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Fusion gene ID: 25855 |
FusionGeneSummary for PALLD_PCGF6 |
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Fusion gene information | Fusion gene name: PALLD_PCGF6 | Fusion gene ID: 25855 | Hgene | Tgene | Gene symbol | PALLD | PCGF6 | Gene ID | 23022 | 84108 |
Gene name | palladin, cytoskeletal associated protein | polycomb group ring finger 6 | |
Synonyms | CGI-151|CGI151|MYN|PNCA1|SIH002 | MBLR|RNF134 | |
Cytomap | 4q32.3 | 10q24.33 | |
Type of gene | protein-coding | protein-coding | |
Description | palladinmyoneurinsarcoma antigen NY-SAR-77 | polycomb group RING finger protein 6Mel18 and Bmi1-like RING finger proteinring finger protein 134 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8WX93 | Q9BYE7 | |
Ensembl transtripts involved in fusion gene | ENST00000335742, ENST00000261509, ENST00000505667, ENST00000333488, ENST00000512127, ENST00000507735, | ENST00000337211, ENST00000369847, ENST00000490296, | |
Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 2 X 2 X 2=8 |
# samples | 8 | 2 | |
** MAII score | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: PALLD [Title/Abstract] AND PCGF6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PCGF6 | GO:0045892 | negative regulation of transcription, DNA-templated | 8521824 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI911829 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000335742 | ENST00000337211 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000335742 | ENST00000369847 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000335742 | ENST00000490296 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000261509 | ENST00000337211 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000261509 | ENST00000369847 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000261509 | ENST00000490296 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000505667 | ENST00000337211 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000505667 | ENST00000369847 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000505667 | ENST00000490296 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000333488 | ENST00000337211 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000333488 | ENST00000369847 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000333488 | ENST00000490296 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000512127 | ENST00000337211 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000512127 | ENST00000369847 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000512127 | ENST00000490296 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000507735 | ENST00000337211 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000507735 | ENST00000369847 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
intron-intron | ENST00000507735 | ENST00000490296 | PALLD | chr4 | 169565990 | + | PCGF6 | chr10 | 105077069 | + |
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FusionProtFeatures for PALLD_PCGF6 |
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Hgene | Tgene |
PALLD | PCGF6 |
Transcriptional repressor (PubMed:12167161). Maymodulate the levels of histone H3K4Me3 by activating KDM5D histonedemethylase (PubMed:17320162). Component of a Polycomb group (PcG)multiprotein PRC1-like complex, a complex class required tomaintain the transcriptionally repressive state of many genes,including Hox genes, throughout development. PcG PRC1 complex actsvia chromatin remodeling and modification of histones; it mediatesmonoubiquitination of histone H2A 'Lys-119', rendering chromatinheritably changed in its expressibility (PubMed:12167161). Withinthe PRC1-like complex, regulates RNF2 ubiquitin ligase activity(PubMed:26151332). {ECO:0000269|PubMed:12167161,ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:26151332}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PALLD_PCGF6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PALLD_PCGF6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PALLD_PCGF6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PALLD_PCGF6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PALLD | C0043094 | Weight Gain | 1 | CTD_human |