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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25852

FusionGeneSummary for PALLD_FAM198B

check button Fusion gene summary
Fusion gene informationFusion gene name: PALLD_FAM198B
Fusion gene ID: 25852
HgeneTgene
Gene symbol

PALLD

FAM198B

Gene ID

23022

51313

Gene namepalladin, cytoskeletal associated proteinfamily with sequence similarity 198 member B
SynonymsCGI-151|CGI151|MYN|PNCA1|SIH002AD021|AD036|C4orf18|ENED
Cytomap

4q32.3

4q32.1

Type of geneprotein-codingprotein-coding
Descriptionpalladinmyoneurinsarcoma antigen NY-SAR-77protein FAM198Bexpressed in nerve and epithelium during development
Modification date2018052320180403
UniProtAcc

Q8WX93

Q6UWH4

Ensembl transtripts involved in fusion geneENST00000335742, ENST00000261509, 
ENST00000505667, ENST00000333488, 
ENST00000512127, ENST00000507735, 
ENST00000585682, ENST00000296530, 
ENST00000393807, ENST00000589306, 
ENST00000592057, 
Fusion gene scores* DoF score8 X 7 X 4=2242 X 2 X 2=8
# samples 82
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: PALLD [Title/Abstract] AND FAM198B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG700758PALLDchr4

169753322

+FAM198Bchr4

159076979

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000335742ENST00000585682PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-3CDSENST00000335742ENST00000296530PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-intronENST00000335742ENST00000393807PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-5UTRENST00000335742ENST00000589306PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-intronENST00000335742ENST00000592057PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-3CDSENST00000261509ENST00000585682PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-3CDSENST00000261509ENST00000296530PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-intronENST00000261509ENST00000393807PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-5UTRENST00000261509ENST00000589306PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-intronENST00000261509ENST00000592057PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-3CDSENST00000505667ENST00000585682PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-3CDSENST00000505667ENST00000296530PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-intronENST00000505667ENST00000393807PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-5UTRENST00000505667ENST00000589306PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-intronENST00000505667ENST00000592057PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-3CDSENST00000333488ENST00000585682PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-3CDSENST00000333488ENST00000296530PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-intronENST00000333488ENST00000393807PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-5UTRENST00000333488ENST00000589306PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-intronENST00000333488ENST00000592057PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-3CDSENST00000512127ENST00000585682PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-3CDSENST00000512127ENST00000296530PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-intronENST00000512127ENST00000393807PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-5UTRENST00000512127ENST00000589306PALLDchr4

169753322

+FAM198Bchr4

159076979

-
intron-intronENST00000512127ENST00000592057PALLDchr4

169753322

+FAM198Bchr4

159076979

-
5UTR-3CDSENST00000507735ENST00000585682PALLDchr4

169753322

+FAM198Bchr4

159076979

-
5UTR-3CDSENST00000507735ENST00000296530PALLDchr4

169753322

+FAM198Bchr4

159076979

-
5UTR-intronENST00000507735ENST00000393807PALLDchr4

169753322

+FAM198Bchr4

159076979

-
5UTR-5UTRENST00000507735ENST00000589306PALLDchr4

169753322

+FAM198Bchr4

159076979

-
5UTR-intronENST00000507735ENST00000592057PALLDchr4

169753322

+FAM198Bchr4

159076979

-

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FusionProtFeatures for PALLD_FAM198B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PALLD

Q8WX93

FAM198B

Q6UWH4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PALLD_FAM198B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PALLD_FAM198B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PALLDEZR, ISG15, SORBS2, ACTN1, ACOX1, SARS, HSP90AA4P, IGBP1, DSTN, HSPB1, NDUFV1, LIG4, SIRT6, GRPEL1, WDFY2, TSG101, NTRK1, SRPK2, CEP162, CEP152, CNTROB, CEP128, NINL, NIN, ODF2, SCLT1, CEP83, CENPJ, FLNA, HSPA5, KDR, LLGL2, MYH9, MYO1C, PDLIM7, MYO19, SKA3, MCM2, NCKIPSD, PFN2, BCHE, TRIM25, G3BP1, BRCA1, TESFAM198B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PALLD_FAM198B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PALLD_FAM198B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePALLDC0043094Weight Gain1CTD_human
TgeneFAM198BC0023893Liver Cirrhosis, Experimental1CTD_human