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Fusion gene ID: 25815 |
FusionGeneSummary for PAK1_KCTD14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PAK1_KCTD14 | Fusion gene ID: 25815 | Hgene | Tgene | Gene symbol | PAK1 | KCTD14 | Gene ID | 5585 | 65987 |
| Gene name | protein kinase N1 | potassium channel tetramerization domain containing 14 | |
| Synonyms | DBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1 | - | |
| Cytomap | 19p13.12 | 11q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase N | BTB/POZ domain-containing protein KCTD14potassium channel tetramerisation domain containing 14 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q13153 | Q9BQ13 | |
| Ensembl transtripts involved in fusion gene | ENST00000356341, ENST00000530617, ENST00000278568, ENST00000528203, ENST00000525542, | ENST00000353172, ENST00000533144, | |
| Fusion gene scores | * DoF score | 21 X 8 X 8=1344 | 5 X 3 X 3=45 |
| # samples | 23 | 5 | |
| ** MAII score | log2(23/1344*10)=-2.54682737183439 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PAK1 [Title/Abstract] AND KCTD14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PAK1 | GO:0006357 | regulation of transcription by RNA polymerase II | 12514133 |
| Hgene | PAK1 | GO:0006468 | protein phosphorylation | 17332740 |
| Hgene | PAK1 | GO:0035407 | histone H3-T11 phosphorylation | 18066052 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AN-A03Y-01A | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| TCGA | LD | BRCA | TCGA-AN-A03Y-01A | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000356341 | ENST00000353172 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| 5CDS-5UTR | ENST00000356341 | ENST00000533144 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| 5CDS-intron | ENST00000530617 | ENST00000353172 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| 5CDS-5UTR | ENST00000530617 | ENST00000533144 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| 5CDS-intron | ENST00000278568 | ENST00000353172 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| 5CDS-5UTR | ENST00000278568 | ENST00000533144 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| 5CDS-intron | ENST00000528203 | ENST00000353172 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| 5CDS-5UTR | ENST00000528203 | ENST00000533144 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| intron-intron | ENST00000525542 | ENST00000353172 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| intron-5UTR | ENST00000525542 | ENST00000533144 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77749804 | - |
| In-frame | ENST00000356341 | ENST00000353172 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
| Frame-shit | ENST00000356341 | ENST00000533144 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
| Frame-shit | ENST00000530617 | ENST00000353172 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
| In-frame | ENST00000530617 | ENST00000533144 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
| In-frame | ENST00000278568 | ENST00000353172 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
| Frame-shit | ENST00000278568 | ENST00000533144 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
| In-frame | ENST00000528203 | ENST00000353172 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
| Frame-shit | ENST00000528203 | ENST00000533144 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
| intron-3CDS | ENST00000525542 | ENST00000353172 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
| intron-3CDS | ENST00000525542 | ENST00000533144 | PAK1 | chr11 | 77090286 | - | KCTD14 | chr11 | 77728316 | - |
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FusionProtFeatures for PAK1_KCTD14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PAK1 | KCTD14 |
| Protein kinase involved in intracellular signalingpathways downstream of integrins and receptor-type kinases thatplays an important role in cytoskeleton dynamics, in celladhesion, migration, proliferation, apoptosis, mitosis, and invesicle-mediated transport processes. Can directly phosphorylateBAD and protects cells against apoptosis. Activated by interactionwith CDC42 and RAC1. Functions as GTPase effector that links theRho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway.Phosphorylates and activates MAP2K1, and thereby mediatesactivation of downstream MAP kinases. Involved in thereorganization of the actin cytoskeleton, actin stress fibers andof focal adhesion complexes. Phosphorylates the tubulin chaperoneTBCB and thereby plays a role in the regulation of microtubulebiogenesis and organization of the tubulin cytoskeleton. Plays arole in the regulation of insulin secretion in response toelevated glucose levels. Part of a ternary complex that containsPAK1, DVL1 and MUSK that is important for MUSK-dependentregulation of AChR clustering during the formation of theneuromuscular junction (NMJ). Activity is inhibited in cellsundergoing apoptosis, potentially due to binding of CDC2L1 andCDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338'and 'Ser-339' resulting in: activation of RAF1, stimulation ofRAF1 translocation to mitochondria, phosphorylation of BAD byRAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246'promoting its transcriptional repressor activity by increasing itsaccumulation in the nucleus. In podocytes, promotes NR3C2 nuclearlocalization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for theup-regulation of ACKR2 from endosomal compartment to cellmembrane, increasing its efficiency in chemokine uptake anddegradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1phosphorylation and inactivation. Plays a role in RUFY3-mediatedfacilitating gastric cancer cells migration and invasion(PubMed:25766321). {ECO:0000269|PubMed:10551809,ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:12624090,ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966,ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477,ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:16278681,ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089,ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23633677,ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:8805275,ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435,ECO:0000269|PubMed:9528787}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PAK1 | chr11:77090286 | chr11:77728316 | ENST00000278568 | - | 4 | 16 | 75_88 | 146 | 554 | Domain | CRIB |
| Hgene | PAK1 | chr11:77090286 | chr11:77728316 | ENST00000356341 | - | 4 | 15 | 75_88 | 146 | 546 | Domain | CRIB |
| Hgene | PAK1 | chr11:77090286 | chr11:77728316 | ENST00000278568 | - | 4 | 16 | 70_140 | 146 | 554 | Region | Note=Autoregulatory region |
| Hgene | PAK1 | chr11:77090286 | chr11:77728316 | ENST00000278568 | - | 4 | 16 | 75_105 | 146 | 554 | Region | Note=GTPase-binding |
| Hgene | PAK1 | chr11:77090286 | chr11:77728316 | ENST00000356341 | - | 4 | 15 | 70_140 | 146 | 546 | Region | Note=Autoregulatory region |
| Hgene | PAK1 | chr11:77090286 | chr11:77728316 | ENST00000356341 | - | 4 | 15 | 75_105 | 146 | 546 | Region | Note=GTPase-binding |
| Tgene | >KCTD14 | chr11:77090286 | chr11:77728316 | ENST00000353172 | - | 0 | 2 | 33_130 | 30 | 256 | Domain | Note=BTB |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PAK1 | chr11:77090286 | chr11:77728316 | ENST00000278568 | - | 4 | 16 | 270_521 | 146 | 554 | Domain | Protein kinase |
| Hgene | >PAK1 | chr11:77090286 | chr11:77728316 | ENST00000356341 | - | 4 | 15 | 270_521 | 146 | 546 | Domain | Protein kinase |
| Hgene | >PAK1 | chr11:77090286 | chr11:77728316 | ENST00000278568 | - | 4 | 16 | 276_284 | 146 | 554 | Nucleotide binding | Note=ATP |
| Hgene | >PAK1 | chr11:77090286 | chr11:77728316 | ENST00000278568 | - | 4 | 16 | 345_347 | 146 | 554 | Nucleotide binding | Note=ATP |
| Hgene | >PAK1 | chr11:77090286 | chr11:77728316 | ENST00000356341 | - | 4 | 15 | 276_284 | 146 | 546 | Nucleotide binding | Note=ATP |
| Hgene | >PAK1 | chr11:77090286 | chr11:77728316 | ENST00000356341 | - | 4 | 15 | 345_347 | 146 | 546 | Nucleotide binding | Note=ATP |
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FusionGeneSequence for PAK1_KCTD14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PAK1_ENST00000356341_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_372aa MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFD AVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDVYCCGAERRGXVPHHHPGYPEEVSGLKAGRDVL XLSQGLHGRGGPLLHRPPQHLFQTHPGLPAHWASAHTAHPXSVPXGSVLRNQAFGQAAGGHATDLWXAGVSEAVFAASAGLQREPGAHGA PGTCRSHNSTEVQRACVPGGNXGAGCILFRGPVFSAGXEDVQVCCQVWALEGGPRQQRPHALPGDGHXGPGVQGILQVLPDVPHQKKRIP >In-frame_PAK1_ENST00000530617_chr11_77090286_-_KCTD14_ENST00000533144_chr11_77728316_-_372aa MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFD AVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDVYCCGAERRGXVPHHHPGYPEEVSGLKAGRDVL XLSQGLHGRGGPLLHRPPQHLFQTHPGLPAHWASAHTAHPXSVPXGSVLRNQAFGQAAGGHATDLWXAGVSEAVFAASAGLQREPGAHGA PGTCRSHNSTEVQRACVPGGNXGAGCILFRGPVFSAGXEDVQVCCQVWALEGGPRQQRPHALPGDGHXGPGVQGILQVLPDVPHQKKRIP >In-frame_PAK1_ENST00000278568_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_372aa MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFD AVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDVYCCGAERRGXVPHHHPGYPEEVSGLKAGRDVL XLSQGLHGRGGPLLHRPPQHLFQTHPGLPAHWASAHTAHPXSVPXGSVLRNQAFGQAAGGHATDLWXAGVSEAVFAASAGLQREPGAHGA PGTCRSHNSTEVQRACVPGGNXGAGCILFRGPVFSAGXEDVQVCCQVWALEGGPRQQRPHALPGDGHXGPGVQGILQVLPDVPHQKKRIP >In-frame_PAK1_ENST00000528203_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_274aa MPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDVYCCGAERRGXVPHHHPGYPEEVSGLKAGRDVLXLSQGLHG RGGPLLHRPPQHLFQTHPGLPAHWASAHTAHPXSVPXGSVLRNQAFGQAAGGHATDLWXAGVSEAVFAASAGLQREPGAHGAPGTCRSHN STEVQRACVPGGNXGAGCILFRGPVFSAGXEDVQVCCQVWALEGGPRQQRPHALPGDGHXGPGVQGILQVLPDVPHQKKRIPFXHLFIHL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PAK1_ENST00000356341_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_1117nt ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT GGAGATAAAACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGAT GCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAAC CCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGT TGTGGAGCTGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTC TAGCTTAGCCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCG CACTGGGCAAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGA CATGCCACAGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCG CCTGGCACGTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGA GGTCCTGTGTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCAT GCACTGCCTGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCA >In-frame_PAK1_ENST00000530617_chr11_77090286_-_KCTD14_ENST00000533144_chr11_77728316_-_1117nt ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT GGAGATAAAACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGAT GCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAAC CCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGT TGTGGAGCTGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTC TAGCTTAGCCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCG CACTGGGCAAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGA CATGCCACAGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCG CCTGGCACGTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGA GGTCCTGTGTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCAT GCACTGCCTGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCA >In-frame_PAK1_ENST00000278568_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_1117nt ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT GGAGATAAAACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGAT GCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAAC CCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGT TGTGGAGCTGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTC TAGCTTAGCCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCG CACTGGGCAAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGA CATGCCACAGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCG CCTGGCACGTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGA GGTCCTGTGTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCAT GCACTGCCTGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCA >In-frame_PAK1_ENST00000528203_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_823nt ATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTTG GAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGTTGTGGAGCTGAACGTCGGGGGTGA GTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTCTAGCTTAGCCAAGGCCTCCACGGA CGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCGCACTGGGCAAGTGCCCACACAGCA CATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGACATGCCACAGATCTTTGGTGAGCA GGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCGCCTGGCACGTGCAGAAGCCATAAC AGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGAGGTCCTGTGTTTTCTGCAGGATAA GAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCATGCACTGCCTGGAGATGGACATTAA GGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCATTTTAACATTTATTCATTCACCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PAK1_ENST00000356341_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_2527nt GCCCTCCCGCGGCTGCAGCCGGAGCCGAAGGTGGTGGCTGCACAGTAGACGCCCCCTCACGGCTTCCCCCACACGCTCCCGCCCCCTCGC TCGCCCATCGCGCTTCCCTCACAGGCTCTGCAGTCCTCCCCCACAGACGCCTTCCCCCTTGGACTCTCATTCCCTTTTCCACGGAGCCCC GCGCTTTCGTGAGCCCCCTCGAGGAACCTGGTCTCCGCATCCAGTTACCACCTCCTGCCTCAGAGGCCATCTGAGCCCTTCGCACCTCGC CCCTCAGTCCCCCCTTCCCCCCCCGCCCGCGTCGCCTCGCTCCCTCCCGCCCCCCCATCATCCCTTCCCTCGCAGTTCCCCTGTCCTGAG GGGAGCCCCGCCACGGGCAGCGCGGCGGCGGCGGCAGGAGGGAGAAAGTGAAGCGGTAGCTCGCGCACACTCGCGCCCTCACTCCCGGCT AGGCGGCACCCACCGCCGGGAGGAGGAGGAGGAGCCGAGAGGAGCTGAGCGAGCGCGGAAGTAGCTGCTGCTGGTGGTGACAATGTCAAA TAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAAC CCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAA AACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCAC AGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGC TGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGTTGTGGAGC TGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTCTAGCTTAG CCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCGCACTGGGC AAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGACATGCCAC AGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCGCCTGGCAC GTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGAGGTCCTGT GTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCATGCACTGCC TGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCATTTTAACA TTTATTCATTCACCTTCACCTGGTGGTGATCCTCAGGAGCAGAGACTGTTATGAATTCTGGCGTGGCTTATGAAATTAAAAGTTGCCATC AAAGCCATTTTCTTTTAATTTCACAAACATCAGGCAATTTCCAGGGTTGGTCTAGAGTCTTGCCACTAAATATTGATCACTCGTTTAAGG ACTTTCCACTCCATTGCAACTGATGCCACTATATTTGCCTAGCAACTTGCAGCTACTTCCTTTTCAAAGCCTCATGTATCTCCCAGACCC TTCTCTTGAAGTCCAATAACAAGACCAAGTAAGAATGTTTCAACAATGCGTTGGCAAGAGATGTGAGATGACAACAGGAACATACAAGAT ACTGTGAATCTAGATGTTCTGACCTAAAGATGTAGTCTACATAGCCCCAGCTTGGGGTCCAATCCATCTGTCCCTGGCATGTGCCTTCAT GTAGTAGGTGCTTTCCTGATCCCCTTTGCGAGATGCTGTGGGTGCTAACACCTCAGAGCTGTCCTCTTCTCTAGAGTGGAGGTTTTCAAA GTGCATCATCAGCATTACCTGTGAACTTGCTGGAAATACAAATCCTCAGGCCCCACCTCAGACCTACTGAATCAGAATCTCTGGGGGTTG GCACAGCATTCTGATTTACCAAACCCTCCAAGTGATTTTGATGTATTCTAATTTTGAGACCATCTCTAGAAAAGAATTGCTACCTCTTGT ATGGAGGTACAAAAGACTGACCTCTTACATCAAGGAACTTCCTTTCCCAGAGCTCCTCATGGAATCAAGCTGAAGTCAGTCTTCTTCTGA GAGCACATTCTTACTCAGTTTTTTTCCTCTGTCCTACGCTGCTTCCCTCACTCCCCTTCTCCTAAGAGCACTCCATCAATAAACCACTTG >In-frame_PAK1_ENST00000530617_chr11_77090286_-_KCTD14_ENST00000533144_chr11_77728316_-_1429nt TGCTTTGCAGAAAAGGAGAAGCGCGCGGCTTCCTCCCGCCTCCTTCCCTCCTTTCTTCCCCCGCCCCTTCTGTTTCGCCAACCCCGACGC GGCGCCTTCGCTGCCGCCCTGCGAGAGCGCGAGCGTGCTGCACCTCGGGAGCTGGCGGCTGAGCTGCCAGGAGCCCAGCCCAGCTGAATC GAGCGGAGCCGGTGGAGCAGGGGCCTTGTGGGTACCCGGTTGGGCAGGGAGAGGTGCGGCTCTGCGACGGAAACAATCGCCAGAGATGCC GGGGCTAGCCTTCCCCACCAGTAGCTGCTGCTGGTGGTGACAATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCG ATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAG GAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAAAACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCT CTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTG CTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACA TCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGTTGTGGAGCTGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTAC CCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTCTAGCTTAGCCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGA CCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCGCACTGGGCAAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGC TCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGACATGCCACAGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCT GCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCGCCTGGCACGTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGT GTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGAGGTCCTGTGTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAA GTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCATGCACTGCCTGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTC >In-frame_PAK1_ENST00000278568_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_2525nt CCTCCCGCGGCTGCAGCCGGAGCCGAAGGTGGTGGCTGCACAGTAGACGCCCCCTCACGGCTTCCCCCACACGCTCCCGCCCCCTCGCTC GCCCATCGCGCTTCCCTCACAGGCTCTGCAGTCCTCCCCCACAGACGCCTTCCCCCTTGGACTCTCATTCCCTTTTCCACGGAGCCCCGC GCTTTCGTGAGCCCCCTCGAGGAACCTGGTCTCCGCATCCAGTTACCACCTCCTGCCTCAGAGGCCATCTGAGCCCTTCGCACCTCGCCC CTCAGTCCCCCCTTCCCCCCCCGCCCGCGTCGCCTCGCTCCCTCCCGCCCCCCCATCATCCCTTCCCTCGCAGTTCCCCTGTCCTGAGGG GAGCCCCGCCACGGGCAGCGCGGCGGCGGCGGCAGGAGGGAGAAAGTGAAGCGGTAGCTCGCGCACACTCGCGCCCTCACTCCCGGCTAG GCGGCACCCACCGCCGGGAGGAGGAGGAGGAGCCGAGAGGAGCTGAGCGAGCGCGGAAGTAGCTGCTGCTGGTGGTGACAATGTCAAATA ACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAACCC TAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAAAA CAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAG GGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTG TTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGTTGTGGAGCTG AACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTCTAGCTTAGCC AAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCGCACTGGGCAA GTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGACATGCCACAG ATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCGCCTGGCACGT GCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGAGGTCCTGTGT TTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCATGCACTGCCTG GAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCATTTTAACATT TATTCATTCACCTTCACCTGGTGGTGATCCTCAGGAGCAGAGACTGTTATGAATTCTGGCGTGGCTTATGAAATTAAAAGTTGCCATCAA AGCCATTTTCTTTTAATTTCACAAACATCAGGCAATTTCCAGGGTTGGTCTAGAGTCTTGCCACTAAATATTGATCACTCGTTTAAGGAC TTTCCACTCCATTGCAACTGATGCCACTATATTTGCCTAGCAACTTGCAGCTACTTCCTTTTCAAAGCCTCATGTATCTCCCAGACCCTT CTCTTGAAGTCCAATAACAAGACCAAGTAAGAATGTTTCAACAATGCGTTGGCAAGAGATGTGAGATGACAACAGGAACATACAAGATAC TGTGAATCTAGATGTTCTGACCTAAAGATGTAGTCTACATAGCCCCAGCTTGGGGTCCAATCCATCTGTCCCTGGCATGTGCCTTCATGT AGTAGGTGCTTTCCTGATCCCCTTTGCGAGATGCTGTGGGTGCTAACACCTCAGAGCTGTCCTCTTCTCTAGAGTGGAGGTTTTCAAAGT