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Fusion gene ID: 25844 |
FusionGeneSummary for PAK4_MALL |
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Fusion gene information | Fusion gene name: PAK4_MALL | Fusion gene ID: 25844 | Hgene | Tgene | Gene symbol | PAK4 | MALL | Gene ID | 10298 | 7851 |
Gene name | p21 (RAC1) activated kinase 4 | mal, T cell differentiation protein like | |
Synonyms | - | BENE | |
Cytomap | 19q13.2 | 2q13 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase PAK 4p21 protein (Cdc42/Rac)-activated kinase 4p21(CDKN1A)-activated kinase 4protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs | MAL-like protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O96013 | Q13021 | |
Ensembl transtripts involved in fusion gene | ENST00000599470, ENST00000321944, ENST00000358301, ENST00000597766, ENST00000593690, ENST00000599386, ENST00000435673, ENST00000360442, | ENST00000272462, ENST00000427178, | |
Fusion gene scores | * DoF score | 13 X 4 X 6=312 | 4 X 4 X 2=32 |
# samples | 13 | 4 | |
** MAII score | log2(13/312*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PAK4 [Title/Abstract] AND MALL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ016010 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000599470 | ENST00000272462 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
intron-3UTR | ENST00000599470 | ENST00000427178 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000321944 | ENST00000272462 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000321944 | ENST00000427178 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000358301 | ENST00000272462 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000358301 | ENST00000427178 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
intron-3UTR | ENST00000597766 | ENST00000272462 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
intron-3UTR | ENST00000597766 | ENST00000427178 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000593690 | ENST00000272462 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000593690 | ENST00000427178 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000599386 | ENST00000272462 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000599386 | ENST00000427178 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000435673 | ENST00000272462 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000435673 | ENST00000427178 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000360442 | ENST00000272462 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
3UTR-3UTR | ENST00000360442 | ENST00000427178 | PAK4 | chr19 | 39669993 | - | MALL | chr2 | 110842708 | + |
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FusionProtFeatures for PAK4_MALL |
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Hgene | Tgene |
PAK4 | MALL |
Serine/threonine protein kinase that plays a role in avariety of different signaling pathways including cytoskeletonregulation, cell migration, growth, proliferation or cellsurvival. Activation by various effectors including growth factorreceptors or active CDC42 and RAC1 results in a conformationalchange and a subsequent autophosphorylation on several serineand/or threonine residues. Phosphorylates and inactivates theprotein phosphatase SSH1, leading to increased inhibitoryphosphorylation of the actin binding/depolymerizing factorcofilin. Decreased cofilin activity may lead to stabilization ofactin filaments. Phosphorylates LIMK1, a kinase that also inhibitsthe activity of cofilin. Phosphorylates integrin beta5/ITGB5 andthus regulates cell motility. Phosphorylates ARHGEF2 and activatesthe downstream target RHOA that plays a role in the regulation ofassembly of focal adhesions and actin stress fibers. Stimulatescell survival by phosphorylating the BCL2 antagonist of cell deathBAD. Alternatively, inhibits apoptosis by preventing caspase-8binding to death domain receptors in a kinase independent manner.Plays a role in cell-cycle progression by controlling levels ofthe cell-cycle regulatory protein CDKN1A and by phosphorylatingRAN. {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478,ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133,ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255,ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26607847}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PAK4_MALL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PAK4_MALL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PAK4_MALL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAK4_MALL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |