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Fusion gene ID: 26007 |
FusionGeneSummary for PARM1_ITGAV |
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Fusion gene information | Fusion gene name: PARM1_ITGAV | Fusion gene ID: 26007 | Hgene | Tgene | Gene symbol | PARM1 | ITGAV | Gene ID | 25849 | 3685 |
Gene name | prostate androgen-regulated mucin-like protein 1 | integrin subunit alpha V | |
Synonyms | Cipar1|DKFZP564O0823|PARM-1|WSC4 | CD51|MSK8|VNRA|VTNR | |
Cytomap | 4q13.3 | 2q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | prostate androgen-regulated mucin-like protein 1WSC4, cell wall integrity and stress response component 4 homologcastration-induced prostatic apoptosis-related protein 1prostatic androgen-regulated mucin-like protein 1prostatic androgen-repressed mess | integrin alpha-Vantigen identified by monoclonal antibody L230integrin alphaVbeta3integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)vitronectin receptor subunit alpha | |
Modification date | 20180329 | 20180520 | |
UniProtAcc | Q6UWI2 | P06756 | |
Ensembl transtripts involved in fusion gene | ENST00000513238, ENST00000307428, | ENST00000261023, ENST00000374907, ENST00000433736, ENST00000474571, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 3=48 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PARM1 [Title/Abstract] AND ITGAV [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ITGAV | GO:0007155 | cell adhesion | 10218736 |
Tgene | ITGAV | GO:0008284 | positive regulation of cell proliferation | 19578119 |
Tgene | ITGAV | GO:0033627 | cell adhesion mediated by integrin | 12807887|17158881 |
Tgene | ITGAV | GO:0034446 | substrate adhesion-dependent cell spreading | 24658351 |
Tgene | ITGAV | GO:0045785 | positive regulation of cell adhesion | 10708943 |
Tgene | ITGAV | GO:0050764 | regulation of phagocytosis | 10570297 |
Tgene | ITGAV | GO:0070588 | calcium ion transmembrane transport | 18395422 |
Tgene | ITGAV | GO:2000536 | negative regulation of entry of bacterium into host cell | 10570297 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF063946 | PARM1 | chr4 | 75972355 | - | ITGAV | chr2 | 187503046 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000513238 | ENST00000261023 | PARM1 | chr4 | 75972355 | - | ITGAV | chr2 | 187503046 | - |
3UTR-intron | ENST00000513238 | ENST00000374907 | PARM1 | chr4 | 75972355 | - | ITGAV | chr2 | 187503046 | - |
3UTR-intron | ENST00000513238 | ENST00000433736 | PARM1 | chr4 | 75972355 | - | ITGAV | chr2 | 187503046 | - |
3UTR-intron | ENST00000513238 | ENST00000474571 | PARM1 | chr4 | 75972355 | - | ITGAV | chr2 | 187503046 | - |
3UTR-intron | ENST00000307428 | ENST00000261023 | PARM1 | chr4 | 75972355 | - | ITGAV | chr2 | 187503046 | - |
3UTR-intron | ENST00000307428 | ENST00000374907 | PARM1 | chr4 | 75972355 | - | ITGAV | chr2 | 187503046 | - |
3UTR-intron | ENST00000307428 | ENST00000433736 | PARM1 | chr4 | 75972355 | - | ITGAV | chr2 | 187503046 | - |
3UTR-intron | ENST00000307428 | ENST00000474571 | PARM1 | chr4 | 75972355 | - | ITGAV | chr2 | 187503046 | - |
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FusionProtFeatures for PARM1_ITGAV |
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Hgene | Tgene |
PARM1 | ITGAV |
May regulate TLP1 expression and telomerase activity,thus enabling certain prostatic cells to resist apoptosis.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PARM1_ITGAV |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PARM1_ITGAV |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PARM1_ITGAV |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ITGAV | P06756 | DB00098 | Antithymocyte immunoglobulin (rabbit) | Integrin alpha-V | biotech | approved |
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RelatedDiseases for PARM1_ITGAV |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ITGAV | C0038454 | Cerebrovascular accident | 1 | CTD_human |
Tgene | ITGAV | C2937358 | Cerebral Hemorrhage | 1 | CTD_human |