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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25854

FusionGeneSummary for PALLD_PALLD

check button Fusion gene summary
Fusion gene informationFusion gene name: PALLD_PALLD
Fusion gene ID: 25854
HgeneTgene
Gene symbol

PALLD

PALLD

Gene ID

23022

23022

Gene namepalladin, cytoskeletal associated proteinpalladin, cytoskeletal associated protein
SynonymsCGI-151|CGI151|MYN|PNCA1|SIH002CGI-151|CGI151|MYN|PNCA1|SIH002
Cytomap

4q32.3

4q32.3

Type of geneprotein-codingprotein-coding
Descriptionpalladinmyoneurinsarcoma antigen NY-SAR-77palladinmyoneurinsarcoma antigen NY-SAR-77
Modification date2018052320180523
UniProtAcc

Q8WX93

Q8WX93

Ensembl transtripts involved in fusion geneENST00000335742, ENST00000261509, 
ENST00000505667, ENST00000333488, 
ENST00000512127, ENST00000507735, 
ENST00000335742, ENST00000261509, 
ENST00000505667, ENST00000333488, 
ENST00000512127, ENST00000507735, 
Fusion gene scores* DoF score8 X 7 X 4=2247 X 6 X 3=126
# samples 87
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PALLD [Title/Abstract] AND PALLD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF990953PALLDchr4

169702291

-PALLDchr4

169702213

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000335742ENST00000335742PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000335742ENST00000261509PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000335742ENST00000505667PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000335742ENST00000333488PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000335742ENST00000512127PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000335742ENST00000507735PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000261509ENST00000335742PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000261509ENST00000261509PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000261509ENST00000505667PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000261509ENST00000333488PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000261509ENST00000512127PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000261509ENST00000507735PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000505667ENST00000335742PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000505667ENST00000261509PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000505667ENST00000505667PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000505667ENST00000333488PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000505667ENST00000512127PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000505667ENST00000507735PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000333488ENST00000335742PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000333488ENST00000261509PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000333488ENST00000505667PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000333488ENST00000333488PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000333488ENST00000512127PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000333488ENST00000507735PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000512127ENST00000335742PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000512127ENST00000261509PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000512127ENST00000505667PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000512127ENST00000333488PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000512127ENST00000512127PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000512127ENST00000507735PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000507735ENST00000335742PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000507735ENST00000261509PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000507735ENST00000505667PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000507735ENST00000333488PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000507735ENST00000512127PALLDchr4

169702291

-PALLDchr4

169702213

+
intron-intronENST00000507735ENST00000507735PALLDchr4

169702291

-PALLDchr4

169702213

+

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FusionProtFeatures for PALLD_PALLD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PALLD

Q8WX93

PALLD

Q8WX93


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PALLD_PALLD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PALLD_PALLD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PALLD_PALLD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PALLD_PALLD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePALLDC0043094Weight Gain1CTD_human
TgenePALLDC0043094Weight Gain1CTD_human