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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 26023

FusionGeneSummary for PARP14_DIRC2

check button Fusion gene summary
Fusion gene informationFusion gene name: PARP14_DIRC2
Fusion gene ID: 26023
HgeneTgene
Gene symbol

PARP14

DIRC2

Gene ID

54625

84925

Gene namepoly(ADP-ribose) polymerase family member 14disrupted in renal carcinoma 2
SynonymsARTD8|BAL2|PARP-14|pART8RCC4
Cytomap

3q21.1

3q21.1

Type of geneprotein-codingprotein-coding
Descriptionpoly [ADP-ribose] polymerase 14ADP-ribosyltransferase diphtheria toxin-like 8B-aggressive lymphoma 2b aggressive lymphoma protein 2collaborator of STAT6disrupted in renal carcinoma protein 2disrupted in renal cancer protein 2renal cell carcinoma 4
Modification date2018051920180523
UniProtAcc

Q460N5

Q96SL1

Ensembl transtripts involved in fusion geneENST00000474629, ENST00000475640, 
ENST00000261038, 
Fusion gene scores* DoF score6 X 7 X 3=1263 X 3 X 3=27
# samples 84
** MAII scorelog2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PARP14 [Title/Abstract] AND DIRC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePARP14

GO:0006471

protein ADP-ribosylation

27796300


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-GU-A764-01APARP14chr3

122439235

+DIRC2chr3

122598110

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000474629ENST00000261038PARP14chr3

122439235

+DIRC2chr3

122598110

+
3UTR-3CDSENST00000475640ENST00000261038PARP14chr3

122439235

+DIRC2chr3

122598110

+

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FusionProtFeatures for PARP14_DIRC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARP14

Q460N5

DIRC2

Q96SL1

ADP-ribosyltransferase (PubMed:16061477,PubMed:27796300). By mono-ADP-ribosylating STAT1 at 'Glu-657' and'Glu-705' and thus decreasing STAT1 phosphorylation, negativelyregulates pro-inflammatory cytokines production in macrophages inresponse to IFNG stimulation (PubMed:27796300). Mono-ADP-ribosylates STAT6 (By similarity). Enhances STAT6-dependenttranscription (By similarity). In macrophages, positivelyregulates MRC1 expression in response to IL4 stimulation bypromoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300).{ECO:0000250|UniProtKB:Q2EMV9, ECO:0000269|PubMed:16061477,ECO:0000269|PubMed:27796300}. Electrogenic metabolite transporter.{ECO:0000269|PubMed:21692750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+15171003_119016471802DomainMacro 2
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+15171216_138716471802DomainMacro 3
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+15171523_160116471802DomainWWE
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+1517791_97816471802DomainMacro 1
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+15171023_102416471802RegionSubstrate 2 binding
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+15171046_104916471802RegionSubstrate 2 binding
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+15171133_113716471802RegionSubstrate 2 binding
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+15171175_117816471802RegionSubstrate 2 binding
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+15171235_123616471802RegionSubstrate 3 binding
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+15171332_133616471802RegionSubstrate 3 binding
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+1517922_92616471802RegionSubstrate 1 binding
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79464_478440479Topological domainCytoplasmic
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79443_463440479TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARP14chr3:122439235chr3:122598110ENST00000474629+15171605_180116471802DomainPARP catalytic
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79111_117440479Topological domainCytoplasmic
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79139_155440479Topological domainLumenal
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79177_184440479Topological domainCytoplasmic
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+791_51440479Topological domainCytoplasmic
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79206_229440479Topological domainLumenal
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79251_281440479Topological domainCytoplasmic
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79303_314440479Topological domainLumenal
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79336_347440479Topological domainCytoplasmic
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79369_384440479Topological domainLumenal
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79406_414440479Topological domainCytoplasmic
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79436_442440479Topological domainLumenal
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+7973_89440479Topological domainLumenal
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79118_138440479TransmembraneHelical
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79156_176440479TransmembraneHelical
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79185_205440479TransmembraneHelical
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79230_250440479TransmembraneHelical
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79282_302440479TransmembraneHelical
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79315_335440479TransmembraneHelical
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79348_368440479TransmembraneHelical
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79385_405440479TransmembraneHelical
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+79415_435440479TransmembraneHelical
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+7952_72440479TransmembraneHelical
TgeneDIRC2chr3:122439235chr3:122598110ENST00000261038+7990_110440479TransmembraneHelical


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FusionGeneSequence for PARP14_DIRC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PARP14_ENST00000474629_chr3_122439235_+_DIRC2_ENST00000261038_chr3_122598110_+_1685aa
MAVPGSFPLLVEGSWGPDPPKNLNTKLQMYFQSPKRSGGGECEVRQDPRSPSRFLVFFYPEDVRQKVLERKNHELVWQGKGTFKLTVQLP
ATPDEIDHVFEEELLTKESKTKEDVKEPDVSEELDTKLPLDGGLDKMEDIPEECENISSLVAFENLKANVTDIMLILLVENISGLSNDDF
QVEIIRDFDVAVVTFQKHIDTIRFVDDCTKHHSIKQLQLSPRLLEVTNTIRVENLPPGADDYSLKLFFENPYNGGGRVANVEYFPEESSA
LIEFFDRKVLDTIMATKLDFNKMPLSVFPYYASLGTALYGKEKPLIKLPAPFEESLDLPLWKFLQKKNHLIEEINDEMRRCHCELTWSQL
SGKVTIRPAATLVNEGRPRIKTWQADTSTTLSSIRSKYKVNPIKVDPTMWDTIKNDVKDDRILIEFDTLKEMVILAGKSEDVQSIEVQVR
ELIESTTQKIKREEQSLKEKMIISPGRYFLLCHSSLLDHLLTECPEIEICYDRVTQHLCLKGPSADVYKAKCEIQEKVYTMAQKNIQVSP
EIFQFLQQVNWKEFSKCLFIAQKILALYELEGTTVLLTSCSSEALLEAEKQMLSALNYKRIEVENKEVLHGKKWKGLTHNLLKKQNSSPN
TVIINELTSETTAEVIITGCVKEVNETYKLLFNFVEQNMKIERLVEVKPSLVIDYLKTEKKLFWPKIKKVNVQVSFNPENKQKGILLTGS
KTEVLKAVDIVKQVWDSVCVKSVHTDKPGAKQFFQDKARFYQSEIKRLFGCYIELQENEVMKEGGSPAGQKCFSRTVLAPGVVLIVQQGD
LARLPVDVVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKREGRLLPGNATISKAGKLPYHHVIHAVGPRWSGYEAPRCVYLLRRA
VQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSAIKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFKATLPDTAAPPG
LPPAAAGPGKTSWEKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVLSRGPLSKSLLEKAGPELQEELDTVGQGVAVSMGTVLKTS
SWNLDCRYVLHVVAPEWRNGSTSSLKIMEDIIRECMEITESLSLKSIAFPAIGTGNLGFPKNIFAELIISEVFKFSSKNQLKTLQEVHFL
LHPSDHENIQAFSDEFARRANGNLVSDKIPKAKDTQGFYGTVSSPDSGVYEMKIGSIIFQVASGDITKEEADVIVNSTSNSFNLKAGVSK
AILECAGQNVERECSQQAQQRKNDYIITGGGFLRCKNIIHVIGGNDVKSSVSSVLQECEKKNYSSICLPAIGTGNAKQHPDKVAEAIIDA
IEDFVQKGSAQSVKKVKVVIFLPQVLDVFYANMKKREGTQLSSQQSVMSKLASFLGFSKQSPQKKNHLVLEKKTESATFRVCGENVTCVE
YAISWLQDLIEKEQCPYTSEDECIKDFDEKEYQELNELQKKLNINISLDHKRPLIKVLGISRDVMQARDEIEAMIKRVRLAKEQESRADC
ISEFIEWQYNDNNTSHCFNKMTNLKLEDARREKKKTVDVKINHRHYTVNLNTYTATDTKGHSLSVQRLTKSKVDIPAHWSDMKQQNFCVV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PARP14_ENST00000474629_chr3_122439235_+_DIRC2_ENST00000261038_chr3_122598110_+_5057nt
ATGGCTGTGCCCGGCTCCTTCCCGCTGCTGGTCGAGGGCTCCTGGGGCCCCGACCCCCCGAAGAACTTGAACACCAAGTTGCAGATGTAC
TTCCAGAGCCCGAAGAGGTCGGGAGGCGGCGAGTGTGAGGTCCGCCAGGATCCCAGGAGCCCATCCCGCTTCCTGGTGTTCTTCTACCCG
GAGGACGTTCGGCAGAAGGTTCTGGAGAGAAAAAATCATGAGTTGGTATGGCAAGGAAAAGGAACATTCAAGTTAACTGTCCAGTTACCT
GCAACCCCAGATGAAATCGATCATGTCTTTGAAGAGGAACTTCTAACAAAAGAATCCAAGACCAAAGAAGATGTTAAAGAACCAGATGTG
TCAGAAGAATTGGATACAAAACTCCCTCTTGATGGTGGATTAGACAAAATGGAAGATATCCCAGAGGAATGTGAAAATATTTCCTCTTTG
GTGGCATTTGAAAACCTCAAGGCAAATGTGACTGACATAATGCTAATCTTGTTAGTGGAGAACATAAGTGGCCTGTCTAATGATGACTTT
CAAGTGGAAATAATAAGAGATTTTGATGTTGCTGTTGTTACCTTTCAAAAGCACATAGATACTATAAGATTTGTTGATGATTGTACCAAG
CACCATTCAATTAAACAACTTCAGCTTTCTCCAAGACTTCTGGAAGTGACAAACACAATCAGGGTTGAAAACCTGCCACCTGGTGCTGAT
GACTACAGTTTAAAACTTTTCTTTGAAAATCCCTATAATGGAGGGGGAAGAGTTGCCAATGTTGAATATTTTCCTGAAGAGAGTTCAGCT
CTGATTGAATTTTTTGACAGAAAAGTGTTAGACACCATCATGGCCACAAAACTCGACTTCAATAAAATGCCACTTTCTGTGTTCCCATAC
TATGCCTCATTGGGCACAGCCTTGTATGGAAAGGAGAAGCCTCTGATCAAGCTTCCAGCACCATTTGAAGAGTCACTAGATCTTCCCTTA
TGGAAGTTCTTACAGAAAAAGAATCACCTCATTGAGGAGATAAACGATGAAATGAGGCGTTGTCACTGTGAGCTCACGTGGTCCCAACTC
AGTGGTAAAGTTACCATCAGACCAGCAGCCACCTTAGTCAATGAAGGAAGACCGAGAATCAAGACCTGGCAGGCAGATACTTCCACAACA
CTCTCTAGCATCAGGTCTAAATATAAAGTCAACCCAATTAAAGTGGATCCAACAATGTGGGACACCATAAAAAATGATGTGAAAGATGAC
AGGATTTTGATTGAGTTTGATACACTTAAGGAGATGGTAATCTTAGCAGGGAAATCAGAGGATGTCCAAAGCATTGAGGTACAAGTCAGG
GAGTTAATAGAAAGCACTACTCAAAAAATTAAAAGGGAAGAGCAAAGTTTGAAGGAAAAAATGATCATTTCTCCAGGCAGGTATTTTCTT
TTGTGTCACAGCAGTCTACTGGACCATTTACTCACGGAGTGCCCAGAGATAGAGATTTGTTACGATAGAGTCACTCAACACTTGTGCTTG
AAAGGACCTAGTGCAGATGTGTATAAAGCAAAGTGTGAAATCCAGGAAAAGGTGTACACCATGGCTCAGAAAAACATTCAGGTTTCTCCT
GAGATTTTTCAGTTTTTGCAACAGGTAAACTGGAAAGAATTCTCTAAGTGTCTTTTCATAGCACAGAAGATTCTTGCACTTTATGAGCTA
GAGGGTACAACTGTTCTCTTAACCAGCTGTTCTTCTGAAGCCCTGTTAGAAGCAGAAAAGCAAATGCTCAGTGCCTTAAATTATAAGCGC
ATTGAAGTTGAGAACAAAGAAGTTCTTCATGGCAAGAAATGGAAAGGGCTCACTCACAATTTGCTTAAGAAACAAAATTCCTCCCCAAAC
ACTGTAATCATCAATGAGTTAACTTCAGAAACCACAGCTGAAGTCATCATTACAGGCTGTGTAAAAGAAGTAAATGAAACCTATAAATTG
CTTTTTAACTTCGTTGAACAAAACATGAAAATAGAGAGACTGGTTGAAGTAAAGCCTTCCTTAGTTATTGACTATTTAAAGACAGAAAAG
AAGCTATTCTGGCCAAAGATAAAGAAGGTAAATGTGCAGGTAAGTTTCAATCCTGAGAACAAACAAAAAGGCATTTTACTAACTGGCTCA
AAGACCGAAGTACTGAAGGCAGTGGACATTGTCAAGCAAGTCTGGGATTCAGTCTGTGTTAAAAGTGTCCATACTGATAAGCCAGGAGCC
AAGCAGTTCTTCCAGGATAAAGCACGGTTTTATCAAAGTGAGATCAAACGGTTGTTTGGTTGTTACATTGAACTACAGGAGAATGAAGTA
ATGAAGGAGGGAGGCAGCCCCGCTGGGCAGAAGTGCTTCTCTCGGACAGTCTTGGCCCCTGGCGTTGTGCTGATTGTGCAGCAGGGTGAC
TTGGCACGGCTTCCTGTCGATGTGGTGGTGAATGCATCTAATGAGGACCTTAAGCATTATGGTGGCCTGGCCGCTGCGCTCTCAAAAGCA
GCTGGCCCTGAGCTCCAGGCCGACTGTGACCAGATAGTGAAGAGAGAGGGCAGACTCCTACCGGGCAATGCCACCATCTCCAAGGCAGGA
AAGCTGCCCTACCACCACGTGATCCATGCAGTGGGGCCCCGCTGGAGCGGATATGAGGCCCCGAGGTGTGTGTACCTATTAAGGAGAGCT
GTGCAACTCAGTCTCTGTCTAGCCGAAAAATACAAGTACCGATCCATAGCCATCCCAGCTATTAGTTCTGGAGTCTTTGGCTTTCCCTTA
GGCCGATGCGTGGAGACCATTGTTTCTGCCATCAAGGAAAACTTCCAATTCAAGAAGGATGGACACTGCTTGAAAGAAATCTACCTTGTG
GATGTATCTGAGAAGACTGTTGAGGCCTTTGCAGAAGCTGTGAAAACTGTATTTAAAGCCACCCTGCCAGATACAGCTGCCCCGCCAGGT
TTACCACCAGCAGCAGCGGGGCCTGGGAAAACATCATGGGAAAAAGGAAGCCTGGTGTCCCCGGGAGGCCTGCAGATGCTGTTGGTGAAA
GAGGGTGTGCAGAATGCTAAGACCGATGTTGTTGTCAACTCCGTTCCCTTGGATCTCGTGCTTAGTAGAGGGCCTCTTTCTAAGTCCCTC
TTGGAAAAAGCTGGACCAGAGCTCCAGGAGGAATTGGACACAGTTGGACAAGGGGTGGCTGTCAGCATGGGCACAGTGCTCAAAACCAGC
AGCTGGAATCTGGACTGTCGCTATGTGCTTCACGTGGTAGCTCCGGAGTGGAGAAATGGTAGCACATCTTCACTCAAGATAATGGAAGAC
ATAATCAGAGAATGTATGGAGATCACTGAGAGCTTGTCCTTAAAATCAATTGCATTTCCAGCAATAGGAACAGGAAACTTGGGATTTCCT
AAAAACATATTCGCTGAATTAATCATTTCAGAGGTGTTCAAATTTAGTAGCAAGAATCAGCTGAAAACTTTACAAGAGGTTCACTTTCTG
CTGCACCCGAGTGATCATGAAAATATTCAGGCATTTTCAGATGAATTTGCCAGAAGGGCTAATGGAAATCTCGTCAGTGACAAAATTCCG
AAGGCTAAAGATACACAAGGTTTTTATGGGACTGTTTCTAGCCCTGATTCAGGTGTGTATGAAATGAAGATTGGCTCCATCATCTTCCAG
GTGGCTTCTGGAGATATCACGAAAGAAGAGGCAGATGTGATTGTAAATTCAACATCAAACTCATTCAATCTCAAAGCAGGGGTCTCCAAA
GCAATTTTAGAATGTGCTGGACAAAATGTAGAAAGGGAATGTTCTCAGCAAGCTCAGCAGCGCAAAAATGATTATATAATCACCGGAGGT
GGATTTTTGAGGTGCAAGAATATCATTCATGTAATTGGTGGAAATGATGTCAAGAGTTCAGTTTCCTCTGTTTTGCAGGAGTGTGAAAAA
AAAAATTACTCATCCATTTGCCTCCCAGCCATTGGGACAGGAAATGCCAAACAACACCCAGATAAGGTTGCTGAAGCCATAATTGATGCC
ATTGAAGACTTTGTCCAGAAAGGATCAGCCCAGTCTGTGAAAAAAGTTAAAGTTGTTATCTTTCTGCCTCAAGTACTGGATGTGTTTTAT
GCCAACATGAAGAAAAGAGAAGGGACTCAGCTTTCTTCCCAACAGTCTGTGATGTCTAAACTTGCATCATTTTTGGGCTTTTCAAAGCAA
TCTCCCCAAAAAAAGAATCATTTGGTTTTGGAAAAGAAAACAGAATCAGCAACTTTTCGGGTGTGTGGTGAAAATGTCACGTGTGTGGAA
TATGCTATCTCCTGGCTACAAGACCTGATTGAAAAAGAACAGTGTCCTTACACCAGTGAAGATGAGTGCATCAAAGACTTTGATGAAAAG
GAGTATCAGGAGTTGAATGAGCTGCAGAAGAAGTTAAATATTAACATTTCCCTGGACCATAAGAGACCTTTGATTAAGGTTTTGGGAATT
AGCAGAGATGTGATGCAGGCTAGAGATGAAATTGAGGCGATGATCAAGAGAGTTCGATTGGCCAAAGAACAGGAATCCCGGGCAGATTGT
ATCAGTGAGTTTATAGAATGGCAGTATAATGACAATAACACTTCTCATTGTTTTAACAAAATGACCAATCTGAAATTAGAGGATGCAAGG
AGAGAAAAGAAAAAAACAGTTGATGTCAAAATTAATCATCGGCACTACACAGTGAACTTGAACACATACACTGCCACAGACACAAAGGGC
CACAGTTTATCTGTTCAGCGCCTCACGAAATCCAAAGTTGACATCCCTGCACACTGGAGTGATATGAAGCAGCAGAATTTCTGTGTGGTG
GAGCTGCTGCCTAGTGATCCTGAGTACAACACGGTGGCAAGCAAGTTTAATCAGACCTGCTCACACTTCAGAATAGAGAAGAGTTGTCTT
GGTTCAACTGGTGCCTTCCCGGGTCGTGTTTGCTCAGTCTCCTCCTCATTCTGTGCTTCAGGGAATCCTATGACAGACTCTATCTTGATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_PARP14_ENST00000474629_chr3_122439235_+_DIRC2_ENST00000261038_chr3_122598110_+_7084nt
CCGTGGAGCACAGGTGAACTGAGGCCGCCTTCCCGGGGCGCCGCTGGCCAGCCCCAAAGGGTTACTTTGGCCTTGGCTGTGGGCCGAATG
CGAAGGTGGGGAGGTGGGCGGGGGATGACTCTGCCATTCCTGGGTCCGCTGTGTTAGGCTGAAGGCAAAAGGAAACCAAGGCCTGGGAGT
TTTCCAGGAAACGAAAGCGAAAGAGTCAAAGTTAGCGGCCCGGAGTTGGCGCGGCCCCTGCAGTCCGGCGGAGAGCGGAGCTGAGGATGG
CTGTGCCCGGCTCCTTCCCGCTGCTGGTCGAGGGCTCCTGGGGCCCCGACCCCCCGAAGAACTTGAACACCAAGTTGCAGATGTACTTCC
AGAGCCCGAAGAGGTCGGGAGGCGGCGAGTGTGAGGTCCGCCAGGATCCCAGGAGCCCATCCCGCTTCCTGGTGTTCTTCTACCCGGAGG
ACGTTCGGCAGAAGGTTCTGGAGAGAAAAAATCATGAGTTGGTATGGCAAGGAAAAGGAACATTCAAGTTAACTGTCCAGTTACCTGCAA
CCCCAGATGAAATCGATCATGTCTTTGAAGAGGAACTTCTAACAAAAGAATCCAAGACCAAAGAAGATGTTAAAGAACCAGATGTGTCAG
AAGAATTGGATACAAAACTCCCTCTTGATGGTGGATTAGACAAAATGGAAGATATCCCAGAGGAATGTGAAAATATTTCCTCTTTGGTGG
CATTTGAAAACCTCAAGGCAAATGTGACTGACATAATGCTAATCTTGTTAGTGGAGAACATAAGTGGCCTGTCTAATGATGACTTTCAAG
TGGAAATAATAAGAGATTTTGATGTTGCTGTTGTTACCTTTCAAAAGCACATAGATACTATAAGATTTGTTGATGATTGTACCAAGCACC
ATTCAATTAAACAACTTCAGCTTTCTCCAAGACTTCTGGAAGTGACAAACACAATCAGGGTTGAAAACCTGCCACCTGGTGCTGATGACT
ACAGTTTAAAACTTTTCTTTGAAAATCCCTATAATGGAGGGGGAAGAGTTGCCAATGTTGAATATTTTCCTGAAGAGAGTTCAGCTCTGA
TTGAATTTTTTGACAGAAAAGTGTTAGACACCATCATGGCCACAAAACTCGACTTCAATAAAATGCCACTTTCTGTGTTCCCATACTATG
CCTCATTGGGCACAGCCTTGTATGGAAAGGAGAAGCCTCTGATCAAGCTTCCAGCACCATTTGAAGAGTCACTAGATCTTCCCTTATGGA
AGTTCTTACAGAAAAAGAATCACCTCATTGAGGAGATAAACGATGAAATGAGGCGTTGTCACTGTGAGCTCACGTGGTCCCAACTCAGTG
GTAAAGTTACCATCAGACCAGCAGCCACCTTAGTCAATGAAGGAAGACCGAGAATCAAGACCTGGCAGGCAGATACTTCCACAACACTCT
CTAGCATCAGGTCTAAATATAAAGTCAACCCAATTAAAGTGGATCCAACAATGTGGGACACCATAAAAAATGATGTGAAAGATGACAGGA
TTTTGATTGAGTTTGATACACTTAAGGAGATGGTAATCTTAGCAGGGAAATCAGAGGATGTCCAAAGCATTGAGGTACAAGTCAGGGAGT
TAATAGAAAGCACTACTCAAAAAATTAAAAGGGAAGAGCAAAGTTTGAAGGAAAAAATGATCATTTCTCCAGGCAGGTATTTTCTTTTGT
GTCACAGCAGTCTACTGGACCATTTACTCACGGAGTGCCCAGAGATAGAGATTTGTTACGATAGAGTCACTCAACACTTGTGCTTGAAAG
GACCTAGTGCAGATGTGTATAAAGCAAAGTGTGAAATCCAGGAAAAGGTGTACACCATGGCTCAGAAAAACATTCAGGTTTCTCCTGAGA
TTTTTCAGTTTTTGCAACAGGTAAACTGGAAAGAATTCTCTAAGTGTCTTTTCATAGCACAGAAGATTCTTGCACTTTATGAGCTAGAGG
GTACAACTGTTCTCTTAACCAGCTGTTCTTCTGAAGCCCTGTTAGAAGCAGAAAAGCAAATGCTCAGTGCCTTAAATTATAAGCGCATTG
AAGTTGAGAACAAAGAAGTTCTTCATGGCAAGAAATGGAAAGGGCTCACTCACAATTTGCTTAAGAAACAAAATTCCTCCCCAAACACTG
TAATCATCAATGAGTTAACTTCAGAAACCACAGCTGAAGTCATCATTACAGGCTGTGTAAAAGAAGTAAATGAAACCTATAAATTGCTTT
TTAACTTCGTTGAACAAAACATGAAAATAGAGAGACTGGTTGAAGTAAAGCCTTCCTTAGTTATTGACTATTTAAAGACAGAAAAGAAGC
TATTCTGGCCAAAGATAAAGAAGGTAAATGTGCAGGTAAGTTTCAATCCTGAGAACAAACAAAAAGGCATTTTACTAACTGGCTCAAAGA
CCGAAGTACTGAAGGCAGTGGACATTGTCAAGCAAGTCTGGGATTCAGTCTGTGTTAAAAGTGTCCATACTGATAAGCCAGGAGCCAAGC
AGTTCTTCCAGGATAAAGCACGGTTTTATCAAAGTGAGATCAAACGGTTGTTTGGTTGTTACATTGAACTACAGGAGAATGAAGTAATGA
AGGAGGGAGGCAGCCCCGCTGGGCAGAAGTGCTTCTCTCGGACAGTCTTGGCCCCTGGCGTTGTGCTGATTGTGCAGCAGGGTGACTTGG
CACGGCTTCCTGTCGATGTGGTGGTGAATGCATCTAATGAGGACCTTAAGCATTATGGTGGCCTGGCCGCTGCGCTCTCAAAAGCAGCTG
GCCCTGAGCTCCAGGCCGACTGTGACCAGATAGTGAAGAGAGAGGGCAGACTCCTACCGGGCAATGCCACCATCTCCAAGGCAGGAAAGC
TGCCCTACCACCACGTGATCCATGCAGTGGGGCCCCGCTGGAGCGGATATGAGGCCCCGAGGTGTGTGTACCTATTAAGGAGAGCTGTGC
AACTCAGTCTCTGTCTAGCCGAAAAATACAAGTACCGATCCATAGCCATCCCAGCTATTAGTTCTGGAGTCTTTGGCTTTCCCTTAGGCC
GATGCGTGGAGACCATTGTTTCTGCCATCAAGGAAAACTTCCAATTCAAGAAGGATGGACACTGCTTGAAAGAAATCTACCTTGTGGATG
TATCTGAGAAGACTGTTGAGGCCTTTGCAGAAGCTGTGAAAACTGTATTTAAAGCCACCCTGCCAGATACAGCTGCCCCGCCAGGTTTAC
CACCAGCAGCAGCGGGGCCTGGGAAAACATCATGGGAAAAAGGAAGCCTGGTGTCCCCGGGAGGCCTGCAGATGCTGTTGGTGAAAGAGG
GTGTGCAGAATGCTAAGACCGATGTTGTTGTCAACTCCGTTCCCTTGGATCTCGTGCTTAGTAGAGGGCCTCTTTCTAAGTCCCTCTTGG
AAAAAGCTGGACCAGAGCTCCAGGAGGAATTGGACACAGTTGGACAAGGGGTGGCTGTCAGCATGGGCACAGTGCTCAAAACCAGCAGCT
GGAATCTGGACTGTCGCTATGTGCTTCACGTGGTAGCTCCGGAGTGGAGAAATGGTAGCACATCTTCACTCAAGATAATGGAAGACATAA
TCAGAGAATGTATGGAGATCACTGAGAGCTTGTCCTTAAAATCAATTGCATTTCCAGCAATAGGAACAGGAAACTTGGGATTTCCTAAAA
ACATATTCGCTGAATTAATCATTTCAGAGGTGTTCAAATTTAGTAGCAAGAATCAGCTGAAAACTTTACAAGAGGTTCACTTTCTGCTGC
ACCCGAGTGATCATGAAAATATTCAGGCATTTTCAGATGAATTTGCCAGAAGGGCTAATGGAAATCTCGTCAGTGACAAAATTCCGAAGG
CTAAAGATACACAAGGTTTTTATGGGACTGTTTCTAGCCCTGATTCAGGTGTGTATGAAATGAAGATTGGCTCCATCATCTTCCAGGTGG
CTTCTGGAGATATCACGAAAGAAGAGGCAGATGTGATTGTAAATTCAACATCAAACTCATTCAATCTCAAAGCAGGGGTCTCCAAAGCAA
TTTTAGAATGTGCTGGACAAAATGTAGAAAGGGAATGTTCTCAGCAAGCTCAGCAGCGCAAAAATGATTATATAATCACCGGAGGTGGAT
TTTTGAGGTGCAAGAATATCATTCATGTAATTGGTGGAAATGATGTCAAGAGTTCAGTTTCCTCTGTTTTGCAGGAGTGTGAAAAAAAAA
ATTACTCATCCATTTGCCTCCCAGCCATTGGGACAGGAAATGCCAAACAACACCCAGATAAGGTTGCTGAAGCCATAATTGATGCCATTG
AAGACTTTGTCCAGAAAGGATCAGCCCAGTCTGTGAAAAAAGTTAAAGTTGTTATCTTTCTGCCTCAAGTACTGGATGTGTTTTATGCCA
ACATGAAGAAAAGAGAAGGGACTCAGCTTTCTTCCCAACAGTCTGTGATGTCTAAACTTGCATCATTTTTGGGCTTTTCAAAGCAATCTC
CCCAAAAAAAGAATCATTTGGTTTTGGAAAAGAAAACAGAATCAGCAACTTTTCGGGTGTGTGGTGAAAATGTCACGTGTGTGGAATATG
CTATCTCCTGGCTACAAGACCTGATTGAAAAAGAACAGTGTCCTTACACCAGTGAAGATGAGTGCATCAAAGACTTTGATGAAAAGGAGT
ATCAGGAGTTGAATGAGCTGCAGAAGAAGTTAAATATTAACATTTCCCTGGACCATAAGAGACCTTTGATTAAGGTTTTGGGAATTAGCA
GAGATGTGATGCAGGCTAGAGATGAAATTGAGGCGATGATCAAGAGAGTTCGATTGGCCAAAGAACAGGAATCCCGGGCAGATTGTATCA
GTGAGTTTATAGAATGGCAGTATAATGACAATAACACTTCTCATTGTTTTAACAAAATGACCAATCTGAAATTAGAGGATGCAAGGAGAG
AAAAGAAAAAAACAGTTGATGTCAAAATTAATCATCGGCACTACACAGTGAACTTGAACACATACACTGCCACAGACACAAAGGGCCACA
GTTTATCTGTTCAGCGCCTCACGAAATCCAAAGTTGACATCCCTGCACACTGGAGTGATATGAAGCAGCAGAATTTCTGTGTGGTGGAGC
TGCTGCCTAGTGATCCTGAGTACAACACGGTGGCAAGCAAGTTTAATCAGACCTGCTCACACTTCAGAATAGAGAAGAGTTGTCTTGGTT
CAACTGGTGCCTTCCCGGGTCGTGTTTGCTCAGTCTCCTCCTCATTCTGTGCTTCAGGGAATCCTATGACAGACTCTATCTTGATGTGGT
TGTCTCCGTTTAATAGCACAGACTTGAAGGAGTTTAAAAGGAGGCTGGAAATCAATACTGCACACTGCACATTTGCTCAGAATTGCACAT
CTAACAGGAAAAGAGGGAGAAGAAAGAAACTTCATTCAGAGGTTTTGTTAGGTTACAGATTATCACATTAATTTAATTACTACTAGGTAA
TAATAATGGGAGACTTGAGTGATAATAGGGGATTTTAAAACTCTACAGATGGCATACCTGTGCCTGCTTCTGGGGTTGGAAGTGTGACTT
CTTACACATAAAGCACTACCTAAGTAATTCTCTCTCTGTTTTGTGCCAGTGCTAAACTACTGATTACTTGTAATTATGAAAAGAAATAAA
GGGTGTCTATCATATGAAGATAACGCCTTCCCTAAGTCACATATCAGAATAGGAAGATATGCCACTAACTTCTAAAGAAGTTCAAACCCT
GTATCCAATTTTAATGATAAAATAGCCAAGAGGTATATCGATGATGGAAATTAGCCACATGTACACTACATTTTTTCTAATAAAGCCATT
TCTTATATGACTCCTTATTTTAATCAGGTCAGAAGCCCTTGGCCATCTTTACTATGGTGATCAGGTGCTTTCCAGTGACTTCTGAGCATA
GGCACTGTGTCTCCATCTCAACTTATCCTTGTTTCTGTGAAATACAATTTCATCTACTAGGCCCTTAAATAATTATGTGAGGGTGTCTAA
ATGTTTAATATGATTACATTAAATATTGTATGAAAAAATGTAATTCCATTAGGATCTAGCACTTTGTTACAAGTGAAATGACAAGTCACA
TGGACATACTGTGTCTTCTGCCTGTATATGGTGGCATGAGATGTAATGTCCAGAGCCAACAATTATTTACCAGGGTTAGATTTTATTCAG
TGACCCTTGTTTAAAAATAATAATTTATCACATTGAAACTTTCAGCTCTGTCGAATGATTTCTGAATTACATCCTGTGTTTCAGCTTAGG
TTGTAAAATACTCCGTTCTCTGTGGAGTCAGCATATTTGAGAGGGCAGCGTTTTGCCAGTACCTATCTTCTTTCTACAGAAGATAGCTTT
TTAAGAAATAAGAGTTCCACATTGAGTGGCTGTCAGACACAGATTTCACTGTGACGTAAAATACACTGCAGTGAGAATATGGTATCACCA
CTATTCATATTTACATCATTCCCCTCACACAGAAAAACCAACCCTTTTCCCAAAAAGTCAAGAATACTGCTATACCTTTATTATTCTCAG
CTTCCTCCAGCCCTTCTTGTTTTTCCTCACTTGAAATTGAACCTTCATTGTCAGCTAAGTATATATACTTTTGTGTTTTCCTGGACAGAG
TGCAAGTGGCTCTTATCAGCCAAGGTGGTGAAGGTTCAGGAAAGCTGGGCAGCACTGGGCCCTGCTCCTCTCTGCACCTGTGTGCGCCAT
GACACACCCACATGCAGATTCCCAAGTCTGTCTCCCCTCCCCCTTAGCAAGTACAAGGCTGTGCATTAACTCACCTCGGTCCTAGAGGAG
TATCCTAGTACTGCTTGGCAACTTCTAAGACCCTAACTTGTGAAACTAGGGAAGTAAGAAACCGTTCAAATTTAACATCTGTCTTCAGTC
ATCTTTAAATCGTCTCTCTTTATAAACACTCTGCTCACTTAGCAGAAGGACTGAAGGAACTAAGGAACTTGCTAAAGAGAAGAAGAAAAC


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FusionGenePPI for PARP14_DIRC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARP14GPI, STAT6, FCER2, HDAC2, HDAC3, CUL2, IKBKG, RPA1, RPA2, RPA3, DTX3L, PARP9, GAN, PARP10DIRC2UPK1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARP14_DIRC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARP14_DIRC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource