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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26029

FusionGeneSummary for PARP15_MAT2A

check button Fusion gene summary
Fusion gene informationFusion gene name: PARP15_MAT2A
Fusion gene ID: 26029
HgeneTgene
Gene symbol

PARP15

MAT2A

Gene ID

165631

4144

Gene namepoly(ADP-ribose) polymerase family member 15methionine adenosyltransferase 2A
SynonymsARTD7|BAL3|pART7MATA2|MATII|SAMS2
Cytomap

3q21.1

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionpoly [ADP-ribose] polymerase 15ADP-ribosyltransferase diphtheria toxin-like 7B-aggressive lymphoma 3B-aggressive lymphoma protein 3PARP-15S-adenosylmethionine synthase isoform type-2MAT 2MAT-IIadoMet synthase 2adoMet synthetase 2methionine adenosyltransferase 2methionine adenosyltransferase II, alphatesticular tissue protein Li 121
Modification date2018051920180523
UniProtAcc

Q460N3

P31153

Ensembl transtripts involved in fusion geneENST00000464300, ENST00000483793, 
ENST00000465304, ENST00000493645, 
ENST00000310366, 
ENST00000306434, 
ENST00000409017, ENST00000490878, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: PARP15 [Title/Abstract] AND MAT2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAT2A

GO:0006556

S-adenosylmethionine biosynthetic process

10644686|25075345

TgeneMAT2A

GO:0034214

protein hexamerization

25075345

TgeneMAT2A

GO:0051291

protein heterooligomerization

25075345


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM823880PARP15chr3

122305561

-MAT2Achr2

85769284

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000464300ENST00000306434PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-3CDSENST00000464300ENST00000409017PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-intronENST00000464300ENST00000490878PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-3CDSENST00000483793ENST00000306434PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-3CDSENST00000483793ENST00000409017PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-intronENST00000483793ENST00000490878PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-3CDSENST00000465304ENST00000306434PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-3CDSENST00000465304ENST00000409017PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-intronENST00000465304ENST00000490878PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-3CDSENST00000493645ENST00000306434PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-3CDSENST00000493645ENST00000409017PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-intronENST00000493645ENST00000490878PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-3CDSENST00000310366ENST00000306434PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-3CDSENST00000310366ENST00000409017PARP15chr3

122305561

-MAT2Achr2

85769284

+
intron-intronENST00000310366ENST00000490878PARP15chr3

122305561

-MAT2Achr2

85769284

+

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FusionProtFeatures for PARP15_MAT2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARP15

Q460N3

MAT2A

P31153

Possesses ADP-ribosyltransferase activity(PubMed:16061477, PubMed:25635049). Transcriptional repressor(PubMed:16061477). {ECO:0000269|PubMed:16061477,ECO:0000269|PubMed:25635049}. Catalyzes the formation of S-adenosylmethionine frommethionine and ATP. The reaction comprises two steps that are bothcatalyzed by the same enzyme: formation of S-adenosylmethionine(AdoMet) and triphosphate, and subsequent hydrolysis of thetriphosphate. {ECO:0000269|PubMed:10644686,ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PARP15_MAT2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PARP15_MAT2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARP15_MAT2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMAT2AP31153DB00118AdemetionineS-adenosylmethionine synthase isoform type-2small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for PARP15_MAT2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource