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Fusion gene ID: 26029 |
FusionGeneSummary for PARP15_MAT2A |
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Fusion gene information | Fusion gene name: PARP15_MAT2A | Fusion gene ID: 26029 | Hgene | Tgene | Gene symbol | PARP15 | MAT2A | Gene ID | 165631 | 4144 |
Gene name | poly(ADP-ribose) polymerase family member 15 | methionine adenosyltransferase 2A | |
Synonyms | ARTD7|BAL3|pART7 | MATA2|MATII|SAMS2 | |
Cytomap | 3q21.1 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | poly [ADP-ribose] polymerase 15ADP-ribosyltransferase diphtheria toxin-like 7B-aggressive lymphoma 3B-aggressive lymphoma protein 3PARP-15 | S-adenosylmethionine synthase isoform type-2MAT 2MAT-IIadoMet synthase 2adoMet synthetase 2methionine adenosyltransferase 2methionine adenosyltransferase II, alphatesticular tissue protein Li 121 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q460N3 | P31153 | |
Ensembl transtripts involved in fusion gene | ENST00000464300, ENST00000483793, ENST00000465304, ENST00000493645, ENST00000310366, | ENST00000306434, ENST00000409017, ENST00000490878, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: PARP15 [Title/Abstract] AND MAT2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MAT2A | GO:0006556 | S-adenosylmethionine biosynthetic process | 10644686|25075345 |
Tgene | MAT2A | GO:0034214 | protein hexamerization | 25075345 |
Tgene | MAT2A | GO:0051291 | protein heterooligomerization | 25075345 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM823880 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000464300 | ENST00000306434 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-3CDS | ENST00000464300 | ENST00000409017 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-intron | ENST00000464300 | ENST00000490878 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-3CDS | ENST00000483793 | ENST00000306434 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-3CDS | ENST00000483793 | ENST00000409017 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-intron | ENST00000483793 | ENST00000490878 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-3CDS | ENST00000465304 | ENST00000306434 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-3CDS | ENST00000465304 | ENST00000409017 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-intron | ENST00000465304 | ENST00000490878 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-3CDS | ENST00000493645 | ENST00000306434 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-3CDS | ENST00000493645 | ENST00000409017 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-intron | ENST00000493645 | ENST00000490878 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-3CDS | ENST00000310366 | ENST00000306434 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-3CDS | ENST00000310366 | ENST00000409017 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
intron-intron | ENST00000310366 | ENST00000490878 | PARP15 | chr3 | 122305561 | - | MAT2A | chr2 | 85769284 | + |
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FusionProtFeatures for PARP15_MAT2A |
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Hgene | Tgene |
PARP15 | MAT2A |
Possesses ADP-ribosyltransferase activity(PubMed:16061477, PubMed:25635049). Transcriptional repressor(PubMed:16061477). {ECO:0000269|PubMed:16061477,ECO:0000269|PubMed:25635049}. | Catalyzes the formation of S-adenosylmethionine frommethionine and ATP. The reaction comprises two steps that are bothcatalyzed by the same enzyme: formation of S-adenosylmethionine(AdoMet) and triphosphate, and subsequent hydrolysis of thetriphosphate. {ECO:0000269|PubMed:10644686,ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PARP15_MAT2A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PARP15_MAT2A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PARP15_MAT2A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | MAT2A | P31153 | DB00118 | Ademetionine | S-adenosylmethionine synthase isoform type-2 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for PARP15_MAT2A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |