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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 25830

FusionGeneSummary for PAK2_DLG1

check button Fusion gene summary
Fusion gene informationFusion gene name: PAK2_DLG1
Fusion gene ID: 25830
HgeneTgene
Gene symbol

PAK2

DLG1

Gene ID

5586

1739

Gene nameprotein kinase N2discs large MAGUK scaffold protein 1
SynonymsPAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7DLGH1|SAP-97|SAP97|dJ1061C18.1.1|hdlg
Cytomap

1p22.2

3q29

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2disks large homolog 1discs large homolog 1, scribble cell polarity complex componentdiscs, large homolog 1 transcript variant 6-v1discs, large homolog 1 transcript variant 6-v2presynaptic protein SAP97synapse-associated protein 97
Modification date2018052320180523
UniProtAcc

Q13177

Q12959

Ensembl transtripts involved in fusion geneENST00000327134, ENST00000357674, 
ENST00000314062, ENST00000346964, 
ENST00000419354, ENST00000452595, 
ENST00000422288, ENST00000448528, 
ENST00000443183, ENST00000450955, 
ENST00000392382, ENST00000485409, 
Fusion gene scores* DoF score9 X 7 X 10=6306 X 7 X 6=252
# samples 137
** MAII scorelog2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAK2 [Title/Abstract] AND DLG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAK2

GO:0006468

protein phosphorylation

17332740

HgenePAK2

GO:0010631

epithelial cell migration

21754995

TgeneDLG1

GO:0001935

endothelial cell proliferation

14699157

TgeneDLG1

GO:0007015

actin filament organization

14699157

TgeneDLG1

GO:0030866

cortical actin cytoskeleton organization

14699157

TgeneDLG1

GO:0042391

regulation of membrane potential

12970345

TgeneDLG1

GO:0043268

positive regulation of potassium ion transport

12970345

TgeneDLG1

GO:0070830

bicellular tight junction assembly

17332497

TgeneDLG1

GO:0098609

cell-cell adhesion

14699157

TgeneDLG1

GO:1903078

positive regulation of protein localization to plasma membrane

12970345


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-JY-A6F8-01APAK2chr3

196467028

+DLG1chr3

196921460

-
TCGARVOVTCGA-25-1328-01APAK2chr3

196532254

+DLG1chr3

196888609

-
TCGALDOVTCGA-25-1328-01APAK2chr3

196532254

+DLG1chr3

196876667

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000327134ENST00000357674PAK2chr3

196467028

+DLG1chr3

196921460

-
5UTR-3CDSENST00000327134ENST00000314062PAK2chr3

196467028

+DLG1chr3

196921460

-
5UTR-3CDSENST00000327134ENST00000346964PAK2chr3

196467028

+DLG1chr3

196921460

-
5UTR-3CDSENST00000327134ENST00000419354PAK2chr3

196467028

+DLG1chr3

196921460

-
5UTR-intronENST00000327134ENST00000452595PAK2chr3

196467028

+DLG1chr3

196921460

-
5UTR-intronENST00000327134ENST00000422288PAK2chr3

196467028

+DLG1chr3

196921460

-
5UTR-intronENST00000327134ENST00000448528PAK2chr3

196467028

+DLG1chr3

196921460

-
5UTR-intronENST00000327134ENST00000443183PAK2chr3

196467028

+DLG1chr3

196921460

-
5UTR-intronENST00000327134ENST00000450955PAK2chr3

196467028

+DLG1chr3

196921460

-
5UTR-intronENST00000327134ENST00000392382PAK2chr3

196467028

+DLG1chr3

196921460

-
5UTR-5UTRENST00000327134ENST00000485409PAK2chr3

196467028

+DLG1chr3

196921460

-
5CDS-intronENST00000327134ENST00000357674PAK2chr3

196532254

+DLG1chr3

196888609

-
5CDS-intronENST00000327134ENST00000314062PAK2chr3

196532254

+DLG1chr3

196888609

-
5CDS-intronENST00000327134ENST00000346964PAK2chr3

196532254

+DLG1chr3

196888609

-
5CDS-intronENST00000327134ENST00000419354PAK2chr3

196532254

+DLG1chr3

196888609

-
5CDS-intronENST00000327134ENST00000452595PAK2chr3

196532254

+DLG1chr3

196888609

-
5CDS-intronENST00000327134ENST00000422288PAK2chr3

196532254

+DLG1chr3

196888609

-
5CDS-intronENST00000327134ENST00000448528PAK2chr3

196532254

+DLG1chr3

196888609

-
5CDS-intronENST00000327134ENST00000443183PAK2chr3

196532254

+DLG1chr3

196888609

-
5CDS-intronENST00000327134ENST00000450955PAK2chr3

196532254

+DLG1chr3

196888609

-
5CDS-intronENST00000327134ENST00000392382PAK2chr3

196532254

+DLG1chr3

196888609

-
5CDS-intronENST00000327134ENST00000485409PAK2chr3

196532254

+DLG1chr3

196888609

-
In-frameENST00000327134ENST00000357674PAK2chr3

196532254

+DLG1chr3

196876667

-
5CDS-intronENST00000327134ENST00000314062PAK2chr3

196532254

+DLG1chr3

196876667

-
5CDS-intronENST00000327134ENST00000346964PAK2chr3

196532254

+DLG1chr3

196876667

-
5CDS-intronENST00000327134ENST00000419354PAK2chr3

196532254

+DLG1chr3

196876667

-
5CDS-intronENST00000327134ENST00000452595PAK2chr3

196532254

+DLG1chr3

196876667

-
5CDS-intronENST00000327134ENST00000422288PAK2chr3

196532254

+DLG1chr3

196876667

-
5CDS-intronENST00000327134ENST00000448528PAK2chr3

196532254

+DLG1chr3

196876667

-
5CDS-intronENST00000327134ENST00000443183PAK2chr3

196532254

+DLG1chr3

196876667

-
5CDS-intronENST00000327134ENST00000450955PAK2chr3

196532254

+DLG1chr3

196876667

-
5CDS-intronENST00000327134ENST00000392382PAK2chr3

196532254

+DLG1chr3

196876667

-
5CDS-intronENST00000327134ENST00000485409PAK2chr3

196532254

+DLG1chr3

196876667

-

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FusionProtFeatures for PAK2_DLG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAK2

Q13177

DLG1

Q12959

Serine/threonine protein kinase that plays a role in avariety of different signaling pathways including cytoskeletonregulation, cell motility, cell cycle progression, apoptosis orproliferation. Acts as downstream effector of the small GTPasesCDC42 and RAC1. Activation by the binding of active CDC42 and RAC1results in a conformational change and a subsequentautophosphorylation on several serine and/or threonine residues.Full-length PAK2 stimulates cell survival and cell growth.Phosphorylates MAPK4 and MAPK6 and activates the downstream targetMAPKAPK5, a regulator of F-actin polymerization and cellmigration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substratesincluding histone H4 to promote assembly of H3.3 and H4 intonucleosomes, BAD, ribosomal protein S6, or MBP. Additionally,associates with ARHGEF7 and GIT1 to perform kinase-independentfunctions such as spindle orientation control during mitosis. Onthe other hand, apoptotic stimuli such as DNA damage lead tocaspase-mediated cleavage of PAK2, generating PAK-2p34, an activep34 fragment that translocates to the nucleus and promotescellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellulartranslation. {ECO:0000269|PubMed:12853446,ECO:0000269|PubMed:15234964, ECO:0000269|PubMed:16617111,ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21177766,ECO:0000269|PubMed:21317288, ECO:0000269|PubMed:21724829,ECO:0000269|PubMed:9171063}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+51574_87156525DomainCRIB
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+51569_112156525RegionGTPase-binding
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+51569_137156525RegionAutoregulatory region
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062-024224_310-64854DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062-024319_405-64854DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062-024466_546-64854DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062-0244_64-64854DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062-024581_651-64854DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062-024714_889-64854DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964-526224_310194927DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964-526319_405194927DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964-526466_546194927DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964-526581_651194927DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964-526714_889194927DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674-425224_310161894DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674-425319_405161894DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674-425466_546161894DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674-425581_651161894DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674-425714_889161894DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382-425224_310161872DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382-425319_405161872DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382-425466_546161872DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382-425581_651161872DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382-425714_889161872DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354-526224_310194905DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354-526319_405194905DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354-526466_546194905DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354-526581_651194905DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354-526714_889194905DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288-023224_3100854DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288-023319_4050854DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288-023466_5460854DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288-0234_640854DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288-023581_6510854DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288-023714_8890854DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183-022224_31078801DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183-022319_40578801DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183-022466_54678801DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183-022581_65178801DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183-022714_88978801DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528-526224_310194905DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528-526319_405194905DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528-526466_546194905DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528-526581_651194905DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528-526714_889194905DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955-324224_310161894DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955-324319_405161894DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955-324466_546161894DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955-324581_651161894DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955-324714_889161894DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595-021224_31078789DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595-021319_40578789DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595-021466_54678789DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595-021581_65178789DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595-021714_88978789DomainGuanylate kinase-like

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+515249_499156525DomainProtein kinase
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+515245_251156525MotifNote=Nuclear localization signal
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+515255_263156525Nucleotide bindingATP
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964-5264_64194927DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674-4254_64161894DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382-4254_64161872DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354-5264_64194905DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183-0224_6478801DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528-5264_64194905DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955-3244_64161894DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595-0214_6478789DomainL27


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FusionGeneSequence for PAK2_DLG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PAK2_ENST00000327134_chr3_196532254_+_DLG1_ENST00000357674_chr3_196876667_-_889aa
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAANPPPVLVNTDSLETPTYVNGTDA
DYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK
RRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV
YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEG
IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRT
SQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKG
QSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFP
DKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PAK2_ENST00000327134_chr3_196532254_+_DLG1_ENST00000357674_chr3_196876667_-_2667nt
ATGTCTGATAACGGAGAACTGGAAGATAAGCCTCCAGCACCTCCTGTGCGAATGAGCAGCACCATCTTTAGCACTGGAGGCAAAGACCCT
TTGTCAGCCAATCACAGTTTGAAACCTTTGCCCTCTGTTCCAGAAGAGAAAAAGCCCAGGCATAAAATCATCTCCATATTCTCAGGCACA
GAGAAAGGAAGTAAAAAGAAAGAAAAGGAACGGCCAGAAATTTCTCCTCCATCTGATTTTGAGCACACCATCCATGTTGGCTTTGATGCT
GTTACTGGAGAATTCACTGGCATGCCAGAACAGTGGGCTCGATTACTACAGACCTCCAATATCACCAAACTAGAGCAAAAGAAGAATCCT
CAGGCTGTGCTGGATGTCCTAAAGTTCTACGACTCCAACACAGTGAAGCAGAAATATCTGAGCTTTACTCCTCCTGAGAAAGATGGCTTT
CCTTCTGGAACACCAGCAGCAAATCCTCCCCCAGTACTGGTCAACACAGATAGCTTGGAAACACCAACTTACGTTAATGGCACAGATGCA
GATTATGAATATGAAGAAATCACACTTGAAAGGGGAAATTCAGGGCTTGGTTTCAGCATTGCAGGAGGTACGGACAACCCACACATTGGA
GATGACTCAAGTATTTTCATTACCAAAATTATCACAGGGGGAGCAGCCGCCCAAGATGGAAGATTGCGGGTCAATGACTGTATATTACGA
