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Fusion gene ID: 25970 |
FusionGeneSummary for PARD3_CAMK1D |
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Fusion gene information | Fusion gene name: PARD3_CAMK1D | Fusion gene ID: 25970 | Hgene | Tgene | Gene symbol | PARD3 | CAMK1D | Gene ID | 56288 | 57118 |
Gene name | par-3 family cell polarity regulator | calcium/calmodulin dependent protein kinase ID | |
Synonyms | ASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2 | CKLiK|CaM-K1|CaMKID | |
Cytomap | 10p11.22-p11.21 | 10p13 | |
Type of gene | protein-coding | protein-coding | |
Description | partitioning defective 3 homologCTCL tumor antigen se2-5PAR3-alphaatypical PKC isotype-specific interacting proteinbazookapar-3 family cell polarity regulator alphapar-3 partitioning defective 3 homologprotein phosphatase 1, regulatory subunit 118 | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8TEW0 | Q8IU85 | |
Ensembl transtripts involved in fusion gene | ENST00000545260, ENST00000545693, ENST00000350537, ENST00000346874, ENST00000374789, ENST00000374790, ENST00000374794, ENST00000374788, ENST00000466092, ENST00000374776, ENST00000340077, ENST00000544292, ENST00000374773, ENST00000374768, | ENST00000378847, ENST00000487696, ENST00000378845, | |
Fusion gene scores | * DoF score | 22 X 13 X 12=3432 | 8 X 9 X 6=432 |
# samples | 26 | 10 | |
** MAII score | log2(26/3432*10)=-3.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PARD3 [Title/Abstract] AND CAMK1D [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-25-1635-01A | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000545260 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000545260 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000545260 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
Frame-shift | ENST00000545693 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000545693 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000545693 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
Frame-shift | ENST00000350537 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000350537 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000350537 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
Frame-shift | ENST00000346874 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000346874 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000346874 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
Frame-shift | ENST00000374789 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000374789 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000374789 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3CDS | ENST00000374790 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000374790 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000374790 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3CDS | ENST00000374794 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000374794 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000374794 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
Frame-shift | ENST00000374788 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000374788 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000374788 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3CDS | ENST00000466092 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000466092 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000466092 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
Frame-shift | ENST00000374776 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000374776 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000374776 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
Frame-shift | ENST00000340077 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000340077 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000340077 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3CDS | ENST00000544292 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000544292 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000544292 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
Frame-shift | ENST00000374773 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000374773 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
5CDS-3UTR | ENST00000374773 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3CDS | ENST00000374768 | ENST00000378847 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000374768 | ENST00000487696 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
intron-3UTR | ENST00000374768 | ENST00000378845 | PARD3 | chr10 | 34739245 | - | CAMK1D | chr10 | 12708735 | + |
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FusionProtFeatures for PARD3_CAMK1D |
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Hgene | Tgene |
PARD3 | CAMK1D |
Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascadeand, upon calcium influx, activates CREB-dependent genetranscription, regulates calcium-mediated granulocyte function andrespiratory burst and promotes basal dendritic growth ofhippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratoryburst. Activates the transcription factor CREB1 in hippocampalneuron nuclei. May play a role in apoptosis of erythroleukemiacells. In vitro, phosphorylates transcription factor CREM isoformBeta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691,ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PARD3_CAMK1D |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PARD3_CAMK1D |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PARD3 | YWHAB, YWHAG, SFN, ECT2, F11R, JAM2, JAM3, PVRL3, PARD6A, PARD6B, PARD6G, PRKCI, PRKCZ, YWHAZ, YWHAH, DCAF7, PNMA1, RASSF8, CCDC88A, PNMA2, LLGL1, SIAH1, HSPA8, HSPA6, HSPD1, PSME3, PSME2, RPS3, RPS18, PFKP, KPNA4, ANP32E, TJP1, VHL, ARHGAP17, AMOT, YWHAE, GAB1, MARK2, INADL, AMOTL2, LATS1, LATS2, YAP1, RASSF7, PSMC3, TP53BP2, RASSF9, RASSF10, SMAD7, SMAD4, SMAD1, SMAD2, SMAD3, CEP19, TMEM17, VAPA, MMGT1, CTNNB1, PPP1CA, CDH1, TRIM25 | CAMK1D | NEDD4, NEDD4L, POT1, APP, BAG3, TNFSF13, ASAH1, CDC25A, CUL3, GMFG, BNIP3L, DCPS, HSPA1L, NAE1, NUCB2, PCYT2, TUBB6, TUFM, UBA3, XPO1, CAMK1, CAMK1G, ZG16B, QPCTL, MUC7, AMY1C, CKS2, CST4, XYLT2, CDH1, LAMP3, CST1, C9orf173, GNRHR, CALM3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PARD3_CAMK1D |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PARD3_CAMK1D |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |