FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 25946

FusionGeneSummary for PAPSS1_RAB13

check button Fusion gene summary
Fusion gene informationFusion gene name: PAPSS1_RAB13
Fusion gene ID: 25946
HgeneTgene
Gene symbol

PAPSS1

RAB13

Gene ID

9061

5872

Gene name3'-phosphoadenosine 5'-phosphosulfate synthase 1RAB13, member RAS oncogene family
SynonymsATPSK1|PAPSS|SK1GIG4
Cytomap

4q25

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionbifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 13-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1PAPS synthase 1PAPSS 1SK 1adenylyl-sulfate kinasesulfate adenylyltransferasesulfurylase kinase 1ras-related protein Rab-13RAS-associated protein RAB13cell growth-inhibiting gene 4 proteingrowth-inhibiting gene 4 protein
Modification date2018052320180523
UniProtAcc

O43252

P51153

Ensembl transtripts involved in fusion geneENST00000265174, ENST00000511304, 
ENST00000368575, ENST00000462680, 
Fusion gene scores* DoF score4 X 4 X 2=326 X 4 X 4=96
# samples 46
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAPSS1 [Title/Abstract] AND RAB13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAPSS1

GO:0000103

sulfate assimilation

14747722

HgenePAPSS1

GO:0050428

3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

14747722|23207770


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA811913PAPSS1chr4

108603212

-RAB13chr1

153958815

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000265174ENST00000368575PAPSS1chr4

108603212

-RAB13chr1

153958815

-
intron-intronENST00000265174ENST00000462680PAPSS1chr4

108603212

-RAB13chr1

153958815

-
intron-5UTRENST00000511304ENST00000368575PAPSS1chr4

108603212

-RAB13chr1

153958815

-
intron-intronENST00000511304ENST00000462680PAPSS1chr4

108603212

-RAB13chr1

153958815

-

Top

FusionProtFeatures for PAPSS1_RAB13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAPSS1

O43252

RAB13

P51153

Bifunctional enzyme with both ATP sulfurylase and APSkinase activity, which mediates two steps in the sulfateactivation pathway. The first step is the transfer of a sulfategroup to ATP to yield adenosine 5'-phosphosulfate (APS), and thesecond step is the transfer of a phosphate group from ATP to APSyielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donorused by sulfotransferase). In mammals, PAPS is the sole source ofsulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121,PubMed:9648242, PubMed:14747722). Required for normal biosynthesisof sulfated L-selectin ligands in endothelial cells(PubMed:9576487). {ECO:0000269|PubMed:14747722,ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242,ECO:0000269|PubMed:9668121}. The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different sets of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. That Rab is involved in endocytic recyclingand regulates the transport to the plasma membrane oftransmembrane proteins like the tight junction proteinOCLN/occludin. Thereby, it regulates the assembly and the activityof tight junctions. Moreover, it may also regulate tight junctionassembly by activating the PKA signaling pathway and byreorganizing the actin cytoskeleton through the activation of thedownstream effectors PRKACA and MICALL2 respectively. Through itsrole in tight junction assembly, may play a role in theestablishment of Sertoli cell barrier. Plays also a role inangiogenesis through regulation of endothelial cells chemotaxis.Also involved in neurite outgrowth. Has also been proposed to playa role in post-Golgi membrane trafficking from the TGN to therecycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucosetransporter GLUT4 and therefore may play a role in glucosehomeostasis. {ECO:0000269|PubMed:12058051,ECO:0000269|PubMed:15096524, ECO:0000269|PubMed:15528189,ECO:0000269|PubMed:16525024, ECO:0000269|PubMed:18779367,ECO:0000269|PubMed:20008558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PAPSS1_RAB13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PAPSS1_RAB13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PAPSS1_RAB13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePAPSS1O43252DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1small moleculeapproved|investigational

Top

RelatedDiseases for PAPSS1_RAB13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource