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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 25920

FusionGeneSummary for PAPOLA_AK7

check button Fusion gene summary
Fusion gene informationFusion gene name: PAPOLA_AK7
Fusion gene ID: 25920
HgeneTgene
Gene symbol

PAPOLA

AK7

Gene ID

10914

122481

Gene namepoly(A) polymerase alphaadenylate kinase 7
SynonymsPAP|PAP-alphaAK 7|SPGF27
Cytomap

14q32.2

14q32.2

Type of geneprotein-codingprotein-coding
Descriptionpoly(A) polymerase alphapolynucleotide adenylyltransferase alphaadenylate kinase 7ATP-AMP transphosphorylase 7putative adenylate kinase 7
Modification date2018052920180519
UniProtAcc

P51003

Q96M32

Ensembl transtripts involved in fusion geneENST00000216277, ENST00000557320, 
ENST00000554130, ENST00000557471, 
ENST00000392990, 		ENST00000267584, 
ENST00000555570, ENST00000554313, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 3 X 3=27
# samples 74
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PAPOLA [Title/Abstract] AND AK7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAPOLA

GO:0006378

mRNA polyadenylation

7590244|19224921

HgenePAPOLA

GO:0031440

regulation of mRNA 3'-end processing

19224921

TgeneAK7

GO:0006165

nucleoside diphosphate phosphorylation

23416111

TgeneAK7

GO:0009142

nucleoside triphosphate biosynthetic process

23416111


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-8094-01APAPOLAchr14

97022750

+AK7chr14

96904172

+
ChiTaRS3.1BU944613PAPOLAchr14

96968938

+AK7chr14

96904172

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000216277ENST00000267584PAPOLAchr14

97022750

+AK7chr14

96904172

+
5CDS-intronENST00000216277ENST00000555570PAPOLAchr14

97022750

+AK7chr14

96904172

+
5CDS-intronENST00000216277ENST00000554313PAPOLAchr14

97022750

+AK7chr14

96904172

+
intron-3CDSENST00000557320ENST00000267584PAPOLAchr14

97022750

+AK7chr14

96904172

+
intron-intronENST00000557320ENST00000555570PAPOLAchr14

97022750

+AK7chr14

96904172

+
intron-intronENST00000557320ENST00000554313PAPOLAchr14

97022750

+AK7chr14

96904172

+
intron-3CDSENST00000554130ENST00000267584PAPOLAchr14

97022750

+AK7chr14

96904172

+
intron-intronENST00000554130ENST00000555570PAPOLAchr14

97022750

+AK7chr14

96904172

+
intron-intronENST00000554130ENST00000554313PAPOLAchr14

97022750

+AK7chr14

96904172

+
intron-3CDSENST00000557471ENST00000267584PAPOLAchr14

97022750

+AK7chr14

96904172

+
intron-intronENST00000557471ENST00000555570PAPOLAchr14

97022750

+AK7chr14

96904172

+
intron-intronENST00000557471ENST00000554313PAPOLAchr14

97022750

+AK7chr14

96904172

+
In-frameENST00000392990ENST00000267584PAPOLAchr14

97022750

+AK7chr14

96904172

+
5CDS-intronENST00000392990ENST00000555570PAPOLAchr14

97022750

+AK7chr14

96904172

+
5CDS-intronENST00000392990ENST00000554313PAPOLAchr14

97022750

+AK7chr14

96904172

+
Frame-shiftENST00000216277ENST00000267584PAPOLAchr14

96968938

+AK7chr14

96904172

+
5CDS-intronENST00000216277ENST00000555570PAPOLAchr14

96968938

+AK7chr14

96904172

+
5CDS-intronENST00000216277ENST00000554313PAPOLAchr14

96968938

+AK7chr14

96904172

+
Frame-shiftENST00000557320ENST00000267584PAPOLAchr14

96968938

+AK7chr14

96904172

+
5CDS-intronENST00000557320ENST00000555570PAPOLAchr14

96968938

+AK7chr14

96904172

+
5CDS-intronENST00000557320ENST00000554313PAPOLAchr14

96968938

+AK7chr14

96904172

+
3UTR-3CDSENST00000554130ENST00000267584PAPOLAchr14

96968938

+AK7chr14

96904172

+
3UTR-intronENST00000554130ENST00000555570PAPOLAchr14

96968938

+AK7chr14

96904172

+
3UTR-intronENST00000554130ENST00000554313PAPOLAchr14

96968938

+AK7chr14

96904172

+
Frame-shiftENST00000557471ENST00000267584PAPOLAchr14

96968938

+AK7chr14

96904172

+
5CDS-intronENST00000557471ENST00000555570PAPOLAchr14

96968938

+AK7chr14

96904172

+
5CDS-intronENST00000557471ENST00000554313PAPOLAchr14

96968938

+AK7chr14

96904172

+
Frame-shiftENST00000392990ENST00000267584PAPOLAchr14

96968938

+AK7chr14

96904172

+
5CDS-intronENST00000392990ENST00000555570PAPOLAchr14

96968938

+AK7chr14

96904172

+
5CDS-intronENST00000392990ENST00000554313PAPOLAchr14

96968938

+AK7chr14

96904172

+

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FusionProtFeatures for PAPOLA_AK7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAPOLA

P51003

AK7

Q96M32

Polymerase that creates the 3'-poly(A) tail of mRNA's.Also required for the endoribonucleolytic cleavage reaction atsome polyadenylation sites. May acquire specificity throughinteraction with a cleavage and polyadenylation specificity factor(CPSF) at its C-terminus. {ECO:0000269|PubMed:19224921}. Nucleoside monophosphate (NMP) kinase that catalyzes thereversible transfer of the terminal phosphate group betweennucleoside triphosphates and monophosphates. Has highest activitytoward AMP, and weaker activity toward dAMP, CMP and dCMP. Alsodisplays broad nucleoside diphosphate kinase activity. Involved inmaintaining ciliary structure and function.{ECO:0000269|PubMed:21080915, ECO:0000269|PubMed:23416111}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPOLAchr14:97022750chr14:96904172ENST00000216277+1922504_507668746Compositional biasNote=Poly-Lys
HgenePAPOLAchr14:97022750chr14:96904172ENST00000216277+192253_57668746Compositional biasNote=Poly-Glu
HgenePAPOLAchr14:97022750chr14:96904172ENST00000216277+1922490_507668746MotifNuclear localization signal 1
HgenePAPOLAchr14:97022750chr14:96904172ENST00000216277+1922650_665668746MotifNuclear localization signal 2
HgenePAPOLAchr14:97022750chr14:96904172ENST00000216277+1922100_102668746Nucleotide bindingATP
HgenePAPOLAchr14:97022750chr14:96904172ENST00000216277+1922113_115668746Nucleotide bindingATP
HgenePAPOLAchr14:97022750chr14:96904172ENST00000216277+1922246_247668746Nucleotide bindingATP
HgenePAPOLAchr14:97022750chr14:96904172ENST00000216277+1922508_643668746RegionNote=Ser/Thr-rich
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418609_677203724Coiled coilOntology_term=ECO:0000255
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418420_432203724Compositional biasNote=Poly-Glu
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418497_502203724Compositional biasNote=Poly-Glu
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418616_674203724Compositional biasNote=Glu-rich
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418377_382203724Nucleotide bindingATP
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418432_455203724Nucleotide bindingAMP
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418482_485203724Nucleotide bindingAMP
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418367_612203724RegionAdenylate kinase
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418397_455203724RegionNMPbind
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418537_547203724RegionLID
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+418679_723203724RegionDPY-30

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557320+19504_507-64286Compositional biasNote=Poly-Lys
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557320+1953_57-64286Compositional biasNote=Poly-Glu
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557471+17504_507-51239Compositional biasNote=Poly-Lys
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557471+1753_57-51239Compositional biasNote=Poly-Glu
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557320+19490_507-64286MotifNuclear localization signal 1
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557320+19650_665-64286MotifNuclear localization signal 2
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557471+17490_507-51239MotifNuclear localization signal 1
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557471+17650_665-51239MotifNuclear localization signal 2
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557320+19100_102-64286Nucleotide bindingATP
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557320+19113_115-64286Nucleotide bindingATP
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557320+19246_247-64286Nucleotide bindingATP
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557471+17100_102-51239Nucleotide bindingATP
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557471+17113_115-51239Nucleotide bindingATP
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557471+17246_247-51239Nucleotide bindingATP
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557320+19508_643-64286RegionNote=Ser/Thr-rich
HgenePAPOLAchr14:97022750chr14:96904172ENST00000557471+17508_643-51239RegionNote=Ser/Thr-rich
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+41846_458203724Coiled coilOntology_term=ECO:0000255
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+4183_6203724Compositional biasNote=Poly-Glu
TgeneAK7chr14:97022750chr14:96904172ENST00000267584+41851_58203724Compositional biasNote=Poly-Glu


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FusionGeneSequence for PAPOLA_AK7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PAPOLA_ENST00000216277_chr14_97022750_+_AK7_ENST00000267584_chr14_96904172_+_1189aa
MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQRRILILGKLNNLVKEWIREISESKNLPQSVI
ENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVH
KFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSE
NLSVDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSG
NAATSGNAATKIPTPIVGVKRTSSPHKEESPKKTKTEEARKFAAYVVAAGLQYGAEGGMLHTFFKMAWLGEIPALPVFGDGTNVIPTIHV
LDLAGVIQNVIDHVPKPHYLVAVDESVHTLEDIVKCISKNTGPGKIQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQ
TGFVENINTILKEYKQSRGLMPIKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVE
DAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALD
ASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTD
EEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECCNVRPE

