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Fusion gene ID: 25991 |
FusionGeneSummary for PARD6G_CHST1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PARD6G_CHST1 | Fusion gene ID: 25991 | Hgene | Tgene | Gene symbol | PARD6G | CHST1 | Gene ID | 84552 | 8534 |
| Gene name | par-6 family cell polarity regulator gamma | carbohydrate sulfotransferase 1 | |
| Synonyms | PAR-6G|PAR6gamma | C6ST|GST-1|KS6ST|KSGal6ST|KSST | |
| Cytomap | 18q23 | 11p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | partitioning defective 6 homolog gammaPAR-6 gamma proteinPAR6Dpar-6 partitioning defective 6 homolog gamma | carbohydrate sulfotransferase 1Keratan sulfotransferasecarbohydrate (chondroitin 6/keratan) sulfotransferase 1carbohydrate (keratan sulfate Gal-6) sulfotransferase 1galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BYG4 | O43916 | |
| Ensembl transtripts involved in fusion gene | ENST00000353265, ENST00000470488, | ENST00000308064, ENST00000533673, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 3 X 1 X 3=9 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PARD6G [Title/Abstract] AND CHST1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CHST1 | GO:0006012 | galactose metabolic process | 10330415 |
| Tgene | CHST1 | GO:0006790 | sulfur compound metabolic process | 10330415 |
| Tgene | CHST1 | GO:0042339 | keratan sulfate metabolic process | 9405439 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-DQ-7591-01A | PARD6G | chr18 | 77960593 | - | CHST1 | chr11 | 45674156 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000353265 | ENST00000308064 | PARD6G | chr18 | 77960593 | - | CHST1 | chr11 | 45674156 | - |
| 5CDS-intron | ENST00000353265 | ENST00000533673 | PARD6G | chr18 | 77960593 | - | CHST1 | chr11 | 45674156 | - |
| 5CDS-5UTR | ENST00000470488 | ENST00000308064 | PARD6G | chr18 | 77960593 | - | CHST1 | chr11 | 45674156 | - |
| 5CDS-intron | ENST00000470488 | ENST00000533673 | PARD6G | chr18 | 77960593 | - | CHST1 | chr11 | 45674156 | - |
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FusionProtFeatures for PARD6G_CHST1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PARD6G | CHST1 |
| Adapter protein involved in asymmetrical cell divisionand cell polarization processes. May play a role in the formationof epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (Bysimilarity). {ECO:0000250}. | Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the transfer ofsulfate to position 6 of galactose (Gal) residues of keratan. Hasa preference for sulfating keratan sulfate, but it also transferssulfate to the unsulfated polymer. The sulfotransferase activityon sialyl LacNAc structures is much higher than the correspondingdesialylated substrate, and only internal Gal residues aresulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached toglycoproteins. Participates in biosynthesis of selectin ligands.Selectin ligands are present in high endothelial cells (HEVs) andplay a central role in lymphocyte homing at sites of inflammation.{ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:10642612}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PARD6G_CHST1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PARD6G_CHST1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PARD6G | PARD3, PRKCZ, RAC1, CDC42, YWHAH, PRKCI, LLGL1, YWHAE, PARD6B, MARK2, LLGL2, BRINP1, HSPA4, PNMA3, PNMA2, PNMAL1, WDR83, RHOJ | CHST1 | SFN, NHP2L1, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PARD6G_CHST1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PARD6G_CHST1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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