GCATCATCAGCATTACCTGTGAACTTGCTGGAAATACAAATCCTCAGGCCCCACCTCAGACCTACTGAATCAGAATCTCTGGGGGTTGGC ACAGCATTCTGATTTACCAAACCCTCCAAGTGATTTTGATGTATTCTAATTTTGAGACCATCTCTAGAAAAGAATTGCTACCTCTTGTAT GGAGGTACAAAAGACTGACCTCTTACATCAAGGAACTTCCTTTCCCAGAGCTCCTCATGGAATCAAGCTGAAGTCAGTCTTCTTCTGAGA GCACATTCTTACTCAGTTTTTTTCCTCTGTCCTACGCTGCTTCCCTCACTCCCCTTCTCCTAAGAGCACTCCATCAATAAACCACTTGCA >In-frame_PAK1_ENST00000528203_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_1936nt GAGCCCAGCCCAGCTGAATCGAGCGGAGCCGGTGGAGCAGGGGCCTTGTGGGTACCCGGTTGGGCAGGGAGAGGTGCGGCTCTGCGACGG AAACAATCGCCAGAGATGCCGGGGCTAGCCTTCCCCACCAGCAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGA TTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATC AAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCA GAAATACATGAGCTTTACAGATGTCTACTGTTGTGGAGCTGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGT TTCCGGGCTCAAAGCTGGCAGAGATGTTCTCTAGCTTAGCCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCA CCTATTTCAGACCCATCCTGGACTACCTGCGCACTGGGCAAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACG AAATCAAGCCTTTGGTCAAGCTGCTGGAGGACATGCCACAGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGG GCTACAGCGAGAACCTGGAGCTCATGGTGCGCCTGGCACGTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGG AAACTGAGGAGCAGGATGCATATTATTCAGAGGTCCTGTGTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCT GGAAGGCGGTCCTAGACAACAGCGACCTCATGCACTGCCTGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACC TGACGTACCCCACCAAAAGAAACGAATTCCATTTTAACATTTATTCATTCACCTTCACCTGGTGGTGATCCTCAGGAGCAGAGACTGTTA TGAATTCTGGCGTGGCTTATGAAATTAAAAGTTGCCATCAAAGCCATTTTCTTTTAATTTCACAAACATCAGGCAATTTCCAGGGTTGGT CTAGAGTCTTGCCACTAAATATTGATCACTCGTTTAAGGACTTTCCACTCCATTGCAACTGATGCCACTATATTTGCCTAGCAACTTGCA GCTACTTCCTTTTCAAAGCCTCATGTATCTCCCAGACCCTTCTCTTGAAGTCCAATAACAAGACCAAGTAAGAATGTTTCAACAATGCGT TGGCAAGAGATGTGAGATGACAACAGGAACATACAAGATACTGTGAATCTAGATGTTCTGACCTAAAGATGTAGTCTACATAGCCCCAGC TTGGGGTCCAATCCATCTGTCCCTGGCATGTGCCTTCATGTAGTAGGTGCTTTCCTGATCCCCTTTGCGAGATGCTGTGGGTGCTAACAC CTCAGAGCTGTCCTCTTCTCTAGAGTGGAGGTTTTCAAAGTGCATCATCAGCATTACCTGTGAACTTGCTGGAAATACAAATCCTCAGGC CCCACCTCAGACCTACTGAATCAGAATCTCTGGGGGTTGGCACAGCATTCTGATTTACCAAACCCTCCAAGTGATTTTGATGTATTCTAA TTTTGAGACCATCTCTAGAAAAGAATTGCTACCTCTTGTATGGAGGTACAAAAGACTGACCTCTTACATCAAGGAACTTCCTTTCCCAGA GCTCCTCATGGAATCAAGCTGAAGTCAGTCTTCTTCTGAGAGCACATTCTTACTCAGTTTTTTTCCTCTGTCCTACGCTGCTTCCCTCAC |
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FusionGenePPI for PAK1_KCTD14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PAK1 | ARHGEF2, ARPC1B, AKT1, RAC1, CDC42, CDK11A, ERBB2, ABI3, DYNLL1, PKLR, PLCG1, PAK1IP1, LIMK1, CDK5, RAF1, HGS, NCK1, ARHGEF7, MYLK, BAIAP2, NCK2, BMX, RHOJ, PAK1, SH3KBP1, HSP90AA1, YWHAG, YWHAZ, DYRK1B, ZBTB18, ZC3H7A, ZNF823, ZNF83, MYNN, C5orf42, ZNF418, HIST1H4A, TGM2, ARHGEF6, ELF3, GNB1, MAP3K1, MYO6, TGFBR1, TGFBR2, APP, CRIPAK, CHORDC1, ESR1, BAD, HIST1H3A, LYN, DYNLL2, PAK2, FBXO28, GIT1, SORBS3, BRSK1, EGFR, PYCARD, GIT2, H2AFX, SLC25A41, TAS2R41, ILKAP, PPAT, RELA, RHOU, SNW1, ICAM1, LPXN, FSD1, OR2K2, SOX2, SETX, FGB, PPM1A, PPP2CA, PPP1CA, MAPK14 | KCTD14 | TCF4, STK16, KCTD14, ACSF3, TUBGCP6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PAK1 | chr11:77090286 | chr11:77728316 | ENST00000278568 | - | 4 | 16 | 132_270 | 146 | 554 | CRIPAK |
| Hgene | PAK1 | chr11:77090286 | chr11:77728316 | ENST00000356341 | - | 4 | 15 | 132_270 | 146 | 546 | CRIPAK |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PAK1_KCTD14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAK1_KCTD14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PAK1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | PAK1 | C0033687 | Proteinuria | 1 | CTD_human |
| Hgene | PAK1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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