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Fusion gene ID: 25858 |
FusionGeneSummary for PALLD_TMEM53 |
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Fusion gene information | Fusion gene name: PALLD_TMEM53 | Fusion gene ID: 25858 | Hgene | Tgene | Gene symbol | PALLD | TMEM53 | Gene ID | 23022 | 79639 |
Gene name | palladin, cytoskeletal associated protein | transmembrane protein 53 | |
Synonyms | CGI-151|CGI151|MYN|PNCA1|SIH002 | NET4 | |
Cytomap | 4q32.3 | 1p34.1 | |
Type of gene | protein-coding | protein-coding | |
Description | palladinmyoneurinsarcoma antigen NY-SAR-77 | transmembrane protein 53novel DUF829 domain-containing protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q8WX93 | Q6P2H8 | |
Ensembl transtripts involved in fusion gene | ENST00000335742, ENST00000261509, ENST00000505667, ENST00000333488, ENST00000512127, ENST00000507735, | ENST00000372242, ENST00000372243, ENST00000372244, ENST00000476724, ENST00000372237, ENST00000372235, | |
Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 3 X 3 X 3=27 |
# samples | 8 | 3 | |
** MAII score | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PALLD [Title/Abstract] AND TMEM53 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-ZF-AA58-01A | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000335742 | ENST00000372242 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-3CDS | ENST00000335742 | ENST00000372243 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000335742 | ENST00000372244 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000335742 | ENST00000476724 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000335742 | ENST00000372237 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000335742 | ENST00000372235 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-3CDS | ENST00000261509 | ENST00000372242 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-3CDS | ENST00000261509 | ENST00000372243 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000261509 | ENST00000372244 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000261509 | ENST00000476724 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000261509 | ENST00000372237 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000261509 | ENST00000372235 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-3CDS | ENST00000505667 | ENST00000372242 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-3CDS | ENST00000505667 | ENST00000372243 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000505667 | ENST00000372244 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000505667 | ENST00000476724 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000505667 | ENST00000372237 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000505667 | ENST00000372235 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-3CDS | ENST00000333488 | ENST00000372242 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-3CDS | ENST00000333488 | ENST00000372243 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000333488 | ENST00000372244 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000333488 | ENST00000476724 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000333488 | ENST00000372237 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000333488 | ENST00000372235 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-3CDS | ENST00000512127 | ENST00000372242 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-3CDS | ENST00000512127 | ENST00000372243 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000512127 | ENST00000372244 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000512127 | ENST00000476724 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000512127 | ENST00000372237 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
intron-intron | ENST00000512127 | ENST00000372235 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
5UTR-3CDS | ENST00000507735 | ENST00000372242 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
5UTR-3CDS | ENST00000507735 | ENST00000372243 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
5UTR-intron | ENST00000507735 | ENST00000372244 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
5UTR-intron | ENST00000507735 | ENST00000476724 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
5UTR-intron | ENST00000507735 | ENST00000372237 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
5UTR-intron | ENST00000507735 | ENST00000372235 | PALLD | chr4 | 169753322 | + | TMEM53 | chr1 | 45125967 | - |
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FusionProtFeatures for PALLD_TMEM53 |
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Hgene | Tgene |
PALLD | TMEM53 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PALLD_TMEM53 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PALLD_TMEM53 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PALLD | EZR, ISG15, SORBS2, ACTN1, ACOX1, SARS, HSP90AA4P, IGBP1, DSTN, HSPB1, NDUFV1, LIG4, SIRT6, GRPEL1, WDFY2, TSG101, NTRK1, SRPK2, CEP162, CEP152, CNTROB, CEP128, NINL, NIN, ODF2, SCLT1, CEP83, CENPJ, FLNA, HSPA5, KDR, LLGL2, MYH9, MYO1C, PDLIM7, MYO19, SKA3, MCM2, NCKIPSD, PFN2, BCHE, TRIM25, G3BP1, BRCA1, TES | TMEM53 | APP, NME2P1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PALLD_TMEM53 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PALLD_TMEM53 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PALLD | C0043094 | Weight Gain | 1 | CTD_human |