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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 25989

FusionGeneSummary for PARD6B_PRPF6

check button Fusion gene summary
Fusion gene informationFusion gene name: PARD6B_PRPF6
Fusion gene ID: 25989
HgeneTgene
Gene symbol

PARD6B

PRPF6

Gene ID

84612

24148

Gene namepar-6 family cell polarity regulator betapre-mRNA processing factor 6
SynonymsPAR6BANT-1|ANT1|C20orf14|Prp6|RP60|SNRNP102|TOM|U5-102K|hPrp6
Cytomap

20q13.13

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionpartitioning defective 6 homolog betaPAR-6 betapar-6 partitioning defective 6 homolog betapre-mRNA-processing factor 6PRP6 homologPRP6 pre-mRNA processing factor 6 homologU5 snRNP-associated 102 kDa proteinU5-102 kDa proteinandrogen receptor N-terminal domain transactivating protein-1p102 U5 small nuclear ribonucleoprotein particle-bindi
Modification date2018052320180523
UniProtAcc

Q9BYG5

O94906

Ensembl transtripts involved in fusion geneENST00000371610, ENST00000396039, 
ENST00000535781, 
Fusion gene scores* DoF score3 X 2 X 2=127 X 7 X 2=98
# samples 36
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/98*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARD6B [Title/Abstract] AND PRPF6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePARD6B

GO:0065003

protein-containing complex assembly

12545177

TgenePRPF6

GO:0000398

mRNA splicing, via spliceosome

28781166

TgenePRPF6

GO:0045944

positive regulation of transcription by RNA polymerase II

16414017


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A1XD-01APARD6Bchr20

49348389

+PRPF6chr20

62630398

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000371610ENST00000535781PARD6Bchr20

49348389

+PRPF6chr20

62630398

+
In-frameENST00000396039ENST00000535781PARD6Bchr20

49348389

+PRPF6chr20

62630398

+

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FusionProtFeatures for PARD6B_PRPF6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARD6B

Q9BYG5

PRPF6

O94906

Adapter protein involved in asymmetrical cell divisionand cell polarization processes. Probably involved in formation ofepithelial tight junctions. Association with PARD3 may prevent theinteraction of PARD3 with F11R/JAM1, thereby preventing tightjunction assembly. The PARD6-PARD3 complex links GTP-bound Rhosmall GTPases to atypical protein kinase C proteins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRPF6chr20:49348389chr20:62630398ENST00000535781+520384_416257902RepeatNote=HAT 1
TgenePRPF6chr20:49348389chr20:62630398ENST00000535781+520418_444257902RepeatNote=HAT 2
TgenePRPF6chr20:49348389chr20:62630398ENST00000535781+520445_476257902RepeatNote=HAT 3
TgenePRPF6chr20:49348389chr20:62630398ENST00000535781+520554_586257902RepeatNote=HAT 4
TgenePRPF6chr20:49348389chr20:62630398ENST00000535781+520588_620257902RepeatNote=HAT 5
TgenePRPF6chr20:49348389chr20:62630398ENST00000535781+520622_654257902RepeatNote=HAT 6
TgenePRPF6chr20:49348389chr20:62630398ENST00000535781+520689_721257902RepeatNote=HAT 7
TgenePRPF6chr20:49348389chr20:62630398ENST00000535781+520723_755257902RepeatNote=HAT 8
TgenePRPF6chr20:49348389chr20:62630398ENST00000535781+520855_887257902RepeatNote=HAT 9

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD6Bchr20:49348389chr20:62630398ENST00000371610+13133_15022373DomainNote=Pseudo-CRIB
HgenePARD6Bchr20:49348389chr20:62630398ENST00000371610+13157_25022373DomainPDZ
HgenePARD6Bchr20:49348389chr20:62630398ENST00000371610+1316_9622373DomainPB1
HgenePARD6Bchr20:49348389chr20:62630398ENST00000396039+13133_15022116DomainNote=Pseudo-CRIB
HgenePARD6Bchr20:49348389chr20:62630398ENST00000396039+13157_25022116DomainPDZ
HgenePARD6Bchr20:49348389chr20:62630398ENST00000396039+1316_9622116DomainPB1
TgenePRPF6chr20:49348389chr20:62630398ENST00000535781+52067_72257902Compositional biasNote=Poly-Asp


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FusionGeneSequence for PARD6B_PRPF6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PARD6B_ENST00000371610_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_667aa
MNRSHRHGAGSGCLGTMEVKSKVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKL
QVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEE
PEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQ
WIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEA
LLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMM
EKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWS
EAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAE

>In-frame_PARD6B_ENST00000396039_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_667aa
MNRSHRHGAGSGCLGTMEVKSKVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKL
QVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEE
PEDARIMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQ
WIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEA
LLQRAVAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMM
EKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWS
EAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PARD6B_ENST00000371610_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_2001nt
ATGAACCGCAGCCACCGGCACGGGGCGGGCAGCGGCTGCCTGGGCACTATGGAGGTGAAGAGCAAGGTGTCTGACTCCGTGAGTGGACAG
ACCGTCGTTGACCCCAAAGGCTACCTGACGGATTTAAATTCCATGATCCCGACACACGGAGGAGACATCAATGATATCAAGAAGGCGCGA
CTGCTCCTCAAGTCTGTTCGGGAGACGAACCCTCATCACCCGCCAGCCTGGATTGCATCAGCCCGCCTGGAAGAAGTCACTGGGAAGCTA
CAAGTAGCTCGGAACCTTATCATGAAGGGGACGGAGATGTGCCCCAAGAGTGAAGATGTCTGGCTGGAAGCAGCCAGGTTGCAGCCTGGG
GACACAGCCAAGGCCGTGGTAGCCCAAGCTGTCCGTCATCTCCCACAGTCTGTCAGGATTTACATCAGAGCCGCAGAGCTGGAAACGGAC
ATTCGTGCAAAGAAGCGGGTTCTTCGGAAAGCCCTCGAGCATGTTCCAAACTCGGTTCGCTTGTGGAAAGCAGCCGTTGAGCTGGAAGAA
CCTGAAGATGCTAGAATCATGCTGAGCCGAGCTGTGGAGTGCTGCCCCACCAGCGTGGAGCTCTGGCTTGCTCTGGCAAGGCTGGAGACC
TATGAAAATGCCCGCAAGGTCTTGAACAAGGCGCGGGAGAACATTCCTACAGACCGACATATCTGGATCACGGCTGCTAAGCTGGAGGAA
GCCAATGGGAACACGCAGATGGTGGAGAAGATCATCGACCGAGCCATCACCTCGCTGCGGGCCAACGGTGTGGAGATCAACCGTGAGCAG
TGGATCCAGGATGCCGAGGAATGTGACAGGGCTGGGAGTGTGGCCACCTGCCAGGCCGTCATGCGTGCCGTGATTGGGATTGGGATTGAG
GAGGAAGATCGGAAGCATACCTGGATGGAGGATGCTGACAGTTGTGTAGCCCACAATGCCCTGGAGTGTGCACGAGCCATCTACGCCTAC
GCCCTGCAGGTGTTCCCCAGCAAGAAGAGTGTGTGGCTGCGCGCCGCGTACTTCGAGAAGAACCATGGCACTCGGGAGTCCCTGGAAGCA
CTCCTGCAGAGGGCTGTGGCCCACTGCCCCAAAGCAGAGGTGCTGTGGCTCATGGGCGCCAAGTCCAAGTGGCTGGCAGGGGATGTGCCT
GCAGCAAGGAGCATCCTGGCCCTGGCCTTCCAGGTGTTCATGAAGTCTGTGAAGCTGGAGTGGGTGCAAGACAACATCAGGGCAGCCCAA
GATCTGTGCGAGGAGGCCCTGCGGCACTATGAGGACTTCCCCAAGCTGTGGATGATGAAGGGGCAGATCGAGGAGCAGAAGGAGATGATG
GAGAAGGCGCGGGAAGCCTATAACCAGGGGTTGAAGAAGTGTCCCCACTCCACACCCCTGTGGCTTTTGCTCTCTCGGCTGGAGGAGAAG
ATTGGGCAGCTTACTCGAGCACGGGCCATTTTGGAAAAGTCTCGTCTGAAGAACCCAAAGAACCCTGGGCTGTGGTTGGAGTCCGTGCGG
CTGGAGTACCGTGCGGGGCTGAAGAACATCGCAAATACACTCATGGCCAAGGCGCTGCAGGAGTGCCCCAACTCCGGTATCCTGTGGTCT
GAGGCCATCTTCCTCGAGGCAAGGCCCCAGAGGAGGACCAAGAGCGTGGATGCCCTGAAGAAGTGTGAGCATGACCCCCATGTGCTCCTG
GCCGTGGCCAAGCTGTTTTGGAGTCAGCGGAAGATCACCAAGGCCAGGGAGTGGTTCCACCGCACTGTGAAGATTGACTCGGACCTGGGG
GATGCCTGGGCCTTCTTCTACAAGTTTGAGCTGCAGCATGGCACTGAGGAGCAGCAGGAGGAGGTGAGGAAGCGCTGTGAGAGTGCAGAG
CCTCGGCATGGGGAGCTGTGGTGCGCCGTGTCCAAGGACATCGCCAACTGGCAGAAGAAGATCGGGGACATCCTTAGGCTGGTGGCCGGC

>In-frame_PARD6B_ENST00000396039_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_2001nt
ATGAACCGCAGCCACCGGCACGGGGCGGGCAGCGGCTGCCTGGGCACTATGGAGGTGAAGAGCAAGGTGTCTGACTCCGTGAGTGGACAG
ACCGTCGTTGACCCCAAAGGCTACCTGACGGATTTAAATTCCATGATCCCGACACACGGAGGAGACATCAATGATATCAAGAAGGCGCGA
CTGCTCCTCAAGTCTGTTCGGGAGACGAACCCTCATCACCCGCCAGCCTGGATTGCATCAGCCCGCCTGGAAGAAGTCACTGGGAAGCTA
CAAGTAGCTCGGAACCTTATCATGAAGGGGACGGAGATGTGCCCCAAGAGTGAAGATGTCTGGCTGGAAGCAGCCAGGTTGCAGCCTGGG
GACACAGCCAAGGCCGTGGTAGCCCAAGCTGTCCGTCATCTCCCACAGTCTGTCAGGATTTACATCAGAGCCGCAGAGCTGGAAACGGAC
ATTCGTGCAAAGAAGCGGGTTCTTCGGAAAGCCCTCGAGCATGTTCCAAACTCGGTTCGCTTGTGGAAAGCAGCCGTTGAGCTGGAAGAA
CCTGAAGATGCTAGAATCATGCTGAGCCGAGCTGTGGAGTGCTGCCCCACCAGCGTGGAGCTCTGGCTTGCTCTGGCAAGGCTGGAGACC
TATGAAAATGCCCGCAAGGTCTTGAACAAGGCGCGGGAGAACATTCCTACAGACCGACATATCTGGATCACGGCTGCTAAGCTGGAGGAA
GCCAATGGGAACACGCAGATGGTGGAGAAGATCATCGACCGAGCCATCACCTCGCTGCGGGCCAACGGTGTGGAGATCAACCGTGAGCAG
TGGATCCAGGATGCCGAGGAATGTGACAGGGCTGGGAGTGTGGCCACCTGCCAGGCCGTCATGCGTGCCGTGATTGGGATTGGGATTGAG
GAGGAAGATCGGAAGCATACCTGGATGGAGGATGCTGACAGTTGTGTAGCCCACAATGCCCTGGAGTGTGCACGAGCCATCTACGCCTAC
GCCCTGCAGGTGTTCCCCAGCAAGAAGAGTGTGTGGCTGCGCGCCGCGTACTTCGAGAAGAACCATGGCACTCGGGAGTCCCTGGAAGCA
CTCCTGCAGAGGGCTGTGGCCCACTGCCCCAAAGCAGAGGTGCTGTGGCTCATGGGCGCCAAGTCCAAGTGGCTGGCAGGGGATGTGCCT
GCAGCAAGGAGCATCCTGGCCCTGGCCTTCCAGGTGTTCATGAAGTCTGTGAAGCTGGAGTGGGTGCAAGACAACATCAGGGCAGCCCAA
GATCTGTGCGAGGAGGCCCTGCGGCACTATGAGGACTTCCCCAAGCTGTGGATGATGAAGGGGCAGATCGAGGAGCAGAAGGAGATGATG
GAGAAGGCGCGGGAAGCCTATAACCAGGGGTTGAAGAAGTGTCCCCACTCCACACCCCTGTGGCTTTTGCTCTCTCGGCTGGAGGAGAAG
ATTGGGCAGCTTACTCGAGCACGGGCCATTTTGGAAAAGTCTCGTCTGAAGAACCCAAAGAACCCTGGGCTGTGGTTGGAGTCCGTGCGG
CTGGAGTACCGTGCGGGGCTGAAGAACATCGCAAATACACTCATGGCCAAGGCGCTGCAGGAGTGCCCCAACTCCGGTATCCTGTGGTCT
GAGGCCATCTTCCTCGAGGCAAGGCCCCAGAGGAGGACCAAGAGCGTGGATGCCCTGAAGAAGTGTGAGCATGACCCCCATGTGCTCCTG
GCCGTGGCCAAGCTGTTTTGGAGTCAGCGGAAGATCACCAAGGCCAGGGAGTGGTTCCACCGCACTGTGAAGATTGACTCGGACCTGGGG
GATGCCTGGGCCTTCTTCTACAAGTTTGAGCTGCAGCATGGCACTGAGGAGCAGCAGGAGGAGGTGAGGAAGCGCTGTGAGAGTGCAGAG
CCTCGGCATGGGGAGCTGTGGTGCGCCGTGTCCAAGGACATCGCCAACTGGCAGAAGAAGATCGGGGACATCCTTAGGCTGGTGGCCGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PARD6B_ENST00000371610_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_2347nt
GAGGGAGGGAGCTGCTTCCCCGCCTGCCGCGCCACCAGTCCGACCCTCGGTCCCGCCGTGTGAGCAGCTGGTGGAGTGGAGCTCAGCGCG
GACGCCGGAGCTGCGGCCGCCCCCTCTGCAGGTGCCTGTGAGGAGGCGCCCGGGCCGCAACCGCTTTCCGAGATCCCCAGTCGCGCACTC
GCTCCCCGCGCTCCTGAGGGGCCGCCCGGCCGGAGGAGGCCGTCGCGGGGCTCGGCGTTCAGCATGAACCGCAGCCACCGGCACGGGGCG
GGCAGCGGCTGCCTGGGCACTATGGAGGTGAAGAGCAAGGTGTCTGACTCCGTGAGTGGACAGACCGTCGTTGACCCCAAAGGCTACCTG
ACGGATTTAAATTCCATGATCCCGACACACGGAGGAGACATCAATGATATCAAGAAGGCGCGACTGCTCCTCAAGTCTGTTCGGGAGACG
AACCCTCATCACCCGCCAGCCTGGATTGCATCAGCCCGCCTGGAAGAAGTCACTGGGAAGCTACAAGTAGCTCGGAACCTTATCATGAAG
GGGACGGAGATGTGCCCCAAGAGTGAAGATGTCTGGCTGGAAGCAGCCAGGTTGCAGCCTGGGGACACAGCCAAGGCCGTGGTAGCCCAA
GCTGTCCGTCATCTCCCACAGTCTGTCAGGATTTACATCAGAGCCGCAGAGCTGGAAACGGACATTCGTGCAAAGAAGCGGGTTCTTCGG
AAAGCCCTCGAGCATGTTCCAAACTCGGTTCGCTTGTGGAAAGCAGCCGTTGAGCTGGAAGAACCTGAAGATGCTAGAATCATGCTGAGC
CGAGCTGTGGAGTGCTGCCCCACCAGCGTGGAGCTCTGGCTTGCTCTGGCAAGGCTGGAGACCTATGAAAATGCCCGCAAGGTCTTGAAC
AAGGCGCGGGAGAACATTCCTACAGACCGACATATCTGGATCACGGCTGCTAAGCTGGAGGAAGCCAATGGGAACACGCAGATGGTGGAG
AAGATCATCGACCGAGCCATCACCTCGCTGCGGGCCAACGGTGTGGAGATCAACCGTGAGCAGTGGATCCAGGATGCCGAGGAATGTGAC
AGGGCTGGGAGTGTGGCCACCTGCCAGGCCGTCATGCGTGCCGTGATTGGGATTGGGATTGAGGAGGAAGATCGGAAGCATACCTGGATG
GAGGATGCTGACAGTTGTGTAGCCCACAATGCCCTGGAGTGTGCACGAGCCATCTACGCCTACGCCCTGCAGGTGTTCCCCAGCAAGAAG
AGTGTGTGGCTGCGCGCCGCGTACTTCGAGAAGAACCATGGCACTCGGGAGTCCCTGGAAGCACTCCTGCAGAGGGCTGTGGCCCACTGC
CCCAAAGCAGAGGTGCTGTGGCTCATGGGCGCCAAGTCCAAGTGGCTGGCAGGGGATGTGCCTGCAGCAAGGAGCATCCTGGCCCTGGCC
TTCCAGGTGTTCATGAAGTCTGTGAAGCTGGAGTGGGTGCAAGACAACATCAGGGCAGCCCAAGATCTGTGCGAGGAGGCCCTGCGGCAC
TATGAGGACTTCCCCAAGCTGTGGATGATGAAGGGGCAGATCGAGGAGCAGAAGGAGATGATGGAGAAGGCGCGGGAAGCCTATAACCAG
GGGTTGAAGAAGTGTCCCCACTCCACACCCCTGTGGCTTTTGCTCTCTCGGCTGGAGGAGAAGATTGGGCAGCTTACTCGAGCACGGGCC
ATTTTGGAAAAGTCTCGTCTGAAGAACCCAAAGAACCCTGGGCTGTGGTTGGAGTCCGTGCGGCTGGAGTACCGTGCGGGGCTGAAGAAC
ATCGCAAATACACTCATGGCCAAGGCGCTGCAGGAGTGCCCCAACTCCGGTATCCTGTGGTCTGAGGCCATCTTCCTCGAGGCAAGGCCC
CAGAGGAGGACCAAGAGCGTGGATGCCCTGAAGAAGTGTGAGCATGACCCCCATGTGCTCCTGGCCGTGGCCAAGCTGTTTTGGAGTCAG
CGGAAGATCACCAAGGCCAGGGAGTGGTTCCACCGCACTGTGAAGATTGACTCGGACCTGGGGGATGCCTGGGCCTTCTTCTACAAGTTT
GAGCTGCAGCATGGCACTGAGGAGCAGCAGGAGGAGGTGAGGAAGCGCTGTGAGAGTGCAGAGCCTCGGCATGGGGAGCTGTGGTGCGCC
GTGTCCAAGGACATCGCCAACTGGCAGAAGAAGATCGGGGACATCCTTAGGCTGGTGGCCGGCCGCATCAAGAACACCTTCTGATTGAGC
GGTTGCCATGGCCGGTCTCCGTGGGGCAGGGTTGGGCCGCATGTGGAAGGGCTCTGAGCTGTGTCCTCCTTCATTAAAAGTTTTTATGTC

>In-frame_PARD6B_ENST00000396039_chr20_49348389_+_PRPF6_ENST00000535781_chr20_62630398_+_2226nt
GTGCCTGTGAGGAGGCGCCCGGGCCGCAACCGCTTTCCGAGATCCCCAGTCGCGCACTCGCTCCCCGCGCTCCTGAGGGGCCGCCCGGCC
GGAGGAGGCCGTCGCGGGGCTCGGCGTTCAGCATGAACCGCAGCCACCGGCACGGGGCGGGCAGCGGCTGCCTGGGCACTATGGAGGTGA
AGAGCAAGGTGTCTGACTCCGTGAGTGGACAGACCGTCGTTGACCCCAAAGGCTACCTGACGGATTTAAATTCCATGATCCCGACACACG
GAGGAGACATCAATGATATCAAGAAGGCGCGACTGCTCCTCAAGTCTGTTCGGGAGACGAACCCTCATCACCCGCCAGCCTGGATTGCAT
CAGCCCGCCTGGAAGAAGTCACTGGGAAGCTACAAGTAGCTCGGAACCTTATCATGAAGGGGACGGAGATGTGCCCCAAGAGTGAAGATG
TCTGGCTGGAAGCAGCCAGGTTGCAGCCTGGGGACACAGCCAAGGCCGTGGTAGCCCAAGCTGTCCGTCATCTCCCACAGTCTGTCAGGA
TTTACATCAGAGCCGCAGAGCTGGAAACGGACATTCGTGCAAAGAAGCGGGTTCTTCGGAAAGCCCTCGAGCATGTTCCAAACTCGGTTC
GCTTGTGGAAAGCAGCCGTTGAGCTGGAAGAACCTGAAGATGCTAGAATCATGCTGAGCCGAGCTGTGGAGTGCTGCCCCACCAGCGTGG
AGCTCTGGCTTGCTCTGGCAAGGCTGGAGACCTATGAAAATGCCCGCAAGGTCTTGAACAAGGCGCGGGAGAACATTCCTACAGACCGAC
ATATCTGGATCACGGCTGCTAAGCTGGAGGAAGCCAATGGGAACACGCAGATGGTGGAGAAGATCATCGACCGAGCCATCACCTCGCTGC
GGGCCAACGGTGTGGAGATCAACCGTGAGCAGTGGATCCAGGATGCCGAGGAATGTGACAGGGCTGGGAGTGTGGCCACCTGCCAGGCCG
TCATGCGTGCCGTGATTGGGATTGGGATTGAGGAGGAAGATCGGAAGCATACCTGGATGGAGGATGCTGACAGTTGTGTAGCCCACAATG
CCCTGGAGTGTGCACGAGCCATCTACGCCTACGCCCTGCAGGTGTTCCCCAGCAAGAAGAGTGTGTGGCTGCGCGCCGCGTACTTCGAGA
AGAACCATGGCACTCGGGAGTCCCTGGAAGCACTCCTGCAGAGGGCTGTGGCCCACTGCCCCAAAGCAGAGGTGCTGTGGCTCATGGGCG
CCAAGTCCAAGTGGCTGGCAGGGGATGTGCCTGCAGCAAGGAGCATCCTGGCCCTGGCCTTCCAGGTGTTCATGAAGTCTGTGAAGCTGG
AGTGGGTGCAAGACAACATCAGGGCAGCCCAAGATCTGTGCGAGGAGGCCCTGCGGCACTATGAGGACTTCCCCAAGCTGTGGATGATGA
AGGGGCAGATCGAGGAGCAGAAGGAGATGATGGAGAAGGCGCGGGAAGCCTATAACCAGGGGTTGAAGAAGTGTCCCCACTCCACACCCC
TGTGGCTTTTGCTCTCTCGGCTGGAGGAGAAGATTGGGCAGCTTACTCGAGCACGGGCCATTTTGGAAAAGTCTCGTCTGAAGAACCCAA
AGAACCCTGGGCTGTGGTTGGAGTCCGTGCGGCTGGAGTACCGTGCGGGGCTGAAGAACATCGCAAATACACTCATGGCCAAGGCGCTGC
AGGAGTGCCCCAACTCCGGTATCCTGTGGTCTGAGGCCATCTTCCTCGAGGCAAGGCCCCAGAGGAGGACCAAGAGCGTGGATGCCCTGA
AGAAGTGTGAGCATGACCCCCATGTGCTCCTGGCCGTGGCCAAGCTGTTTTGGAGTCAGCGGAAGATCACCAAGGCCAGGGAGTGGTTCC
ACCGCACTGTGAAGATTGACTCGGACCTGGGGGATGCCTGGGCCTTCTTCTACAAGTTTGAGCTGCAGCATGGCACTGAGGAGCAGCAGG
AGGAGGTGAGGAAGCGCTGTGAGAGTGCAGAGCCTCGGCATGGGGAGCTGTGGTGCGCCGTGTCCAAGGACATCGCCAACTGGCAGAAGA
AGATCGGGGACATCCTTAGGCTGGTGGCCGGCCGCATCAAGAACACCTTCTGATTGAGCGGTTGCCATGGCCGGTCTCCGTGGGGCAGGG


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FusionGenePPI for PARD6B_PRPF6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARD6BRHOQ, CDC42, PARD3, PRKCZ, RAC1, YWHAH, PRKCI, LLGL1, LLGL2, PARD6A, DMBT1, PARD6G, APP, NPM1, WDR83, CRB3, GOLGA2, RHOJ, GMCL1, CEP76, PTPN14, ZZEF1, WWC1, ATAD3C, ARL10, KBTBD7, KBTBD6, PTPN21, RASSF8, HECTD3, CLPTM1, DR1, FOXM1, GNS, HNRNPA1, INPP5B, KIFC1, MYO10, P4HA1, PHKA1, PPP1CA, PSMD5, ROBO1, ROBO2, ICAM5, TP53BP2, SF1, RBM10, AGPS, MKNK1, CCNK, RECQL5, YWHAQ, PROSC, DLGAP4, AVL9, UBR2, LTN1, GOLIM4, VPS28, EPB41L4B, AGGF1, IARS2, EEFSEC, PDF, IFT22, RNF170, CDCA3, ANKRD32, MSANTD4, LRCH3, KIAA2013, MRPL55, EME1, TMEM92PRPF6TXNL4B, CD2BP2, SNRNP40, RNPS1, RNU11, ARAF, RAF1, TIMM44, PRPF6, YWHAB, AR, USP39, PRPF4, MEPCE, GIGYF2, SMARCA2, TADA2A, MYC, SF3A2, SIRT7, PRPF31, SART1, TXNL4A, EFTUD2, SNRNP200, PRPF8, PRPF3, SNRPD1, SNRPD3, SF3B3, SNRPD2, SNRPA1, SRSF7, NHP2L1, HNRNPM, U2AF1, SRSF5, U2AF2, PRPF19, EIF4A3, ACIN1, SRRM2, SAP18, SON, TPBG, THRAP3, NCSTN, NPM1, RPS13, RPS24, DDX18, RBM14, SUPT16H, TRA2A, ZNF326, NOTCH1, IK, CTNNB1, MMS19, HDAC11, PRPF4B, PARK2, RPA1, RPA2, RPA3, PASK, CUL7, OBSL1, CCDC8, EED, GCFC2, DDX23, TSSC4, BSG, LUC7L2, SF3A1, SNRPA, SF3A3, RNU12, NTRK1, SCARNA22, TP53, KIF21B, RAB4B, SNW1, CDC5L, MEX3C, RC3H1, ZNF746, SNRPG, SNRPE, SNRPN, SNRPF, KIAA1143, GPR156, RBM42, SMU1, RIOK1, ZNHIT2, AAR2, EAPP, DLST, PDHA1, FOXA1, TRIM25, BRCA1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePARD6Bchr20:49348389chr20:62630398ENST00000371610+13126_25322373PARD3 and CDC42
HgenePARD6Bchr20:49348389chr20:62630398ENST00000396039+13126_25322116PARD3 and CDC42


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARD6B_PRPF6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARD6B_PRPF6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRPF6C3151434RETINITIS PIGMENTOSA 601UNIPROT