 944 | Repeat | Note=ANK 5 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 231_260 | -8 | 944 | Repeat | Note=ANK 6 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 39_68 | -8 | 944 | Repeat | Note=ANK 1 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 72_101 | -8 | 944 | Repeat | Note=ANK 2 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 105_134 | 79 | 975 | Repeat | Note=ANK 3 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 138_164 | 79 | 975 | Repeat | Note=ANK 4 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 198_227 | 79 | 975 | Repeat | Note=ANK 5 |
| Tgene | >PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 231_260 | 79 | 975 | Repeat | Note=ANK 6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PAWR | chr12:80083509 | chr12:80266718 | ENST00000328827 | - | 2 | 7 | 186_206 | 172 | 341 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PAWR | chr12:80083509 | chr12:80266718 | ENST00000328827 | - | 2 | 7 | 145_203 | 172 | 341 | Region | Note=Selective for apoptosis induction in cancer cells (SAC) |
| Hgene | >PAWR | chr12:80083509 | chr12:80266718 | ENST00000328827 | - | 2 | 7 | 300_340 | 172 | 341 | Region | Note=Leucine-zipper |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 35_38 | 79 | 1031 | Motif | Note=KVKF motif |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 35_38 | 79 | 996 | Motif | Note=KVKF motif |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 35_38 | 79 | 1031 | Motif | Note=KVKF motif |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 35_38 | 79 | 975 | Motif | Note=KVKF motif |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 39_68 | 79 | 1031 | Repeat | Note=ANK 1 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 72_101 | 79 | 1031 | Repeat | Note=ANK 2 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 39_68 | 79 | 996 | Repeat | Note=ANK 1 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 72_101 | 79 | 996 | Repeat | Note=ANK 2 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 39_68 | 79 | 1031 | Repeat | Note=ANK 1 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 72_101 | 79 | 1031 | Repeat | Note=ANK 2 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 39_68 | 79 | 975 | Repeat | Note=ANK 1 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 72_101 | 79 | 975 | Repeat | Note=ANK 2 |
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FusionGeneSequence for PAWR_PPP1R12A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PPP1R12A_ENST00000261207_chr12_80266718_-_1124aa MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVN CAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAEACIDDNVD MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIM LRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSS EEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDL KKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRST RTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSA GDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PPP1R12A_ENST00000450142_chr12_80266718_-_1124aa MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVN CAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAEACIDDNVD MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIM LRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSS EEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDL KKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRST RTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSA GDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRER >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PPP1R12A_ENST00000437004_chr12_80266718_-_1089aa MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGGGSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVN CAVGSAMLTRAAPGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAEACIDDNVD MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIM LRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCSS EEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTSSSYTRRKWEDDL KKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRST RTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGIT SAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSA GDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PPP1R12A_ENST00000261207_chr12_80266718_-_3372nt ATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTGGAGGAGTGGAAGGCGAAACGCGAGAAGATG CGCGCCAAGCAGAACCCCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGGGGCTCTGGGCACC CCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCACCTGCCGTCCCCGGTCCCGGGGGCGTGAAC TGCGCGGTCGGCTCCGCCATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTCTGCCTCGGCTGCA CCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCGGGCCCCAGTGCCAGGAAAGGCAAGGGGCAG ATCGAGAAGAGGAAGCTGCGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGGCTTGCATTGATGACAATGTTGAT ATGGTGAAGTTTCTGGTAGAAAATGGAGCAAATATTAATCAACCTGATAATGAAGGCTGGATACCACTACATGCAGCAGCTTCCTGTGGA TATCTTGATATTGCAGAGTTTTTGATTGGTCAAGGAGCACATGTAGGGGCTGTCAACAGTGAAGGAGATACACCTTTAGATATTGCGGAG GAGGAGGCAATGGAAGAGCTACTTCAAAATGAAGTTAATCGGCAAGGGGTTGATATAGAAGCAGCTCGAAAGGAAGAAGAACGGATCATG CTTAGAGATGCCAGGCAGTGGCTAAATAGTGGTCATATAAATGATGTCCGGCATGCAAAATCTGGAGGTACAGCACTTCACGTTGCAGCT GCTAAAGGCTATACGGAAGTTTTAAAACTTTTAATACAGGCAGGCTATGATGTTAATATTAAAGACTATGATGGCTGGACACCTCTTCAT GCTGCAGCTCATTGGGGTAAAGAAGAAGCATGTCGAATTTTAGTGGACAATCTGTGTGATATGGAGATGGTCAACAAAGTGGGCCAAACA GCCTTTGATGTAGCAGATGAAGACATTTTAGGATATTTAGAAGAGTTGCAAAAGAAACAAAATCTGCTCCATAGTGAAAAACGGGACAAG AAATCTCCACTAATTGAATCAACAGCAAATATGGACAATAATCAGTCACAGAAGACCTTTAAAAACAAAGAGACGTTGATTATTGAACCA GAGAAAAATGCATCCCGTATTGAATCTCTGGAACAAGAAAAGGTTGATGAAGAAGAAGAAGGAAAGAAGGATGAGTCTAGCTGCTCTAGT GAAGAAGATGAGGAAGATGACTCGGAATCAGAAGCTGAAACAGATAAGACAAAACCCCTGGCTTCTGTAACTAATGCCAACACTTCTAGT ACACAAGCAGCTCCTGTAGCTGTTACAACACCTACTGTGTCATCAGGTCAAGCAACACCTACATCACCTATTAAAAAGTTTCCAACCACA GCTACAAAAATTTCTCCCAAAGAAGAAGAGAGAAAAGATGAGTCTCCTGCAACTTGGAGGTTAGGACTTAGAAAGACGGGCAGCTATGGT GCACTTGCTGAAATCACAGCATCTAAAGAGGGTCAGAAAGAAAAAGATACTGCAGGTGTTACACGTTCAGCTTCAAGTCCCAGACTTTCC TCCTCTTTGGATAATAAAGAAAAGGAGAAAGATAGTAAAGGAACTAGGCTTGCATATGTTGCACCTACAATACCAAGACGACTAGCCAGT ACATCTGACATTGAAGAGAAAGAAAACAGAGATTCTTCAAGTTTGCGAACAAGTAGTTCATATACAAGGAGAAAATGGGAAGATGATCTT AAAAAAAATAGCTCAGTTAATGAAGGATCAACGTATCATAAAAGTTGCTCCTTTGGTAGAAGACAAGATGATTTGATTAGTTCTAGTGTT CCAAGCACCACATCAACACCAACAGTTACCTCTGCAGCTGGGCTTCAGAAAAGCCTGCTTTCCAGCACAAGCACTACTACAAAGATTACA ACGGGTTCTTCCTCAGCAGGCACACAAAGCAGTACCTCAAATCGTTTGTGGGCTGAGGATAGTACTGAGAAAGAAAAGGACAGTGTTCCT ACGGCAGTGACCATTCCTGTTGCTCCAACTGTTGTAAATGCTGCAGCTTCTACCACAACCCTGACTACAACTACTGCTGGCACTGTCTCC TCCACAACAGAGGTCAGGGAGAGACGCAGATCATACCTCACTCCTGTTAGGGATGAAGAGTCTGAATCCCAAAGAAAAGCAAGATCTAGA CAAGCAAGACAATCTAGAAGATCAACACAGGGAGTGACATTAACTGATCTTCAAGAAGCTGAGAAAACAATAGGAAGAAGTCGTTCTACC CGAACCAGAGAACAAGAAAATGAAGAAAAAGAAAAAGAGGAAAAAGAGAAACAAGATAAAGAGAAACAAGAAGAAAAGAAGGAGTCAGAA ACATCTAGAGAAGATGAATATAAACAAAAGTACTCCAGAACGTATGATGAGACTTACCAGCGTTATAGGCCAGTATCAACTTCAAGTTCA ACCACTCCATCCTCTTCACTTTCTACTATGAGCAGTTCACTGTATGCTTCAAGTCAACTAAACAGGCCAAATAGTCTTGTAGGCATAACT TCTGCTTACTCCAGAGGAATAACAAAAGAAAATGAAAGAGAGGGAGAAAAAAGAGAAGAGGAGAAAGAAGGAGAAGATAAATCACAACCT AAATCAATCAGAGAACGACGACGACCAAGAGAGAAAAGAAGATCTACAGGAGTTTCATTTTGGACACAAGATAGTGATGAAAATGAACAA GAACAACAATCAGACACAGAAGAGGGATCCAATAAGAAAGAAACTCAGACGGATTCCATTTCTAGATATGAAACCAGTTCTACATCAGCT GGTGATCGATATGATTCCTTGCTGGGTCGCTCTGGATCATACAGTTACTTAGAAGAAAGAAAACCTTACAGCAGCAGGCTAGAAAAGGAT GACTCAACTGACTTTAAAAAGCTTTATGAACAAATTCTAGCTGAAAATGAAAAGCTGAAGGCACAGCTACATGATACAAATATGGAACTA ACAGATCTTAAATTACAGTTGGAAAAGGCCACCCAGAGACAAGAAAGATTTGCTGATAGATCACTGTTGGAAATGGAAAAAAGGGAACGA AGAGCTCTAGAAAGAAGAATATCTGAAATGGAAGAAGAGCTCAAAATGTTACCAGACCTAAAAGCAGACAACCAGAGGCTAAAGGATGAA >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PPP1R12A_ENST00000450142_chr12_80266718_-_3372nt ATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTGGAGGAGTGGAAGGCGAAACGCGAGAAGATG CGCGCCAAGCAGAACCCCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGGGGCTCTGGGCACC CCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCACCTGCCGTCCCCGGTCCCGGGGGCGTGAAC TGCGCGGTCGGCTCCGCCATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTCTGCCTCGGCTGCA CCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCGGGCCCCAGTGCCAGGAAAGGCAAGGGGCAG ATCGAGAAGAGGAAGCTGCGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGGCTTGCATTGATGACAATGTTGAT ATGGTGAAGTTTCTGGTAGAAAATGGAGCAAATATTAATCAACCTGATAATGAAGGCTGGATACCACTACATGCAGCAGCTTCCTGTGGA TATCTTGATATTGCAGAGTTTTTGATTGGTCAAGGAGCACATGTAGGGGCTGTCAACAGTGAAGGAGATACACCTTTAGATATTGCGGAG GAGGAGGCAATGGAAGAGCTACTTCAAAATGAAGTTAATCGGCAAGGGGTTGATATAGAAGCAGCTCGAAAGGAAGAAGAACGGATCATG CTTAGAGATGCCAGGCAGTGGCTAAATAGTGGTCATATAAATGATGTCCGGCATGCAAAATCTGGAGGTACAGCACTTCACGTTGCAGCT