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Fusion gene ID: 25857 |
FusionGeneSummary for PALLD_SRSF4 |
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Fusion gene information | Fusion gene name: PALLD_SRSF4 | Fusion gene ID: 25857 | Hgene | Tgene | Gene symbol | PALLD | SRSF4 | Gene ID | 23022 | 6429 |
Gene name | palladin, cytoskeletal associated protein | serine and arginine rich splicing factor 4 | |
Synonyms | CGI-151|CGI151|MYN|PNCA1|SIH002 | SFRS4|SRP75 | |
Cytomap | 4q32.3 | 1p35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | palladinmyoneurinsarcoma antigen NY-SAR-77 | serine/arginine-rich splicing factor 4SR splicing factor 4SRP001LBpre-mRNA-splicing factor SRP75splicing factor, arginine/serine-rich 4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8WX93 | Q08170 | |
Ensembl transtripts involved in fusion gene | ENST00000335742, ENST00000261509, ENST00000505667, ENST00000333488, ENST00000512127, ENST00000507735, | ENST00000373795, ENST00000546138, ENST00000466448, | |
Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 6 X 6 X 2=72 |
# samples | 8 | 6 | |
** MAII score | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PALLD [Title/Abstract] AND SRSF4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SRSF4 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome | 15009664 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ313599 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000335742 | ENST00000373795 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000335742 | ENST00000546138 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000335742 | ENST00000466448 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000261509 | ENST00000373795 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000261509 | ENST00000546138 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000261509 | ENST00000466448 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000505667 | ENST00000373795 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000505667 | ENST00000546138 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000505667 | ENST00000466448 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000333488 | ENST00000373795 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000333488 | ENST00000546138 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000333488 | ENST00000466448 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000512127 | ENST00000373795 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000512127 | ENST00000546138 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000512127 | ENST00000466448 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000507735 | ENST00000373795 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000507735 | ENST00000546138 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
intron-intron | ENST00000507735 | ENST00000466448 | PALLD | chr4 | 169567689 | - | SRSF4 | chr1 | 29506065 | + |
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FusionProtFeatures for PALLD_SRSF4 |
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Hgene | Tgene |
PALLD | SRSF4 |
Plays a role in alternative splice site selection duringpre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.{ECO:0000269|PubMed:15009664}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PALLD_SRSF4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PALLD_SRSF4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PALLD_SRSF4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SRSF4 | Q08170 | DB11638 | Artenimol | Serine/arginine-rich splicing factor 4 | small molecule | approved|investigational |
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RelatedDiseases for PALLD_SRSF4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PALLD | C0043094 | Weight Gain | 1 | CTD_human |