GTAAATGAAGTAGATGTTCGTGATGTAACACATAGCAAAGCAGTTGAAGCGTTGAAAGAAGCAGGGTCTATTGTACGCTTGTATGTAAAA
AGAAGGAAACCAGTGTCAGAAAAAATAATGGAAATAAAGCTCATTAAAGGTCCTAAAGGTCTTGGGTTTAGCATTGCTGGAGGTGTTGGA
AATCAGCATATTCCTGGGGATAATAGCATCTATGTAACCAAAATAATTGAAGGAGGTGCAGCACATAAGGATGGCAAACTTCAGATTGGA
GATAAACTTTTAGCAGTGAATAACGTATGTTTAGAAGAAGTTACTCATGAAGAAGCAGTAACTGCCTTAAAGAACACATCTGATTTTGTT
TATTTGAAAGTGGCAAAACCCACAAGTATGTATATGAATGATGGCTATGCACCACCTGATATCACCAACTCTTCTTCTCAGCCTGTTGAT
AACCATGTTAGCCCATCTTCCTTCTTGGGCCAGACACCAGCATCTCCAGCCAGATACTCCCCAGTTTCTAAAGCAGTACTTGGAGATGAT
GAAATTACAAGGGAACCTAGAAAAGTTGTTCTTCATCGTGGCTCAACGGGCCTTGGTTTCAACATTGTAGGAGGAGAAGATGGAGAAGGA
ATATTTATTTCCTTTATCTTAGCCGGAGGACCTGCTGATCTAAGTGGAGAGCTCAGAAAAGGAGATCGTATTATATCGGTAAACAGTGTT
GACCTCAGAGCTGCTAGTCATGAGCAGGCAGCAGCTGCATTGAAAAATGCTGGCCAGGCTGTCACAATTGTTGCACAATATCGACCTGAA
GAATACAGTCGTTTTGAAGCTAAAATACATGATTTACGGGAGCAGATGATGAATAGTAGTATTAGTTCAGGGTCAGGTTCTCTTCGAACT
AGCCAGAAGCGATCCCTCTATGTCAGAGCCCTTTTTGATTATGACAAGACTAAAGACAGTGGGCTTCCCAGTCAGGGACTGAACTTCAAA
TTTGGAGATATCCTCCATGTTATTAATGCTTCTGATGATGAATGGTGGCAAGCCAGGCAGGTTACACCAGATGGTGAGAGCGATGAGGTC
GGAGTGATTCCCAGTAAACGCAGAGTTGAGAAGAAAGAACGAGCCCGATTAAAAACAGTGAAATTCAATTCTAAAACGAGAGATAAAGGG
CAGTCATTCAATGACAAGCGTAAAAAGAACCTCTTTTCCCGAAAATTCCCCTTCTACAAGAACAAGGACCAGAGTGAGCAGGAAACAAGT
GATGCTGACCAGCATGTAACTTCTAATGCCAGCGATAGTGAAAGTAGTTACCGTGGTCAAGAAGAATACGTCTTATCTTATGAACCAGTG
AATCAACAAGAAGTTAATTATACTCGACCAGTGATCATATTGGGACCTATGAAAGACAGGATAAATGATGACTTGATCTCAGAATTTCCT
GACAAATTTGGATCCTGTGTTCCTCATACAACTAGACCAAAACGAGATTATGAGGTAGATGGAAGAGATTATCATTTTGTGACTTCAAGA
GAGCAGATGGAAAAAGATATCCAGGAACATAAATTCATTGAAGCTGGCCAGTATAACAATCATCTATATGGAACAAGTGTTCAGTCTGTA
CGAGAAGTAGCAGAAAAGGGCAAACACTGTATCCTTGATGTGTCTGGAAATGCCATAAAGAGATTACAGATTGCACAGCTTTACCCTATC
TCCATTTTTATTAAACCCAAATCCATGGAAAATATCATGGAAATGAATAAGCGTCTAACAGAAGAACAAGCCAGAAAAACATTTGAGAGA
GCCATGAAACTGGAACAGGAGTTTACTGAACATTTCACAGCTATTGTACAGGGGGATACGCTGGAAGACATTTACAACCAAGTGAAACAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_PAK2_ENST00000327134_chr3_196532254_+_DLG1_ENST00000357674_chr3_196876667_-_5052nt
GTCTTCCTCCCCCAGGGTTGTGGCCACGCGCAGCGGCGGCGGTTGTTCCGCTTCCCCTCCGGCCCGGGCCGTCGCCATTGCCGAAGGCTC
CCTCCCCTCCCCTCCCTGGCGTGCGCAGGACTCCGCCGCCGCTGGGCCTAGCGGTAGCAGCGGCTGCTCCAGCGCGGCGTCTCTTCCCGC
CCCGCTTCCCCTTCCCTCCCCTCCCCTCCCCGCACCGCGCGCTAGCCCGGGGCGGCTCCGCAGCCCGCCGGGAGCTCTGACCGAGGCGCC
TCGCTGGGGCGGGGACCTTGCCTTGCCCGGGGCCATTTCATAATTCTGAATCATGTCTGATAACGGAGAACTGGAAGATAAGCCTCCAGC