GCTAAAGGCTATACGGAAGTTTTAAAACTTTTAATACAGGCAGGCTATGATGTTAATATTAAAGACTATGATGGCTGGACACCTCTTCAT GCTGCAGCTCATTGGGGTAAAGAAGAAGCATGTCGAATTTTAGTGGACAATCTGTGTGATATGGAGATGGTCAACAAAGTGGGCCAAACA GCCTTTGATGTAGCAGATGAAGACATTTTAGGATATTTAGAAGAGTTGCAAAAGAAACAAAATCTGCTCCATAGTGAAAAACGGGACAAG AAATCTCCACTAATTGAATCAACAGCAAATATGGACAATAATCAGTCACAGAAGACCTTTAAAAACAAAGAGACGTTGATTATTGAACCA GAGAAAAATGCATCCCGTATTGAATCTCTGGAACAAGAAAAGGTTGATGAAGAAGAAGAAGGAAAGAAGGATGAGTCTAGCTGCTCTAGT GAAGAAGATGAGGAAGATGACTCGGAATCAGAAGCTGAAACAGATAAGACAAAACCCCTGGCTTCTGTAACTAATGCCAACACTTCTAGT ACACAAGCAGCTCCTGTAGCTGTTACAACACCTACTGTGTCATCAGGTCAAGCAACACCTACATCACCTATTAAAAAGTTTCCAACCACA GCTACAAAAATTTCTCCCAAAGAAGAAGAGAGAAAAGATGAGTCTCCTGCAACTTGGAGGTTAGGACTTAGAAAGACGGGCAGCTATGGT GCACTTGCTGAAATCACAGCATCTAAAGAGGGTCAGAAAGAAAAAGATACTGCAGGTGTTACACGTTCAGCTTCAAGTCCCAGACTTTCC TCCTCTTTGGATAATAAAGAAAAGGAGAAAGATAGTAAAGGAACTAGGCTTGCATATGTTGCACCTACAATACCAAGACGACTAGCCAGT ACATCTGACATTGAAGAGAAAGAAAACAGAGATTCTTCAAGTTTGCGAACAAGTAGTTCATATACAAGGAGAAAATGGGAAGATGATCTT AAAAAAAATAGCTCAGTTAATGAAGGATCAACGTATCATAAAAGTTGCTCCTTTGGTAGAAGACAAGATGATTTGATTAGTTCTAGTGTT CCAAGCACCACATCAACACCAACAGTTACCTCTGCAGCTGGGCTTCAGAAAAGCCTGCTTTCCAGCACAAGCACTACTACAAAGATTACA ACGGGTTCTTCCTCAGCAGGCACACAAAGCAGTACCTCAAATCGTTTGTGGGCTGAGGATAGTACTGAGAAAGAAAAGGACAGTGTTCCT ACGGCAGTGACCATTCCTGTTGCTCCAACTGTTGTAAATGCTGCAGCTTCTACCACAACCCTGACTACAACTACTGCTGGCACTGTCTCC TCCACAACAGAGGTCAGGGAGAGACGCAGATCATACCTCACTCCTGTTAGGGATGAAGAGTCTGAATCCCAAAGAAAAGCAAGATCTAGA CAAGCAAGACAATCTAGAAGATCAACACAGGGAGTGACATTAACTGATCTTCAAGAAGCTGAGAAAACAATAGGAAGAAGTCGTTCTACC CGAACCAGAGAACAAGAAAATGAAGAAAAAGAAAAAGAGGAAAAAGAGAAACAAGATAAAGAGAAACAAGAAGAAAAGAAGGAGTCAGAA ACATCTAGAGAAGATGAATATAAACAAAAGTACTCCAGAACGTATGATGAGACTTACCAGCGTTATAGGCCAGTATCAACTTCAAGTTCA ACCACTCCATCCTCTTCACTTTCTACTATGAGCAGTTCACTGTATGCTTCAAGTCAACTAAACAGGCCAAATAGTCTTGTAGGCATAACT TCTGCTTACTCCAGAGGAATAACAAAAGAAAATGAAAGAGAGGGAGAAAAAAGAGAAGAGGAGAAAGAAGGAGAAGATAAATCACAACCT AAATCAATCAGAGAACGACGACGACCAAGAGAGAAAAGAAGATCTACAGGAGTTTCATTTTGGACACAAGATAGTGATGAAAATGAACAA GAACAACAATCAGACACAGAAGAGGGATCCAATAAGAAAGAAACTCAGACGGATTCCATTTCTAGATATGAAACCAGTTCTACATCAGCT GGTGATCGATATGATTCCTTGCTGGGTCGCTCTGGATCATACAGTTACTTAGAAGAAAGAAAACCTTACAGCAGCAGGCTAGAAAAGGAT GACTCAACTGACTTTAAAAAGCTTTATGAACAAATTCTAGCTGAAAATGAAAAGCTGAAGGCACAGCTACATGATACAAATATGGAACTA ACAGATCTTAAATTACAGTTGGAAAAGGCCACCCAGAGACAAGAAAGATTTGCTGATAGATCACTGTTGGAAATGGAAAAAAGGGAACGA AGAGCTCTAGAAAGAAGAATATCTGAAATGGAAGAAGAGCTCAAAATGTTACCAGACCTAAAAGCAGACAACCAGAGGCTAAAGGATGAA >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PPP1R12A_ENST00000437004_chr12_80266718_-_3267nt ATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTGGAGGAGTGGAAGGCGAAACGCGAGAAGATG CGCGCCAAGCAGAACCCCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGGGGCTCTGGGCACC CCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCACCTGCCGTCCCCGGTCCCGGGGGCGTGAAC TGCGCGGTCGGCTCCGCCATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTCTGCCTCGGCTGCA CCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCGGGCCCCAGTGCCAGGAAAGGCAAGGGGCAG ATCGAGAAGAGGAAGCTGCGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGGCTTGCATTGATGACAATGTTGAT ATGGTGAAGTTTCTGGTAGAAAATGGAGCAAATATTAATCAACCTGATAATGAAGGCTGGATACCACTACATGCAGCAGCTTCCTGTGGA TATCTTGATATTGCAGAGTTTTTGATTGGTCAAGGAGCACATGTAGGGGCTGTCAACAGTGAAGGAGATACACCTTTAGATATTGCGGAG GAGGAGGCAATGGAAGAGCTACTTCAAAATGAAGTTAATCGGCAAGGGGTTGATATAGAAGCAGCTCGAAAGGAAGAAGAACGGATCATG CTTAGAGATGCCAGGCAGTGGCTAAATAGTGGTCATATAAATGATGTCCGGCATGCAAAATCTGGAGGTACAGCACTTCACGTTGCAGCT GCTAAAGGCTATACGGAAGTTTTAAAACTTTTAATACAGGCAGGCTATGATGTTAATATTAAAGACTATGATGGCTGGACACCTCTTCAT GCTGCAGCTCATTGGGGTAAAGAAGAAGCATGTCGAATTTTAGTGGACAATCTGTGTGATATGGAGATGGTCAACAAAGTGGGCCAAACA GCCTTTGATGTAGCAGATGAAGACATTTTAGGATATTTAGAAGAGTTGCAAAAGAAACAAAATCTGCTCCATAGTGAAAAACGGGACAAG AAATCTCCACTAATTGAATCAACAGCAAATATGGACAATAATCAGTCACAGAAGACCTTTAAAAACAAAGAGACGTTGATTATTGAACCA GAGAAAAATGCATCCCGTATTGAATCTCTGGAACAAGAAAAGGTTGATGAAGAAGAAGAAGGAAAGAAGGATGAGTCTAGCTGCTCTAGT GAAGAAGATGAGGAAGATGACTCGGAATCAGAAGCTGAAACAGATAAGACAAAACCCCTGGCTTCTGTAACTAATGCCAACACTTCTAGT ACACAAGCAGCTCCTGTAGCTGTTACAACACCTACTGTGTCATCAGGTCAAGCAACACCTACATCACCTATTAAAAAGTTTCCAACCACA GCTACAAAAATTTCTCCCAAAGAAGAAGAGAGAAAAGATGAGTCTCCTGCAACTTGGAGGTTAGGACTTAGAAAGACGGGCAGCTATGGT GCACTTGCTGAAATCACAGCATCTAAAGAGGGTCAGAAAGAAAAAGATACTGCAGGTGTTACACGTTCAGCTTCAAGTCCCAGACTTTCC TCCTCTTTGGATAATAAAGAAAAGGAGAAAGATAGTAAAGGAACTAGGCTTGCATATGTTGCACCTACAATACCAAGACGACTAGCCAGT ACATCTGACATTGAAGAGAAAGAAAACAGAGATTCTTCAAGTTTGCGAACAAGTAGTTCATATACAAGGAGAAAATGGGAAGATGATCTT AAAAAAAATAGCTCAGTTAATGAAGGATCAACGTATCATAAAAGTTGCTCCTTTGGTAGAAGACAAGATGATTTGATTAGTTCTAGTGTT CCAAGCACCACATCAACACCAACAGTTACCTCTGCAGCTGGGCTTCAGAAAAGCCTGCTTTCCAGCACAAGCACTACTACAAAGATTACA ACGGGTTCTTCCTCAGCAGGCACACAAAGCAGTACCTCAAATCGTTTGTGGGCTGAGGATAGTACTGAGAAAGAAAAGGACAGTGTTCCT ACGGCAGTGACCATTCCTGTTGCTCCAACTGTTGTAAATGCTGCAGCTTCTACCACAACCCTGACTACAACTACTGCTGGCACTGTCTCC TCCACAACAGAGGTCAGGGAGAGACGCAGATCATACCTCACTCCTGTTAGGGATGAAGAGTCTGAATCCCAAAGAAAAGCAAGATCTAGA CAAGCAAGACAATCTAGAAGATCAACACAGGGAGTGACATTAACTGATCTTCAAGAAGCTGAGAAAACAATAGGAAGAAGTCGTTCTACC CGAACCAGAGAACAAGAAAATGAAGAAAAAGAAAAAGAGGAAAAAGAGAAACAAGATAAAGAGAAACAAGAAGAAAAGAAGGAGTCAGAA ACATCTAGAGAAGATGAATATAAACAAAAGTACTCCAGAACGTATGATGAGACTTACCAGCGTTATAGGCCAGTATCAACTTCAAGTTCA ACCACTCCATCCTCTTCACTTTCTACTATGAGCAGTTCACTGTATGCTTCAAGTCAACTAAACAGGCCAAATAGTCTTGTAGGCATAACT TCTGCTTACTCCAGAGGAATAACAAAAGAAAATGAAAGAGAGGGAGAAAAAAGAGAAGAGGAGAAAGAAGGAGAAGATAAATCACAACCT AAATCAATCAGAGAACGACGACGACCAAGAGAGAAAAGAAGATCTACAGGAGTTTCATTTTGGACACAAGATAGTGATGAAAATGAACAA GAACAACAATCAGACACAGAAGAGGGATCCAATAAGAAAGAAACTCAGACGGATTCCATTTCTAGATATGAAACCAGTTCTACATCAGCT GGTGATCGATATGATTCCTTGCTGGGTCGCTCTGGATCATACAGTTACTTAGAAGAAAGAAAACCTTACAGCAGCAGGCTAGAAAAGGAT GACTCAACTGACTTTAAAAAGAGACAAGAAAGATTTGCTGATAGATCACTGTTGGAAATGGAAAAAAGGGAACGAAGAGCTCTAGAAAGA AGAATATCTGAAATGGAAGAAGAGCTCAAAATGTTACCAGACCTAAAAGCAGACAACCAGAGGCTAAAGGATGAAAATGGGGCCTTGATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PPP1R12A_ENST00000261207_chr12_80266718_-_6111nt TTTTCCGCTCGTGCTTCGGCGCCGCTCGGCTCCCTTCCCGCCCCTGGCTCCCTCCCTCCCTCCCTCCCTCCTTCTTCTCCCTCCCTCCTG TCCTGGGATTGCCTGGAGCTCCGCACCGCGAGTTTGCCGCGGCACTTTCCGCGCGGCGGAAGAGCGCGCGCCAGCTTCGGCACACCTGGG AGCCGGATCCCAGCCCTACGCCTCGTCCCCTACAAGCTCCTCCAAGCCCCGCCGGCTGCTGTGGGAGCGGCGGCCGTCCCTCTCCTGGAG GTCGTCTCCTGGCATCCTCGGGGCCGCAGGAAGGAAGAGGAGGCAGCGGCCGGAGCCCTGGTGGGCGGCCTGAGGTGAGAGCCCGACCGG CCCCTTTGGGAATATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTGGAGGAGTGGAAGGCGAA ACGCGAGAAGATGCGCGCCAAGCAGAACCCCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGG GGCTCTGGGCACCCCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCACCTGCCGTCCCCGGTCC CGGGGGCGTGAACTGCGCGGTCGGCTCCGCCATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTC TGCCTCGGCTGCACCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCGGGCCCCAGTGCCAGGAA AGGCAAGGGGCAGATCGAGAAGAGGAAGCTGCGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGGCTTGCATTGA TGACAATGTTGATATGGTGAAGTTTCTGGTAGAAAATGGAGCAAATATTAATCAACCTGATAATGAAGGCTGGATACCACTACATGCAGC AGCTTCCTGTGGATATCTTGATATTGCAGAGTTTTTGATTGGTCAAGGAGCACATGTAGGGGCTGTCAACAGTGAAGGAGATACACCTTT AGATATTGCGGAGGAGGAGGCAATGGAAGAGCTACTTCAAAATGAAGTTAATCGGCAAGGGGTTGATATAGAAGCAGCTCGAAAGGAAGA AGAACGGATCATGCTTAGAGATGCCAGGCAGTGGCTAAATAGTGGTCATATAAATGATGTCCGGCATGCAAAATCTGGAGGTACAGCACT TCACGTTGCAGCTGCTAAAGGCTATACGGAAGTTTTAAAACTTTTAATACAGGCAGGCTATGATGTTAATATTAAAGACTATGATGGCTG GACACCTCTTCATGCTGCAGCTCATTGGGGTAAAGAAGAAGCATGTCGAATTTTAGTGGACAATCTGTGTGATATGGAGATGGTCAACAA AGTGGGCCAAACAGCCTTTGATGTAGCAGATGAAGACATTTTAGGATATTTAGAAGAGTTGCAAAAGAAACAAAATCTGCTCCATAGTGA AAAACGGGACAAGAAATCTCCACTAATTGAATCAACAGCAAATATGGACAATAATCAGTCACAGAAGACCTTTAAAAACAAAGAGACGTT GATTATTGAACCAGAGAAAAATGCATCCCGTATTGAATCTCTGGAACAAGAAAAGGTTGATGAAGAAGAAGAAGGAAAGAAGGATGAGTC TAGCTGCTCTAGTGAAGAAGATGAGGAAGATGACTCGGAATCAGAAGCTGAAACAGATAAGACAAAACCCCTGGCTTCTGTAACTAATGC CAACACTTCTAGTACACAAGCAGCTCCTGTAGCTGTTACAACACCTACTGTGTCATCAGGTCAAGCAACACCTACATCACCTATTAAAAA GTTTCCAACCACAGCTACAAAAATTTCTCCCAAAGAAGAAGAGAGAAAAGATGAGTCTCCTGCAACTTGGAGGTTAGGACTTAGAAAGAC GGGCAGCTATGGTGCACTTGCTGAAATCACAGCATCTAAAGAGGGTCAGAAAGAAAAAGATACTGCAGGTGTTACACGTTCAGCTTCAAG TCCCAGACTTTCCTCCTCTTTGGATAATAAAGAAAAGGAGAAAGATAGTAAAGGAACTAGGCTTGCATATGTTGCACCTACAATACCAAG ACGACTAGCCAGTACATCTGACATTGAAGAGAAAGAAAACAGAGATTCTTCAAGTTTGCGAACAAGTAGTTCATATACAAGGAGAAAATG GGAAGATGATCTTAAAAAAAATAGCTCAGTTAATGAAGGATCAACGTATCATAAAAGTTGCTCCTTTGGTAGAAGACAAGATGATTTGAT TAGTTCTAGTGTTCCAAGCACCACATCAACACCAACAGTTACCTCTGCAGCTGGGCTTCAGAAAAGCCTGCTTTCCAGCACAAGCACTAC TACAAAGATTACAACGGGTTCTTCCTCAGCAGGCACACAAAGCAGTACCTCAAATCGTTTGTGGGCTGAGGATAGTACTGAGAAAGAAAA GGACAGTGTTCCTACGGCAGTGACCATTCCTGTTGCTCCAACTGTTGTAAATGCTGCAGCTTCTACCACAACCCTGACTACAACTACTGC TGGCACTGTCTCCTCCACAACAGAGGTCAGGGAGAGACGCAGATCATACCTCACTCCTGTTAGGGATGAAGAGTCTGAATCCCAAAGAAA AGCAAGATCTAGACAAGCAAGACAATCTAGAAGATCAACACAGGGAGTGACATTAACTGATCTTCAAGAAGCTGAGAAAACAATAGGAAG AAGTCGTTCTACCCGAACCAGAGAACAAGAAAATGAAGAAAAAGAAAAAGAGGAAAAAGAGAAACAAGATAAAGAGAAACAAGAAGAAAA GAAGGAGTCAGAAACATCTAGAGAAGATGAATATAAACAAAAGTACTCCAGAACGTATGATGAGACTTACCAGCGTTATAGGCCAGTATC AACTTCAAGTTCAACCACTCCATCCTCTTCACTTTCTACTATGAGCAGTTCACTGTATGCTTCAAGTCAACTAAACAGGCCAAATAGTCT TGTAGGCATAACTTCTGCTTACTCCAGAGGAATAACAAAAGAAAATGAAAGAGAGGGAGAAAAAAGAGAAGAGGAGAAAGAAGGAGAAGA TAAATCACAACCTAAATCAATCAGAGAACGACGACGACCAAGAGAGAAAAGAAGATCTACAGGAGTTTCATTTTGGACACAAGATAGTGA TGAAAATGAACAAGAACAACAATCAGACACAGAAGAGGGATCCAATAAGAAAGAAACTCAGACGGATTCCATTTCTAGATATGAAACCAG TTCTACATCAGCTGGTGATCGATATGATTCCTTGCTGGGTCGCTCTGGATCATACAGTTACTTAGAAGAAAGAAAACCTTACAGCAGCAG GCTAGAAAAGGATGACTCAACTGACTTTAAAAAGCTTTATGAACAAATTCTAGCTGAAAATGAAAAGCTGAAGGCACAGCTACATGATAC AAATATGGAACTAACAGATCTTAAATTACAGTTGGAAAAGGCCACCCAGAGACAAGAAAGATTTGCTGATAGATCACTGTTGGAAATGGA AAAAAGGGAACGAAGAGCTCTAGAAAGAAGAATATCTGAAATGGAAGAAGAGCTCAAAATGTTACCAGACCTAAAAGCAGACAACCAGAG GCTAAAGGATGAAAATGGGGCCTTGATCAGAGTTATAAGCAAACTTTCCAAATAAAAAAAAAAAAAGCAGCAAGTAATGGAATTGCACAT ATTAGTAACCCAGTGGACCATAATTGGCAGTCACTGGAAGTCTGGGAAGAATCCTTGGAGACTGTCATTTTCGGATATCCTGCCAAATGC CCTCTTATCTAGAATTTTTGTTTCATTTTGTTTAATTTTCTGGGGTGTTTTTGTTGTTGTTGGTTTGTTTTTTGTTTTTTTTTTTTAATC AAGACCATTGTTTCATGTTAATGCAGCTGCTGAGAAGATTTTTTTTTAATGACTGAGAAAACTTGTTTACAGCTCCAGCATATAAGGAAA GTGTTCAAGGCCAGATATGCCTCAGATATTTAACCAGTAAGCCTTAGTTGTACATAAATACTTTTGTGTCAACAAAAACTTTCAGCTCTC ACAGAAGACAGTTACTCAACATTTTTTGATGTGCCACAGTTTCGAGTTTTTCGATATTTAAATTTTTTGGCTTTTCATCTAAGTTTGGGT TTGTATTTTTTCCTTCTAAACTCTTCATGTGGCAGAGTCTTCTATGTTTTCACAGCTTTTTCATTACAGAAAAGAACACTTGCTCTTCTG TGATTATTGTCATGTATTAGGCTAATGCTGTGTTGTCTCCCACCTGGAACTGAATTGCTTGGTGGAACATATGCTTTCACTGTTTGTGCA ATATGCATTTATTTCTTATATGAATGCTTTAAAGTCATTTGAGGTTAGATCTTTTAATTCCTATTTTCTGCTTCATTGGTCACTTTTTTT TTATTGTAGTATAAGATGTTAGATTCTGTAATCTTCACATTCATTTTAGCAGGTACTGAGTGATGCTGTATATACAAATAAGTGTATTGT TTTGATTTTTAGACCACCACATGGCATGCTTGACTATTTCTTATTTCAAATGTCTGCTAATGCAGAGTAGGCTACTCCATGATAGTGTTA AAAAACAAAATTTGCTAACAATGTGATATAAAGACTTTAAAAGTTACACATTATGTGGAGCCCTATCTTTACAAAAGTTTCCTACTGTAA AGTGCTTTTATTTTCAGTTTTCACTTGATAGTACTCAACCATAATTAAAGTTGCATAAGATAATTGCTTTACATTTCACATACCTATATT TATCTGAGTGCTGTCTAAAACTGTTGTGCTAGCCAAAGTAATGCTATGAAATCATTTGCAGAATTAACCCGTGAGTTAATGTTAAATGCA CTGTTATTGCCATGTGAAGAGGCATCGACTTTGATACCACCATCATGTTCAGACCATTTTATACATTTCAGTGGCCTTTTTTTTTTTTTA AGGAAAAAAAAGCGCAAAACCAAGTACATAGTGACGATGGCTTTTATTTGGACAAATAGCTTTTATATTTTCATTAAACCATGCAAAAAA TACTACATCTTTCTGGCACATAACTGTCTCCTTAACCACTGAACAGTTCAGCCATTTGAATAAATTGTACATTGTAAAGCTTATAGTAGC TGATTGTATTATTGATTGTATTGTATACTATATTAAATGTGAATTTGTACCCCTTCATTTTAAAAGGTCATTGTGTTCTACTGCCTATTT TAGATTACTTTGGGGTTGGGGAAGGGTGTTTTGGTAAGCAGGATTTTAAGTCCTCTCTCTCTCGATTGGTTTTATGAAGATATAAGGTTA TGCTCTTACTACCAAGCTCAGGATTCTTGATTTTAAAGGTACAAGGATAGTTGTGGGAGTTTTATTTTTGGTTATATTTGAACTGTATGA ATGGTAGGTCTGAATATTGAGAATTTCCATGGTCTTATGTGGAGGTAAAATATACAGATAACTGATCAGTTTGAGTGACTGCAACATGTT CTGGTTGCACAACAGTTAGGCATGCTATGGTTTATATTTGTGAAGTTTGGATGCCTGTGAAGAATGATTAAATACATGTTTCTAATATTT TAGTGTTTTGTATTTAGGTTATTTATTCTTTGTATCTAAAACTGAACAGCTACTGTGCTATATTGATTTTATTGGTAGTATTGAGCAGAC CTTGTTTCTGCATGAAACTAGTTGCAAAACCCACTATTTTGGAAATAAAAATGTATTTTGACATATACAAATAAAATGAATAAAACTATT TTAAATGTGTGAACTTTTAATGAAGACATTTTAAATTTTGTTCTGAGATATTTAAATTCTGCATGGGTATTTTTTCACTAATTGCTTTAC TTGGATACCAATTTGAATAATTTCTGAAATTGTAATATTGTGATAATTTGCACAGCATTGTACATGCACATCTGTAAATGCAATCTTAAT >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PPP1R12A_ENST00000450142_chr12_80266718_-_6106nt TTTTCCGCTCGTGCTTCGGCGCCGCTCGGCTCCCTTCCCGCCCCTGGCTCCCTCCCTCCCTCCCTCCCTCCTTCTTCTCCCTCCCTCCTG TCCTGGGATTGCCTGGAGCTCCGCACCGCGAGTTTGCCGCGGCACTTTCCGCGCGGCGGAAGAGCGCGCGCCAGCTTCGGCACACCTGGG AGCCGGATCCCAGCCCTACGCCTCGTCCCCTACAAGCTCCTCCAAGCCCCGCCGGCTGCTGTGGGAGCGGCGGCCGTCCCTCTCCTGGAG GTCGTCTCCTGGCATCCTCGGGGCCGCAGGAAGGAAGAGGAGGCAGCGGCCGGAGCCCTGGTGGGCGGCCTGAGGTGAGAGCCCGACCGG CCCCTTTGGGAATATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTGGAGGAGTGGAAGGCGAA ACGCGAGAAGATGCGCGCCAAGCAGAACCCCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGG GGCTCTGGGCACCCCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCACCTGCCGTCCCCGGTCC CGGGGGCGTGAACTGCGCGGTCGGCTCCGCCATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTC TGCCTCGGCTGCACCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCGGGCCCCAGTGCCAGGAA AGGCAAGGGGCAGATCGAGAAGAGGAAGCTGCGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGGCTTGCATTGA TGACAATGTTGATATGGTGAAGTTTCTGGTAGAAAATGGAGCAAATATTAATCAACCTGATAATGAAGGCTGGATACCACTACATGCAGC AGCTTCCTGTGGATATCTTGATATTGCAGAGTTTTTGATTGGTCAAGGAGCACATGTAGGGGCTGTCAACAGTGAAGGAGATACACCTTT AGATATTGCGGAGGAGGAGGCAATGGAAGAGCTACTTCAAAATGAAGTTAATCGGCAAGGGGTTGATATAGAAGCAGCTCGAAAGGAAGA AGAACGGATCATGCTTAGAGATGCCAGGCAGTGGCTAAATAGTGGTCATATAAATGATGTCCGGCATGCAAAATCTGGAGGTACAGCACT TCACGTTGCAGCTGCTAAAGGCTATACGGAAGTTTTAAAACTTTTAATACAGGCAGGCTATGATGTTAATATTAAAGACTATGATGGCTG GACACCTCTTCATGCTGCAGCTCATTGGGGTAAAGAAGAAGCATGTCGAATTTTAGTGGACAATCTGTGTGATATGGAGATGGTCAACAA AGTGGGCCAAACAGCCTTTGATGTAGCAGATGAAGACATTTTAGGATATTTAGAAGAGTTGCAAAAGAAACAAAATCTGCTCCATAGTGA AAAACGGGACAAGAAATCTCCACTAATTGAATCAACAGCAAATATGGACAATAATCAGTCACAGAAGACCTTTAAAAACAAAGAGACGTT GATTATTGAACCAGAGAAAAATGCATCCCGTATTGAATCTCTGGAACAAGAAAAGGTTGATGAAGAAGAAGAAGGAAAGAAGGATGAGTC TAGCTGCTCTAGTGAAGAAGATGAGGAAGATGACTCGGAATCAGAAGCTGAAACAGATAAGACAAAACCCCTGGCTTCTGTAACTAATGC CAACACTTCTAGTACACAAGCAGCTCCTGTAGCTGTTACAACACCTACTGTGTCATCAGGTCAAGCAACACCTACATCACCTATTAAAAA GTTTCCAACCACAGCTACAAAAATTTCTCCCAAAGAAGAAGAGAGAAAAGATGAGTCTCCTGCAACTTGGAGGTTAGGACTTAGAAAGAC GGGCAGCTATGGTGCACTTGCTGAAATCACAGCATCTAAAGAGGGTCAGAAAGAAAAAGATACTGCAGGTGTTACACGTTCAGCTTCAAG TCCCAGACTTTCCTCCTCTTTGGATAATAAAGAAAAGGAGAAAGATAGTAAAGGAACTAGGCTTGCATATGTTGCACCTACAATACCAAG ACGACTAGCCAGTACATCTGACATTGAAGAGAAAGAAAACAGAGATTCTTCAAGTTTGCGAACAAGTAGTTCATATACAAGGAGAAAATG GGAAGATGATCTTAAAAAAAATAGCTCAGTTAATGAAGGATCAACGTATCATAAAAGTTGCTCCTTTGGTAGAAGACAAGATGATTTGAT TAGTTCTAGTGTTCCAAGCACCACATCAACACCAACAGTTACCTCTGCAGCTGGGCTTCAGAAAAGCCTGCTTTCCAGCACAAGCACTAC TACAAAGATTACAACGGGTTCTTCCTCAGCAGGCACACAAAGCAGTACCTCAAATCGTTTGTGGGCTGAGGATAGTACTGAGAAAGAAAA GGACAGTGTTCCTACGGCAGTGACCATTCCTGTTGCTCCAACTGTTGTAAATGCTGCAGCTTCTACCACAACCCTGACTACAACTACTGC TGGCACTGTCTCCTCCACAACAGAGGTCAGGGAGAGACGCAGATCATACCTCACTCCTGTTAGGGATGAAGAGTCTGAATCCCAAAGAAA AGCAAGATCTAGACAAGCAAGACAATCTAGAAGATCAACACAGGGAGTGACATTAACTGATCTTCAAGAAGCTGAGAAAACAATAGGAAG AAGTCGTTCTACCCGAACCAGAGAACAAGAAAATGAAGAAAAAGAAAAAGAGGAAAAAGAGAAACAAGATAAAGAGAAACAAGAAGAAAA GAAGGAGTCAGAAACATCTAGAGAAGATGAATATAAACAAAAGTACTCCAGAACGTATGATGAGACTTACCAGCGTTATAGGCCAGTATC AACTTCAAGTTCAACCACTCCATCCTCTTCACTTTCTACTATGAGCAGTTCACTGTATGCTTCAAGTCAACTAAACAGGCCAAATAGTCT TGTAGGCATAACTTCTGCTTACTCCAGAGGAATAACAAAAGAAAATGAAAGAGAGGGAGAAAAAAGAGAAGAGGAGAAAGAAGGAGAAGA TAAATCACAACCTAAATCAATCAGAGAACGACGACGACCAAGAGAGAAAAGAAGATCTACAGGAGTTTCATTTTGGACACAAGATAGTGA TGAAAATGAACAAGAACAACAATCAGACACAGAAGAGGGATCCAATAAGAAAGAAACTCAGACGGATTCCATTTCTAGATATGAAACCAG TTCTACATCAGCTGGTGATCGATATGATTCCTTGCTGGGTCGCTCTGGATCATACAGTTACTTAGAAGAAAGAAAACCTTACAGCAGCAG GCTAGAAAAGGATGACTCAACTGACTTTAAAAAGCTTTATGAACAAATTCTAGCTGAAAATGAAAAGCTGAAGGCACAGCTACATGATAC AAATATGGAACTAACAGATCTTAAATTACAGTTGGAAAAGGCCACCCAGAGACAAGAAAGATTTGCTGATAGATCACTGTTGGAAATGGA AAAAAGGGAACGAAGAGCTCTAGAAAGAAGAATATCTGAAATGGAAGAAGAGCTCAAAATGTTACCAGACCTAAAAGCAGACAACCAGAG GCTAAAGGATGAAAATGGGGCCTTGATCAGAGTTATAAGCAAACTTTCCAAATAAAAAAAAAAAAAGCAGCAAGTAATGGAATTGCACAT ATTAGTAACCCAGTGGACCATAATTGGCAGTCACTGGAAGTCTGGGAAGAATCCTTGGAGACTGTCATTTTCGGATATCCTGCCAAATGC CCTCTTATCTAGAATTTTTGTTTCATTTTGTTTAATTTTCTGGGGTGTTTTTGTTGTTGTTGGTTTGTTTTTTGTTTTTTTTTTTTAATC AAGACCATTGTTTCATGTTAATGCAGCTGCTGAGAAGATTTTTTTTTAATGACTGAGAAAACTTGTTTACAGCTCCAGCATATAAGGAAA GTGTTCAAGGCCAGATATGCCTCAGATATTTAACCAGTAAGCCTTAGTTGTACATAAATACTTTTGTGTCAACAAAAACTTTCAGCTCTC ACAGAAGACAGTTACTCAACATTTTTTGATGTGCCACAGTTTCGAGTTTTTCGATATTTAAATTTTTTGGCTTTTCATCTAAGTTTGGGT TTGTATTTTTTCCTTCTAAACTCTTCATGTGGCAGAGTCTTCTATGTTTTCACAGCTTTTTCATTACAGAAAAGAACACTTGCTCTTCTG TGATTATTGTCATGTATTAGGCTAATGCTGTGTTGTCTCCCACCTGGAACTGAATTGCTTGGTGGAACATATGCTTTCACTGTTTGTGCA ATATGCATTTATTTCTTATATGAATGCTTTAAAGTCATTTGAGGTTAGATCTTTTAATTCCTATTTTCTGCTTCATTGGTCACTTTTTTT TTATTGTAGTATAAGATGTTAGATTCTGTAATCTTCACATTCATTTTAGCAGGTACTGAGTGATGCTGTATATACAAATAAGTGTATTGT TTTGATTTTTAGACCACCACATGGCATGCTTGACTATTTCTTATTTCAAATGTCTGCTAATGCAGAGTAGGCTACTCCATGATAGTGTTA AAAAACAAAATTTGCTAACAATGTGATATAAAGACTTTAAAAGTTACACATTATGTGGAGCCCTATCTTTACAAAAGTTTCCTACTGTAA AGTGCTTTTATTTTCAGTTTTCACTTGATAGTACTCAACCATAATTAAAGTTGCATAAGATAATTGCTTTACATTTCACATACCTATATT TATCTGAGTGCTGTCTAAAACTGTTGTGCTAGCCAAAGTAATGCTATGAAATCATTTGCAGAATTAACCCGTGAGTTAATGTTAAATGCA CTGTTATTGCCATGTGAAGAGGCATCGACTTTGATACCACCATCATGTTCAGACCATTTTATACATTTCAGTGGCCTTTTTTTTTTTTTA