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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25857

FusionGeneSummary for PALLD_SRSF4

check button Fusion gene summary
Fusion gene informationFusion gene name: PALLD_SRSF4
Fusion gene ID: 25857
HgeneTgene
Gene symbol

PALLD

SRSF4

Gene ID

23022

6429

Gene namepalladin, cytoskeletal associated proteinserine and arginine rich splicing factor 4
SynonymsCGI-151|CGI151|MYN|PNCA1|SIH002SFRS4|SRP75
Cytomap

4q32.3

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionpalladinmyoneurinsarcoma antigen NY-SAR-77serine/arginine-rich splicing factor 4SR splicing factor 4SRP001LBpre-mRNA-splicing factor SRP75splicing factor, arginine/serine-rich 4
Modification date2018052320180523
UniProtAcc

Q8WX93

Q08170

Ensembl transtripts involved in fusion geneENST00000335742, ENST00000261509, 
ENST00000505667, ENST00000333488, 
ENST00000512127, ENST00000507735, 
ENST00000373795, ENST00000546138, 
ENST00000466448, 
Fusion gene scores* DoF score8 X 7 X 4=2246 X 6 X 2=72
# samples 86
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PALLD [Title/Abstract] AND SRSF4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRSF4

GO:0048025

negative regulation of mRNA splicing, via spliceosome

15009664


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ313599PALLDchr4

169567689

-SRSF4chr1

29506065

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000335742ENST00000373795PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000335742ENST00000546138PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000335742ENST00000466448PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000261509ENST00000373795PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000261509ENST00000546138PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000261509ENST00000466448PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000505667ENST00000373795PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000505667ENST00000546138PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000505667ENST00000466448PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000333488ENST00000373795PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000333488ENST00000546138PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000333488ENST00000466448PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000512127ENST00000373795PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000512127ENST00000546138PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000512127ENST00000466448PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000507735ENST00000373795PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000507735ENST00000546138PALLDchr4

169567689

-SRSF4chr1

29506065

+
intron-intronENST00000507735ENST00000466448PALLDchr4

169567689

-SRSF4chr1

29506065

+

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FusionProtFeatures for PALLD_SRSF4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PALLD

Q8WX93

SRSF4

Q08170

Plays a role in alternative splice site selection duringpre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.{ECO:0000269|PubMed:15009664}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PALLD_SRSF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PALLD_SRSF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PALLD_SRSF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSRSF4Q08170DB11638ArtenimolSerine/arginine-rich splicing factor 4small moleculeapproved|investigational

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RelatedDiseases for PALLD_SRSF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePALLDC0043094Weight Gain1CTD_human