ACCTCCTGTGCGAATGAGCAGCACCATCTTTAGCACTGGAGGCAAAGACCCTTTGTCAGCCAATCACAGTTTGAAACCTTTGCCCTCTGT
TCCAGAAGAGAAAAAGCCCAGGCATAAAATCATCTCCATATTCTCAGGCACAGAGAAAGGAAGTAAAAAGAAAGAAAAGGAACGGCCAGA
AATTTCTCCTCCATCTGATTTTGAGCACACCATCCATGTTGGCTTTGATGCTGTTACTGGAGAATTCACTGGCATGCCAGAACAGTGGGC
TCGATTACTACAGACCTCCAATATCACCAAACTAGAGCAAAAGAAGAATCCTCAGGCTGTGCTGGATGTCCTAAAGTTCTACGACTCCAA
CACAGTGAAGCAGAAATATCTGAGCTTTACTCCTCCTGAGAAAGATGGCTTTCCTTCTGGAACACCAGCAGCAAATCCTCCCCCAGTACT
GGTCAACACAGATAGCTTGGAAACACCAACTTACGTTAATGGCACAGATGCAGATTATGAATATGAAGAAATCACACTTGAAAGGGGAAA
TTCAGGGCTTGGTTTCAGCATTGCAGGAGGTACGGACAACCCACACATTGGAGATGACTCAAGTATTTTCATTACCAAAATTATCACAGG
GGGAGCAGCCGCCCAAGATGGAAGATTGCGGGTCAATGACTGTATATTACGAGTAAATGAAGTAGATGTTCGTGATGTAACACATAGCAA
AGCAGTTGAAGCGTTGAAAGAAGCAGGGTCTATTGTACGCTTGTATGTAAAAAGAAGGAAACCAGTGTCAGAAAAAATAATGGAAATAAA
GCTCATTAAAGGTCCTAAAGGTCTTGGGTTTAGCATTGCTGGAGGTGTTGGAAATCAGCATATTCCTGGGGATAATAGCATCTATGTAAC
CAAAATAATTGAAGGAGGTGCAGCACATAAGGATGGCAAACTTCAGATTGGAGATAAACTTTTAGCAGTGAATAACGTATGTTTAGAAGA
AGTTACTCATGAAGAAGCAGTAACTGCCTTAAAGAACACATCTGATTTTGTTTATTTGAAAGTGGCAAAACCCACAAGTATGTATATGAA
TGATGGCTATGCACCACCTGATATCACCAACTCTTCTTCTCAGCCTGTTGATAACCATGTTAGCCCATCTTCCTTCTTGGGCCAGACACC
AGCATCTCCAGCCAGATACTCCCCAGTTTCTAAAGCAGTACTTGGAGATGATGAAATTACAAGGGAACCTAGAAAAGTTGTTCTTCATCG
TGGCTCAACGGGCCTTGGTTTCAACATTGTAGGAGGAGAAGATGGAGAAGGAATATTTATTTCCTTTATCTTAGCCGGAGGACCTGCTGA
TCTAAGTGGAGAGCTCAGAAAAGGAGATCGTATTATATCGGTAAACAGTGTTGACCTCAGAGCTGCTAGTCATGAGCAGGCAGCAGCTGC
ATTGAAAAATGCTGGCCAGGCTGTCACAATTGTTGCACAATATCGACCTGAAGAATACAGTCGTTTTGAAGCTAAAATACATGATTTACG
GGAGCAGATGATGAATAGTAGTATTAGTTCAGGGTCAGGTTCTCTTCGAACTAGCCAGAAGCGATCCCTCTATGTCAGAGCCCTTTTTGA
TTATGACAAGACTAAAGACAGTGGGCTTCCCAGTCAGGGACTGAACTTCAAATTTGGAGATATCCTCCATGTTATTAATGCTTCTGATGA
TGAATGGTGGCAAGCCAGGCAGGTTACACCAGATGGTGAGAGCGATGAGGTCGGAGTGATTCCCAGTAAACGCAGAGTTGAGAAGAAAGA
ACGAGCCCGATTAAAAACAGTGAAATTCAATTCTAAAACGAGAGATAAAGGGCAGTCATTCAATGACAAGCGTAAAAAGAACCTCTTTTC
CCGAAAATTCCCCTTCTACAAGAACAAGGACCAGAGTGAGCAGGAAACAAGTGATGCTGACCAGCATGTAACTTCTAATGCCAGCGATAG
TGAAAGTAGTTACCGTGGTCAAGAAGAATACGTCTTATCTTATGAACCAGTGAATCAACAAGAAGTTAATTATACTCGACCAGTGATCAT
ATTGGGACCTATGAAAGACAGGATAAATGATGACTTGATCTCAGAATTTCCTGACAAATTTGGATCCTGTGTTCCTCATACAACTAGACC
AAAACGAGATTATGAGGTAGATGGAAGAGATTATCATTTTGTGACTTCAAGAGAGCAGATGGAAAAAGATATCCAGGAACATAAATTCAT
TGAAGCTGGCCAGTATAACAATCATCTATATGGAACAAGTGTTCAGTCTGTACGAGAAGTAGCAGAAAAGGGCAAACACTGTATCCTTGA
TGTGTCTGGAAATGCCATAAAGAGATTACAGATTGCACAGCTTTACCCTATCTCCATTTTTATTAAACCCAAATCCATGGAAAATATCAT
GGAAATGAATAAGCGTCTAACAGAAGAACAAGCCAGAAAAACATTTGAGAGAGCCATGAAACTGGAACAGGAGTTTACTGAACATTTCAC
AGCTATTGTACAGGGGGATACGCTGGAAGACATTTACAACCAAGTGAAACAGATCATAGAAGAACAATCTGGTTCTTACATCTGGGTTCC
GGCAAAAGAAAAGCTATGAAAACTCATGTTTCTCTGTTTCTCTTTTCCACAATTCCATTTTCTTTGGCATCTCTTTGCCCTTTCCTCTGG
AGTCTTTCTTGAGTACTGATTTCATGTTGAATTGTATCCCACACATCATGGTCTGCAGCTTCTTTTTCACATGTAGTGTCTCCTTCAAGT
TACATCGTGTGTATTATTTAATGTCACTATTGGTTAGTGGCCATTTTTCAGAACTGAAGATGGAATGGCCTGACCAGCTATTAAGAACGT
GGGGAGACGCAGAAATTGTGGTAAAATTCCTTAATGTTTAAGGGAAAGTAACTTTAAGAGATTTTTGGAAAAGCTTTATATACATTCTTT
TCAAATTTCAGTACAAATGAAAAAGTGGTTTTAATCAGTGATTTAGTAGACTTTGAGCAACTGTGCACGCTTCAGTTTAATAGCATGGTT
TGGCCAGTGTATTACTCTCAAGTCCTTTTCTCAATCAACTTCTATCATCAAAGCAATTGTTTCATTATAGATAAATAAGGACATTTTTTA
ATTTAAAAATTCATGTCTGAGTTGACTTTCATAAGGGATTTCATTTTTTCCTCAACATTCTTAAAGCCTTTTAGTATTTGACGGTTCTTT
TTTCCCAGGACATTTGCTAGGAATAACAACGTTTCAATGTTTTTAATCTACTTGAGCAACACTATCGTGTCTTACAAAAGTTGTTCATAT
GTAAATGATCATCACATTTCGTGAATTGAGGCCATGTTCAGGTGCTAAGGAAGTTCGCCTTTTACACAGAAGATTGAGAAAATTTCCTAG
ATATAAATACAGATAAATCAGACGTTACAGTGGTGACGTAGTAACCATCATGGCAATGGAAAGGAGTCCAATTCATAGCCTAAAACTTCA
AATGTATTCTTAGGAGTCAGATTTTACTGAATATTTTACCCACAATAGCTGCCTATTTTGTTATAATAAAATATATATAAATATATATAT
AAAACTTTCTTTAAACTGTAACTATGGGAATTATTTTCTTTACATAGTTGCGCACACACACAAACATATATATATATTTAAAATATATTT
TGTTTCTTTTGCCACCTACTCCTAACTTTTTGTTTGGTTTTTAAATTAAATATTAATTGAATAGACTTATCTTCCTTAATCATGTGAACT
GAAAATGGGGGCATGGTGGTCATGAGGAGGAAACATTTAGGGAAATTAGATTATAAGTAAAAGTGTGGGCATATTCTCCTCTTTTCTACA
AAGGTTTTCAAATGGTTCCTGAGGTTTTTTGTTGTTGTCCGTGTTGTTACTGTTGTTCTTGTCATCAGGTTTGATTTTGGTCCTTGCCCT
TTCCTTCTAGTTCTCCTTTTATTAATAGGAAGGCAGGCAAAAGCCCCATTTATGTGTGTGTTTTCCCCTCAGACAGCTTTCATCCACTGC
TCTGCACTAGAATTGCACAAATCTTCATGGTGAGCAATTTTAAGAAATGTTAGTGAAAGGTAGAAATTATTTCACAAATCAGTTTCTCTG
GTCCTTCATATTAATAATAATATTTGGCTTCCCATTGCTCTTTGGAGTTGTTTATTAAATATGTGTTTTTGACAACCTCCTCATTAGTTT
CTTAAATGAGTACTGGTTTGTAAAGAATTATCAACATTATCCATTCCATTTATGAAGAAGAGGAGAACAGCTAATAAACTGTATTGTAAA
ATCCATATGTTAAGTGTGTCTTGAATTTTGAAAGAAAAAATATATTTTGCAAGCTAACATTTTCTTGAAACAATTTGAGGCATCATGTAA
CTTATAACCGAATCCAAGAGCCGTTAGGCAGCAGAGTGTGTTACCACATTGAAATACACAGTGCTGCTGTTAGACTAAATGTCGTAGGTT
GTTAACCACATAGAAACACACTAGTATGAAGAAAACTGTTGTAAAATCTCAAGAGCTTCAGAAACTGCCTTACAAGACCGCAGCATAAGC
TATTTTGAAGTATTTACCAAATAGTCACATGTTGTAAAATATCAAGTGGTTATAAAAGGATGCCATTTATATATTAAAATTTACATAACA


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FusionGenePPI for PAK2_DLG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAK2GIT1, GIT2, MYH10, MCM3, SH3KBP1, CDC42, ABI3, MYL2, DOCK2, RAC2, ABL1, RAC1, DST, EP300, BRAF, ELAVL1, HIST1H4F, HCK, LCK, SRC, SH3RF3, SORBS3, ARHGEF7, APP, MYC, HSPA5, PAK2, RIOK3, G6PD, NPEPPS, CAPNS1, CKB, EEF2, ERP44, ISOC1, LDHB, PAFAH1B1, SCLY, YWHAB, YWHAH, YWHAZ, PFAS, SFN, TGM2, UBE2R2, UBFD1, YWHAE, YWHAG, ZFYVE19, PAK1, RHOJ, FSD1, OR10H3, SOX2, NCK2, PLK2, GDI1, MYO6, ILKAP, MAPK3, PLAA, PSME1, THOC3, PDIA3, STAT1, NTRK1, SCLT1, CDKN2AIP, SKP1, FBXO28, CASP3, MKNK1, CDH1, ARHGEF6, SNRNP27, OCRL, ICAM1, FGB, KIFAP3, LPXN, USP47, PPM1A, MAPK14DLG1KCNA4, ADAM17, KCNJ12, KCNJ4, GPR124, CASK, LIN7A, LIN7C, APBA1, KCNA5, GRIN2A, CAMK2A, GRIA1, BTRC, ACTN2, CACNG2, GRIN2B, EPB41, ATP2B4, CRIPT, DLGAP1, KCNJ6, GRIK2, TJAP1, LRRC1, ERBB4, ATP2B2, EZR, KIF13B, CTNNA1, KCNJ2, GUCY1A2, LCK, KCNA3, MARCH2, AMOT, UBE3A, NET1, KHDRBS1, KCNC1, MAP1A, BAI1, HUWE1, ADAM10, NTRK1, TMEM17, DLG3, KIF26B, MAPK12, PARK2, CDH1, TGFA, PTPRE, PTEN, MPP2, EFNB3, GJB7, PRDM1, GPRC5B, WWC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062-024162_212-64854SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674-425162_212161894SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382-425162_212161872SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288-023162_2120854SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183-022162_21278801SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955-324162_212161894SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595-021162_21278789SH3 domains


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964-526162_212194927SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354-526162_212194905SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528-526162_212194905SH3 domains


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAK2_DLG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAK2_DLG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePAK2C0033687Proteinuria1CTD_human
HgenePAK2C0036341Schizophrenia1CTD_human
TgeneDLG1C0036341Schizophrenia3CTD_human
TgeneDLG1C0008925Cleft Palate1CTD_human