>In-frame_PAPOLA_ENST00000392990_chr14_97022750_+_AK7_ENST00000267584_chr14_96904172_+_1189aa
MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQRRILILGKLNNLVKEWIREISESKNLPQSVI
ENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVH
KFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENPDKEEFRTMWVIGLVFKKTENSE
NLSVDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSG
NAATSGNAATKIPTPIVGVKRTSSPHKEESPKKTKTEEARKFAAYVVAAGLQYGAEGGMLHTFFKMAWLGEIPALPVFGDGTNVIPTIHV
LDLAGVIQNVIDHVPKPHYLVAVDESVHTLEDIVKCISKNTGPGKIQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQ
TGFVENINTILKEYKQSRGLMPIKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVE
DAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALD
ASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTD
EEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECCNVRPE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PAPOLA_ENST00000216277_chr14_97022750_+_AK7_ENST00000267584_chr14_96904172_+_3567nt
ATGCCGTTTCCAGTTACAACACAGGGATCACAACAAACACAACCGCCACAGAAGCACTATGGCATTACTTCTCCTATCAGCTTAGCAGCC
CCCAAGGAGACTGACTGCGTACTTACACAGAAACTAATTGAGACATTGAAACCCTTTGGGGTTTTTGAAGAGGAAGAGGAACTGCAGCGC
AGGATTTTAATTTTGGGAAAACTAAATAACCTGGTAAAAGAGTGGATACGAGAAATCAGTGAAAGCAAGAATCTTCCACAATCTGTAATT
GAAAATGTTGGAGGAAAAATTTTTACATTTGGATCTTACAGATTAGGAGTGCATACAAAAGGTGCTGATATTGATGCGTTGTGTGTTGCA
CCAAGACATGTTGATCGAAGTGACTTTTTCACCTCATTCTATGATAAGTTGAAATTACAGGAAGAAGTAAAAGATTTAAGAGCTGTTGAA
GAGGCATTCGTACCAGTTATTAAACTCTGTTTTGATGGGATAGAGATTGATATTTTGTTTGCAAGATTAGCACTGCAGACAATTCCTGAA
GATTTGGATCTACGAGATGACAGTCTGCTAAAAAATTTAGATATAAGATGTATAAGAAGTCTTAACGGTTGCAGGGTAACCGATGAAATT
TTACATCTAGTACCAAACATTGACAACTTCAGGTTAACTCTGAGAGCTATCAAACTATGGGCCAAACGCCACAACATCTATTCCAATATA
TTAGGTTTCCTCGGTGGTGTTTCCTGGGCTATGCTAGTAGCAAGAACTTGCCAGCTTTATCCAAATGCAATAGCATCAACTCTTGTACAT
AAATTTTTCTTGGTATTTTCTAAATGGGAATGGCCAAATCCAGTGCTATTGAAACAGCCTGAAGAATGCAATCTTAATTTGCCTGTATGG
GACCCAAGGGTAAACCCCAGTGATAGGTACCATCTTATGCCTATAATTACACCAGCATACCCACAACAGAACTCCACGTACAATGTGTCC
GTTTCAACACGGATGGTCATGGTTGAGGAGTTTAAACAAGGTCTTGCTATCACAGATGAAATTTTGCTGAGTAAGGCAGAGTGGTCCAAA
CTTTTTGAAGCTCCAAACTTCTTTCAAAAGTACAAGCATTATATTGTACTTCTAGCAAGTGCACCAACAGAAAAACAACGCCTGGAATGG
GTGGGCTTGGTGGAATCAAAAATCCGAATCCTGGTTGGAAGCTTGGAGAAGAATGAATTTATTACACTGGCTCATGTGAATCCCCAGTCA
TTTCCAGCACCCAAAGAAAATCCCGACAAGGAAGAATTTCGCACGATGTGGGTGATTGGGTTAGTGTTTAAAAAAACAGAAAACTCTGAA
AACCTCAGTGTTGATCTCACCTATGATATTCAGTCTTTCACAGATACAGTTTATAGGCAAGCAATAAACAGCAAGATGTTTGAGGTGGAT
ATGAAAATTGCTGCAATGCATGTAAAAAGAAAGCAACTCCATCAACTACTACCTAATCATGTGCTTCAGAAAAAGAAAAAGCATTCAACA
GAAGGTGTCAAATTGACAGCTCTCAATGACAGCAGCCTCGACTTGTCTATGGACAGTGATAACAGCATGTCTGTGCCTTCACCTACTAGT
GCTACGAAGACCAGTCCATTGAACAGTTCTGGCAGCTCTCAGGGCAGAAACAGTCCTGCTCCAGCTGTAACAGCAGCATCTGTGACCAAC
ATACAGGCTACTGAAGTTTCTGTGCCACAAGTAAATTCCAGTGAAAGCTCAGGGGGTACATCGAGTGAAAGCATTCCTCAAACTGCCACA
CAACCAGCCATTTCTCCACCACCAAAGCCTACGGTCTCCAGAGTTGTTTCTTCAACACGTCTGGTAAACCCACCACCTAGATCTTCAGGA
AATGCAGCAACTTCAGGAAATGCAGCAACAAAAATACCTACTCCTATAGTAGGAGTCAAGAGGACATCCTCACCTCATAAAGAAGAGAGT
CCCAAGAAAACCAAAACAGAAGAGGCCAGAAAATTTGCAGCATACGTAGTTGCTGCTGGACTCCAGTATGGAGCGGAAGGAGGCATGTTA
CACACATTTTTTAAGATGGCTTGGTTGGGCGAGATTCCTGCATTACCAGTTTTTGGCGATGGAACAAATGTAATTCCAACAATCCATGTT
CTTGATCTAGCAGGAGTGATACAAAACGTCATAGATCACGTGCCAAAGCCTCACTACCTGGTTGCTGTGGATGAGTCTGTTCATACCCTG
GAAGACATAGTCAAGTGTATCAGTAAAAATACTGGCCCTGGGAAAATCCAGAAAATACCCAGAGAAAATGCATACCTAACCAAGGACTTA
ACGCAAGATTGTCTTGACCATTTACTGGTCAACTTAAGAATGGAAGCGCTCTTTGTGAAGGAGAATTTTAATATTCGATGGGCTGCCCAA
ACAGGATTTGTGGAAAATATCAACACTATCCTCAAGGAGTACAAGCAAAGCAGAGGATTGATGCCAATCAAGATCTGCATTCTTGGTCCC
CCTGCTGTGGGAAAATCCAGTATTGCTAAAGAATTGGCCAACTACTACAAACTGCATCACATCCAACTGAAGGATGTCATTTCTGAAGCC
ATAGCAAAACTGGAGGCGATTGTTGCCCCTAACGATGTAGGGGAAGGAGAAGAAGAAGTCGAAGAGGAAGAGGAGGAGGAGAATGTGGAA
GATGCACAGGAGCTCCTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTCAACTAGACGATCAATATATAATTAGATTTATGAAA
GAAAAGCTAAAATCAATGCCTTGCAGGAATCAAGGTTATATTTTGGATGGATTCCCAAAGACCTATGATCAAGCAAAAGACCTGTTCAAT
CAGGAAGATGAGGAGGAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATAAATTAATTATACCTGAATTCGTTTGTGCACTGGAT
GCTTCGGATGAGTTTCTGAAGGAGCGTGTGATAAACCTTCCTGAGAGCATCGTGGCGGGGACCCACTACAGCCAAGACCGATTCCTCCGG
GCTCTGAGCAACTACCGGGACATCAATATCGACGATGAGACTGTCTTCAACTATTTTGATGAACTTGAAATTCACCCGATACATATTGAT
GTAGGAAAACTTGAAGATGCTCAGAATAGACTTGCTATCAAACAGCTCATCAAAGAGATTGGGGAGCCTCGAAATTATGGTTTAACAGAC
GAAGAAAAGGCAGAAGAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGGCTGCTGAGGAAGCAGAACGCGAGCACCAGGAGGCC
GTGGAGATGGCAGAGAAGATAGCTCGCTGGGAGGAGTGGAATAAACGACTGGAGGAAGTGAAAAGAGAAGAAAGAGAATTACTGGAGGCT
CAGTCAATTCCCCTGAGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTCAGGGCCTGAATGAATGTTGCAACGTCCGACCCGAA

>In-frame_PAPOLA_ENST00000392990_chr14_97022750_+_AK7_ENST00000267584_chr14_96904172_+_3567nt
ATGCCGTTTCCAGTTACAACACAGGGATCACAACAAACACAACCGCCACAGAAGCACTATGGCATTACTTCTCCTATCAGCTTAGCAGCC
CCCAAGGAGACTGACTGCGTACTTACACAGAAACTAATTGAGACATTGAAACCCTTTGGGGTTTTTGAAGAGGAAGAGGAACTGCAGCGC
AGGATTTTAATTTTGGGAAAACTAAATAACCTGGTAAAAGAGTGGATACGAGAAATCAGTGAAAGCAAGAATCTTCCACAATCTGTAATT
GAAAATGTTGGAGGAAAAATTTTTACATTTGGATCTTACAGATTAGGAGTGCATACAAAAGGTGCTGATATTGATGCGTTGTGTGTTGCA
CCAAGACATGTTGATCGAAGTGACTTTTTCACCTCATTCTATGATAAGTTGAAATTACAGGAAGAAGTAAAAGATTTAAGAGCTGTTGAA
GAGGCATTCGTACCAGTTATTAAACTCTGTTTTGATGGGATAGAGATTGATATTTTGTTTGCAAGATTAGCACTGCAGACAATTCCTGAA
GATTTGGATCTACGAGATGACAGTCTGCTAAAAAATTTAGATATAAGATGTATAAGAAGTCTTAACGGTTGCAGGGTAACCGATGAAATT
TTACATCTAGTACCAAACATTGACAACTTCAGGTTAACTCTGAGAGCTATCAAACTATGGGCCAAACGCCACAACATCTATTCCAATATA
TTAGGTTTCCTCGGTGGTGTTTCCTGGGCTATGCTAGTAGCAAGAACTTGCCAGCTTTATCCAAATGCAATAGCATCAACTCTTGTACAT
AAATTTTTCTTGGTATTTTCTAAATGGGAATGGCCAAATCCAGTGCTATTGAAACAGCCTGAAGAATGCAATCTTAATTTGCCTGTATGG
GACCCAAGGGTAAACCCCAGTGATAGGTACCATCTTATGCCTATAATTACACCAGCATACCCACAACAGAACTCCACGTACAATGTGTCC
GTTTCAACACGGATGGTCATGGTTGAGGAGTTTAAACAAGGTCTTGCTATCACAGATGAAATTTTGCTGAGTAAGGCAGAGTGGTCCAAA
CTTTTTGAAGCTCCAAACTTCTTTCAAAAGTACAAGCATTATATTGTACTTCTAGCAAGTGCACCAACAGAAAAACAACGCCTGGAATGG
GTGGGCTTGGTGGAATCAAAAATCCGAATCCTGGTTGGAAGCTTGGAGAAGAATGAATTTATTACACTGGCTCATGTGAATCCCCAGTCA
TTTCCAGCACCCAAAGAAAATCCCGACAAGGAAGAATTTCGCACGATGTGGGTGATTGGGTTAGTGTTTAAAAAAACAGAAAACTCTGAA
AACCTCAGTGTTGATCTCACCTATGATATTCAGTCTTTCACAGATACAGTTTATAGGCAAGCAATAAACAGCAAGATGTTTGAGGTGGAT
ATGAAAATTGCTGCAATGCATGTAAAAAGAAAGCAACTCCATCAACTACTACCTAATCATGTGCTTCAGAAAAAGAAAAAGCATTCAACA
GAAGGTGTCAAATTGACAGCTCTCAATGACAGCAGCCTCGACTTGTCTATGGACAGTGATAACAGCATGTCTGTGCCTTCACCTACTAGT
GCTACGAAGACCAGTCCATTGAACAGTTCTGGCAGCTCTCAGGGCAGAAACAGTCCTGCTCCAGCTGTAACAGCAGCATCTGTGACCAAC
ATACAGGCTACTGAAGTTTCTGTGCCACAAGTAAATTCCAGTGAAAGCTCAGGGGGTACATCGAGTGAAAGCATTCCTCAAACTGCCACA
CAACCAGCCATTTCTCCACCACCAAAGCCTACGGTCTCCAGAGTTGTTTCTTCAACACGTCTGGTAAACCCACCACCTAGATCTTCAGGA
AATGCAGCAACTTCAGGAAATGCAGCAACAAAAATACCTACTCCTATAGTAGGAGTCAAGAGGACATCCTCACCTCATAAAGAAGAGAGT
CCCAAGAAAACCAAAACAGAAGAGGCCAGAAAATTTGCAGCATACGTAGTTGCTGCTGGACTCCAGTATGGAGCGGAAGGAGGCATGTTA
CACACATTTTTTAAGATGGCTTGGTTGGGCGAGATTCCTGCATTACCAGTTTTTGGCGATGGAACAAATGTAATTCCAACAATCCATGTT
CTTGATCTAGCAGGAGTGATACAAAACGTCATAGATCACGTGCCAAAGCCTCACTACCTGGTTGCTGTGGATGAGTCTGTTCATACCCTG
GAAGACATAGTCAAGTGTATCAGTAAAAATACTGGCCCTGGGAAAATCCAGAAAATACCCAGAGAAAATGCATACCTAACCAAGGACTTA
ACGCAAGATTGTCTTGACCATTTACTGGTCAACTTAAGAATGGAAGCGCTCTTTGTGAAGGAGAATTTTAATATTCGATGGGCTGCCCAA
ACAGGATTTGTGGAAAATATCAACACTATCCTCAAGGAGTACAAGCAAAGCAGAGGATTGATGCCAATCAAGATCTGCATTCTTGGTCCC
CCTGCTGTGGGAAAATCCAGTATTGCTAAAGAATTGGCCAACTACTACAAACTGCATCACATCCAACTGAAGGATGTCATTTCTGAAGCC
ATAGCAAAACTGGAGGCGATTGTTGCCCCTAACGATGTAGGGGAAGGAGAAGAAGAAGTCGAAGAGGAAGAGGAGGAGGAGAATGTGGAA
GATGCACAGGAGCTCCTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTCAACTAGACGATCAATATATAATTAGATTTATGAAA
GAAAAGCTAAAATCAATGCCTTGCAGGAATCAAGGTTATATTTTGGATGGATTCCCAAAGACCTATGATCAAGCAAAAGACCTGTTCAAT
CAGGAAGATGAGGAGGAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATAAATTAATTATACCTGAATTCGTTTGTGCACTGGAT
GCTTCGGATGAGTTTCTGAAGGAGCGTGTGATAAACCTTCCTGAGAGCATCGTGGCGGGGACCCACTACAGCCAAGACCGATTCCTCCGG
GCTCTGAGCAACTACCGGGACATCAATATCGACGATGAGACTGTCTTCAACTATTTTGATGAACTTGAAATTCACCCGATACATATTGAT
GTAGGAAAACTTGAAGATGCTCAGAATAGACTTGCTATCAAACAGCTCATCAAAGAGATTGGGGAGCCTCGAAATTATGGTTTAACAGAC
GAAGAAAAGGCAGAAGAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGGCTGCTGAGGAAGCAGAACGCGAGCACCAGGAGGCC
GTGGAGATGGCAGAGAAGATAGCTCGCTGGGAGGAGTGGAATAAACGACTGGAGGAAGTGAAAAGAGAAGAAAGAGAATTACTGGAGGCT
CAGTCAATTCCCCTGAGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTCAGGGCCTGAATGAATGTTGCAACGTCCGACCCGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PAPOLA_ENST00000216277_chr14_97022750_+_AK7_ENST00000267584_chr14_96904172_+_4871nt
AGCAGTTCTAGAACGTTGCTGTGGTAGCGCTCGGGCGCCATGTTAGGACGAAGGGGAAGGAGGAGAAGCGCTTAAAGCGGCGGGAGCGGT
GCGGGAGAGGGGTTGGACCCAGGGCTGAGGCAGGCCCCCCCCTCCCTCCCGCCTCAGTGGATCATGCCCAGGGCGGCAGCGGCGGCGGTT
GCGGGGGGGAAGTGACTGGGCGGTGCCGGCGCCGGAGACGATGCCGTTTCCAGTTACAACACAGGGATCACAACAAACACAACCGCCACA
GAAGCACTATGGCATTACTTCTCCTATCAGCTTAGCAGCCCCCAAGGAGACTGACTGCGTACTTACACAGAAACTAATTGAGACATTGAA
ACCCTTTGGGGTTTTTGAAGAGGAAGAGGAACTGCAGCGCAGGATTTTAATTTTGGGAAAACTAAATAACCTGGTAAAAGAGTGGATACG
AGAAATCAGTGAAAGCAAGAATCTTCCACAATCTGTAATTGAAAATGTTGGAGGAAAAATTTTTACATTTGGATCTTACAGATTAGGAGT
GCATACAAAAGGTGCTGATATTGATGCGTTGTGTGTTGCACCAAGACATGTTGATCGAAGTGACTTTTTCACCTCATTCTATGATAAGTT
GAAATTACAGGAAGAAGTAAAAGATTTAAGAGCTGTTGAAGAGGCATTCGTACCAGTTATTAAACTCTGTTTTGATGGGATAGAGATTGA
TATTTTGTTTGCAAGATTAGCACTGCAGACAATTCCTGAAGATTTGGATCTACGAGATGACAGTCTGCTAAAAAATTTAGATATAAGATG
TATAAGAAGTCTTAACGGTTGCAGGGTAACCGATGAAATTTTACATCTAGTACCAAACATTGACAACTTCAGGTTAACTCTGAGAGCTAT
CAAACTATGGGCCAAACGCCACAACATCTATTCCAATATATTAGGTTTCCTCGGTGGTGTTTCCTGGGCTATGCTAGTAGCAAGAACTTG
CCAGCTTTATCCAAATGCAATAGCATCAACTCTTGTACATAAATTTTTCTTGGTATTTTCTAAATGGGAATGGCCAAATCCAGTGCTATT
GAAACAGCCTGAAGAATGCAATCTTAATTTGCCTGTATGGGACCCAAGGGTAAACCCCAGTGATAGGTACCATCTTATGCCTATAATTAC
ACCAGCATACCCACAACAGAACTCCACGTACAATGTGTCCGTTTCAACACGGATGGTCATGGTTGAGGAGTTTAAACAAGGTCTTGCTAT
CACAGATGAAATTTTGCTGAGTAAGGCAGAGTGGTCCAAACTTTTTGAAGCTCCAAACTTCTTTCAAAAGTACAAGCATTATATTGTACT
TCTAGCAAGTGCACCAACAGAAAAACAACGCCTGGAATGGGTGGGCTTGGTGGAATCAAAAATCCGAATCCTGGTTGGAAGCTTGGAGAA
GAATGAATTTATTACACTGGCTCATGTGAATCCCCAGTCATTTCCAGCACCCAAAGAAAATCCCGACAAGGAAGAATTTCGCACGATGTG
GGTGATTGGGTTAGTGTTTAAAAAAACAGAAAACTCTGAAAACCTCAGTGTTGATCTCACCTATGATATTCAGTCTTTCACAGATACAGT
TTATAGGCAAGCAATAAACAGCAAGATGTTTGAGGTGGATATGAAAATTGCTGCAATGCATGTAAAAAGAAAGCAACTCCATCAACTACT
ACCTAATCATGTGCTTCAGAAAAAGAAAAAGCATTCAACAGAAGGTGTCAAATTGACAGCTCTCAATGACAGCAGCCTCGACTTGTCTAT
GGACAGTGATAACAGCATGTCTGTGCCTTCACCTACTAGTGCTACGAAGACCAGTCCATTGAACAGTTCTGGCAGCTCTCAGGGCAGAAA
CAGTCCTGCTCCAGCTGTAACAGCAGCATCTGTGACCAACATACAGGCTACTGAAGTTTCTGTGCCACAAGTAAATTCCAGTGAAAGCTC
AGGGGGTACATCGAGTGAAAGCATTCCTCAAACTGCCACACAACCAGCCATTTCTCCACCACCAAAGCCTACGGTCTCCAGAGTTGTTTC
TTCAACACGTCTGGTAAACCCACCACCTAGATCTTCAGGAAATGCAGCAACTTCAGGAAATGCAGCAACAAAAATACCTACTCCTATAGT
AGGAGTCAAGAGGACATCCTCACCTCATAAAGAAGAGAGTCCCAAGAAAACCAAAACAGAAGAGGCCAGAAAATTTGCAGCATACGTAGT
TGCTGCTGGACTCCAGTATGGAGCGGAAGGAGGCATGTTACACACATTTTTTAAGATGGCTTGGTTGGGCGAGATTCCTGCATTACCAGT
TTTTGGCGATGGAACAAATGTAATTCCAACAATCCATGTTCTTGATCTAGCAGGAGTGATACAAAACGTCATAGATCACGTGCCAAAGCC
TCACTACCTGGTTGCTGTGGATGAGTCTGTTCATACCCTGGAAGACATAGTCAAGTGTATCAGTAAAAATACTGGCCCTGGGAAAATCCA
GAAAATACCCAGAGAAAATGCATACCTAACCAAGGACTTAACGCAAGATTGTCTTGACCATTTACTGGTCAACTTAAGAATGGAAGCGCT
CTTTGTGAAGGAGAATTTTAATATTCGATGGGCTGCCCAAACAGGATTTGTGGAAAATATCAACACTATCCTCAAGGAGTACAAGCAAAG
CAGAGGATTGATGCCAATCAAGATCTGCATTCTTGGTCCCCCTGCTGTGGGAAAATCCAGTATTGCTAAAGAATTGGCCAACTACTACAA
ACTGCATCACATCCAACTGAAGGATGTCATTTCTGAAGCCATAGCAAAACTGGAGGCGATTGTTGCCCCTAACGATGTAGGGGAAGGAGA
AGAAGAAGTCGAAGAGGAAGAGGAGGAGGAGAATGTGGAAGATGCACAGGAGCTCCTAGATGGCATCAAGGAGAGCATGGAGCAGAATGC
AGGTCAACTAGACGATCAATATATAATTAGATTTATGAAAGAAAAGCTAAAATCAATGCCTTGCAGGAATCAAGGTTATATTTTGGATGG
ATTCCCAAAGACCTATGATCAAGCAAAAGACCTGTTCAATCAGGAAGATGAGGAGGAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTT
TGATAAATTAATTATACCTGAATTCGTTTGTGCACTGGATGCTTCGGATGAGTTTCTGAAGGAGCGTGTGATAAACCTTCCTGAGAGCAT
CGTGGCGGGGACCCACTACAGCCAAGACCGATTCCTCCGGGCTCTGAGCAACTACCGGGACATCAATATCGACGATGAGACTGTCTTCAA
CTATTTTGATGAACTTGAAATTCACCCGATACATATTGATGTAGGAAAACTTGAAGATGCTCAGAATAGACTTGCTATCAAACAGCTCAT
CAAAGAGATTGGGGAGCCTCGAAATTATGGTTTAACAGACGAAGAAAAGGCAGAAGAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAG
GGAGGCTGCTGAGGAAGCAGAACGCGAGCACCAGGAGGCCGTGGAGATGGCAGAGAAGATAGCTCGCTGGGAGGAGTGGAATAAACGACT
GGAGGAAGTGAAAAGAGAAGAAAGAGAATTACTGGAGGCTCAGTCAATTCCCCTGAGAAACTATTTAATGACCTATGTGATGCCAACTCT
TATTCAGGGCCTGAATGAATGTTGCAACGTCCGACCCGAAGACCCTGTTGATTTTCTGGCAGAATATCTCTTCAAGAACAATCCTGAAGC
ACAGTGAAACTTGAAAGATCTGGTATTATCTACCTTTACAGAACCACAGATCACTTATTATACTTTGAAAAATTGCTTTGAAAAATGCTT
TTCCAGTTCTTAGAAAATTCTTTTTTTGTAGACAAATATTCTATAAACTAGAATCTCTATTAAAAGCTATATGACATGACTATGTCATTA
AAACTATATTTGAAATGTAAATTGATAAAGACATTTGTGCATAGCTCATGAGACAAATACTGATTTAATATTTTATTCTTTAGTCAGATC
TAAATATACCGCTTCTGTACACTAATGTTTATAGGTATTTATAGCATGAAGAAAATCAGACTATATATTGTAGACTATGTATTATTCTAA
CATGTAGGCTAATTTACATGACTTGTTATCGCCCCAATAACAATGTTATTAGAAATGGAAATAAATTGAAGTGATTTATGCCTGTTGACT
CACAGTAAATCAGACAAGATTGGTGCCTGTAAGGTGGCTTTTTTTTTTTTTTTTTTTAAATGAAGCAATGGTTAGGGAAAGGTTGCTTTG
AGTTCAGGGTCAGGATCCCAGACAATGAATCGGAGAGAACTGTAAACCTTTAGGCGGAGAAATCTGCATAACAGGATAATTCCAATCTTT
GTGATAAGTGAGAAGTTGCTAAATATTTTCAACACACTTTATAACATAGGCATAAGTTATCAATCCTATAGTCTTTTCCAGTTCTAAAAA
TCCCATAAGATTCCTAGAATTACCCTAAATGAGAAATTAGTTTAGGTTTAATGGCATATGTATTTTATCTCTTTAAATAATGTAACCTAA
TATAACTGCCCGACTTTTTATTTGTGCTAAAATACATGTAACATAAAATTGACCACTGTAACCATTTTAAAGTGTATAATTCAGTGGCAC
TAAGTTCATTCACAATGATCTGCAGCCACCACTATCTAGTCCAGAACTTTCTCATCACCCCAAATGGAAACCCAGCACCTATTAGGCAGT
CACGCTCCATTATTCCCTCCCCCCAGTTCCAGGCAACCACGAATCTGCTTTCTGTCTCTATGGATTTACCTATTATAAATAAAACCATAT

>In-frame_PAPOLA_ENST00000392990_chr14_97022750_+_AK7_ENST00000267584_chr14_96904172_+_4686nt
GGGGAAGTGACTGGGCGGTGCCGGCGCCGGAGACGATGCCGTTTCCAGTTACAACACAGGGATCACAACAAACACAACCGCCACAGAAGC
ACTATGGCATTACTTCTCCTATCAGCTTAGCAGCCCCCAAGGAGACTGACTGCGTACTTACACAGAAACTAATTGAGACATTGAAACCCT
TTGGGGTTTTTGAAGAGGAAGAGGAACTGCAGCGCAGGATTTTAATTTTGGGAAAACTAAATAACCTGGTAAAAGAGTGGATACGAGAAA
TCAGTGAAAGCAAGAATCTTCCACAATCTGTAATTGAAAATGTTGGAGGAAAAATTTTTACATTTGGATCTTACAGATTAGGAGTGCATA
CAAAAGGTGCTGATATTGATGCGTTGTGTGTTGCACCAAGACATGTTGATCGAAGTGACTTTTTCACCTCATTCTATGATAAGTTGAAAT
TACAGGAAGAAGTAAAAGATTTAAGAGCTGTTGAAGAGGCATTCGTACCAGTTATTAAACTCTGTTTTGATGGGATAGAGATTGATATTT
TGTTTGCAAGATTAGCACTGCAGACAATTCCTGAAGATTTGGATCTACGAGATGACAGTCTGCTAAAAAATTTAGATATAAGATGTATAA
GAAGTCTTAACGGTTGCAGGGTAACCGATGAAATTTTACATCTAGTACCAAACATTGACAACTTCAGGTTAACTCTGAGAGCTATCAAAC
TATGGGCCAAACGCCACAACATCTATTCCAATATATTAGGTTTCCTCGGTGGTGTTTCCTGGGCTATGCTAGTAGCAAGAACTTGCCAGC
TTTATCCAAATGCAATAGCATCAACTCTTGTACATAAATTTTTCTTGGTATTTTCTAAATGGGAATGGCCAAATCCAGTGCTATTGAAAC
AGCCTGAAGAATGCAATCTTAATTTGCCTGTATGGGACCCAAGGGTAAACCCCAGTGATAGGTACCATCTTATGCCTATAATTACACCAG
CATACCCACAACAGAACTCCACGTACAATGTGTCCGTTTCAACACGGATGGTCATGGTTGAGGAGTTTAAACAAGGTCTTGCTATCACAG
ATGAAATTTTGCTGAGTAAGGCAGAGTGGTCCAAACTTTTTGAAGCTCCAAACTTCTTTCAAAAGTACAAGCATTATATTGTACTTCTAG
CAAGTGCACCAACAGAAAAACAACGCCTGGAATGGGTGGGCTTGGTGGAATCAAAAATCCGAATCCTGGTTGGAAGCTTGGAGAAGAATG
AATTTATTACACTGGCTCATGTGAATCCCCAGTCATTTCCAGCACCCAAAGAAAATCCCGACAAGGAAGAATTTCGCACGATGTGGGTGA
TTGGGTTAGTGTTTAAAAAAACAGAAAACTCTGAAAACCTCAGTGTTGATCTCACCTATGATATTCAGTCTTTCACAGATACAGTTTATA
GGCAAGCAATAAACAGCAAGATGTTTGAGGTGGATATGAAAATTGCTGCAATGCATGTAAAAAGAAAGCAACTCCATCAACTACTACCTA
ATCATGTGCTTCAGAAAAAGAAAAAGCATTCAACAGAAGGTGTCAAATTGACAGCTCTCAATGACAGCAGCCTCGACTTGTCTATGGACA
GTGATAACAGCATGTCTGTGCCTTCACCTACTAGTGCTACGAAGACCAGTCCATTGAACAGTTCTGGCAGCTCTCAGGGCAGAAACAGTC
CTGCTCCAGCTGTAACAGCAGCATCTGTGACCAACATACAGGCTACTGAAGTTTCTGTGCCACAAGTAAATTCCAGTGAAAGCTCAGGGG
GTACATCGAGTGAAAGCATTCCTCAAACTGCCACACAACCAGCCATTTCTCCACCACCAAAGCCTACGGTCTCCAGAGTTGTTTCTTCAA
CACGTCTGGTAAACCCACCACCTAGATCTTCAGGAAATGCAGCAACTTCAGGAAATGCAGCAACAAAAATACCTACTCCTATAGTAGGAG
TCAAGAGGACATCCTCACCTCATAAAGAAGAGAGTCCCAAGAAAACCAAAACAGAAGAGGCCAGAAAATTTGCAGCATACGTAGTTGCTG
CTGGACTCCAGTATGGAGCGGAAGGAGGCATGTTACACACATTTTTTAAGATGGCTTGGTTGGGCGAGATTCCTGCATTACCAGTTTTTG
GCGATGGAACAAATGTAATTCCAACAATCCATGTTCTTGATCTAGCAGGAGTGATACAAAACGTCATAGATCACGTGCCAAAGCCTCACT
ACCTGGTTGCTGTGGATGAGTCTGTTCATACCCTGGAAGACATAGTCAAGTGTATCAGTAAAAATACTGGCCCTGGGAAAATCCAGAAAA
TACCCAGAGAAAATGCATACCTAACCAAGGACTTAACGCAAGATTGTCTTGACCATTTACTGGTCAACTTAAGAATGGAAGCGCTCTTTG
TGAAGGAGAATTTTAATATTCGATGGGCTGCCCAAACAGGATTTGTGGAAAATATCAACACTATCCTCAAGGAGTACAAGCAAAGCAGAG
GATTGATGCCAATCAAGATCTGCATTCTTGGTCCCCCTGCTGTGGGAAAATCCAGTATTGCTAAAGAATTGGCCAACTACTACAAACTGC
ATCACATCCAACTGAAGGATGTCATTTCTGAAGCCATAGCAAAACTGGAGGCGATTGTTGCCCCTAACGATGTAGGGGAAGGAGAAGAAG
AAGTCGAAGAGGAAGAGGAGGAGGAGAATGTGGAAGATGCACAGGAGCTCCTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTC
AACTAGACGATCAATATATAATTAGATTTATGAAAGAAAAGCTAAAATCAATGCCTTGCAGGAATCAAGGTTATATTTTGGATGGATTCC
CAAAGACCTATGATCAAGCAAAAGACCTGTTCAATCAGGAAGATGAGGAGGAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATA
AATTAATTATACCTGAATTCGTTTGTGCACTGGATGCTTCGGATGAGTTTCTGAAGGAGCGTGTGATAAACCTTCCTGAGAGCATCGTGG
CGGGGACCCACTACAGCCAAGACCGATTCCTCCGGGCTCTGAGCAACTACCGGGACATCAATATCGACGATGAGACTGTCTTCAACTATT
TTGATGAACTTGAAATTCACCCGATACATATTGATGTAGGAAAACTTGAAGATGCTCAGAATAGACTTGCTATCAAACAGCTCATCAAAG
AGATTGGGGAGCCTCGAAATTATGGTTTAACAGACGAAGAAAAGGCAGAAGAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGG
CTGCTGAGGAAGCAGAACGCGAGCACCAGGAGGCCGTGGAGATGGCAGAGAAGATAGCTCGCTGGGAGGAGTGGAATAAACGACTGGAGG
AAGTGAAAAGAGAAGAAAGAGAATTACTGGAGGCTCAGTCAATTCCCCTGAGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTC
AGGGCCTGAATGAATGTTGCAACGTCCGACCCGAAGACCCTGTTGATTTTCTGGCAGAATATCTCTTCAAGAACAATCCTGAAGCACAGT
GAAACTTGAAAGATCTGGTATTATCTACCTTTACAGAACCACAGATCACTTATTATACTTTGAAAAATTGCTTTGAAAAATGCTTTTCCA
GTTCTTAGAAAATTCTTTTTTTGTAGACAAATATTCTATAAACTAGAATCTCTATTAAAAGCTATATGACATGACTATGTCATTAAAACT
ATATTTGAAATGTAAATTGATAAAGACATTTGTGCATAGCTCATGAGACAAATACTGATTTAATATTTTATTCTTTAGTCAGATCTAAAT
ATACCGCTTCTGTACACTAATGTTTATAGGTATTTATAGCATGAAGAAAATCAGACTATATATTGTAGACTATGTATTATTCTAACATGT
AGGCTAATTTACATGACTTGTTATCGCCCCAATAACAATGTTATTAGAAATGGAAATAAATTGAAGTGATTTATGCCTGTTGACTCACAG
TAAATCAGACAAGATTGGTGCCTGTAAGGTGGCTTTTTTTTTTTTTTTTTTTAAATGAAGCAATGGTTAGGGAAAGGTTGCTTTGAGTTC
AGGGTCAGGATCCCAGACAATGAATCGGAGAGAACTGTAAACCTTTAGGCGGAGAAATCTGCATAACAGGATAATTCCAATCTTTGTGAT
AAGTGAGAAGTTGCTAAATATTTTCAACACACTTTATAACATAGGCATAAGTTATCAATCCTATAGTCTTTTCCAGTTCTAAAAATCCCA
TAAGATTCCTAGAATTACCCTAAATGAGAAATTAGTTTAGGTTTAATGGCATATGTATTTTATCTCTTTAAATAATGTAACCTAATATAA
CTGCCCGACTTTTTATTTGTGCTAAAATACATGTAACATAAAATTGACCACTGTAACCATTTTAAAGTGTATAATTCAGTGGCACTAAGT
TCATTCACAATGATCTGCAGCCACCACTATCTAGTCCAGAACTTTCTCATCACCCCAAATGGAAACCCAGCACCTATTAGGCAGTCACGC
TCCATTATTCCCTCCCCCCAGTTCCAGGCAACCACGAATCTGCTTTCTGTCTCTATGGATTTACCTATTATAAATAAAACCATATAATGG


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FusionGenePPI for PAPOLA_AK7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAPOLAREL, CREBBP, HDAC1, HDAC3, HDAC10, SIRT1, SIRT2, CPSF6, NUDT21, KPNB1, CPSF1, ELAVL1, PPP1CB, SMAD2, LMNA, CORO1B, CORO1C, FAM129B, NARS, NUDC, PUF60, TARS, UGP2, YAP1, ZYX, HUWE1, GNA11, ADRBK1, CSTF2, CSTF2T, CSTF3, HNRNPA1, CPSF2, MTHFD1, MTHFD1L, PABPC1, PABPC3, PICALM, PROSC, SARS, UFD1L, WDR33, SUPT5H, NTRK1, FIP1L1, CIRBP, RSRC1, NRAS, FGBAK7TNPO3, GPKOW, MUC13, ZC3H14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAPOLA_AK7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAPOLA_AK7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource