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Fusion gene ID: 25989 |
FusionGeneSummary for PARD6B_PRPF6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PARD6B_PRPF6 | Fusion gene ID: 25989 | Hgene | Tgene | Gene symbol | PARD6B | PRPF6 | Gene ID | 84612 | 24148 |
| Gene name | par-6 family cell polarity regulator beta | pre-mRNA processing factor 6 | |
| Synonyms | PAR6B | ANT-1|ANT1|C20orf14|Prp6|RP60|SNRNP102|TOM|U5-102K|hPrp6 | |
| Cytomap | 20q13.13 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | partitioning defective 6 homolog betaPAR-6 betapar-6 partitioning defective 6 homolog beta | pre-mRNA-processing factor 6PRP6 homologPRP6 pre-mRNA processing factor 6 homologU5 snRNP-associated 102 kDa proteinU5-102 kDa proteinandrogen receptor N-terminal domain transactivating protein-1p102 U5 small nuclear ribonucleoprotein particle-bindi | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BYG5 | O94906 | |
| Ensembl transtripts involved in fusion gene | ENST00000371610, ENST00000396039, | ENST00000535781, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 7 X 7 X 2=98 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/98*10)=-0.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PARD6B [Title/Abstract] AND PRPF6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PARD6B | GO:0065003 | protein-containing complex assembly | 12545177 |
| Tgene | PRPF6 | GO:0000398 | mRNA splicing, via spliceosome | 28781166 |
| Tgene | PRPF6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16414017 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1XD-01A | PARD6B | chr20 | 49348389 | + | PRPF6 | chr20 | 62630398 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000371610 | ENST00000535781 | PARD6B | chr20 | 49348389 | + | PRPF6 | chr20 | 62630398 | + |
| In-frame | ENST00000396039 | ENST00000535781 | PARD6B | chr20 | 49348389 | + | PRPF6 | chr20 | 62630398 | + |
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FusionProtFeatures for PARD6B_PRPF6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PARD6B | PRPF6 |
| Adapter protein involved in asymmetrical cell divisionand cell polarization processes. Probably involved in formation ofepithelial tight junctions. Association with PARD3 may prevent theinteraction of PARD3 with F11R/JAM1, thereby preventing tightjunction assembly. The PARD6-PARD3 complex links GTP-bound Rhosmall GTPases to atypical protein kinase C proteins. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PRPF6 | chr20:49348389 | chr20:62630398 | ENST00000535781 | + | 5 | 20 | 384_416 | 257 | 902 | Repeat | Note=HAT 1 |
| Tgene | >PRPF6 | chr20:49348389 | chr20:62630398 | ENST00000535781 | + | 5 | 20 | 418_444 | 257 | 902 | Repeat | Note=HAT 2 |
| Tgene | >PRPF6 | chr20:49348389 | chr20:62630398 | ENST00000535781 | + | 5 | 20 | 445_476 | 257 | 902 | Repeat | Note=HAT 3 |
| Tgene | >PRPF6 | chr20:49348389 | chr20:62630398 | ENST00000535781 | + | 5 | 20 | 554_586 | 257 | 902 | Repeat | Note=HAT 4 |
| Tgene | >PRPF6 | chr20:49348389 | chr20:62630398 | ENST00000535781 | + | 5 | 20 | 588_620 | 257 | 902 | Repeat | Note=HAT 5 |
| Tgene | >PRPF6 | chr20:49348389 | chr20:62630398 | ENST00000535781 | + | 5 | 20 | 622_654 | 257 | 902 | Repeat | Note=HAT 6 |
| Tgene | >PRPF6 | chr20:49348389 | chr20:62630398 | ENST00000535781 | + | 5 | 20 | 689_721 | 257 | 902 | Repeat | Note=HAT 7 |
| Tgene | >PRPF6 | chr20:49348389 | chr20:62630398 | ENST00000535781 | + | 5 | 20 | 723_755 | 257 | 902 | Repeat | Note=HAT 8 |
| Tgene | >PRPF6 | chr20:49348389 | chr20:62630398 | ENST00000535781 | + | 5 | 20 | 855_887 | 257 | 902 | Repeat | Note=HAT 9 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PARD6B | chr20:49348389 | chr20:62630398 | ENST00000371610 | + | 1 | 3 | 133_150 | 22 | 373 | Domain | Note=Pseudo-CRIB |
| Hgene | >PARD6B | chr20:49348389 | chr20:62630398 | ENST00000371610 | + | 1 | 3 | 157_250 | 22 | 373 | Domain | PDZ |
| Hgene | >PARD6B | chr20:49348389 | chr20:62630398 | ENST00000371610 | + | 1 | 3 | 16_96 | 22 | 373 | Domain | PB1 |
| Hgene | >PARD6B | chr20:49348389 | chr20:62630398 | ENST00000396039 | + | 1 | 3 | 133_150 | 22 | 116 | Domain | Note=Pseudo-CRIB |
| Hgene | >PARD6B | chr20:49348389 | chr20:62630398 | ENST00000396039 | + | 1 | 3 | 157_250 | 22 | 116 | Domain | PDZ |
| Hgene | >PARD6B | chr20:49348389 | chr20:62630398 | ENST00000396039 | + | 1 | 3 | 16_96 | 22 | 116 | Domain | PB1 |
| Tgene | PRPF6 | chr20:49348389 | chr20:62630398 | ENST00000535781 | + | 5 | 20 | 67_72 | 257 | 902 | Compositional bias | Note=Poly-Asp |
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FusionGeneSequence for PARD6B_PRPF6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PARD6B_ENST00000371610_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_667aa MNRSHRHGAGSGCLGTMEVKSKVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKL QVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEE PEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQ WIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEA LLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMM EKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWS EAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAE >In-frame_PARD6B_ENST00000396039_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_667aa MNRSHRHGAGSGCLGTMEVKSKVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKL QVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEE PEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQ WIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEA LLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMM EKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWS EAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PARD6B_ENST00000371610_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_2001nt ATGAACCGCAGCCACCGGCACGGGGCGGGCAGCGGCTGCCTGGGCACTATGGAGGTGAAGAGCAAGGTGTCTGACTCCGTGAGTGGACAG ACCGTCGTTGACCCCAAAGGCTACCTGACGGATTTAAATTCCATGATCCCGACACACGGAGGAGACATCAATGATATCAAGAAGGCGCGA CTGCTCCTCAAGTCTGTTCGGGAGACGAACCCTCATCACCCGCCAGCCTGGATTGCATCAGCCCGCCTGGAAGAAGTCACTGGGAAGCTA CAAGTAGCTCGGAACCTTATCATGAAGGGGACGGAGATGTGCCCCAAGAGTGAAGATGTCTGGCTGGAAGCAGCCAGGTTGCAGCCTGGG GACACAGCCAAGGCCGTGGTAGCCCAAGCTGTCCGTCATCTCCCACAGTCTGTCAGGATTTACATCAGAGCCGCAGAGCTGGAAACGGAC ATTCGTGCAAAGAAGCGGGTTCTTCGGAAAGCCCTCGAGCATGTTCCAAACTCGGTTCGCTTGTGGAAAGCAGCCGTTGAGCTGGAAGAA CCTGAAGATGCTAGAATCATGCTGAGCCGAGCTGTGGAGTGCTGCCCCACCAGCGTGGAGCTCTGGCTTGCTCTGGCAAGGCTGGAGACC TATGAAAATGCCCGCAAGGTCTTGAACAAGGCGCGGGAGAACATTCCTACAGACCGACATATCTGGATCACGGCTGCTAAGCTGGAGGAA GCCAATGGGAACACGCAGATGGTGGAGAAGATCATCGACCGAGCCATCACCTCGCTGCGGGCCAACGGTGTGGAGATCAACCGTGAGCAG TGGATCCAGGATGCCGAGGAATGTGACAGGGCTGGGAGTGTGGCCACCTGCCAGGCCGTCATGCGTGCCGTGATTGGGATTGGGATTGAG GAGGAAGATCGGAAGCATACCTGGATGGAGGATGCTGACAGTTGTGTAGCCCACAATGCCCTGGAGTGTGCACGAGCCATCTACGCCTAC GCCCTGCAGGTGTTCCCCAGCAAGAAGAGTGTGTGGCTGCGCGCCGCGTACTTCGAGAAGAACCATGGCACTCGGGAGTCCCTGGAAGCA CTCCTGCAGAGGGCTGTGGCCCACTGCCCCAAAGCAGAGGTGCTGTGGCTCATGGGCGCCAAGTCCAAGTGGCTGGCAGGGGATGTGCCT GCAGCAAGGAGCATCCTGGCCCTGGCCTTCCAGGTGTTCATGAAGTCTGTGAAGCTGGAGTGGGTGCAAGACAACATCAGGGCAGCCCAA GATCTGTGCGAGGAGGCCCTGCGGCACTATGAGGACTTCCCCAAGCTGTGGATGATGAAGGGGCAGATCGAGGAGCAGAAGGAGATGATG