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Fusion gene ID: 26031 |
FusionGeneSummary for PARP1_LIN9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PARP1_LIN9 | Fusion gene ID: 26031 | Hgene | Tgene | Gene symbol | PARP1 | LIN9 | Gene ID | 142 | 286826 |
| Gene name | poly(ADP-ribose) polymerase 1 | lin-9 DREAM MuvB core complex component | |
| Synonyms | ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PPOL|pADPRT-1 | BARA|BARPsv|Lin-9|TGS|TGS1|TGS2 | |
| Cytomap | 1q42.12 | 1q42.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | poly [ADP-ribose] polymerase 1ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)ADP-ribosyltransferase NAD(+)ADP-ribosyltransferase diphtheria toxin-like 1NAD(+) ADP-ribosyltransferase 1poly (ADP-ribose) polymerase family, member 1poly(ADP- | protein lin-9 homologTUDOR gene similar proteinbeta subunit-associated regulator of apoptosislin-9 homologpRB-associated proteinrb related pathway actortype I interferon receptor beta chain-associated protein | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P09874 | Q5TKA1 | |
| Ensembl transtripts involved in fusion gene | ENST00000366794, ENST00000490921, ENST00000366792, ENST00000366791, ENST00000366790, | ENST00000328205, ENST00000366801, ENST00000481685, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 1 X 3=9 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PARP1 [Title/Abstract] AND LIN9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PARP1 | GO:0006471 | protein ADP-ribosylation | 17396150|27067600 |
| Hgene | PARP1 | GO:0006915 | apoptotic process | 15565177 |
| Hgene | PARP1 | GO:0018312 | peptidyl-serine ADP-ribosylation | 28190768 |
| Hgene | PARP1 | GO:0032869 | cellular response to insulin stimulus | 19303849 |
| Hgene | PARP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11112786 |
| Hgene | PARP1 | GO:0050790 | regulation of catalytic activity | 25749521 |
| Hgene | PARP1 | GO:0070212 | protein poly-ADP-ribosylation | 15674325|19470756 |
| Hgene | PARP1 | GO:1990966 | ATP generation from poly-ADP-D-ribose | 27257257 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CQ-5332-01A | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000366794 | ENST00000328205 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| In-frame | ENST00000366794 | ENST00000366801 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| In-frame | ENST00000366794 | ENST00000481685 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000490921 | ENST00000328205 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000490921 | ENST00000366801 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000490921 | ENST00000481685 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000366792 | ENST00000328205 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000366792 | ENST00000366801 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000366792 | ENST00000481685 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000366791 | ENST00000328205 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000366791 | ENST00000366801 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000366791 | ENST00000481685 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000366790 | ENST00000328205 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000366790 | ENST00000366801 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
| intron-3CDS | ENST00000366790 | ENST00000481685 | PARP1 | chr1 | 226561927 | - | LIN9 | chr1 | 226438620 | - |
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FusionProtFeatures for PARP1_LIN9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PARP1 | LIN9 |
| Involved in the base excision repair (BER) pathway, bycatalyzing the poly(ADP-ribosyl)ation of a limited number ofacceptor proteins involved in chromatin architecture and in DNAmetabolism. This modification follows DNA damages and appears asan obligatory step in a detection/signaling pathway leading to thereparation of DNA strand breaks (PubMed:17177976, PubMed:18172500,PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates thepoly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150).Positively regulates the transcription of MTUS1 and negativelyregulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK,forms a complex that acts as a T-helper 1 (Th1) cell-specifictranscription factor and binds the promoter of IFN-gamma todirectly regulate its transcription, and is thus involvedimportantly in Th1 cytokine production (PubMed:17177976). Requiredfor PARP9 and DTX3L recruitment to DNA damage sites(PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediatedubiquitination promotes the rapid and specific recruitment of53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites(PubMed:23230272). Mediates serine ADP-ribosylation of targetproteins following interaction with HPF1; HPF1 conferring serinespecificity (PubMed:28190768). Mediates the poly(ADP-ribosyl)ationof histones in a HPF1-dependent manner (PubMed:27067600). Involvedin the synthesis of ATP in the nucleus, together with NMNAT1, PARGand NUDT5 (PubMed:27257257). Nuclear ATP generation is requiredfor extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). {ECO:0000269|PubMed:17177976,ECO:0000269|PubMed:17396150, ECO:0000269|PubMed:18172500,ECO:0000269|PubMed:19344625, ECO:0000269|PubMed:19661379,ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:27067600,ECO:0000269|PubMed:27257257, ECO:0000269|PubMed:28190768}. | Acts as a tumor suppressor. Inhibits DNA synthesis. Itsability to inhibit oncogenic transformation is mediated throughits association with RB1. Plays a role in the expression of genesrequired for the G1/S transition. {ECO:0000269|PubMed:15538385,ECO:0000269|PubMed:16730350}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PARP1 | chr1:226561927 | chr1:226438620 | ENST00000366794 | - | 14 | 23 | 2_372 | 690 | 1015 | DNA binding | . |
| Hgene | PARP1 | chr1:226561927 | chr1:226438620 | ENST00000366794 | - | 14 | 23 | 385_476 | 690 | 1015 | Domain | BRCT |
| Hgene | PARP1 | chr1:226561927 | chr1:226438620 | ENST00000366794 | - | 14 | 23 | 207_209 | 690 | 1015 | Motif | Nuclear localization signal |
| Hgene | PARP1 | chr1:226561927 | chr1:226438620 | ENST00000366794 | - | 14 | 23 | 221_226 | 690 | 1015 | Motif | Nuclear localization signal |
| Hgene | PARP1 | chr1:226561927 | chr1:226438620 | ENST00000366794 | - | 14 | 23 | 373_524 | 690 | 1015 | Region | Note=Automodification domain |
| Hgene | PARP1 | chr1:226561927 | chr1:226438620 | ENST00000366794 | - | 14 | 23 | 113_203 | 690 | 1015 | Zinc finger | PARP-type 2 |
| Hgene | PARP1 | chr1:226561927 | chr1:226438620 | ENST00000366794 | - | 14 | 23 | 9_93 | 690 | 1015 | Zinc finger | PARP-type 1 |
| Tgene | >LIN9 | chr1:226561927 | chr1:226438620 | ENST00000366801 | - | 8 | 14 | 354_413 | 311 | 508 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PARP1 | chr1:226561927 | chr1:226438620 | ENST00000366794 | - | 14 | 23 | 662_779 | 690 | 1015 | Domain | PARP alpha-helical |
| Hgene | >PARP1 | chr1:226561927 | chr1:226438620 | ENST00000366794 | - | 14 | 23 | 788_1014 | 690 | 1015 | Domain | PARP catalytic |
| Tgene | LIN9 | chr1:226561927 | chr1:226438620 | ENST00000328205 | - | 9 | 15 | 354_413 | 362 | 559 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for PARP1_LIN9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PARP1_ENST00000366794_chr1_226561927_-_LIN9_ENST00000328205_chr1_226438620_-_887aa MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAE AGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQ QVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN FTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYETRLSKILMIKKEHIKKLREMNTEAEKLKSY SMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISR >In-frame_PARP1_ENST00000366794_chr1_226561927_-_LIN9_ENST00000366801_chr1_226438620_-_887aa MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAE AGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQ QVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN FTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYETRLSKILMIKKEHIKKLREMNTEAEKLKSY SMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISR >In-frame_PARP1_ENST00000366794_chr1_226561927_-_LIN9_ENST00000481685_chr1_226438620_-_853aa MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAE AGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQ QVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKN FTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYETRLSKILMIKKEHIKKLREMNTEAEKLKSY SMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PARP1_ENST00000366794_chr1_226561927_-_LIN9_ENST00000328205_chr1_226438620_-_2661nt ATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAGTACGCCAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAG GACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCCATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTG GGCCACTCCATCCGGCACCCTGACGTTGAGGTGGATGGGTTCTCTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAA GCTGGAGGAGTGACAGGCAAAGGCCAGGATGGAATTGGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAGCAGAGTATGCCAAGTCC AACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATAGAAAAGGGCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAG CTAGGCATGATTGACCGCTGGTACCATCCAGGCTGCTTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCGAGTACAGTGCGAGTCAG CTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAAGAAGCCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGC GATGAGGTGGATGGAGTGGATGAAGTGGCGAAGAAGAAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTGAAAAAGCCCTAAAGGCT CAGAACGACCTGATCTGGAACATCAAGGACGAGCTAAAGAAAGTGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAG CAAGTGCCTTCTGGGGAGTCGGCGATCTTGGACCGAGTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCTGCGAGGAATGCTCGGGT CAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACTGGGGACGTCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGG AAGGAGTGGGTAACCCCAAAGGAATTCCGAGAAATCTCTTACCTCAAGAAATTGAAGGTTAAAAAACAGGACCGTATATTCCCCCCAGAA ACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCCACAGCCTCGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTA TCCAACATGAAGATCCTGACTCTCGGGAAGCTGTCCCGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAACTCGGGGGGAAGTTGACG GGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACCAAAAAGGAGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAAC ATCCGAGTTGTGTCTGAGGACTTCCTCCAGGACGTCTCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAGCGCACATCTTGTCCCCT TGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTTGTGGCCCCAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAG GTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGAATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGATTCTGGACTGGAA CACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTCTTCAGTGCCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTAC AAGCTGCAGCTTCTGGAGGACGACAAGGAAAACAGGTATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGGTGATCGGTAGCAACAAA CTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAGCACTTCATGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAAT TTCACGAAGTATCCCAAAAAGTTCTACCCCCTGGAGATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAAATCCTGGC ACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTCATCAAGATGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAG ACCAGATTATCAAAAATTCTCATGATTAAAAAGGAACATATCAAGAAATTAAGGGAAATGAACACAGAAGCAGAAAAATTGAAATCATAT TCCATGCCCATCAGCATTGAATTTCAGCGGAGATATGCAACAATTGTTCTGGAGCTTGAACAGCTGAACAAGGACCTAAACAAAGTTTTG CATAAAGTTCAACAGTATTGCTATGAGCTTGCTCCAGACCAGGGGCTCCAGCCTGCAGATCAGCCAACAGATATGAGACGCAGGTGTGAG GAAGAAGCACAGGAAATTGTTCGGCATGCAAATTCCTCAACAGGACAGCCCTGCGTTGAAAATGAAAATCTGACAGACTTAATTTCCAGG CTTACAGCTATTTTGTTACAAATTAAGTGTCTAGCAGAAGGAGGAGACCTGAATTCCTTTGAATTCAAATCACTTACAGACTCATTAAAT GATATCAAGAGTACAATAGACGCTTCTAATATCAGTTGCTTTCAGAATAATGTAGAAATCCATGTTGCACATATTCAGAGTGGCCTGAGC >In-frame_PARP1_ENST00000366794_chr1_226561927_-_LIN9_ENST00000366801_chr1_226438620_-_2661nt ATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAGTACGCCAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAG GACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCCATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTG GGCCACTCCATCCGGCACCCTGACGTTGAGGTGGATGGGTTCTCTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAA GCTGGAGGAGTGACAGGCAAAGGCCAGGATGGAATTGGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAGCAGAGTATGCCAAGTCC AACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATAGAAAAGGGCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAG CTAGGCATGATTGACCGCTGGTACCATCCAGGCTGCTTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCGAGTACAGTGCGAGTCAG CTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAAGAAGCCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGC GATGAGGTGGATGGAGTGGATGAAGTGGCGAAGAAGAAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTGAAAAAGCCCTAAAGGCT CAGAACGACCTGATCTGGAACATCAAGGACGAGCTAAAGAAAGTGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAG CAAGTGCCTTCTGGGGAGTCGGCGATCTTGGACCGAGTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCTGCGAGGAATGCTCGGGT CAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACTGGGGACGTCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGG AAGGAGTGGGTAACCCCAAAGGAATTCCGAGAAATCTCTTACCTCAAGAAATTGAAGGTTAAAAAACAGGACCGTATATTCCCCCCAGAA ACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCCACAGCCTCGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTA TCCAACATGAAGATCCTGACTCTCGGGAAGCTGTCCCGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAACTCGGGGGGAAGTTGACG GGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACCAAAAAGGAGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAAC ATCCGAGTTGTGTCTGAGGACTTCCTCCAGGACGTCTCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAGCGCACATCTTGTCCCCT TGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTTGTGGCCCCAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAG GTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGAATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGATTCTGGACTGGAA CACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTCTTCAGTGCCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTAC AAGCTGCAGCTTCTGGAGGACGACAAGGAAAACAGGTATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGGTGATCGGTAGCAACAAA CTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAGCACTTCATGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAAT TTCACGAAGTATCCCAAAAAGTTCTACCCCCTGGAGATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAAATCCTGGC ACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTCATCAAGATGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAG ACCAGATTATCAAAAATTCTCATGATTAAAAAGGAACATATCAAGAAATTAAGGGAAATGAACACAGAAGCAGAAAAATTGAAATCATAT TCCATGCCCATCAGCATTGAATTTCAGCGGAGATATGCAACAATTGTTCTGGAGCTTGAACAGCTGAACAAGGACCTAAACAAAGTTTTG CATAAAGTTCAACAGTATTGCTATGAGCTTGCTCCAGACCAGGGGCTCCAGCCTGCAGATCAGCCAACAGATATGAGACGCAGGTGTGAG GAAGAAGCACAGGAAATTGTTCGGCATGCAAATTCCTCAACAGGACAGCCCTGCGTTGAAAATGAAAATCTGACAGACTTAATTTCCAGG CTTACAGCTATTTTGTTACAAATTAAGTGTCTAGCAGAAGGAGGAGACCTGAATTCCTTTGAATTCAAATCACTTACAGACTCATTAAAT GATATCAAGAGTACAATAGACGCTTCTAATATCAGTTGCTTTCAGAATAATGTAGAAATCCATGTTGCACATATTCAGAGTGGCCTGAGC >In-frame_PARP1_ENST00000366794_chr1_226561927_-_LIN9_ENST00000481685_chr1_226438620_-_2559nt ATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAGTACGCCAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAG GACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCCATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTG GGCCACTCCATCCGGCACCCTGACGTTGAGGTGGATGGGTTCTCTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAA GCTGGAGGAGTGACAGGCAAAGGCCAGGATGGAATTGGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAGCAGAGTATGCCAAGTCC AACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATAGAAAAGGGCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAG CTAGGCATGATTGACCGCTGGTACCATCCAGGCTGCTTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCGAGTACAGTGCGAGTCAG CTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAAGAAGCCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGC GATGAGGTGGATGGAGTGGATGAAGTGGCGAAGAAGAAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTGAAAAAGCCCTAAAGGCT CAGAACGACCTGATCTGGAACATCAAGGACGAGCTAAAGAAAGTGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAG CAAGTGCCTTCTGGGGAGTCGGCGATCTTGGACCGAGTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCTGCGAGGAATGCTCGGGT CAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACTGGGGACGTCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGG AAGGAGTGGGTAACCCCAAAGGAATTCCGAGAAATCTCTTACCTCAAGAAATTGAAGGTTAAAAAACAGGACCGTATATTCCCCCCAGAA ACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCCACAGCCTCGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTA TCCAACATGAAGATCCTGACTCTCGGGAAGCTGTCCCGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAACTCGGGGGGAAGTTGACG GGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACCAAAAAGGAGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAAC ATCCGAGTTGTGTCTGAGGACTTCCTCCAGGACGTCTCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAGCGCACATCTTGTCCCCT TGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTTGTGGCCCCAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAG GTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGAATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGATTCTGGACTGGAA CACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTCTTCAGTGCCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTAC AAGCTGCAGCTTCTGGAGGACGACAAGGAAAACAGGTATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGGTGATCGGTAGCAACAAA CTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAGCACTTCATGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAAT TTCACGAAGTATCCCAAAAAGTTCTACCCCCTGGAGATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAAATCCTGGC ACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTCATCAAGATGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAG ACCAGATTATCAAAAATTCTCATGATTAAAAAGGAACATATCAAGAAATTAAGGGAAATGAACACAGAAGCAGAAAAATTGAAATCATAT TCCATGCCCATCAGCATTGAATTTCAGCGGAGATATGCAACAATTGTTCTGGAGCTTGAACAGCTGAACAAGGACCTAAACAAAGTTTTG CATAAAGTTCAACAGTATTGCTATGAGCTTGCTCCAGACCAGGGGCTCCAGCCTGCAGATCAGCCAACAGATATGAGACGCAGGTGTGAG GAAGAAGCACAGGAAATTGTTCGGCATGCAAATTCCTCAACAGGACAGCCCTGCGTTGAAAATGAAAATCTGACAGACTTAATTTCCAGG CTTACAGCTATTTTGTTACAAATTAAGTGTCTAGCAGAAGGAGGAGACCTGAATTCCTTTGAATTCAAATCACTTACAGACTCATTAAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PARP1_ENST00000366794_chr1_226561927_-_LIN9_ENST00000328205_chr1_226438620_-_4149nt CGGTGGCCGGTGCGGCGTGTTCGGTGGCGGCTCTGGCCGCTCAGGCGCCTGCGGCTGGGTGAGCGCACGCGAGGCGGCGAGGCGGCAGCG TGTTTCTAGGTCGTGGCGTCGGGCTTCCGGAGCTTTGGCGGCAGCTAGGGGAGGATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAG TACGCCAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCC ATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTGGGCCACTCCATCCGGCACCCTGACGTTGAGGTGGAT GGGTTCTCTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAAGCTGGAGGAGTGACAGGCAAAGGCCAGGATGGAATT GGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAGCAGAGTATGCCAAGTCCAACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATA GAAAAGGGCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAGCTAGGCATGATTGACCGCTGGTACCATCCAGGCTGC TTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCGAGTACAGTGCGAGTCAGCTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAA GAAGCCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGCGATGAGGTGGATGGAGTGGATGAAGTGGCGAAGAAG AAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTGAAAAAGCCCTAAAGGCTCAGAACGACCTGATCTGGAACATCAAGGACGAGCTA AAGAAAGTGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAGCAAGTGCCTTCTGGGGAGTCGGCGATCTTGGACCGA GTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCTGCGAGGAATGCTCGGGTCAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACT GGGGACGTCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGGAAGGAGTGGGTAACCCCAAAGGAATTCCGAGAAATC TCTTACCTCAAGAAATTGAAGGTTAAAAAACAGGACCGTATATTCCCCCCAGAAACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCC ACAGCCTCGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTATCCAACATGAAGATCCTGACTCTCGGGAAGCTGTCC CGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAACTCGGGGGGAAGTTGACGGGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACC AAAAAGGAGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAACATCCGAGTTGTGTCTGAGGACTTCCTCCAGGACGTC TCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAGCGCACATCTTGTCCCCTTGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTT GTGGCCCCAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAGGTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGA ATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGATTCTGGACTGGAACACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTC TTCAGTGCCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTACAAGCTGCAGCTTCTGGAGGACGACAAGGAAAACAGG TATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGGTGATCGGTAGCAACAAACTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAG CACTTCATGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAATTTCACGAAGTATCCCAAAAAGTTCTACCCCCTGGAG ATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAAATCCTGGCACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTC ATCAAGATGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAGACCAGATTATCAAAAATTCTCATGATTAAAAAGGAA CATATCAAGAAATTAAGGGAAATGAACACAGAAGCAGAAAAATTGAAATCATATTCCATGCCCATCAGCATTGAATTTCAGCGGAGATAT GCAACAATTGTTCTGGAGCTTGAACAGCTGAACAAGGACCTAAACAAAGTTTTGCATAAAGTTCAACAGTATTGCTATGAGCTTGCTCCA GACCAGGGGCTCCAGCCTGCAGATCAGCCAACAGATATGAGACGCAGGTGTGAGGAAGAAGCACAGGAAATTGTTCGGCATGCAAATTCC TCAACAGGACAGCCCTGCGTTGAAAATGAAAATCTGACAGACTTAATTTCCAGGCTTACAGCTATTTTGTTACAAATTAAGTGTCTAGCA GAAGGAGGAGACCTGAATTCCTTTGAATTCAAATCACTTACAGACTCATTAAATGATATCAAGAGTACAATAGACGCTTCTAATATCAGT TGCTTTCAGAATAATGTAGAAATCCATGTTGCACATATTCAGAGTGGCCTGAGCCAGATGGGAAACTTACATGCCTTTGCAGCAAATAAC ACCAACAGAGACTGAGTAAAGATTTCATTATTCCAACTGCACGGGACATTGTTTTTGAGAAGTTCTTTTCCTTTATATAGGCTTCCAACA CCAAATAACCTAACTGCTGGAAAACAAGGGAAATTTAAATCTCCAAATAAGGCATTTTAATAGACTGTACTGCTTCTTAAACCAGCATTG CTGACCAGCATTATATTTATTTTTCTTTTATTATTCAGATGCAGTAGCATTGCTTATGTTACATATGTTTATATTCACAAATATTTTTAA ACTGAAATATCTGAACATAATATAATTTCGTGGAAGAATACATTGACCATTTTTTTTAATGTGCATGAATTCACCGCAACACATGCAGAC AACTGCTGCAATGGAGAGTATGAAGAAACCTGGTCTTTTTATTCATGTCGGTGGCAGTGTGGAAATTCCATCCAGAAAATTACAACTCCA CTTGATTTAGTTGATCACCATCTCAGTCTTCAAAAGATAACATCATGAGGTGTGGGAAGTCCTAGTTTTAAGGAAACCACTGAAATATAG ATGGGAAATGTGGACTTTACAAGTATATGTTATATATACTTGCAATGTGACATGGTTCTGTAGATCATTTTATAATAATAAATATTTTAA TTTATCATAACATATAAAAGAAACCTTTGTTGTTTGTTGAAAGAAAATGAAGGAACAGGGGGAAAAAAGGTGCAAAATGCTAAATTTCTA AAAATGGATTTGGCATGTCTTCCCATCAGTTCAGGTCAAAAGTGCATTGTTGTGAGATTTATTAAAAAAAAAATGATAACACACTATTTT CATATTTTTTTGTTTATTTGCACAACTTTTAAACCAGATTACTGGTTAAAATCCAACAGTACACAATTTATAAAGTAAAAAGATTTTATA AGGAAAACAAATATAATAACCAGTGCTGTGAAATGCAGAAGAAAGGCTTGTTTTGGTTGTTTTTCTTTTTTAGGAAAACGCTGCCTAAAA TGTTAATCTTGTAAAAAGTATGTATTTGGAATTTTCTTCGTTTTAATAGAATATTATAAACTCAAAATATAAATTTTTTTCAAATTTGGA GTTTAAGATATAGCTGTAGAGGTGGTTTTAATTCCTTTAGATGTCTCATAAAATGAGACTTTTTATATGTTAATGTATAATAAAACTGAA ACAAGATTATTTTCCATTTGAAATTTTTGTATAGTTTAAAAAGGCTTCCGTATTCTTTGTTGGTATTGTGCCACTGCAGAACTTTAGTGC AGAGTTTATATTTAGCTAAACTGTTATGTTAATTAAGAAATGCATAAATCTTCTATTCTTAATATTTGTAATTCTAAATAAATTGATCTA >In-frame_PARP1_ENST00000366794_chr1_226561927_-_LIN9_ENST00000366801_chr1_226438620_-_4142nt CGGTGGCCGGTGCGGCGTGTTCGGTGGCGGCTCTGGCCGCTCAGGCGCCTGCGGCTGGGTGAGCGCACGCGAGGCGGCGAGGCGGCAGCG TGTTTCTAGGTCGTGGCGTCGGGCTTCCGGAGCTTTGGCGGCAGCTAGGGGAGGATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAG TACGCCAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCC ATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTGGGCCACTCCATCCGGCACCCTGACGTTGAGGTGGAT GGGTTCTCTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAAGCTGGAGGAGTGACAGGCAAAGGCCAGGATGGAATT GGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAGCAGAGTATGCCAAGTCCAACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATA GAAAAGGGCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAGCTAGGCATGATTGACCGCTGGTACCATCCAGGCTGC TTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCGAGTACAGTGCGAGTCAGCTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAA GAAGCCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGCGATGAGGTGGATGGAGTGGATGAAGTGGCGAAGAAG AAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTGAAAAAGCCCTAAAGGCTCAGAACGACCTGATCTGGAACATCAAGGACGAGCTA AAGAAAGTGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAGCAAGTGCCTTCTGGGGAGTCGGCGATCTTGGACCGA GTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCTGCGAGGAATGCTCGGGTCAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACT GGGGACGTCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGGAAGGAGTGGGTAACCCCAAAGGAATTCCGAGAAATC TCTTACCTCAAGAAATTGAAGGTTAAAAAACAGGACCGTATATTCCCCCCAGAAACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCC ACAGCCTCGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTATCCAACATGAAGATCCTGACTCTCGGGAAGCTGTCC CGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAACTCGGGGGGAAGTTGACGGGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACC AAAAAGGAGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAACATCCGAGTTGTGTCTGAGGACTTCCTCCAGGACGTC TCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAGCGCACATCTTGTCCCCTTGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTT GTGGCCCCAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAGGTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGA ATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGATTCTGGACTGGAACACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTC TTCAGTGCCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTACAAGCTGCAGCTTCTGGAGGACGACAAGGAAAACAGG TATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGGTGATCGGTAGCAACAAACTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAG CACTTCATGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAATTTCACGAAGTATCCCAAAAAGTTCTACCCCCTGGAG ATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAAATCCTGGCACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTC ATCAAGATGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAGACCAGATTATCAAAAATTCTCATGATTAAAAAGGAA CATATCAAGAAATTAAGGGAAATGAACACAGAAGCAGAAAAATTGAAATCATATTCCATGCCCATCAGCATTGAATTTCAGCGGAGATAT GCAACAATTGTTCTGGAGCTTGAACAGCTGAACAAGGACCTAAACAAAGTTTTGCATAAAGTTCAACAGTATTGCTATGAGCTTGCTCCA GACCAGGGGCTCCAGCCTGCAGATCAGCCAACAGATATGAGACGCAGGTGTGAGGAAGAAGCACAGGAAATTGTTCGGCATGCAAATTCC TCAACAGGACAGCCCTGCGTTGAAAATGAAAATCTGACAGACTTAATTTCCAGGCTTACAGCTATTTTGTTACAAATTAAGTGTCTAGCA GAAGGAGGAGACCTGAATTCCTTTGAATTCAAATCACTTACAGACTCATTAAATGATATCAAGAGTACAATAGACGCTTCTAATATCAGT TGCTTTCAGAATAATGTAGAAATCCATGTTGCACATATTCAGAGTGGCCTGAGCCAGATGGGAAACTTACATGCCTTTGCAGCAAATAAC ACCAACAGAGACTGAGTAAAGATTTCATTATTCCAACTGCACGGGACATTGTTTTTGAGAAGTTCTTTTCCTTTATATAGGCTTCCAACA CCAAATAACCTAACTGCTGGAAAACAAGGGAAATTTAAATCTCCAAATAAGGCATTTTAATAGACTGTACTGCTTCTTAAACCAGCATTG CTGACCAGCATTATATTTATTTTTCTTTTATTATTCAGATGCAGTAGCATTGCTTATGTTACATATGTTTATATTCACAAATATTTTTAA ACTGAAATATCTGAACATAATATAATTTCGTGGAAGAATACATTGACCATTTTTTTTAATGTGCATGAATTCACCGCAACACATGCAGAC AACTGCTGCAATGGAGAGTATGAAGAAACCTGGTCTTTTTATTCATGTCGGTGGCAGTGTGGAAATTCCATCCAGAAAATTACAACTCCA CTTGATTTAGTTGATCACCATCTCAGTCTTCAAAAGATAACATCATGAGGTGTGGGAAGTCCTAGTTTTAAGGAAACCACTGAAATATAG ATGGGAAATGTGGACTTTACAAGTATATGTTATATATACTTGCAATGTGACATGGTTCTGTAGATCATTTTATAATAATAAATATTTTAA TTTATCATAACATATAAAAGAAACCTTTGTTGTTTGTTGAAAGAAAATGAAGGAACAGGGGGAAAAAAGGTGCAAAATGCTAAATTTCTA AAAATGGATTTGGCATGTCTTCCCATCAGTTCAGGTCAAAAGTGCATTGTTGTGAGATTTATTAAAAAAAAAATGATAACACACTATTTT CATATTTTTTTGTTTATTTGCACAACTTTTAAACCAGATTACTGGTTAAAATCCAACAGTACACAATTTATAAAGTAAAAAGATTTTATA AGGAAAACAAATATAATAACCAGTGCTGTGAAATGCAGAAGAAAGGCTTGTTTTGGTTGTTTTTCTTTTTTAGGAAAACGCTGCCTAAAA TGTTAATCTTGTAAAAAGTATGTATTTGGAATTTTCTTCGTTTTAATAGAATATTATAAACTCAAAATATAAATTTTTTTCAAATTTGGA GTTTAAGATATAGCTGTAGAGGTGGTTTTAATTCCTTTAGATGTCTCATAAAATGAGACTTTTTATATGTTAATGTATAATAAAACTGAA ACAAGATTATTTTCCATTTGAAATTTTTGTATAGTTTAAAAAGGCTTCCGTATTCTTTGTTGGTATTGTGCCACTGCAGAACTTTAGTGC AGAGTTTATATTTAGCTAAACTGTTATGTTAATTAAGAAATGCATAAATCTTCTATTCTTAATATTTGTAATTCTAAATAAATTGATCTA >In-frame_PARP1_ENST00000366794_chr1_226561927_-_LIN9_ENST00000481685_chr1_226438620_-_3082nt CGGTGGCCGGTGCGGCGTGTTCGGTGGCGGCTCTGGCCGCTCAGGCGCCTGCGGCTGGGTGAGCGCACGCGAGGCGGCGAGGCGGCAGCG TGTTTCTAGGTCGTGGCGTCGGGCTTCCGGAGCTTTGGCGGCAGCTAGGGGAGGATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAG TACGCCAAGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCC ATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCTCCTGCTTCTGGAAGGTGGGCCACTCCATCCGGCACCCTGACGTTGAGGTGGAT GGGTTCTCTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAAGCTGGAGGAGTGACAGGCAAAGGCCAGGATGGAATT GGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAGCAGAGTATGCCAAGTCCAACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATA GAAAAGGGCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAGCTAGGCATGATTGACCGCTGGTACCATCCAGGCTGC TTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCGAGTACAGTGCGAGTCAGCTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAA GAAGCCCTGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGCGATGAGGTGGATGGAGTGGATGAAGTGGCGAAGAAG AAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTGAAAAAGCCCTAAAGGCTCAGAACGACCTGATCTGGAACATCAAGGACGAGCTA AAGAAAGTGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAGCAAGTGCCTTCTGGGGAGTCGGCGATCTTGGACCGA GTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCTGCGAGGAATGCTCGGGTCAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACT GGGGACGTCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGGAAGGAGTGGGTAACCCCAAAGGAATTCCGAGAAATC TCTTACCTCAAGAAATTGAAGGTTAAAAAACAGGACCGTATATTCCCCCCAGAAACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCC ACAGCCTCGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTATCCAACATGAAGATCCTGACTCTCGGGAAGCTGTCC CGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAACTCGGGGGGAAGTTGACGGGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACC AAAAAGGAGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAACATCCGAGTTGTGTCTGAGGACTTCCTCCAGGACGTC TCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAGCGCACATCTTGTCCCCTTGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTT GTGGCCCCAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAGGTCAAGGAGGAAGGTATCAACAAATCTGAAAAGAGA ATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATCCTGATTCTGGACTGGAACACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTC TTCAGTGCCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTACAAGCTGCAGCTTCTGGAGGACGACAAGGAAAACAGG TATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGGTGATCGGTAGCAACAAACTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAG CACTTCATGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAATTTCACGAAGTATCCCAAAAAGTTCTACCCCCTGGAG ATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAAATCCTGGCACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTC ATCAAGATGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAGACCAGATTATCAAAAATTCTCATGATTAAAAAGGAA CATATCAAGAAATTAAGGGAAATGAACACAGAAGCAGAAAAATTGAAATCATATTCCATGCCCATCAGCATTGAATTTCAGCGGAGATAT GCAACAATTGTTCTGGAGCTTGAACAGCTGAACAAGGACCTAAACAAAGTTTTGCATAAAGTTCAACAGTATTGCTATGAGCTTGCTCCA GACCAGGGGCTCCAGCCTGCAGATCAGCCAACAGATATGAGACGCAGGTGTGAGGAAGAAGCACAGGAAATTGTTCGGCATGCAAATTCC TCAACAGGACAGCCCTGCGTTGAAAATGAAAATCTGACAGACTTAATTTCCAGGCTTACAGCTATTTTGTTACAAATTAAGTGTCTAGCA GAAGGAGGAGACCTGAATTCCTTTGAATTCAAATCACTTACAGACTCATTAAATGATATCAAGAGTACAATAGACGCTTCTAATATCAGG TAATTCGTTAGGTATACTCTAATCATTTTAATGTGAAGTTCATAGTAATTTTCAGTCCAGGTTTTAAGAATTATGCATATTTGTGAAGTA CTCATATATTATTATCCGTTAAATATATTTGTAAGAGCTTTTCACTTATATCCAGCCTATGGACAGAATAGAAATTTCACATGGATTTTG TATATAAAGAAATCAGGACATATATTTAGGTTTGGGGTCAGCATGGAGGTTGAGCTTAGAGGTAGAGCTTCCCCAGTCAGTGAGAGACTC ATCTTCTCCTTCCAGCCCCCCGTGGCTCCTTTGCTTCTTTAGAGCATATTTGTTCAACTACTACTGAAGTAGAATTATGGCTAATATATT 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FusionGenePPI for PARP1_LIN9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PARP1 | APTX, TERF2IP, TP53, XRCC1, ZNF423, PCNA, CDKN1A, PARP3, RBM14, CENPA, CENPB, BUB3, TAL1, SWAP70, NCOA6, RELA, POLA1, POLA2, MYBL2, PARP2, RPS3A, BCL2, PTK2, RRP1B, H2AFY, USP36, MEPCE, TAF13, TCEA2, AIRE, GBAS, PRKAA1, FOXO1, NRF1, HIST1H1A, PIAS4, IMMT, BANF1, CHD1L, SENP1, SENP3, EP300, HSPA2, LZTR1, TRIM29, ZBTB9, MYB, SMARCA1, ESR1, TOP2B, PRKDC, XRCC5, XRCC6, SUPT16H, TRIM28, NCAPD2, NCAPG, H2AFX, BUB1B, CREBBP, GTF2F1, MED1, MED14, MED23, MED24, MED17, MED7, CDK8, THRAP3, MED6, HMGA1, NFKB1, PARP1, HDAC1, HDAC2, HDAC3, RARA, THRA, HIF1A, CARM1, PRMT1, HIST1H1C, NFATC1, SP1, ATM, H3F3A, TOPORS, THRB, BMI1, HDAC9, POLB, HIST2H2AA3, HIST1H2BA, HIST1H4C, HIST1H3E, CTCF, RYK, KLF8, USF1, HDAC5, APLF, TOP1, LIG3, HOXB7, VHL, RNF146, SMARCAD1, SREK1, TCF7L2, NPM1, HDGF, HES1, WRN, CEBPA, ELAVL1, CHFR, ERG, CDK2, COPS5, CAND1, UBE2I, ZBTB16, DDX21, PGR, CASP1, NOTCH1, FMNL1, CTSB, CTSG, PNKP, GZMM, FN1, VCAM1, ITGA4, CBX2, CBX4, CTNNB1, CASP3, CASP7, E2F1, PAN2, ERCC6, LMNA, BAG3, CD86, BLM, RPL19, SPP1, MAFG, MAFK, MAFF, ABL1, CETN2, RPL35, CETN1, RPL27A, PHB, RPL14, RPS8, TUBB, ATP5A1, DDX39A, TUBB1, POLG2, PDLIM7, RAD23A, HNRNPH1, NQO1, RPA1, RPA2, RPA3, UHRF1, RIOK2, PARP9, DDB2, IVNS1ABP, DNMT1, HUWE1, BANP, SHMT2, MOV10, NXF1, KAT2B, HIST1H4A, SIRT1, JUN, CUL7, OBSL1, CCDC8, CASP8, MAST3, WDR76, RPA4, RNF166, LGALS3, NTRK1, SCARNA22, KLF5, TCF3, POU2F1, BLID, IL24, MTA3, RASL10B, THRSP, EWSR1, DAXX, RPL10, EXOSC1, UIMC1, BRCA1, FAM175A, BARD1, MACROD1, IKBKG, NF2, CDC5L, UHRF2, DTX3L, RC3H1, NFATC2, C4orf27, HIST1H1B, HIST3H3, HMGB1, HMGN1, HMGN2, HMGN4, HIST1H3A, HIST1H2BC, H1F0, EGFR, HIPK2, HSPA1A, STUB1, CHD4, RRM2, CHEK1, DERL1, ZNF746, PPM1G, XPC, SNRNP27, SSRP1, NR3C1, BRCA2, FEN1, FANCD2, CYLD, ECD, YAP1, MTF1, AIMP2, TXNIP | LIN9 | RB1, LIN54, LIN37, LIN52, MYBL2, E2F4, RBL2, TFDP1, TFDP2, LIN9, MYBL1, RBBP4, RBL1, SHMT2, MOV10, NXF1, PHF20L1, RBBP7, HIST1H2BG, XPO1, TEAD2, FOXM1, DIS3L, FAM167A, RGS13, SLMAP, RPN2, COL1A1, TCF19, HBS1L, MOCS3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PARP1_LIN9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PARP1 | P09874 | DB00277 | Theophylline | Poly [ADP-ribose] polymerase 1 | small molecule | approved |
| Hgene | PARP1 | P09874 | DB09074 | Olaparib | Poly [ADP-ribose] polymerase 1 | small molecule | approved |
| Hgene | PARP1 | P09874 | DB01593 | Zinc | Poly [ADP-ribose] polymerase 1 | small molecule | approved|investigational |
| Hgene | PARP1 | P09874 | DB02701 | Nicotinamide | Poly [ADP-ribose] polymerase 1 | small molecule | approved|investigational |
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RelatedDiseases for PARP1_LIN9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PARP1 | C0022658 | Kidney Diseases | 2 | CTD_human |
| Hgene | PARP1 | C0002170 | Alopecia | 1 | CTD_human |
| Hgene | PARP1 | C0002871 | Anemia | 1 | CTD_human |
| Hgene | PARP1 | C0004096 | Asthma | 1 | CTD_human |
| Hgene | PARP1 | C0004153 | Atherosclerosis | 1 | CTD_human |
| Hgene | PARP1 | C0007786 | Brain Ischemia | 1 | CTD_human |
| Hgene | PARP1 | C0011603 | Dermatitis | 1 | CTD_human |
| Hgene | PARP1 | C0019158 | Hepatitis | 1 | CTD_human |
| Hgene | PARP1 | C0021368 | Inflammation | 1 | CTD_human |
| Hgene | PARP1 | C0022821 | Kyphosis deformity of spine | 1 | CTD_human |
| Hgene | PARP1 | C0026764 | Multiple Myeloma | 1 | CTD_human |
| Hgene | PARP1 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | PARP1 | C0032285 | Pneumonia | 1 | CTD_human |
| Hgene | PARP1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | PARP1 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
| Hgene | PARP1 | C0042842 | Vitamin A Deficiency | 1 | CTD_human |
| Hgene | PARP1 | C0242422 | Parkinsonian Disorders | 1 | CTD_human |
| Hgene | PARP1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Hgene | PARP1 | C0878544 | Cardiomyopathies | 1 | CTD_human |
| Hgene | PARP1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | PARP1 | C2931673 | Ceroid lipofuscinosis, neuronal 1, infantile | 1 | CTD_human |
| Hgene | PARP1 | C2936350 | Plaque, Atherosclerotic | 1 | CTD_human |
| Hgene | PARP1 | C3714756 | Intellectual Disability | 1 | CTD_human |
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