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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25924

FusionGeneSummary for PAPOLA_NPAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: PAPOLA_NPAS3
Fusion gene ID: 25924
HgeneTgene
Gene symbol

PAPOLA

NPAS3

Gene ID

10914

64067

Gene namepoly(A) polymerase alphaneuronal PAS domain protein 3
SynonymsPAP|PAP-alphaMOP6|PASD6|bHLHe12
Cytomap

14q32.2

14q13.1

Type of geneprotein-codingprotein-coding
Descriptionpoly(A) polymerase alphapolynucleotide adenylyltransferase alphaneuronal PAS domain-containing protein 3PAS domain-containing protein 6basic-helix-loop-helix-PAS protein MOP6class E basic helix-loop-helix protein 12member of PAS protein 6neuronal PAS3
Modification date2018052920180523
UniProtAcc

P51003

Q8IXF0

Ensembl transtripts involved in fusion geneENST00000216277, ENST00000557320, 
ENST00000554130, ENST00000557471, 
ENST00000392990, 		ENST00000551492, 
ENST00000346562, ENST00000341321, 
ENST00000548645, ENST00000356141, 
ENST00000357798, ENST00000547068, 
ENST00000551008, ENST00000550662, 
Fusion gene scores* DoF score6 X 5 X 5=1509 X 7 X 6=378
# samples 710
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAPOLA [Title/Abstract] AND NPAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAPOLA

GO:0006378

mRNA polyadenylation

7590244|19224921

HgenePAPOLA

GO:0031440

regulation of mRNA 3'-end processing

19224921


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-EK-A2R7-01APAPOLAchr14

96968937

+NPAS3chr14

34145417

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000216277ENST00000551492PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000216277ENST00000346562PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000216277ENST00000341321PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000216277ENST00000548645PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000216277ENST00000356141PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000216277ENST00000357798PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000216277ENST00000547068PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000216277ENST00000551008PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
5CDS-intronENST00000216277ENST00000550662PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557320ENST00000551492PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557320ENST00000346562PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557320ENST00000341321PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557320ENST00000548645PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557320ENST00000356141PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557320ENST00000357798PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557320ENST00000547068PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557320ENST00000551008PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
5CDS-intronENST00000557320ENST00000550662PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
3UTR-3CDSENST00000554130ENST00000551492PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
3UTR-3CDSENST00000554130ENST00000346562PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
3UTR-3CDSENST00000554130ENST00000341321PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
3UTR-3CDSENST00000554130ENST00000548645PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
3UTR-3CDSENST00000554130ENST00000356141PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
3UTR-3CDSENST00000554130ENST00000357798PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
3UTR-3CDSENST00000554130ENST00000547068PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
3UTR-3CDSENST00000554130ENST00000551008PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
3UTR-intronENST00000554130ENST00000550662PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557471ENST00000551492PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557471ENST00000346562PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557471ENST00000341321PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557471ENST00000548645PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557471ENST00000356141PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557471ENST00000357798PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557471ENST00000547068PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000557471ENST00000551008PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
5CDS-intronENST00000557471ENST00000550662PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000392990ENST00000551492PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000392990ENST00000346562PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000392990ENST00000341321PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000392990ENST00000548645PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000392990ENST00000356141PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000392990ENST00000357798PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000392990ENST00000547068PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
Frame-shiftENST00000392990ENST00000551008PAPOLAchr14

96968937

+NPAS3chr14

34145417

+
5CDS-intronENST00000392990ENST00000550662PAPOLAchr14

96968937

+NPAS3chr14

34145417

+

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FusionProtFeatures for PAPOLA_NPAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAPOLA

P51003

NPAS3

Q8IXF0

Polymerase that creates the 3'-poly(A) tail of mRNA's.Also required for the endoribonucleolytic cleavage reaction atsome polyadenylation sites. May acquire specificity throughinteraction with a cleavage and polyadenylation specificity factor(CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. May play a broad role in neurogenesis. May controlregulatory pathways relevant to schizophrenia and to psychoticillness (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PAPOLA_NPAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PAPOLA_NPAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAPOLAREL, CREBBP, HDAC1, HDAC3, HDAC10, SIRT1, SIRT2, CPSF6, NUDT21, KPNB1, CPSF1, ELAVL1, PPP1CB, SMAD2, LMNA, CORO1B, CORO1C, FAM129B, NARS, NUDC, PUF60, TARS, UGP2, YAP1, ZYX, HUWE1, GNA11, ADRBK1, CSTF2, CSTF2T, CSTF3, HNRNPA1, CPSF2, MTHFD1, MTHFD1L, PABPC1, PABPC3, PICALM, PROSC, SARS, UFD1L, WDR33, SUPT5H, NTRK1, FIP1L1, CIRBP, RSRC1, NRAS, FGBNPAS3ARNT2, TP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAPOLA_NPAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAPOLA_NPAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNPAS3C0036341Schizophrenia4PSYGENET
TgeneNPAS3C0005586Bipolar Disorder3PSYGENET
TgeneNPAS3C0033975Psychotic Disorders1PSYGENET
TgeneNPAS3C0041696Unipolar Depression1PSYGENET
TgeneNPAS3C0349204Nonorganic psychosis1PSYGENET
TgeneNPAS3C1269683Major Depressive Disorder1PSYGENET