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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2598

FusionGeneSummary for ARHGEF7_TUSC3

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF7_TUSC3
Fusion gene ID: 2598
HgeneTgene
Gene symbol

ARHGEF7

TUSC3

Gene ID

8874

7991

Gene nameRho guanine nucleotide exchange factor 7tumor suppressor candidate 3
SynonymsBETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXBD8S1992|M33|MRT22|MRT7|MagT2|N33|OST3A
Cytomap

13q34

8p22

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich proteintumor suppressor candidate 3magnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog Aputative prostate cancer tumor suppressor
Modification date2018052220180523
UniProtAcc

Q14155

Q13454

Ensembl transtripts involved in fusion geneENST00000317133, ENST00000375741, 
ENST00000375739, ENST00000370623, 
ENST00000544132, ENST00000218789, 
ENST00000375736, ENST00000426073, 
ENST00000375737, ENST00000375723, 
ENST00000478679, ENST00000483189, 
ENST00000503191, ENST00000382020, 
ENST00000506802, ENST00000509380, 
ENST00000503731, 
Fusion gene scores* DoF score11 X 9 X 7=6934 X 4 X 2=32
# samples 114
** MAII scorelog2(11/693*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARHGEF7 [Title/Abstract] AND TUSC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF7

GO:0043547

positive regulation of GTPase activity

21048939


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF990912ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000317133ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000317133ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000317133ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000317133ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000317133ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375741ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375741ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375741ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375741ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375741ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375739ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375739ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375739ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375739ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375739ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000370623ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000370623ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000370623ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000370623ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000370623ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000544132ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000544132ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000544132ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000544132ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000544132ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000218789ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000218789ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000218789ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000218789ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000218789ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000375736ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000375736ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000375736ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000375736ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000375736ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000426073ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000426073ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000426073ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000426073ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
3UTR-intronENST00000426073ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375737ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375737ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375737ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375737ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375737ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375723ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375723ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375723ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375723ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000375723ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000478679ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000478679ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000478679ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000478679ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000478679ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000483189ENST00000503191ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000483189ENST00000382020ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000483189ENST00000506802ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000483189ENST00000509380ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+
intron-intronENST00000483189ENST00000503731ARHGEF7chr13

111955946

-TUSC3chr8

15397987

+

Top

FusionProtFeatures for ARHGEF7_TUSC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF7

Q14155

TUSC3

Q13454

Acts as accessory component of the N-oligosaccharyltransferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donorto an asparagine residue within an Asn-X-Ser/Thr consensus motifin nascent polypeptide chains. Involved in N-glycosylation ofSTT3B-dependent substrates. Specifically required for theglycosylation of a subset of acceptor sites that are near cysteineresidues; in this function seems to act redundantly with MAGT1. Inits oxidized form proposed to form transient mixed disulfides witha glycoprotein substrate to facilitate access of STT3B to theunmodified acceptor site. Has also oxidoreductase-independentfunctions in the STT3B-containing OST complex possibly involvingsubstrate recognition. {ECO:0000269|PubMed:25135935,ECO:0000305|PubMed:12887896, ECO:0000305|PubMed:24685145}. Magnesium transporter. {ECO:0000269|PubMed:19717468}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARHGEF7_TUSC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGEF7_TUSC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ARHGEF7_TUSC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ARHGEF7_TUSC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTUSC3C0023893Liver Cirrhosis, Experimental1CTD_human