GAGAAGGCGCGGGAAGCCTATAACCAGGGGTTGAAGAAGTGTCCCCACTCCACACCCCTGTGGCTTTTGCTCTCTCGGCTGGAGGAGAAG ATTGGGCAGCTTACTCGAGCACGGGCCATTTTGGAAAAGTCTCGTCTGAAGAACCCAAAGAACCCTGGGCTGTGGTTGGAGTCCGTGCGG CTGGAGTACCGTGCGGGGCTGAAGAACATCGCAAATACACTCATGGCCAAGGCGCTGCAGGAGTGCCCCAACTCCGGTATCCTGTGGTCT GAGGCCATCTTCCTCGAGGCAAGGCCCCAGAGGAGGACCAAGAGCGTGGATGCCCTGAAGAAGTGTGAGCATGACCCCCATGTGCTCCTG GCCGTGGCCAAGCTGTTTTGGAGTCAGCGGAAGATCACCAAGGCCAGGGAGTGGTTCCACCGCACTGTGAAGATTGACTCGGACCTGGGG GATGCCTGGGCCTTCTTCTACAAGTTTGAGCTGCAGCATGGCACTGAGGAGCAGCAGGAGGAGGTGAGGAAGCGCTGTGAGAGTGCAGAG CCTCGGCATGGGGAGCTGTGGTGCGCCGTGTCCAAGGACATCGCCAACTGGCAGAAGAAGATCGGGGACATCCTTAGGCTGGTGGCCGGC >In-frame_PARD6B_ENST00000396039_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_2001nt ATGAACCGCAGCCACCGGCACGGGGCGGGCAGCGGCTGCCTGGGCACTATGGAGGTGAAGAGCAAGGTGTCTGACTCCGTGAGTGGACAG ACCGTCGTTGACCCCAAAGGCTACCTGACGGATTTAAATTCCATGATCCCGACACACGGAGGAGACATCAATGATATCAAGAAGGCGCGA CTGCTCCTCAAGTCTGTTCGGGAGACGAACCCTCATCACCCGCCAGCCTGGATTGCATCAGCCCGCCTGGAAGAAGTCACTGGGAAGCTA CAAGTAGCTCGGAACCTTATCATGAAGGGGACGGAGATGTGCCCCAAGAGTGAAGATGTCTGGCTGGAAGCAGCCAGGTTGCAGCCTGGG GACACAGCCAAGGCCGTGGTAGCCCAAGCTGTCCGTCATCTCCCACAGTCTGTCAGGATTTACATCAGAGCCGCAGAGCTGGAAACGGAC ATTCGTGCAAAGAAGCGGGTTCTTCGGAAAGCCCTCGAGCATGTTCCAAACTCGGTTCGCTTGTGGAAAGCAGCCGTTGAGCTGGAAGAA CCTGAAGATGCTAGAATCATGCTGAGCCGAGCTGTGGAGTGCTGCCCCACCAGCGTGGAGCTCTGGCTTGCTCTGGCAAGGCTGGAGACC TATGAAAATGCCCGCAAGGTCTTGAACAAGGCGCGGGAGAACATTCCTACAGACCGACATATCTGGATCACGGCTGCTAAGCTGGAGGAA GCCAATGGGAACACGCAGATGGTGGAGAAGATCATCGACCGAGCCATCACCTCGCTGCGGGCCAACGGTGTGGAGATCAACCGTGAGCAG TGGATCCAGGATGCCGAGGAATGTGACAGGGCTGGGAGTGTGGCCACCTGCCAGGCCGTCATGCGTGCCGTGATTGGGATTGGGATTGAG GAGGAAGATCGGAAGCATACCTGGATGGAGGATGCTGACAGTTGTGTAGCCCACAATGCCCTGGAGTGTGCACGAGCCATCTACGCCTAC GCCCTGCAGGTGTTCCCCAGCAAGAAGAGTGTGTGGCTGCGCGCCGCGTACTTCGAGAAGAACCATGGCACTCGGGAGTCCCTGGAAGCA CTCCTGCAGAGGGCTGTGGCCCACTGCCCCAAAGCAGAGGTGCTGTGGCTCATGGGCGCCAAGTCCAAGTGGCTGGCAGGGGATGTGCCT GCAGCAAGGAGCATCCTGGCCCTGGCCTTCCAGGTGTTCATGAAGTCTGTGAAGCTGGAGTGGGTGCAAGACAACATCAGGGCAGCCCAA GATCTGTGCGAGGAGGCCCTGCGGCACTATGAGGACTTCCCCAAGCTGTGGATGATGAAGGGGCAGATCGAGGAGCAGAAGGAGATGATG GAGAAGGCGCGGGAAGCCTATAACCAGGGGTTGAAGAAGTGTCCCCACTCCACACCCCTGTGGCTTTTGCTCTCTCGGCTGGAGGAGAAG ATTGGGCAGCTTACTCGAGCACGGGCCATTTTGGAAAAGTCTCGTCTGAAGAACCCAAAGAACCCTGGGCTGTGGTTGGAGTCCGTGCGG CTGGAGTACCGTGCGGGGCTGAAGAACATCGCAAATACACTCATGGCCAAGGCGCTGCAGGAGTGCCCCAACTCCGGTATCCTGTGGTCT GAGGCCATCTTCCTCGAGGCAAGGCCCCAGAGGAGGACCAAGAGCGTGGATGCCCTGAAGAAGTGTGAGCATGACCCCCATGTGCTCCTG GCCGTGGCCAAGCTGTTTTGGAGTCAGCGGAAGATCACCAAGGCCAGGGAGTGGTTCCACCGCACTGTGAAGATTGACTCGGACCTGGGG GATGCCTGGGCCTTCTTCTACAAGTTTGAGCTGCAGCATGGCACTGAGGAGCAGCAGGAGGAGGTGAGGAAGCGCTGTGAGAGTGCAGAG CCTCGGCATGGGGAGCTGTGGTGCGCCGTGTCCAAGGACATCGCCAACTGGCAGAAGAAGATCGGGGACATCCTTAGGCTGGTGGCCGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PARD6B_ENST00000371610_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_2347nt GAGGGAGGGAGCTGCTTCCCCGCCTGCCGCGCCACCAGTCCGACCCTCGGTCCCGCCGTGTGAGCAGCTGGTGGAGTGGAGCTCAGCGCG GACGCCGGAGCTGCGGCCGCCCCCTCTGCAGGTGCCTGTGAGGAGGCGCCCGGGCCGCAACCGCTTTCCGAGATCCCCAGTCGCGCACTC GCTCCCCGCGCTCCTGAGGGGCCGCCCGGCCGGAGGAGGCCGTCGCGGGGCTCGGCGTTCAGCATGAACCGCAGCCACCGGCACGGGGCG GGCAGCGGCTGCCTGGGCACTATGGAGGTGAAGAGCAAGGTGTCTGACTCCGTGAGTGGACAGACCGTCGTTGACCCCAAAGGCTACCTG ACGGATTTAAATTCCATGATCCCGACACACGGAGGAGACATCAATGATATCAAGAAGGCGCGACTGCTCCTCAAGTCTGTTCGGGAGACG AACCCTCATCACCCGCCAGCCTGGATTGCATCAGCCCGCCTGGAAGAAGTCACTGGGAAGCTACAAGTAGCTCGGAACCTTATCATGAAG GGGACGGAGATGTGCCCCAAGAGTGAAGATGTCTGGCTGGAAGCAGCCAGGTTGCAGCCTGGGGACACAGCCAAGGCCGTGGTAGCCCAA GCTGTCCGTCATCTCCCACAGTCTGTCAGGATTTACATCAGAGCCGCAGAGCTGGAAACGGACATTCGTGCAAAGAAGCGGGTTCTTCGG AAAGCCCTCGAGCATGTTCCAAACTCGGTTCGCTTGTGGAAAGCAGCCGTTGAGCTGGAAGAACCTGAAGATGCTAGAATCATGCTGAGC CGAGCTGTGGAGTGCTGCCCCACCAGCGTGGAGCTCTGGCTTGCTCTGGCAAGGCTGGAGACCTATGAAAATGCCCGCAAGGTCTTGAAC AAGGCGCGGGAGAACATTCCTACAGACCGACATATCTGGATCACGGCTGCTAAGCTGGAGGAAGCCAATGGGAACACGCAGATGGTGGAG AAGATCATCGACCGAGCCATCACCTCGCTGCGGGCCAACGGTGTGGAGATCAACCGTGAGCAGTGGATCCAGGATGCCGAGGAATGTGAC AGGGCTGGGAGTGTGGCCACCTGCCAGGCCGTCATGCGTGCCGTGATTGGGATTGGGATTGAGGAGGAAGATCGGAAGCATACCTGGATG GAGGATGCTGACAGTTGTGTAGCCCACAATGCCCTGGAGTGTGCACGAGCCATCTACGCCTACGCCCTGCAGGTGTTCCCCAGCAAGAAG AGTGTGTGGCTGCGCGCCGCGTACTTCGAGAAGAACCATGGCACTCGGGAGTCCCTGGAAGCACTCCTGCAGAGGGCTGTGGCCCACTGC CCCAAAGCAGAGGTGCTGTGGCTCATGGGCGCCAAGTCCAAGTGGCTGGCAGGGGATGTGCCTGCAGCAAGGAGCATCCTGGCCCTGGCC TTCCAGGTGTTCATGAAGTCTGTGAAGCTGGAGTGGGTGCAAGACAACATCAGGGCAGCCCAAGATCTGTGCGAGGAGGCCCTGCGGCAC TATGAGGACTTCCCCAAGCTGTGGATGATGAAGGGGCAGATCGAGGAGCAGAAGGAGATGATGGAGAAGGCGCGGGAAGCCTATAACCAG GGGTTGAAGAAGTGTCCCCACTCCACACCCCTGTGGCTTTTGCTCTCTCGGCTGGAGGAGAAGATTGGGCAGCTTACTCGAGCACGGGCC ATTTTGGAAAAGTCTCGTCTGAAGAACCCAAAGAACCCTGGGCTGTGGTTGGAGTCCGTGCGGCTGGAGTACCGTGCGGGGCTGAAGAAC ATCGCAAATACACTCATGGCCAAGGCGCTGCAGGAGTGCCCCAACTCCGGTATCCTGTGGTCTGAGGCCATCTTCCTCGAGGCAAGGCCC CAGAGGAGGACCAAGAGCGTGGATGCCCTGAAGAAGTGTGAGCATGACCCCCATGTGCTCCTGGCCGTGGCCAAGCTGTTTTGGAGTCAG CGGAAGATCACCAAGGCCAGGGAGTGGTTCCACCGCACTGTGAAGATTGACTCGGACCTGGGGGATGCCTGGGCCTTCTTCTACAAGTTT GAGCTGCAGCATGGCACTGAGGAGCAGCAGGAGGAGGTGAGGAAGCGCTGTGAGAGTGCAGAGCCTCGGCATGGGGAGCTGTGGTGCGCC GTGTCCAAGGACATCGCCAACTGGCAGAAGAAGATCGGGGACATCCTTAGGCTGGTGGCCGGCCGCATCAAGAACACCTTCTGATTGAGC GGTTGCCATGGCCGGTCTCCGTGGGGCAGGGTTGGGCCGCATGTGGAAGGGCTCTGAGCTGTGTCCTCCTTCATTAAAAGTTTTTATGTC >In-frame_PARD6B_ENST00000396039_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_2226nt GTGCCTGTGAGGAGGCGCCCGGGCCGCAACCGCTTTCCGAGATCCCCAGTCGCGCACTCGCTCCCCGCGCTCCTGAGGGGCCGCCCGGCC GGAGGAGGCCGTCGCGGGGCTCGGCGTTCAGCATGAACCGCAGCCACCGGCACGGGGCGGGCAGCGGCTGCCTGGGCACTATGGAGGTGA AGAGCAAGGTGTCTGACTCCGTGAGTGGACAGACCGTCGTTGACCCCAAAGGCTACCTGACGGATTTAAATTCCATGATCCCGACACACG GAGGAGACATCAATGATATCAAGAAGGCGCGACTGCTCCTCAAGTCTGTTCGGGAGACGAACCCTCATCACCCGCCAGCCTGGATTGCAT CAGCCCGCCTGGAAGAAGTCACTGGGAAGCTACAAGTAGCTCGGAACCTTATCATGAAGGGGACGGAGATGTGCCCCAAGAGTGAAGATG TCTGGCTGGAAGCAGCCAGGTTGCAGCCTGGGGACACAGCCAAGGCCGTGGTAGCCCAAGCTGTCCGTCATCTCCCACAGTCTGTCAGGA TTTACATCAGAGCCGCAGAGCTGGAAACGGACATTCGTGCAAAGAAGCGGGTTCTTCGGAAAGCCCTCGAGCATGTTCCAAACTCGGTTC GCTTGTGGAAAGCAGCCGTTGAGCTGGAAGAACCTGAAGATGCTAGAATCATGCTGAGCCGAGCTGTGGAGTGCTGCCCCACCAGCGTGG AGCTCTGGCTTGCTCTGGCAAGGCTGGAGACCTATGAAAATGCCCGCAAGGTCTTGAACAAGGCGCGGGAGAACATTCCTACAGACCGAC ATATCTGGATCACGGCTGCTAAGCTGGAGGAAGCCAATGGGAACACGCAGATGGTGGAGAAGATCATCGACCGAGCCATCACCTCGCTGC GGGCCAACGGTGTGGAGATCAACCGTGAGCAGTGGATCCAGGATGCCGAGGAATGTGACAGGGCTGGGAGTGTGGCCACCTGCCAGGCCG TCATGCGTGCCGTGATTGGGATTGGGATTGAGGAGGAAGATCGGAAGCATACCTGGATGGAGGATGCTGACAGTTGTGTAGCCCACAATG CCCTGGAGTGTGCACGAGCCATCTACGCCTACGCCCTGCAGGTGTTCCCCAGCAAGAAGAGTGTGTGGCTGCGCGCCGCGTACTTCGAGA AGAACCATGGCACTCGGGAGTCCCTGGAAGCACTCCTGCAGAGGGCTGTGGCCCACTGCCCCAAAGCAGAGGTGCTGTGGCTCATGGGCG CCAAGTCCAAGTGGCTGGCAGGGGATGTGCCTGCAGCAAGGAGCATCCTGGCCCTGGCCTTCCAGGTGTTCATGAAGTCTGTGAAGCTGG AGTGGGTGCAAGACAACATCAGGGCAGCCCAAGATCTGTGCGAGGAGGCCCTGCGGCACTATGAGGACTTCCCCAAGCTGTGGATGATGA AGGGGCAGATCGAGGAGCAGAAGGAGATGATGGAGAAGGCGCGGGAAGCCTATAACCAGGGGTTGAAGAAGTGTCCCCACTCCACACCCC TGTGGCTTTTGCTCTCTCGGCTGGAGGAGAAGATTGGGCAGCTTACTCGAGCACGGGCCATTTTGGAAAAGTCTCGTCTGAAGAACCCAA AGAACCCTGGGCTGTGGTTGGAGTCCGTGCGGCTGGAGTACCGTGCGGGGCTGAAGAACATCGCAAATACACTCATGGCCAAGGCGCTGC AGGAGTGCCCCAACTCCGGTATCCTGTGGTCTGAGGCCATCTTCCTCGAGGCAAGGCCCCAGAGGAGGACCAAGAGCGTGGATGCCCTGA AGAAGTGTGAGCATGACCCCCATGTGCTCCTGGCCGTGGCCAAGCTGTTTTGGAGTCAGCGGAAGATCACCAAGGCCAGGGAGTGGTTCC ACCGCACTGTGAAGATTGACTCGGACCTGGGGGATGCCTGGGCCTTCTTCTACAAGTTTGAGCTGCAGCATGGCACTGAGGAGCAGCAGG AGGAGGTGAGGAAGCGCTGTGAGAGTGCAGAGCCTCGGCATGGGGAGCTGTGGTGCGCCGTGTCCAAGGACATCGCCAACTGGCAGAAGA AGATCGGGGACATCCTTAGGCTGGTGGCCGGCCGCATCAAGAACACCTTCTGATTGAGCGGTTGCCATGGCCGGTCTCCGTGGGGCAGGG |
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FusionGenePPI for PARD6B_PRPF6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PARD6B | RHOQ, CDC42, PARD3, PRKCZ, RAC1, YWHAH, PRKCI, LLGL1, LLGL2, PARD6A, DMBT1, PARD6G, APP, NPM1, WDR83, CRB3, GOLGA2, RHOJ, GMCL1, CEP76, PTPN14, ZZEF1, WWC1, ATAD3C, ARL10, KBTBD7, KBTBD6, PTPN21, RASSF8, HECTD3, CLPTM1, DR1, FOXM1, GNS, HNRNPA1, INPP5B, KIFC1, MYO10, P4HA1, PHKA1, PPP1CA, PSMD5, ROBO1, ROBO2, ICAM5, TP53BP2, SF1, RBM10, AGPS, MKNK1, CCNK, RECQL5, YWHAQ, PROSC, DLGAP4, AVL9, UBR2, LTN1, GOLIM4, VPS28, EPB41L4B, AGGF1, IARS2, EEFSEC, PDF, IFT22, RNF170, CDCA3, ANKRD32, MSANTD4, LRCH3, KIAA2013, MRPL55, EME1, TMEM92 | PRPF6 | TXNL4B, CD2BP2, SNRNP40, RNPS1, RNU11, ARAF, RAF1, TIMM44, PRPF6, YWHAB, AR, USP39, PRPF4, MEPCE, GIGYF2, SMARCA2, TADA2A, MYC, SF3A2, SIRT7, PRPF31, SART1, TXNL4A, EFTUD2, SNRNP200, PRPF8, PRPF3, SNRPD1, SNRPD3, SF3B3, SNRPD2, SNRPA1, SRSF7, NHP2L1, HNRNPM, U2AF1, SRSF5, U2AF2, PRPF19, EIF4A3, ACIN1, SRRM2, SAP18, SON, TPBG, THRAP3, NCSTN, NPM1, RPS13, RPS24, DDX18, RBM14, SUPT16H, TRA2A, ZNF326, NOTCH1, IK, CTNNB1, MMS19, HDAC11, PRPF4B, PARK2, RPA1, RPA2, RPA3, PASK, CUL7, OBSL1, CCDC8, EED, GCFC2, DDX23, TSSC4, BSG, LUC7L2, SF3A1, SNRPA, SF3A3, RNU12, NTRK1, SCARNA22, TP53, KIF21B, RAB4B, SNW1, CDC5L, MEX3C, RC3H1, ZNF746, SNRPG, SNRPE, SNRPN, SNRPF, KIAA1143, GPR156, RBM42, SMU1, RIOK1, ZNHIT2, AAR2, EAPP, DLST, PDHA1, FOXA1, TRIM25, BRCA1, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PARD6B | chr20:49348389 | chr20:62630398 | ENST00000371610 | + | 1 | 3 | 126_253 | 22 | 373 | PARD3 and CDC42 |
| Hgene | PARD6B | chr20:49348389 | chr20:62630398 | ENST00000396039 | + | 1 | 3 | 126_253 | 22 | 116 | PARD3 and CDC42 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PARD6B_PRPF6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PARD6B_PRPF6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PRPF6 | C3151434 | RETINITIS PIGMENTOSA 60 | 1 | UNIPROT |
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