AGGAAAAAAAAGCGCAAAACCAAGTACATAGTGACGATGGCTTTTATTTGGACAAATAGCTTTTATATTTTCATTAAACCATGCAAAAAA TACTACATCTTTCTGGCACATAACTGTCTCCTTAACCACTGAACAGTTCAGCCATTTGAATAAATTGTACATTGTAAAGCTTATAGTAGC TGATTGTATTATTGATTGTATTGTATACTATATTAAATGTGAATTTGTACCCCTTCATTTTAAAAGGTCATTGTGTTCTACTGCCTATTT TAGATTACTTTGGGGTTGGGGAAGGGTGTTTTGGTAAGCAGGATTTTAAGTCCTCTCTCTCTCGATTGGTTTTATGAAGATATAAGGTTA TGCTCTTACTACCAAGCTCAGGATTCTTGATTTTAAAGGTACAAGGATAGTTGTGGGAGTTTTATTTTTGGTTATATTTGAACTGTATGA ATGGTAGGTCTGAATATTGAGAATTTCCATGGTCTTATGTGGAGGTAAAATATACAGATAACTGATCAGTTTGAGTGACTGCAACATGTT CTGGTTGCACAACAGTTAGGCATGCTATGGTTTATATTTGTGAAGTTTGGATGCCTGTGAAGAATGATTAAATACATGTTTCTAATATTT TAGTGTTTTGTATTTAGGTTATTTATTCTTTGTATCTAAAACTGAACAGCTACTGTGCTATATTGATTTTATTGGTAGTATTGAGCAGAC CTTGTTTCTGCATGAAACTAGTTGCAAAACCCACTATTTTGGAAATAAAAATGTATTTTGACATATACAAATAAAATGAATAAAACTATT TTAAATGTGTGAACTTTTAATGAAGACATTTTAAATTTTGTTCTGAGATATTTAAATTCTGCATGGGTATTTTTTCACTAATTGCTTTAC TTGGATACCAATTTGAATAATTTCTGAAATTGTAATATTGTGATAATTTGCACAGCATTGTACATGCACATCTGTAAATGCAATCTTAAT >In-frame_PAWR_ENST00000328827_chr12_80083509_-_PPP1R12A_ENST00000437004_chr12_80266718_-_5163nt TTTTCCGCTCGTGCTTCGGCGCCGCTCGGCTCCCTTCCCGCCCCTGGCTCCCTCCCTCCCTCCCTCCCTCCTTCTTCTCCCTCCCTCCTG TCCTGGGATTGCCTGGAGCTCCGCACCGCGAGTTTGCCGCGGCACTTTCCGCGCGGCGGAAGAGCGCGCGCCAGCTTCGGCACACCTGGG AGCCGGATCCCAGCCCTACGCCTCGTCCCCTACAAGCTCCTCCAAGCCCCGCCGGCTGCTGTGGGAGCGGCGGCCGTCCCTCTCCTGGAG GTCGTCTCCTGGCATCCTCGGGGCCGCAGGAAGGAAGAGGAGGCAGCGGCCGGAGCCCTGGTGGGCGGCCTGAGGTGAGAGCCCGACCGG CCCCTTTGGGAATATGGCGACCGGTGGCTACCGGACCAGCAGCGGCCTCGGCGGCAGCACCACAGACTTCCTGGAGGAGTGGAAGGCGAA ACGCGAGAAGATGCGCGCCAAGCAGAACCCCCCGGGCCCGGCCCCCCCGGGAGGGGGCAGCAGCGACGCCGCTGGGAAGCCCCCCGCGGG GGCTCTGGGCACCCCGGCGGCCGCCGCTGCCAACGAGCTCAACAACAACCTCCCGGGCGGCGCGCCGGCCGCACCTGCCGTCCCCGGTCC CGGGGGCGTGAACTGCGCGGTCGGCTCCGCCATGCTGACGCGGGCGGCCCCCGGCCCGCGGCGGTCGGAGGACGAGCCCCCAGCCGCCTC TGCCTCGGCTGCACCGCCGCCCCAGCGTGACGAGGAGGAGCCGGACGGCGTCCCAGAGAAGGGCAAGAGCTCGGGCCCCAGTGCCAGGAA AGGCAAGGGGCAGATCGAGAAGAGGAAGCTGCGGGAGAAGCGGCGCTCCACCGGCGTGGTCAACATCCCTGCCGCAGAGGCTTGCATTGA TGACAATGTTGATATGGTGAAGTTTCTGGTAGAAAATGGAGCAAATATTAATCAACCTGATAATGAAGGCTGGATACCACTACATGCAGC AGCTTCCTGTGGATATCTTGATATTGCAGAGTTTTTGATTGGTCAAGGAGCACATGTAGGGGCTGTCAACAGTGAAGGAGATACACCTTT AGATATTGCGGAGGAGGAGGCAATGGAAGAGCTACTTCAAAATGAAGTTAATCGGCAAGGGGTTGATATAGAAGCAGCTCGAAAGGAAGA AGAACGGATCATGCTTAGAGATGCCAGGCAGTGGCTAAATAGTGGTCATATAAATGATGTCCGGCATGCAAAATCTGGAGGTACAGCACT TCACGTTGCAGCTGCTAAAGGCTATACGGAAGTTTTAAAACTTTTAATACAGGCAGGCTATGATGTTAATATTAAAGACTATGATGGCTG GACACCTCTTCATGCTGCAGCTCATTGGGGTAAAGAAGAAGCATGTCGAATTTTAGTGGACAATCTGTGTGATATGGAGATGGTCAACAA AGTGGGCCAAACAGCCTTTGATGTAGCAGATGAAGACATTTTAGGATATTTAGAAGAGTTGCAAAAGAAACAAAATCTGCTCCATAGTGA AAAACGGGACAAGAAATCTCCACTAATTGAATCAACAGCAAATATGGACAATAATCAGTCACAGAAGACCTTTAAAAACAAAGAGACGTT GATTATTGAACCAGAGAAAAATGCATCCCGTATTGAATCTCTGGAACAAGAAAAGGTTGATGAAGAAGAAGAAGGAAAGAAGGATGAGTC TAGCTGCTCTAGTGAAGAAGATGAGGAAGATGACTCGGAATCAGAAGCTGAAACAGATAAGACAAAACCCCTGGCTTCTGTAACTAATGC CAACACTTCTAGTACACAAGCAGCTCCTGTAGCTGTTACAACACCTACTGTGTCATCAGGTCAAGCAACACCTACATCACCTATTAAAAA GTTTCCAACCACAGCTACAAAAATTTCTCCCAAAGAAGAAGAGAGAAAAGATGAGTCTCCTGCAACTTGGAGGTTAGGACTTAGAAAGAC GGGCAGCTATGGTGCACTTGCTGAAATCACAGCATCTAAAGAGGGTCAGAAAGAAAAAGATACTGCAGGTGTTACACGTTCAGCTTCAAG TCCCAGACTTTCCTCCTCTTTGGATAATAAAGAAAAGGAGAAAGATAGTAAAGGAACTAGGCTTGCATATGTTGCACCTACAATACCAAG ACGACTAGCCAGTACATCTGACATTGAAGAGAAAGAAAACAGAGATTCTTCAAGTTTGCGAACAAGTAGTTCATATACAAGGAGAAAATG GGAAGATGATCTTAAAAAAAATAGCTCAGTTAATGAAGGATCAACGTATCATAAAAGTTGCTCCTTTGGTAGAAGACAAGATGATTTGAT TAGTTCTAGTGTTCCAAGCACCACATCAACACCAACAGTTACCTCTGCAGCTGGGCTTCAGAAAAGCCTGCTTTCCAGCACAAGCACTAC TACAAAGATTACAACGGGTTCTTCCTCAGCAGGCACACAAAGCAGTACCTCAAATCGTTTGTGGGCTGAGGATAGTACTGAGAAAGAAAA GGACAGTGTTCCTACGGCAGTGACCATTCCTGTTGCTCCAACTGTTGTAAATGCTGCAGCTTCTACCACAACCCTGACTACAACTACTGC TGGCACTGTCTCCTCCACAACAGAGGTCAGGGAGAGACGCAGATCATACCTCACTCCTGTTAGGGATGAAGAGTCTGAATCCCAAAGAAA AGCAAGATCTAGACAAGCAAGACAATCTAGAAGATCAACACAGGGAGTGACATTAACTGATCTTCAAGAAGCTGAGAAAACAATAGGAAG AAGTCGTTCTACCCGAACCAGAGAACAAGAAAATGAAGAAAAAGAAAAAGAGGAAAAAGAGAAACAAGATAAAGAGAAACAAGAAGAAAA GAAGGAGTCAGAAACATCTAGAGAAGATGAATATAAACAAAAGTACTCCAGAACGTATGATGAGACTTACCAGCGTTATAGGCCAGTATC AACTTCAAGTTCAACCACTCCATCCTCTTCACTTTCTACTATGAGCAGTTCACTGTATGCTTCAAGTCAACTAAACAGGCCAAATAGTCT TGTAGGCATAACTTCTGCTTACTCCAGAGGAATAACAAAAGAAAATGAAAGAGAGGGAGAAAAAAGAGAAGAGGAGAAAGAAGGAGAAGA TAAATCACAACCTAAATCAATCAGAGAACGACGACGACCAAGAGAGAAAAGAAGATCTACAGGAGTTTCATTTTGGACACAAGATAGTGA TGAAAATGAACAAGAACAACAATCAGACACAGAAGAGGGATCCAATAAGAAAGAAACTCAGACGGATTCCATTTCTAGATATGAAACCAG TTCTACATCAGCTGGTGATCGATATGATTCCTTGCTGGGTCGCTCTGGATCATACAGTTACTTAGAAGAAAGAAAACCTTACAGCAGCAG GCTAGAAAAGGATGACTCAACTGACTTTAAAAAGAGACAAGAAAGATTTGCTGATAGATCACTGTTGGAAATGGAAAAAAGGGAACGAAG AGCTCTAGAAAGAAGAATATCTGAAATGGAAGAAGAGCTCAAAATGTTACCAGACCTAAAAGCAGACAACCAGAGGCTAAAGGATGAAAA TGGGGCCTTGATCAGAGTTATAAGCAAACTTTCCAAATAAAAAAAAAAAAAGCAGCAAGTAATGGAATTGCACATATTAGTAACCCAGTG GACCATAATTGGCAGTCACTGGAAGTCTGGGAAGAATCCTTGGAGACTGTCATTTTCGGATATCCTGCCAAATGCCCTCTTATCTAGAAT TTTTGTTTCATTTTGTTTAATTTTCTGGGGTGTTTTTGTTGTTGTTGGTTTGTTTTTTGTTTTTTTTTTTTAATCAAGACCATTGTTTCA TGTTAATGCAGCTGCTGAGAAGATTTTTTTTTAATGACTGAGAAAACTTGTTTACAGCTCCAGCATATAAGGAAAGTGTTCAAGGCCAGA TATGCCTCAGATATTTAACCAGTAAGCCTTAGTTGTACATAAATACTTTTGTGTCAACAAAAACTTTCAGCTCTCACAGAAGACAGTTAC TCAACATTTTTTGATGTGCCACAGTTTCGAGTTTTTCGATATTTAAATTTTTTGGCTTTTCATCTAAGTTTGGGTTTGTATTTTTTCCTT CTAAACTCTTCATGTGGCAGAGTCTTCTATGTTTTCACAGCTTTTTCATTACAGAAAAGAACACTTGCTCTTCTGTGATTATTGTCATGT ATTAGGCTAATGCTGTGTTGTCTCCCACCTGGAACTGAATTGCTTGGTGGAACATATGCTTTCACTGTTTGTGCAATATGCATTTATTTC TTATATGAATGCTTTAAAGTCATTTGAGGTTAGATCTTTTAATTCCTATTTTCTGCTTCATTGGTCACTTTTTTTTTATTGTAGTATAAG ATGTTAGATTCTGTAATCTTCACATTCATTTTAGCAGGTACTGAGTGATGCTGTATATACAAATAAGTGTATTGTTTTGATTTTTAGACC ACCACATGGCATGCTTGACTATTTCTTATTTCAAATGTCTGCTAATGCAGAGTAGGCTACTCCATGATAGTGTTAAAAAACAAAATTTGC TAACAATGTGATATAAAGACTTTAAAAGTTACACATTATGTGGAGCCCTATCTTTACAAAAGTTTCCTACTGTAAAGTGCTTTTATTTTC AGTTTTCACTTGATAGTACTCAACCATAATTAAAGTTGCATAAGATAATTGCTTTACATTTCACATACCTATATTTATCTGAGTGCTGTC TAAAACTGTTGTGCTAGCCAAAGTAATGCTATGAAATCATTTGCAGAATTAACCCGTGAGTTAATGTTAAATGCACTGTTATTGCCATGT GAAGAGGCATCGACTTTGATACCACCATCATGTTCAGACCATTTTATACATTTCAGTGGCCTTTTTTTTTTTTTAAGGAAAAAAAAGCGC AAAACCAAGTACATAGTGACGATGGCTTTTATTTGGACAAATAGCTTTTATATTTTCATTAAACCATGCAAAAAATACTACATCTTTCTG GCACATAACTGTCTCCTTAACCACTGAACAGTTCAGCCATTTGAATAAATTGTACATTGTAAAGCTTATAGTAGCTGATTGTATTATTGA |
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FusionGenePPI for PAWR_PPP1R12A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PAWR | THAP1, SLC5A7, SLC5A1, AATF, DAPK3, PRKCZ, WT1, HSPA5, FBXO25, SPSB1, SPSB2, SPSB4, SQSTM1, DRD2, PAN2, APEH, CAND1, CARS, FAM129B, H3F3A, IDE, JMJD6, ATP6V1C1, SHMT1, PPM1G, SHMT2, SNX2, SNX6, STAT1, VPS29, FBXO45, CCDC8, EED, LUZP4, DDX39A, CEP290, CEP128, MYH9, HMG20A, IKBIP, SCOC, SLC25A41, G3BP1, HDAC6 | PPP1R12A | IL16, PPP1CB, PRKG1, HDAC7, KDM1A, SETD7, ELAVL1, ARRB2, FBXO25, SIAH2, ATXN10, LRRK2, RHOA, CDV3, IDH3G, PAXIP1, FMNL1, PAN2, LATS1, AARSD1, ACTR3, ARPC2, CUL1, P3H1, NRD1, NSUN2, NUDT5, NUSAP1, OSGEP, PFDN1, PFDN5, RPRD1B, XPO5, PUS1, RPA1, TPP2, TRIM47, TTLL12, RPA3, RPA2, NUAK1, TP53, LUZP4, FKBP6, PHF7, CDK8, NTRK1, MED23, RPGRIP1L, CAPZA2, CDK2, CRK, DBN1, FLNA, MYH9, MYO1C, IQGAP1, ACTR2, SYNPO, ANLN, MYO5C, MYO19, MYO18A, FOS, CDKN3, JUNB, SERPINB2, NUAK2, SH3BP5L, ZNF263, TULP3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000261207 | - | 1 | 26 | 682_864 | 79 | 1031 | ROCK2 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000437004 | - | 1 | 25 | 682_864 | 79 | 996 | ROCK2 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000450142 | - | 0 | 25 | 682_864 | 79 | 1031 | ROCK2 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000546369 | - | 0 | 25 | 682_864 | -8 | 944 | ROCK2 |
| Tgene | PPP1R12A | chr12:80083509 | chr12:80266718 | ENST00000550107 | - | 0 | 24 | 682_864 | 79 | 975 | ROCK2 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PAWR_PPP1R12A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAWR_PPP1R12A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PAWR | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | PAWR | C0041696 | Unipolar Depression | 2 | PSYGENET |
| Hgene | PAWR | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
| Hgene | PAWR | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | PAWR | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | PAWR | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Hgene | PAWR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | PAWR | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | PAWR | C0525045 | Mood Disorders | 1 | PSYGENET |
| Hgene | PAWR | C0600427 | Cocaine Dependence | 1 | PSYGENET |
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