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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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Fusion gene ID: 25881

FusionGeneSummary for PAN3_NTRK2

check button Fusion gene summary
Fusion gene informationFusion gene name: PAN3_NTRK2
Fusion gene ID: 25881
HgeneTgene
Gene symbol

PAN3

NTRK2

Gene ID

255967

4915

Gene namepoly(A) specific ribonuclease subunit PAN3neurotrophic receptor tyrosine kinase 2
Synonyms-EIEE58|GP145-TrkB|OBHD|TRKB|trk-B
Cytomap

13q12.2

9q21.33

Type of geneprotein-codingprotein-coding
DescriptionPAN2-PAN3 deadenylation complex subunit PAN3PAB-dependent poly(A)-specific ribonuclease subunit 3PAB-dependent poly(A)-specific ribonuclease subunit PAN3PAB1P-dependent poly(A)-nucleasePAB1P-dependent poly(A)-specific ribonucleasePABP-dependent poly(BDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
Modification date2018052320180523
UniProtAcc

Q58A45

Q16620

Ensembl transtripts involved in fusion geneENST00000380958, ENST00000399613, 
ENST00000282391, ENST00000483842, 
ENST00000376214, ENST00000376213, 
ENST00000395882, ENST00000304053, 
ENST00000376208, ENST00000277120, 
ENST00000323115, ENST00000359847, 
ENST00000395866, 
Fusion gene scores* DoF score10 X 7 X 7=4905 X 4 X 4=80
# samples 115
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAN3 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-BB-4223-01APAN3chr13

28713224

+NTRK2chr9

87549077

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000380958ENST00000376214PAN3chr13

28713224

+NTRK2chr9

87549077

+
In-frameENST00000380958ENST00000376213PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000395882PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000304053PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000376208PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000277120PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000323115PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000359847PAN3chr13

28713224

+NTRK2chr9

87549077

+
5CDS-intronENST00000380958ENST00000395866PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-3CDSENST00000399613ENST00000376214PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-3CDSENST00000399613ENST00000376213PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000395882PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000304053PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000376208PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000277120PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000323115PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000359847PAN3chr13

28713224

+NTRK2chr9

87549077

+
5UTR-intronENST00000399613ENST00000395866PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-3CDSENST00000282391ENST00000376214PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-3CDSENST00000282391ENST00000376213PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000395882PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000304053PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000376208PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000277120PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000323115PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000359847PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000282391ENST00000395866PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-3CDSENST00000483842ENST00000376214PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-3CDSENST00000483842ENST00000376213PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000395882PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000304053PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000376208PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000277120PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000323115PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000359847PAN3chr13

28713224

+NTRK2chr9

87549077

+
intron-intronENST00000483842ENST00000395866PAN3chr13

28713224

+NTRK2chr9

87549077

+

Top

FusionProtFeatures for PAN3_NTRK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAN3

Q58A45

NTRK2

Q16620

Receptor tyrosine kinase involved in the development andthe maturation of the central and the peripheral nervous systemsthrough regulation of neuron survival, proliferation, migration,differentiation, and synapse formation and plasticity. Receptorfor BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is lessefficient in activating the receptor but regulates neuron survivalthrough NTRK2. Upon ligand-binding, undergoes homodimerization,autophosphorylation and activation. Recruits, phosphorylatesand/or activates several downstream effectors including SHC1,FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlappingsignaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates theGRB2-Ras-MAPK cascade that regulates for instance neuronaldifferentiation including neurite outgrowth. Through the sameeffectors controls the Ras-PI3 kinase-AKT1 signaling cascade thatmainly regulates growth and survival. Through PLCG1 and thedownstream protein kinase C-regulated pathways controls synapticplasticity. Thereby, plays a role in learning and memory byregulating both short term synaptic function and long-termpotentiation. PLCG1 also leads to NF-Kappa-B activation and thetranscription of genes involved in cell survival. Hence, it isable to suppress anoikis, the apoptosis resulting from loss ofcell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediatecommunication between neurons and glia.{ECO:0000269|PubMed:15494731}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+11943_71143888Zinc fingerC3H1-type
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+015148_196-161554DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+015197_282-161554DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+015295_365-161554DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+01532_61-161554DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+015538_807-161554DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+1117538_807528823DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+012148_196-30478DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+012197_282-30478DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+012295_365-30478DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+01232_61-30478DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+012538_807-30478DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+014148_196-161538DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+014197_282-161538DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+014295_365-161538DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+01432_61-161538DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+014538_807-161538DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+1420538_807528823DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+012148_196-114322DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+012197_282-114322DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+012295_365-114322DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+01232_61-114322DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+012538_807-114322DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+013148_196-184478DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+013197_282-184478DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+013295_365-184478DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+01332_61-184478DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+013538_807-184478DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+1319544_552544839Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+015544_552-161554Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+1117544_552528823Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+012544_552-30478Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+014544_552-161538Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+1420544_552528823Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+1521544_552544839Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+012544_552-114322Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+013544_552-184478Nucleotide bindingATP
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+015116_137-161554RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+01592_113-161554RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+012116_137-30478RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+01292_113-30478RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+014116_137-161538RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+01492_113-161538RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+012116_137-114322RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+01292_113-114322RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+013116_137-184478RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+01392_113-184478RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+01532_430-161554Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+015455_822-161554Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+01232_430-30478Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+012455_822-30478Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+01432_430-161538Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+014455_822-161538Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+01232_430-114322Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+012455_822-114322Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+01332_430-184478Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+013455_822-184478Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000304053+015431_454-161554TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000359847+012431_454-30478TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376208+014431_454-161538TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395866+012431_454-114322TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000395882+013431_454-184478TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114751_7890576Coiled coilOntology_term=ECO:0000255
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119751_789143888Coiled coilOntology_term=ECO:0000255
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118751_789-3688Coiled coilOntology_term=ECO:0000255
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114284_2990576MotifPABPC-interacting motif-2 (PAM-2)
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119284_299143888MotifPABPC-interacting motif-2 (PAM-2)
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118284_299-3688MotifPABPC-interacting motif-2 (PAM-2)
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114570_5770576Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114644_6450576Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119570_577143888Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119644_645143888Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118570_577-3688Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118644_645-3688Nucleotide bindingATP
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114463_7500576RegionPseudokinase domain
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+114790_8870576RegionKnob domain
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119463_750143888RegionPseudokinase domain
HgenePAN3chr13:28713224chr9:87549077ENST00000380958+119790_887143888RegionKnob domain
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118463_750-3688RegionPseudokinase domain
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+118790_887-3688RegionKnob domain
HgenePAN3chr13:28713224chr9:87549077ENST00000282391+11443_710576Zinc fingerC3H1-type
HgenePAN3chr13:28713224chr9:87549077ENST00000399613+11843_71-3688Zinc fingerC3H1-type
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+1319148_196544839DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+1319197_282544839DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+1319295_365544839DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+131932_61544839DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+1319538_807544839DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+1117148_196528823DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+1117197_282528823DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+1117295_365528823DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+111732_61528823DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+1420148_196528823DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+1420197_282528823DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+1420295_365528823DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+142032_61528823DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+1521148_196544839DomainNote=LRRCT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+1521197_282544839DomainNote=Ig-like C2-type 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+1521295_365544839DomainNote=Ig-like C2-type 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+152132_61544839DomainNote=LRRNT
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+1521538_807544839DomainProtein kinase
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+1319116_137544839RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+131992_113544839RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+1117116_137528823RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+111792_113528823RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+1420116_137528823RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+142092_113528823RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+1521116_137544839RepeatNote=LRR 2
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+152192_113544839RepeatNote=LRR 1
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+131932_430544839Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+1319455_822544839Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+111732_430528823Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+1117455_822528823Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+142032_430528823Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+1420455_822528823Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+152132_430544839Topological domainExtracellular
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+1521455_822544839Topological domainCytoplasmic
TgeneNTRK2chr13:28713224chr9:87549077ENST00000277120+1319431_454544839TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000323115+1117431_454528823TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376213+1420431_454528823TransmembraneHelical
TgeneNTRK2chr13:28713224chr9:87549077ENST00000376214+1521431_454544839TransmembraneHelical


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FusionGeneSequence for PAN3_NTRK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PAN3_ENST00000380958_chr13_28713224_+_NTRK2_ENST00000376214_chr9_87549077_+_438aa
MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLAL
AGAPVAGFPPGAVAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIVQHIKRHNIVLKRELGEGAFGKVFLAECTNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFTGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE

>In-frame_PAN3_ENST00000380958_chr13_28713224_+_NTRK2_ENST00000376213_chr9_87549077_+_438aa
MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLAL
AGAPVAGFPPGAVAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIVQHIKRHNIVLKRELGEGAFGKVFLAECTNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFTGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PAN3_ENST00000380958_chr13_28713224_+_NTRK2_ENST00000376214_chr9_87549077_+_1314nt
ATGAACAGTGGCGGCGGCCTCCCGCCCCCCTCGGCCGCCGCCTCCCCTTCCTCCTCCTCGCTGGCGGCGGCGGTGGCGGTGGTGGCCCCG
CCGGGGGTCGGGGGTGTCCCCGGCGGGGCGGCGGTAGGAGTGAAGCTGAAGTACTGCCGCTACTACGCTAAGGATAAGACTTGCTTCTAC
GGGGAGGAGTGTCAGTTCCTGCATGAGGACCCTGCCGCCGGGGCTGCCCCGGGCCTCGGCCTCCATAGCAACAGCGTCCCCCTGGCTCTG
GCTGGTGCACCCGTGGCCGGCTTTCCGCCGGGAGCCGTCGCGGGCGGGGGAGCTGGGCCGCCCCCCGGGCCCAAGAAGCCGGACCTGGGG
GACCCGGGGACCGGAGCCGCAGCCGGCGGAGGAGGCAGTAGCGGGGGACTCGATGGACCGCGGCTGGCAATTGTTCAGCACATCAAGCGA
CATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGAC
AAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTC
CAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTC
AACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCAT
ATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGG
GAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTG
CCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAG
ATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCC
CGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACC

>In-frame_PAN3_ENST00000380958_chr13_28713224_+_NTRK2_ENST00000376213_chr9_87549077_+_1314nt
ATGAACAGTGGCGGCGGCCTCCCGCCCCCCTCGGCCGCCGCCTCCCCTTCCTCCTCCTCGCTGGCGGCGGCGGTGGCGGTGGTGGCCCCG
CCGGGGGTCGGGGGTGTCCCCGGCGGGGCGGCGGTAGGAGTGAAGCTGAAGTACTGCCGCTACTACGCTAAGGATAAGACTTGCTTCTAC
GGGGAGGAGTGTCAGTTCCTGCATGAGGACCCTGCCGCCGGGGCTGCCCCGGGCCTCGGCCTCCATAGCAACAGCGTCCCCCTGGCTCTG
GCTGGTGCACCCGTGGCCGGCTTTCCGCCGGGAGCCGTCGCGGGCGGGGGAGCTGGGCCGCCCCCCGGGCCCAAGAAGCCGGACCTGGGG
GACCCGGGGACCGGAGCCGCAGCCGGCGGAGGAGGCAGTAGCGGGGGACTCGATGGACCGCGGCTGGCAATTGTTCAGCACATCAAGCGA
CATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGAC
AAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTC
CAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTC
AACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCAT
ATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGG
GAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTG
CCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAG
ATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCC
CGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PAN3_ENST00000380958_chr13_28713224_+_NTRK2_ENST00000376214_chr9_87549077_+_3619nt
CTCCCCGGGCGGCTCCGGCTCCCGCAGCGGGACAGACCCACCCGCCCAGGCTTTTATCCGGCACCGGCAGCGTCTTCCTTTCCTCCCCCG
TCTATGGTGGTGGCGGCGGCGGCTCCTCGGGCGGCGGCGGAAGACGAGGCTGCGGCGTTGCCATGAACAGTGGCGGCGGCCTCCCGCCCC
CCTCGGCCGCCGCCTCCCCTTCCTCCTCCTCGCTGGCGGCGGCGGTGGCGGTGGTGGCCCCGCCGGGGGTCGGGGGTGTCCCCGGCGGGG
CGGCGGTAGGAGTGAAGCTGAAGTACTGCCGCTACTACGCTAAGGATAAGACTTGCTTCTACGGGGAGGAGTGTCAGTTCCTGCATGAGG
ACCCTGCCGCCGGGGCTGCCCCGGGCCTCGGCCTCCATAGCAACAGCGTCCCCCTGGCTCTGGCTGGTGCACCCGTGGCCGGCTTTCCGC
CGGGAGCCGTCGCGGGCGGGGGAGCTGGGCCGCCCCCCGGGCCCAAGAAGCCGGACCTGGGGGACCCGGGGACCGGAGCCGCAGCCGGCG
GAGGAGGCAGTAGCGGGGGACTCGATGGACCGCGGCTGGCAATTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAG
GCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGA
AGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATG
GCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTG
ATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGG
TCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACT
TTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCA
TCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGT
ACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGC
TGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTC
CGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATC
TTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAG
TGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTC
TTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTA
CTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCT
TGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGA
GTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTT
GTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGA
CAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGA
GGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAG
CAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGT
TTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAA
GCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACC
CCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACT
GCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTTTATTAGCT
GAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCA
CAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTGTACACAGG
TCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTC
CATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATA
GTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAAAATATTTC
TGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAGGGAGTGAT
TTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTG
GAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCA
ACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGGGTCGTTTG

>In-frame_PAN3_ENST00000380958_chr13_28713224_+_NTRK2_ENST00000376213_chr9_87549077_+_3619nt
CTCCCCGGGCGGCTCCGGCTCCCGCAGCGGGACAGACCCACCCGCCCAGGCTTTTATCCGGCACCGGCAGCGTCTTCCTTTCCTCCCCCG
TCTATGGTGGTGGCGGCGGCGGCTCCTCGGGCGGCGGCGGAAGACGAGGCTGCGGCGTTGCCATGAACAGTGGCGGCGGCCTCCCGCCCC
CCTCGGCCGCCGCCTCCCCTTCCTCCTCCTCGCTGGCGGCGGCGGTGGCGGTGGTGGCCCCGCCGGGGGTCGGGGGTGTCCCCGGCGGGG
CGGCGGTAGGAGTGAAGCTGAAGTACTGCCGCTACTACGCTAAGGATAAGACTTGCTTCTACGGGGAGGAGTGTCAGTTCCTGCATGAGG
ACCCTGCCGCCGGGGCTGCCCCGGGCCTCGGCCTCCATAGCAACAGCGTCCCCCTGGCTCTGGCTGGTGCACCCGTGGCCGGCTTTCCGC
CGGGAGCCGTCGCGGGCGGGGGAGCTGGGCCGCCCCCCGGGCCCAAGAAGCCGGACCTGGGGGACCCGGGGACCGGAGCCGCAGCCGGCG
GAGGAGGCAGTAGCGGGGGACTCGATGGACCGCGGCTGGCAATTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAG
GCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGA
AGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATG
GCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTG
ATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGG
TCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACT
TTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCA
TCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGT
ACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGC
TGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTC
CGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATC
TTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAG
TGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTC
TTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTA
CTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCT
TGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGA
GTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTT
GTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGA
CAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGA
GGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAG
CAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGT
TTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAA
GCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACC
CCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACT
GCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTTTATTAGCT
GAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCA
CAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTGTACACAGG
TCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTC
CATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATA
GTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAAAATATTTC
TGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAGGGAGTGAT
TTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTG
GAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCA
ACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGGGTCGTTTG


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FusionGenePPI for PAN3_NTRK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAN3PAN2, PABPC1, SVIL, ELAVL1, TNRC6C, TNRC6A, TNRC6B, PABPC3, XPO1, ASF1A, ASF1B, KIAA0430, HELZNTRK2NTF3, FYN, FRS2, SHC1, PLCG1, BDNF, NTF4, SHC3, GIPC1, SQSTM1, PIK3R1, SH2B1, NCK2, PTPN1, TRAF6, HSP90AA1, POLR2G, AP1B1, NMNAT1, RANBP9, TNK2, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAN3_NTRK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNTRK2Q16620DB00321AmitriptylineBDNF/NT-3 growth factors receptorsmall moleculeapproved

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RelatedDiseases for PAN3_NTRK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNTRK2C0011570Mental Depression5PSYGENET
TgeneNTRK2C0011581Depressive disorder5PSYGENET
TgeneNTRK2C0041696Unipolar Depression5PSYGENET
TgeneNTRK2C0525045Mood Disorders5PSYGENET
TgeneNTRK2C1269683Major Depressive Disorder5PSYGENET
TgeneNTRK2C0005586Bipolar Disorder3CTD_human;PSYGENET
TgeneNTRK2C0036341Schizophrenia2PSYGENET
TgeneNTRK2C0038220Status Epilepticus2CTD_human
TgeneNTRK2C0236736Cocaine-Related Disorders2CTD_human
TgeneNTRK2C0424295Hyperactive behavior2CTD_human
TgeneNTRK2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNTRK2C0004114Astrocytoma1CTD_human
TgeneNTRK2C0004352Autistic Disorder1CTD_human
TgeneNTRK2C0008073Developmental Disabilities1CTD_human
TgeneNTRK2C0013415Dysthymic Disorder1PSYGENET
TgeneNTRK2C0017638Glioma1CTD_human
TgeneNTRK2C0020505Hyperphagia1CTD_human;HPO
TgeneNTRK2C0027819Neuroblastoma1CTD_human
TgeneNTRK2C0028754Obesity1CTD_human;HPO
TgeneNTRK2C0036349Paranoid Schizophrenia1PSYGENET
TgeneNTRK2C0678807prenatal alcohol exposure1PSYGENET
TgeneNTRK2C0752347Lewy Body Disease1CTD_human
TgeneNTRK2C3146244Alcohol Related Birth Defect1PSYGENET
TgeneNTRK2C3151303Obesity, Hyperphagia, and Developmental Delay1UNIPROT