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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25968

FusionGeneSummary for PARD3_ARHGAP24

check button Fusion gene summary
Fusion gene informationFusion gene name: PARD3_ARHGAP24
Fusion gene ID: 25968
HgeneTgene
Gene symbol

PARD3

ARHGAP24

Gene ID

56288

83478

Gene namepar-3 family cell polarity regulatorRho GTPase activating protein 24
SynonymsASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2FILGAP|RC-GAP72|RCGAP72|p73|p73RhoGAP
Cytomap

10p11.22-p11.21

4q21.23-q21.3

Type of geneprotein-codingprotein-coding
Descriptionpartitioning defective 3 homologCTCL tumor antigen se2-5PAR3-alphaatypical PKC isotype-specific interacting proteinbazookapar-3 family cell polarity regulator alphapar-3 partitioning defective 3 homologprotein phosphatase 1, regulatory subunit 118rho GTPase-activating protein 24RAC1- and CDC42-specific GTPase-activating protein of 72 kDafilamin-A-associated RhoGAPrhoGAP of 73 kDasarcoma antigen NY-SAR-88
Modification date2018052320180519
UniProtAcc

Q8TEW0

Q8N264

Ensembl transtripts involved in fusion geneENST00000545260, ENST00000545693, 
ENST00000350537, ENST00000346874, 
ENST00000374789, ENST00000374790, 
ENST00000374794, ENST00000374788, 
ENST00000466092, ENST00000374776, 
ENST00000340077, ENST00000544292, 
ENST00000374773, ENST00000374768, 
ENST00000395184, ENST00000503995, 
ENST00000506421, ENST00000395183, 
ENST00000264343, 
Fusion gene scores* DoF score22 X 13 X 12=34324 X 4 X 3=48
# samples 266
** MAII scorelog2(26/3432*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PARD3 [Title/Abstract] AND ARHGAP24 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-09-1673-01APARD3chr10

34805907

-ARHGAP24chr4

86491675

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000545260ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000545260ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000545260ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000545260ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000545260ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000545693ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000545693ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000545693ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000545693ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000545693ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000350537ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000350537ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000350537ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000350537ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000350537ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000346874ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000346874ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000346874ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000346874ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000346874ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374789ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374789ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000374789ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374789ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374789ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374790ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374790ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000374790ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374790ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374790ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374794ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374794ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000374794ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374794ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374794ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374788ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374788ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000374788ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374788ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374788ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-5UTRENST00000466092ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-5UTRENST00000466092ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-3UTRENST00000466092ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-intronENST00000466092ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-intronENST00000466092ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374776ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374776ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000374776ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374776ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374776ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000340077ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000340077ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000340077ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000340077ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000340077ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-5UTRENST00000544292ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-5UTRENST00000544292ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-3UTRENST00000544292ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-intronENST00000544292ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-intronENST00000544292ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374773ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-5UTRENST00000374773ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-3UTRENST00000374773ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374773ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
5CDS-intronENST00000374773ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-5UTRENST00000374768ENST00000395184PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-5UTRENST00000374768ENST00000503995PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-3UTRENST00000374768ENST00000506421PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-intronENST00000374768ENST00000395183PARD3chr10

34805907

-ARHGAP24chr4

86491675

+
intron-intronENST00000374768ENST00000264343PARD3chr10

34805907

-ARHGAP24chr4

86491675

+

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FusionProtFeatures for PARD3_ARHGAP24


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PARD3

Q8TEW0

ARHGAP24

Q8N264

Rho GTPase-activating protein involved in cell polarity,cell morphology and cytoskeletal organization. Acts as a GTPaseactivator for the Rac-type GTPase by converting it to an inactiveGDP-bound state. Controls actin remodeling by inactivating Racdownstream of Rho leading to suppress leading edge protrusion andpromotes cell retraction to achieve cellular polarity. Able tosuppress RAC1 and CDC42 activity in vitro. Overexpression inducescell rounding with partial or complete disruption of actin stressfibers and formation of membrane ruffles, lamellipodia, andfilopodia. Isoform 2 is a vascular cell-specific GAP involved inmodulation of angiogenesis. {ECO:0000269|PubMed:15302923,ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PARD3_ARHGAP24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PARD3_ARHGAP24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PARD3YWHAB, YWHAG, SFN, ECT2, F11R, JAM2, JAM3, PVRL3, PARD6A, PARD6B, PARD6G, PRKCI, PRKCZ, YWHAZ, YWHAH, DCAF7, PNMA1, RASSF8, CCDC88A, PNMA2, LLGL1, SIAH1, HSPA8, HSPA6, HSPD1, PSME3, PSME2, RPS3, RPS18, PFKP, KPNA4, ANP32E, TJP1, VHL, ARHGAP17, AMOT, YWHAE, GAB1, MARK2, INADL, AMOTL2, LATS1, LATS2, YAP1, RASSF7, PSMC3, TP53BP2, RASSF9, RASSF10, SMAD7, SMAD4, SMAD1, SMAD2, SMAD3, CEP19, TMEM17, VAPA, MMGT1, CTNNB1, PPP1CA, CDH1, TRIM25ARHGAP24APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PARD3_ARHGAP24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PARD3_ARHGAP24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource