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Fusion gene ID: 26049 |
FusionGeneSummary for PARVA_MICALCL |
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Fusion gene information | Fusion gene name: PARVA_MICALCL | Fusion gene ID: 26049 | Hgene | Tgene | Gene symbol | PARVA | MICALCL | Gene ID | 55742 | 84953 |
Gene name | parvin alpha | MICAL C-terminal like | |
Synonyms | CH-ILKBP|MXRA2 | Ebitein1 | |
Cytomap | 11p15.3 | 11p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | alpha-parvinactopaxincalponin-like integrin-linked kinase-binding proteinmatrix-remodeling-associated protein 2 | MICAL C-terminal-like proteinERK2-binding testicular protein 1ebitein-1mical-cL | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NVD7 | Q6ZW33 | |
Ensembl transtripts involved in fusion gene | ENST00000334956, ENST00000539723, ENST00000550549, ENST00000538608, ENST00000526746, | ENST00000256186, ENST00000529028, | |
Fusion gene scores | * DoF score | 9 X 6 X 5=270 | 1 X 1 X 1=1 |
# samples | 9 | 1 | |
** MAII score | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PARVA [Title/Abstract] AND MICALCL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-55-A491-01A | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000334956 | ENST00000256186 | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
5CDS-intron | ENST00000334956 | ENST00000529028 | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
In-frame | ENST00000539723 | ENST00000256186 | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
5CDS-intron | ENST00000539723 | ENST00000529028 | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
In-frame | ENST00000550549 | ENST00000256186 | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
5CDS-intron | ENST00000550549 | ENST00000529028 | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
intron-3CDS | ENST00000538608 | ENST00000256186 | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
intron-intron | ENST00000538608 | ENST00000529028 | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
intron-3CDS | ENST00000526746 | ENST00000256186 | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
intron-intron | ENST00000526746 | ENST00000529028 | PARVA | chr11 | 12399330 | + | MICALCL | chr11 | 12341243 | + |
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FusionProtFeatures for PARVA_MICALCL |
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Hgene | Tgene |
PARVA | MICALCL |
Plays a role in sarcomere organization and in smoothmuscle cell contraction. Required for normal development of theembryonic cardiovascular system, and for normal septation of theheart outflow tract. Plays a role in sprouting angiogenesis and isrequired for normal adhesion of vascular smooth muscle cells toendothelial cells during blood vessel development (By similarity).Plays a role in the reorganization of the actin cytoskeleton,formation of lamellipodia and ciliogenesis. Plays a role in theestablishement of cell polarity, cell adhesion, cell spreading,and directed cell migration. {ECO:0000250,ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308,ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563}. | May cooperate with MAPK1/ERK2 via an intracellularsignal transduction pathway in the morphogenetic development ofround spermatids to spermatozoa. May act as Rab effector proteinand play a role in vesicle trafficking.{ECO:0000250|UniProtKB:Q9D5U9, ECO:0000305|PubMed:27552051}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >MICALCL | chr11:12399330 | chr11:12341243 | ENST00000256186 | + | 2 | 9 | 513_674 | 475 | 696 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >MICALCL | chr11:12399330 | chr11:12341243 | ENST00000256186 | + | 2 | 9 | 490_500 | 475 | 696 | Compositional bias | Note=Poly-Ser |
Tgene | >MICALCL | chr11:12399330 | chr11:12341243 | ENST00000256186 | + | 2 | 9 | 534_683 | 475 | 696 | Domain | bMERB |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PARVA | chr11:12399330 | chr11:12341243 | ENST00000550549 | + | 1 | 13 | 262_369 | 45 | 373 | Domain | Calponin-homology (CH) 2 |
Hgene | >PARVA | chr11:12399330 | chr11:12341243 | ENST00000550549 | + | 1 | 13 | 95_202 | 45 | 373 | Domain | Calponin-homology (CH) 1 |
Tgene | MICALCL | chr11:12399330 | chr11:12341243 | ENST00000256186 | + | 2 | 9 | 457_470 | 475 | 696 | Compositional bias | Note=Poly-Pro |
Tgene | MICALCL | chr11:12399330 | chr11:12341243 | ENST00000256186 | + | 2 | 9 | 8_54 | 475 | 696 | Compositional bias | Note=Ser-rich |
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FusionGeneSequence for PARVA_MICALCL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PARVA_MICALCL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PARVA | ILK, DHX36, UBE3A, ELAVL1, APP, MLH1, SOX2, HSPH1, CARM1, CORO1B, CRMP1, OSBP, OTUD6B, PPAT, TBC1D17, UGP2, ZRANB2, RSU1, SEC24C, MOCOS, LIMS1, PARVB, IQGAP1, VPS11, GCA, DDX47, CHMP2A, CMTR2, DDX17, DPH5, HSPB2, UBQLN1, SNW1, CDC5L, CDH1, LPXN, CCNB1 | MICALCL |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Hgene | PARVA | chr11:12399330 | chr11:12341243 | ENST00000550549 | + | 1 | 13 | 21_25 | 45 | 373 | ARHGAP31 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | MICALCL | chr11:12399330 | chr11:12341243 | ENST00000256186 | + | 2 | 9 | 62_101 | 475 | 696 | MAPK1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PARVA_MICALCL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PARVA_MICALCL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PARVA | C0236969 | Substance-Related Disorders | 1 | CTD_human |