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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26049

FusionGeneSummary for PARVA_MICALCL

check button Fusion gene summary
Fusion gene informationFusion gene name: PARVA_MICALCL
Fusion gene ID: 26049
HgeneTgene
Gene symbol

PARVA

MICALCL

Gene ID

55742

84953

Gene nameparvin alphaMICAL C-terminal like
SynonymsCH-ILKBP|MXRA2Ebitein1
Cytomap

11p15.3

11p15.3

Type of geneprotein-codingprotein-coding
Descriptionalpha-parvinactopaxincalponin-like integrin-linked kinase-binding proteinmatrix-remodeling-associated protein 2MICAL C-terminal-like proteinERK2-binding testicular protein 1ebitein-1mical-cL
Modification date2018052320180523
UniProtAcc

Q9NVD7

Q6ZW33

Ensembl transtripts involved in fusion geneENST00000334956, ENST00000539723, 
ENST00000550549, ENST00000538608, 
ENST00000526746, 
ENST00000256186, 
ENST00000529028, 
Fusion gene scores* DoF score9 X 6 X 5=2701 X 1 X 1=1
# samples 91
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PARVA [Title/Abstract] AND MICALCL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-A491-01APARVAchr11

12399330

+MICALCLchr11

12341243

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000334956ENST00000256186PARVAchr11

12399330

+MICALCLchr11

12341243

+
5CDS-intronENST00000334956ENST00000529028PARVAchr11

12399330

+MICALCLchr11

12341243

+
In-frameENST00000539723ENST00000256186PARVAchr11

12399330

+MICALCLchr11

12341243

+
5CDS-intronENST00000539723ENST00000529028PARVAchr11

12399330

+MICALCLchr11

12341243

+
In-frameENST00000550549ENST00000256186PARVAchr11

12399330

+MICALCLchr11

12341243

+
5CDS-intronENST00000550549ENST00000529028PARVAchr11

12399330

+MICALCLchr11

12341243

+
intron-3CDSENST00000538608ENST00000256186PARVAchr11

12399330

+MICALCLchr11

12341243

+
intron-intronENST00000538608ENST00000529028PARVAchr11

12399330

+MICALCLchr11

12341243

+
intron-3CDSENST00000526746ENST00000256186PARVAchr11

12399330

+MICALCLchr11

12341243

+
intron-intronENST00000526746ENST00000529028PARVAchr11

12399330

+MICALCLchr11

12341243

+

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FusionProtFeatures for PARVA_MICALCL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARVA

Q9NVD7

MICALCL

Q6ZW33

Plays a role in sarcomere organization and in smoothmuscle cell contraction. Required for normal development of theembryonic cardiovascular system, and for normal septation of theheart outflow tract. Plays a role in sprouting angiogenesis and isrequired for normal adhesion of vascular smooth muscle cells toendothelial cells during blood vessel development (By similarity).Plays a role in the reorganization of the actin cytoskeleton,formation of lamellipodia and ciliogenesis. Plays a role in theestablishement of cell polarity, cell adhesion, cell spreading,and directed cell migration. {ECO:0000250,ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308,ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563}. May cooperate with MAPK1/ERK2 via an intracellularsignal transduction pathway in the morphogenetic development ofround spermatids to spermatozoa. May act as Rab effector proteinand play a role in vesicle trafficking.{ECO:0000250|UniProtKB:Q9D5U9, ECO:0000305|PubMed:27552051}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMICALCLchr11:12399330chr11:12341243ENST00000256186+29513_674475696Coiled coilOntology_term=ECO:0000255
TgeneMICALCLchr11:12399330chr11:12341243ENST00000256186+29490_500475696Compositional biasNote=Poly-Ser
TgeneMICALCLchr11:12399330chr11:12341243ENST00000256186+29534_683475696DomainbMERB

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARVAchr11:12399330chr11:12341243ENST00000550549+113262_36945373DomainCalponin-homology (CH) 2
HgenePARVAchr11:12399330chr11:12341243ENST00000550549+11395_20245373DomainCalponin-homology (CH) 1
TgeneMICALCLchr11:12399330chr11:12341243ENST00000256186+29457_470475696Compositional biasNote=Poly-Pro
TgeneMICALCLchr11:12399330chr11:12341243ENST00000256186+298_54475696Compositional biasNote=Ser-rich


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FusionGeneSequence for PARVA_MICALCL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PARVA_MICALCL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARVAILK, DHX36, UBE3A, ELAVL1, APP, MLH1, SOX2, HSPH1, CARM1, CORO1B, CRMP1, OSBP, OTUD6B, PPAT, TBC1D17, UGP2, ZRANB2, RSU1, SEC24C, MOCOS, LIMS1, PARVB, IQGAP1, VPS11, GCA, DDX47, CHMP2A, CMTR2, DDX17, DPH5, HSPB2, UBQLN1, SNW1, CDC5L, CDH1, LPXN, CCNB1MICALCL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgenePARVAchr11:12399330chr11:12341243ENST00000550549+11321_2545373ARHGAP31


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMICALCLchr11:12399330chr11:12341243ENST00000256186+2962_101475696MAPK1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARVA_MICALCL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARVA_MICALCL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePARVAC0236969Substance-Related Disorders1CTD_human