FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 25943

FusionGeneSummary for PAPSS1_GRID2

check button Fusion gene summary
Fusion gene informationFusion gene name: PAPSS1_GRID2
Fusion gene ID: 25943
HgeneTgene
Gene symbol

PAPSS1

GRID2

Gene ID

9061

2895

Gene name3'-phosphoadenosine 5'-phosphosulfate synthase 1glutamate ionotropic receptor delta type subunit 2
SynonymsATPSK1|PAPSS|SK1GluD2|SCAR18
Cytomap

4q25

4q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionbifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 13-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1PAPS synthase 1PAPSS 1SK 1adenylyl-sulfate kinasesulfate adenylyltransferasesulfurylase kinase 1glutamate receptor ionotropic, delta-2gluR delta-2 subunitglutamate receptor delta-2 subunitglutamate receptor, ionotropic, delta 2
Modification date2018052320180523
UniProtAcc

O43252

O43424

Ensembl transtripts involved in fusion geneENST00000265174, ENST00000511304, 
ENST00000282020, ENST00000505687, 
ENST00000510992, 
Fusion gene scores* DoF score4 X 4 X 2=325 X 5 X 5=125
# samples 45
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAPSS1 [Title/Abstract] AND GRID2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAPSS1

GO:0000103

sulfate assimilation

14747722

HgenePAPSS1

GO:0050428

3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

14747722|23207770


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A3U5-01APAPSS1chr4

108565958

-GRID2chr4

94436367

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265174ENST00000282020PAPSS1chr4

108565958

-GRID2chr4

94436367

+
5CDS-intronENST00000265174ENST00000505687PAPSS1chr4

108565958

-GRID2chr4

94436367

+
5CDS-intronENST00000265174ENST00000510992PAPSS1chr4

108565958

-GRID2chr4

94436367

+
intron-3CDSENST00000511304ENST00000282020PAPSS1chr4

108565958

-GRID2chr4

94436367

+
intron-intronENST00000511304ENST00000505687PAPSS1chr4

108565958

-GRID2chr4

94436367

+
intron-intronENST00000511304ENST00000510992PAPSS1chr4

108565958

-GRID2chr4

94436367

+

Top

FusionProtFeatures for PAPSS1_GRID2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAPSS1

O43252

GRID2

O43424

Bifunctional enzyme with both ATP sulfurylase and APSkinase activity, which mediates two steps in the sulfateactivation pathway. The first step is the transfer of a sulfategroup to ATP to yield adenosine 5'-phosphosulfate (APS), and thesecond step is the transfer of a phosphate group from ATP to APSyielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donorused by sulfotransferase). In mammals, PAPS is the sole source ofsulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121,PubMed:9648242, PubMed:14747722). Required for normal biosynthesisof sulfated L-selectin ligands in endothelial cells(PubMed:9576487). {ECO:0000269|PubMed:14747722,ECO:0000269|PubMed:9576487, ECO:0000269|PubMed:9648242,ECO:0000269|PubMed:9668121}. Receptor for glutamate. L-glutamate acts as anexcitatory neurotransmitter at many synapses in the centralnervous system. The postsynaptic actions of Glu are mediated by avariety of receptors that are named according to their selectiveagonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptorendocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC)synapses through the beta-NRX1-CBLN1-GRID2 triad complex(PubMed:27418511). {ECO:0000269|PubMed:27418511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PAPSS1_GRID2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PAPSS1_GRID2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAPSS1PPP1R16A, EEF1A1, UNC119, ATIC, HMGB3, MTRR, PAFAH1B1, ACAT2, AHCY, ASNS, CAPN2, CAPZB, CTPS1, DHX15, FH, MSN, NAE1, NSFL1C, PPP5C, TATDN1, TUBB3, UBA3, XPOT, PTMA, NTRK1, NCK1, RNASEH2A, TMEM132A, FANCI, ERRFI1, PAPSS2, DYNC1I2, CCDC116, C2orf44, FANCG, C4orf26, SNRNP27, GPX7, FGB, TFCP2, GNL1GRID2GRID2IP, GRIA1, GRIK2, GRIK5, GRIA2, GOPC, PTPN4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PAPSS1_GRID2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePAPSS1O43252DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1small moleculeapproved|investigational
TgeneGRID2O43424DB00142Glutamic AcidGlutamate receptor ionotropic, delta-2small moleculeapproved|nutraceutical

Top

RelatedDiseases for PAPSS1_GRID2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGRID2C4015505SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 181ORPHANET;UNIPROT