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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 26028

FusionGeneSummary for PARP14_TASP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PARP14_TASP1
Fusion gene ID: 26028
HgeneTgene
Gene symbol

PARP14

TASP1

Gene ID

54625

55617

Gene namepoly(ADP-ribose) polymerase family member 14taspase 1
SynonymsARTD8|BAL2|PARP-14|pART8C20orf13|dJ585I14.2
Cytomap

3q21.1

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionpoly [ADP-ribose] polymerase 14ADP-ribosyltransferase diphtheria toxin-like 8B-aggressive lymphoma 2b aggressive lymphoma protein 2collaborator of STAT6threonine aspartase 1
Modification date2018051920180523
UniProtAcc

Q460N5

Q9H6P5

Ensembl transtripts involved in fusion geneENST00000474629, ENST00000475640, 
ENST00000539805, ENST00000480436, 
ENST00000337743, ENST00000544472, 
Fusion gene scores* DoF score6 X 7 X 3=1266 X 6 X 4=144
# samples 88
** MAII scorelog2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARP14 [Title/Abstract] AND TASP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePARP14

GO:0006471

protein ADP-ribosylation

27796300


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-A493-01APARP14chr3

122420482

+TASP1chr20

13514788

-
TCGALDLUADTCGA-55-A493-01APARP14chr3

122420482

+TASP1chr20

13539761

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000474629ENST00000539805PARP14chr3

122420482

+TASP1chr20

13514788

-
5CDS-5UTRENST00000474629ENST00000480436PARP14chr3

122420482

+TASP1chr20

13514788

-
5CDS-5UTRENST00000474629ENST00000337743PARP14chr3

122420482

+TASP1chr20

13514788

-
5CDS-intronENST00000474629ENST00000544472PARP14chr3

122420482

+TASP1chr20

13514788

-
intron-intronENST00000475640ENST00000539805PARP14chr3

122420482

+TASP1chr20

13514788

-
intron-5UTRENST00000475640ENST00000480436PARP14chr3

122420482

+TASP1chr20

13514788

-
intron-5UTRENST00000475640ENST00000337743PARP14chr3

122420482

+TASP1chr20

13514788

-
intron-intronENST00000475640ENST00000544472PARP14chr3

122420482

+TASP1chr20

13514788

-
5CDS-intronENST00000474629ENST00000539805PARP14chr3

122420482

+TASP1chr20

13539761

-
5CDS-5UTRENST00000474629ENST00000480436PARP14chr3

122420482

+TASP1chr20

13539761

-
5CDS-5UTRENST00000474629ENST00000337743PARP14chr3

122420482

+TASP1chr20

13539761

-
5CDS-intronENST00000474629ENST00000544472PARP14chr3

122420482

+TASP1chr20

13539761

-
intron-intronENST00000475640ENST00000539805PARP14chr3

122420482

+TASP1chr20

13539761

-
intron-5UTRENST00000475640ENST00000480436PARP14chr3

122420482

+TASP1chr20

13539761

-
intron-5UTRENST00000475640ENST00000337743PARP14chr3

122420482

+TASP1chr20

13539761

-
intron-intronENST00000475640ENST00000544472PARP14chr3

122420482

+TASP1chr20

13539761

-

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FusionProtFeatures for PARP14_TASP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARP14

Q460N5

TASP1

Q9H6P5

ADP-ribosyltransferase (PubMed:16061477,PubMed:27796300). By mono-ADP-ribosylating STAT1 at 'Glu-657' and'Glu-705' and thus decreasing STAT1 phosphorylation, negativelyregulates pro-inflammatory cytokines production in macrophages inresponse to IFNG stimulation (PubMed:27796300). Mono-ADP-ribosylates STAT6 (By similarity). Enhances STAT6-dependenttranscription (By similarity). In macrophages, positivelyregulates MRC1 expression in response to IL4 stimulation bypromoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300).{ECO:0000250|UniProtKB:Q2EMV9, ECO:0000269|PubMed:16061477,ECO:0000269|PubMed:27796300}. Protease involved in KMT2A/MLL1 processing and,consequently, in the correct expression of the early HOXA genecluster. {ECO:0000269|PubMed:14636557}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PARP14_TASP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PARP14_TASP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARP14GPI, STAT6, FCER2, HDAC2, HDAC3, CUL2, IKBKG, RPA1, RPA2, RPA3, DTX3L, PARP9, GAN, PARP10TASP1APP, KMT2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARP14_TASP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARP14_TASP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource