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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25970

FusionGeneSummary for PARD3_CAMK1D

check button Fusion gene summary
Fusion gene informationFusion gene name: PARD3_CAMK1D
Fusion gene ID: 25970
HgeneTgene
Gene symbol

PARD3

CAMK1D

Gene ID

56288

57118

Gene namepar-3 family cell polarity regulatorcalcium/calmodulin dependent protein kinase ID
SynonymsASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2CKLiK|CaM-K1|CaMKID
Cytomap

10p11.22-p11.21

10p13

Type of geneprotein-codingprotein-coding
Descriptionpartitioning defective 3 homologCTCL tumor antigen se2-5PAR3-alphaatypical PKC isotype-specific interacting proteinbazookapar-3 family cell polarity regulator alphapar-3 partitioning defective 3 homologprotein phosphatase 1, regulatory subunit 118calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta
Modification date2018052320180523
UniProtAcc

Q8TEW0

Q8IU85

Ensembl transtripts involved in fusion geneENST00000545260, ENST00000545693, 
ENST00000350537, ENST00000346874, 
ENST00000374789, ENST00000374790, 
ENST00000374794, ENST00000374788, 
ENST00000466092, ENST00000374776, 
ENST00000340077, ENST00000544292, 
ENST00000374773, ENST00000374768, 
ENST00000378847, ENST00000487696, 
ENST00000378845, 
Fusion gene scores* DoF score22 X 13 X 12=34328 X 9 X 6=432
# samples 2610
** MAII scorelog2(26/3432*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PARD3 [Title/Abstract] AND CAMK1D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAMK1D

GO:0032793

positive regulation of CREB transcription factor activity

16324104


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-25-1635-01APARD3chr10

34739245

-CAMK1Dchr10

12708735

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000545260ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000545260ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000545260ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
Frame-shitENST00000545693ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000545693ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000545693ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
Frame-shitENST00000350537ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000350537ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000350537ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
Frame-shitENST00000346874ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000346874ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000346874ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
Frame-shitENST00000374789ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000374789ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000374789ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3CDSENST00000374790ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000374790ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000374790ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3CDSENST00000374794ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000374794ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000374794ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
Frame-shitENST00000374788ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000374788ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000374788ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3CDSENST00000466092ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000466092ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000466092ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
Frame-shitENST00000374776ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000374776ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000374776ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
Frame-shitENST00000340077ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000340077ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000340077ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3CDSENST00000544292ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000544292ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000544292ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
Frame-shitENST00000374773ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000374773ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
5CDS-3UTRENST00000374773ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3CDSENST00000374768ENST00000378847PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000374768ENST00000487696PARD3chr10

34739245

-CAMK1Dchr10

12708735

+
intron-3UTRENST00000374768ENST00000378845PARD3chr10

34739245

-CAMK1Dchr10

12708735

+

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FusionProtFeatures for PARD3_CAMK1D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARD3

Q8TEW0

CAMK1D

Q8IU85

Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascadeand, upon calcium influx, activates CREB-dependent genetranscription, regulates calcium-mediated granulocyte function andrespiratory burst and promotes basal dendritic growth ofhippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratoryburst. Activates the transcription factor CREB1 in hippocampalneuron nuclei. May play a role in apoptosis of erythroleukemiacells. In vitro, phosphorylates transcription factor CREM isoformBeta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691,ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PARD3_CAMK1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PARD3_CAMK1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARD3YWHAB, YWHAG, SFN, ECT2, F11R, JAM2, JAM3, PVRL3, PARD6A, PARD6B, PARD6G, PRKCI, PRKCZ, YWHAZ, YWHAH, DCAF7, PNMA1, RASSF8, CCDC88A, PNMA2, LLGL1, SIAH1, HSPA8, HSPA6, HSPD1, PSME3, PSME2, RPS3, RPS18, PFKP, KPNA4, ANP32E, TJP1, VHL, ARHGAP17, AMOT, YWHAE, GAB1, MARK2, INADL, AMOTL2, LATS1, LATS2, YAP1, RASSF7, PSMC3, TP53BP2, RASSF9, RASSF10, SMAD7, SMAD4, SMAD1, SMAD2, SMAD3, CEP19, TMEM17, VAPA, MMGT1, CTNNB1, PPP1CA, CDH1, TRIM25CAMK1DNEDD4, NEDD4L, POT1, APP, BAG3, TNFSF13, ASAH1, CDC25A, CUL3, GMFG, BNIP3L, DCPS, HSPA1L, NAE1, NUCB2, PCYT2, TUBB6, TUFM, UBA3, XPO1, CAMK1, CAMK1G, ZG16B, QPCTL, MUC7, AMY1C, CKS2, CST4, XYLT2, CDH1, LAMP3, CST1, C9orf173, GNRHR, CALM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARD3_CAMK1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARD3_CAMK1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource