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Fusion gene ID: 25905 |
FusionGeneSummary for PANX1_PANX1 |
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Fusion gene information | Fusion gene name: PANX1_PANX1 | Fusion gene ID: 25905 | Hgene | Tgene | Gene symbol | PANX1 | PANX1 | Gene ID | 24145 | 24145 |
Gene name | pannexin 1 | pannexin 1 | |
Synonyms | MRS1|PX1|UNQ2529 | MRS1|PX1|UNQ2529 | |
Cytomap | 11q21 | 11q21 | |
Type of gene | protein-coding | protein-coding | |
Description | pannexin-1innexin | pannexin-1innexin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96RD7 | Q96RD7 | |
Ensembl transtripts involved in fusion gene | ENST00000227638, ENST00000436171, | ENST00000227638, ENST00000436171, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 2 X 1=2 |
# samples | 8 | 4 | |
** MAII score | log2(8/48*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/2*10)=4.32192809488736 | |
Context | PubMed: PANX1 [Title/Abstract] AND PANX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PANX1 | GO:0006812 | cation transport | 17036048 |
Hgene | PANX1 | GO:0034214 | protein hexamerization | 17715132 |
Hgene | PANX1 | GO:0050718 | positive regulation of interleukin-1 beta secretion | 17036048 |
Tgene | PANX1 | GO:0006812 | cation transport | 17036048 |
Tgene | PANX1 | GO:0034214 | protein hexamerization | 17715132 |
Tgene | PANX1 | GO:0050718 | positive regulation of interleukin-1 beta secretion | 17036048 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA420506 | PANX1 | chr11 | 93867609 | + | PANX1 | chr11 | 93867488 | - | ||
ChiTaRS3.1 | AA470573 | PANX1 | chr11 | 93867488 | + | PANX1 | chr11 | 93867609 | - | ||
ChiTaRS3.1 | AA420507 | PANX1 | chr11 | 93867488 | + | PANX1 | chr11 | 93867609 | - | ||
ChiTaRS3.1 | AI732676 | PANX1 | chr11 | 93867488 | + | PANX1 | chr11 | 93867609 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000227638 | ENST00000227638 | PANX1 | chr11 | 93867609 | + | PANX1 | chr11 | 93867488 | - |
intron-intron | ENST00000227638 | ENST00000436171 | PANX1 | chr11 | 93867609 | + | PANX1 | chr11 | 93867488 | - |
intron-intron | ENST00000436171 | ENST00000227638 | PANX1 | chr11 | 93867609 | + | PANX1 | chr11 | 93867488 | - |
intron-intron | ENST00000436171 | ENST00000436171 | PANX1 | chr11 | 93867609 | + | PANX1 | chr11 | 93867488 | - |
intron-intron | ENST00000227638 | ENST00000227638 | PANX1 | chr11 | 93867488 | + | PANX1 | chr11 | 93867609 | - |
intron-intron | ENST00000227638 | ENST00000436171 | PANX1 | chr11 | 93867488 | + | PANX1 | chr11 | 93867609 | - |
intron-intron | ENST00000436171 | ENST00000227638 | PANX1 | chr11 | 93867488 | + | PANX1 | chr11 | 93867609 | - |
intron-intron | ENST00000436171 | ENST00000436171 | PANX1 | chr11 | 93867488 | + | PANX1 | chr11 | 93867609 | - |
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FusionProtFeatures for PANX1_PANX1 |
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Hgene | Tgene |
PANX1 | PANX1 |
Structural component of the gap junctions and thehemichannels. May play a role as a Ca(2+)-leak channel to regulateER Ca(2+) homeostasis. {ECO:0000269|PubMed:16908669,ECO:0000269|PubMed:20829356}. | Structural component of the gap junctions and thehemichannels. May play a role as a Ca(2+)-leak channel to regulateER Ca(2+) homeostasis. {ECO:0000269|PubMed:16908669,ECO:0000269|PubMed:20829356}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PANX1_PANX1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PANX1_PANX1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PANX1_PANX1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PANX1 | Q96RD7 | DB01032 | Probenecid | Pannexin-1 | small molecule | approved|investigational |
Tgene | PANX1 | Q96RD7 | DB01032 | Probenecid | Pannexin-1 | small molecule | approved|investigational |
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RelatedDiseases for PANX1_PANX1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |