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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 25815

FusionGeneSummary for PAK1_KCTD14

check button Fusion gene summary
Fusion gene informationFusion gene name: PAK1_KCTD14
Fusion gene ID: 25815
HgeneTgene
Gene symbol

PAK1

KCTD14

Gene ID

5585

65987

Gene nameprotein kinase N1potassium channel tetramerization domain containing 14
SynonymsDBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1-
Cytomap

19p13.12

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase NBTB/POZ domain-containing protein KCTD14potassium channel tetramerisation domain containing 14
Modification date2018052320180519
UniProtAcc

Q13153

Q9BQ13

Ensembl transtripts involved in fusion geneENST00000356341, ENST00000530617, 
ENST00000278568, ENST00000528203, 
ENST00000525542, 
ENST00000353172, 
ENST00000533144, 
Fusion gene scores* DoF score21 X 8 X 8=13445 X 3 X 3=45
# samples 235
** MAII scorelog2(23/1344*10)=-2.54682737183439
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PAK1 [Title/Abstract] AND KCTD14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAK1

GO:0006357

regulation of transcription by RNA polymerase II

12514133

HgenePAK1

GO:0006468

protein phosphorylation

17332740

HgenePAK1

GO:0035407

histone H3-T11 phosphorylation

18066052


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AN-A03Y-01APAK1chr11

77090286

-KCTD14chr11

77749804

-
TCGALDBRCATCGA-AN-A03Y-01APAK1chr11

77090286

-KCTD14chr11

77728316

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356341ENST00000353172PAK1chr11

77090286

-KCTD14chr11

77749804

-
5CDS-5UTRENST00000356341ENST00000533144PAK1chr11

77090286

-KCTD14chr11

77749804

-
5CDS-intronENST00000530617ENST00000353172PAK1chr11

77090286

-KCTD14chr11

77749804

-
5CDS-5UTRENST00000530617ENST00000533144PAK1chr11

77090286

-KCTD14chr11

77749804

-
5CDS-intronENST00000278568ENST00000353172PAK1chr11

77090286

-KCTD14chr11

77749804

-
5CDS-5UTRENST00000278568ENST00000533144PAK1chr11

77090286

-KCTD14chr11

77749804

-
5CDS-intronENST00000528203ENST00000353172PAK1chr11

77090286

-KCTD14chr11

77749804

-
5CDS-5UTRENST00000528203ENST00000533144PAK1chr11

77090286

-KCTD14chr11

77749804

-
intron-intronENST00000525542ENST00000353172PAK1chr11

77090286

-KCTD14chr11

77749804

-
intron-5UTRENST00000525542ENST00000533144PAK1chr11

77090286

-KCTD14chr11

77749804

-
In-frameENST00000356341ENST00000353172PAK1chr11

77090286

-KCTD14chr11

77728316

-
Frame-shitENST00000356341ENST00000533144PAK1chr11

77090286

-KCTD14chr11

77728316

-
Frame-shitENST00000530617ENST00000353172PAK1chr11

77090286

-KCTD14chr11

77728316

-
In-frameENST00000530617ENST00000533144PAK1chr11

77090286

-KCTD14chr11

77728316

-
In-frameENST00000278568ENST00000353172PAK1chr11

77090286

-KCTD14chr11

77728316

-
Frame-shitENST00000278568ENST00000533144PAK1chr11

77090286

-KCTD14chr11

77728316

-
In-frameENST00000528203ENST00000353172PAK1chr11

77090286

-KCTD14chr11

77728316

-
Frame-shitENST00000528203ENST00000533144PAK1chr11

77090286

-KCTD14chr11

77728316

-
intron-3CDSENST00000525542ENST00000353172PAK1chr11

77090286

-KCTD14chr11

77728316

-
intron-3CDSENST00000525542ENST00000533144PAK1chr11

77090286

-KCTD14chr11

77728316

-

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FusionProtFeatures for PAK1_KCTD14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAK1

Q13153

KCTD14

Q9BQ13

Protein kinase involved in intracellular signalingpathways downstream of integrins and receptor-type kinases thatplays an important role in cytoskeleton dynamics, in celladhesion, migration, proliferation, apoptosis, mitosis, and invesicle-mediated transport processes. Can directly phosphorylateBAD and protects cells against apoptosis. Activated by interactionwith CDC42 and RAC1. Functions as GTPase effector that links theRho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway.Phosphorylates and activates MAP2K1, and thereby mediatesactivation of downstream MAP kinases. Involved in thereorganization of the actin cytoskeleton, actin stress fibers andof focal adhesion complexes. Phosphorylates the tubulin chaperoneTBCB and thereby plays a role in the regulation of microtubulebiogenesis and organization of the tubulin cytoskeleton. Plays arole in the regulation of insulin secretion in response toelevated glucose levels. Part of a ternary complex that containsPAK1, DVL1 and MUSK that is important for MUSK-dependentregulation of AChR clustering during the formation of theneuromuscular junction (NMJ). Activity is inhibited in cellsundergoing apoptosis, potentially due to binding of CDC2L1 andCDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338'and 'Ser-339' resulting in: activation of RAF1, stimulation ofRAF1 translocation to mitochondria, phosphorylation of BAD byRAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246'promoting its transcriptional repressor activity by increasing itsaccumulation in the nucleus. In podocytes, promotes NR3C2 nuclearlocalization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for theup-regulation of ACKR2 from endosomal compartment to cellmembrane, increasing its efficiency in chemokine uptake anddegradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1phosphorylation and inactivation. Plays a role in RUFY3-mediatedfacilitating gastric cancer cells migration and invasion(PubMed:25766321). {ECO:0000269|PubMed:10551809,ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:12624090,ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966,ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477,ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:16278681,ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089,ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23633677,ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:8805275,ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435,ECO:0000269|PubMed:9528787}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAK1chr11:77090286chr11:77728316ENST00000278568-41675_88146554DomainCRIB
HgenePAK1chr11:77090286chr11:77728316ENST00000356341-41575_88146546DomainCRIB
HgenePAK1chr11:77090286chr11:77728316ENST00000278568-41670_140146554RegionNote=Autoregulatory region
HgenePAK1chr11:77090286chr11:77728316ENST00000278568-41675_105146554RegionNote=GTPase-binding
HgenePAK1chr11:77090286chr11:77728316ENST00000356341-41570_140146546RegionNote=Autoregulatory region
HgenePAK1chr11:77090286chr11:77728316ENST00000356341-41575_105146546RegionNote=GTPase-binding
TgeneKCTD14chr11:77090286chr11:77728316ENST00000353172-0233_13030256DomainNote=BTB

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAK1chr11:77090286chr11:77728316ENST00000278568-416270_521146554DomainProtein kinase
HgenePAK1chr11:77090286chr11:77728316ENST00000356341-415270_521146546DomainProtein kinase
HgenePAK1chr11:77090286chr11:77728316ENST00000278568-416276_284146554Nucleotide bindingNote=ATP
HgenePAK1chr11:77090286chr11:77728316ENST00000278568-416345_347146554Nucleotide bindingNote=ATP
HgenePAK1chr11:77090286chr11:77728316ENST00000356341-415276_284146546Nucleotide bindingNote=ATP
HgenePAK1chr11:77090286chr11:77728316ENST00000356341-415345_347146546Nucleotide bindingNote=ATP


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FusionGeneSequence for PAK1_KCTD14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PAK1_ENST00000356341_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_372aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFD
AVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDVYCCGAERRGXVPHHHPGYPEEVSGLKAGRDVL
XLSQGLHGRGGPLLHRPPQHLFQTHPGLPAHWASAHTAHPXSVPXGSVLRNQAFGQAAGGHATDLWXAGVSEAVFAASAGLQREPGAHGA
PGTCRSHNSTEVQRACVPGGNXGAGCILFRGPVFSAGXEDVQVCCQVWALEGGPRQQRPHALPGDGHXGPGVQGILQVLPDVPHQKKRIP

>In-frame_PAK1_ENST00000530617_chr11_77090286_-_KCTD14_ENST00000533144_chr11_77728316_-_372aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFD
AVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDVYCCGAERRGXVPHHHPGYPEEVSGLKAGRDVL
XLSQGLHGRGGPLLHRPPQHLFQTHPGLPAHWASAHTAHPXSVPXGSVLRNQAFGQAAGGHATDLWXAGVSEAVFAASAGLQREPGAHGA
PGTCRSHNSTEVQRACVPGGNXGAGCILFRGPVFSAGXEDVQVCCQVWALEGGPRQQRPHALPGDGHXGPGVQGILQVLPDVPHQKKRIP

>In-frame_PAK1_ENST00000278568_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_372aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFD
AVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDVYCCGAERRGXVPHHHPGYPEEVSGLKAGRDVL
XLSQGLHGRGGPLLHRPPQHLFQTHPGLPAHWASAHTAHPXSVPXGSVLRNQAFGQAAGGHATDLWXAGVSEAVFAASAGLQREPGAHGA
PGTCRSHNSTEVQRACVPGGNXGAGCILFRGPVFSAGXEDVQVCCQVWALEGGPRQQRPHALPGDGHXGPGVQGILQVLPDVPHQKKRIP

>In-frame_PAK1_ENST00000528203_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_274aa
MPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDVYCCGAERRGXVPHHHPGYPEEVSGLKAGRDVLXLSQGLHG
RGGPLLHRPPQHLFQTHPGLPAHWASAHTAHPXSVPXGSVLRNQAFGQAAGGHATDLWXAGVSEAVFAASAGLQREPGAHGAPGTCRSHN
STEVQRACVPGGNXGAGCILFRGPVFSAGXEDVQVCCQVWALEGGPRQQRPHALPGDGHXGPGVQGILQVLPDVPHQKKRIPFXHLFIHL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PAK1_ENST00000356341_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_1117nt
ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT
GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT
GGAGATAAAACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGAT
GCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAAC
CCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGT
TGTGGAGCTGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTC
TAGCTTAGCCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCG
CACTGGGCAAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGA
CATGCCACAGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCG
CCTGGCACGTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGA
GGTCCTGTGTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCAT
GCACTGCCTGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCA

>In-frame_PAK1_ENST00000530617_chr11_77090286_-_KCTD14_ENST00000533144_chr11_77728316_-_1117nt
ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT
GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT
GGAGATAAAACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGAT
GCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAAC
CCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGT
TGTGGAGCTGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTC
TAGCTTAGCCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCG
CACTGGGCAAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGA
CATGCCACAGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCG
CCTGGCACGTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGA
GGTCCTGTGTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCAT
GCACTGCCTGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCA

>In-frame_PAK1_ENST00000278568_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_1117nt
ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT
GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT
GGAGATAAAACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGAT
GCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAAC
CCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGT
TGTGGAGCTGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTC
TAGCTTAGCCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCG
CACTGGGCAAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGA
CATGCCACAGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCG
CCTGGCACGTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGA
GGTCCTGTGTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCAT
GCACTGCCTGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCA

>In-frame_PAK1_ENST00000528203_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_823nt
ATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTTG
GAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGTTGTGGAGCTGAACGTCGGGGGTGA
GTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTCTAGCTTAGCCAAGGCCTCCACGGA
CGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCGCACTGGGCAAGTGCCCACACAGCA
CATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGACATGCCACAGATCTTTGGTGAGCA
GGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCGCCTGGCACGTGCAGAAGCCATAAC
AGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGAGGTCCTGTGTTTTCTGCAGGATAA
GAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCATGCACTGCCTGGAGATGGACATTAA
GGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCATTTTAACATTTATTCATTCACCTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PAK1_ENST00000356341_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_2527nt
GCCCTCCCGCGGCTGCAGCCGGAGCCGAAGGTGGTGGCTGCACAGTAGACGCCCCCTCACGGCTTCCCCCACACGCTCCCGCCCCCTCGC
TCGCCCATCGCGCTTCCCTCACAGGCTCTGCAGTCCTCCCCCACAGACGCCTTCCCCCTTGGACTCTCATTCCCTTTTCCACGGAGCCCC
GCGCTTTCGTGAGCCCCCTCGAGGAACCTGGTCTCCGCATCCAGTTACCACCTCCTGCCTCAGAGGCCATCTGAGCCCTTCGCACCTCGC
CCCTCAGTCCCCCCTTCCCCCCCCGCCCGCGTCGCCTCGCTCCCTCCCGCCCCCCCATCATCCCTTCCCTCGCAGTTCCCCTGTCCTGAG
GGGAGCCCCGCCACGGGCAGCGCGGCGGCGGCGGCAGGAGGGAGAAAGTGAAGCGGTAGCTCGCGCACACTCGCGCCCTCACTCCCGGCT
AGGCGGCACCCACCGCCGGGAGGAGGAGGAGGAGCCGAGAGGAGCTGAGCGAGCGCGGAAGTAGCTGCTGCTGGTGGTGACAATGTCAAA
TAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAAC
CCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAA
AACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCAC
AGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGC
TGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGTTGTGGAGC
TGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTCTAGCTTAG
CCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCGCACTGGGC
AAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGACATGCCAC
AGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCGCCTGGCAC
GTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGAGGTCCTGT
GTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCATGCACTGCC
TGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCATTTTAACA
TTTATTCATTCACCTTCACCTGGTGGTGATCCTCAGGAGCAGAGACTGTTATGAATTCTGGCGTGGCTTATGAAATTAAAAGTTGCCATC
AAAGCCATTTTCTTTTAATTTCACAAACATCAGGCAATTTCCAGGGTTGGTCTAGAGTCTTGCCACTAAATATTGATCACTCGTTTAAGG
ACTTTCCACTCCATTGCAACTGATGCCACTATATTTGCCTAGCAACTTGCAGCTACTTCCTTTTCAAAGCCTCATGTATCTCCCAGACCC
TTCTCTTGAAGTCCAATAACAAGACCAAGTAAGAATGTTTCAACAATGCGTTGGCAAGAGATGTGAGATGACAACAGGAACATACAAGAT
ACTGTGAATCTAGATGTTCTGACCTAAAGATGTAGTCTACATAGCCCCAGCTTGGGGTCCAATCCATCTGTCCCTGGCATGTGCCTTCAT
GTAGTAGGTGCTTTCCTGATCCCCTTTGCGAGATGCTGTGGGTGCTAACACCTCAGAGCTGTCCTCTTCTCTAGAGTGGAGGTTTTCAAA
GTGCATCATCAGCATTACCTGTGAACTTGCTGGAAATACAAATCCTCAGGCCCCACCTCAGACCTACTGAATCAGAATCTCTGGGGGTTG
GCACAGCATTCTGATTTACCAAACCCTCCAAGTGATTTTGATGTATTCTAATTTTGAGACCATCTCTAGAAAAGAATTGCTACCTCTTGT
ATGGAGGTACAAAAGACTGACCTCTTACATCAAGGAACTTCCTTTCCCAGAGCTCCTCATGGAATCAAGCTGAAGTCAGTCTTCTTCTGA
GAGCACATTCTTACTCAGTTTTTTTCCTCTGTCCTACGCTGCTTCCCTCACTCCCCTTCTCCTAAGAGCACTCCATCAATAAACCACTTG

>In-frame_PAK1_ENST00000530617_chr11_77090286_-_KCTD14_ENST00000533144_chr11_77728316_-_1429nt
TGCTTTGCAGAAAAGGAGAAGCGCGCGGCTTCCTCCCGCCTCCTTCCCTCCTTTCTTCCCCCGCCCCTTCTGTTTCGCCAACCCCGACGC
GGCGCCTTCGCTGCCGCCCTGCGAGAGCGCGAGCGTGCTGCACCTCGGGAGCTGGCGGCTGAGCTGCCAGGAGCCCAGCCCAGCTGAATC
GAGCGGAGCCGGTGGAGCAGGGGCCTTGTGGGTACCCGGTTGGGCAGGGAGAGGTGCGGCTCTGCGACGGAAACAATCGCCAGAGATGCC
GGGGCTAGCCTTCCCCACCAGTAGCTGCTGCTGGTGGTGACAATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCG
ATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAG
GAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAAAACAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCT
CTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTG
CTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACA
TCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGTTGTGGAGCTGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTAC
CCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTCTAGCTTAGCCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGA
CCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCGCACTGGGCAAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGC
TCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGACATGCCACAGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCT
GCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCGCCTGGCACGTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGT
GTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGAGGTCCTGTGTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAA
GTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCATGCACTGCCTGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTC

>In-frame_PAK1_ENST00000278568_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_2525nt
CCTCCCGCGGCTGCAGCCGGAGCCGAAGGTGGTGGCTGCACAGTAGACGCCCCCTCACGGCTTCCCCCACACGCTCCCGCCCCCTCGCTC
GCCCATCGCGCTTCCCTCACAGGCTCTGCAGTCCTCCCCCACAGACGCCTTCCCCCTTGGACTCTCATTCCCTTTTCCACGGAGCCCCGC
GCTTTCGTGAGCCCCCTCGAGGAACCTGGTCTCCGCATCCAGTTACCACCTCCTGCCTCAGAGGCCATCTGAGCCCTTCGCACCTCGCCC
CTCAGTCCCCCCTTCCCCCCCCGCCCGCGTCGCCTCGCTCCCTCCCGCCCCCCCATCATCCCTTCCCTCGCAGTTCCCCTGTCCTGAGGG
GAGCCCCGCCACGGGCAGCGCGGCGGCGGCGGCAGGAGGGAGAAAGTGAAGCGGTAGCTCGCGCACACTCGCGCCCTCACTCCCGGCTAG
GCGGCACCCACCGCCGGGAGGAGGAGGAGGAGCCGAGAGGAGCTGAGCGAGCGCGGAAGTAGCTGCTGCTGGTGGTGACAATGTCAAATA
ACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAACCC
TAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAAAA
CAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGATTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAG
GGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATCAAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTG
TTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCAGAAATACATGAGCTTTACAGATGTCTACTGTTGTGGAGCTG
AACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGTTTCCGGGCTCAAAGCTGGCAGAGATGTTCTCTAGCTTAGCC
AAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCACCTATTTCAGACCCATCCTGGACTACCTGCGCACTGGGCAA
GTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACGAAATCAAGCCTTTGGTCAAGCTGCTGGAGGACATGCCACAG
ATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGGGCTACAGCGAGAACCTGGAGCTCATGGTGCGCCTGGCACGT
GCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGGAAACTGAGGAGCAGGATGCATATTATTCAGAGGTCCTGTGT
TTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCTGGAAGGCGGTCCTAGACAACAGCGACCTCATGCACTGCCTG
GAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACCTGACGTACCCCACCAAAAGAAACGAATTCCATTTTAACATT
TATTCATTCACCTTCACCTGGTGGTGATCCTCAGGAGCAGAGACTGTTATGAATTCTGGCGTGGCTTATGAAATTAAAAGTTGCCATCAA
AGCCATTTTCTTTTAATTTCACAAACATCAGGCAATTTCCAGGGTTGGTCTAGAGTCTTGCCACTAAATATTGATCACTCGTTTAAGGAC
TTTCCACTCCATTGCAACTGATGCCACTATATTTGCCTAGCAACTTGCAGCTACTTCCTTTTCAAAGCCTCATGTATCTCCCAGACCCTT
CTCTTGAAGTCCAATAACAAGACCAAGTAAGAATGTTTCAACAATGCGTTGGCAAGAGATGTGAGATGACAACAGGAACATACAAGATAC
TGTGAATCTAGATGTTCTGACCTAAAGATGTAGTCTACATAGCCCCAGCTTGGGGTCCAATCCATCTGTCCCTGGCATGTGCCTTCATGT
AGTAGGTGCTTTCCTGATCCCCTTTGCGAGATGCTGTGGGTGCTAACACCTCAGAGCTGTCCTCTTCTCTAGAGTGGAGGTTTTCAAAGT
GCATCATCAGCATTACCTGTGAACTTGCTGGAAATACAAATCCTCAGGCCCCACCTCAGACCTACTGAATCAGAATCTCTGGGGGTTGGC
ACAGCATTCTGATTTACCAAACCCTCCAAGTGATTTTGATGTATTCTAATTTTGAGACCATCTCTAGAAAAGAATTGCTACCTCTTGTAT
GGAGGTACAAAAGACTGACCTCTTACATCAAGGAACTTCCTTTCCCAGAGCTCCTCATGGAATCAAGCTGAAGTCAGTCTTCTTCTGAGA
GCACATTCTTACTCAGTTTTTTTCCTCTGTCCTACGCTGCTTCCCTCACTCCCCTTCTCCTAAGAGCACTCCATCAATAAACCACTTGCA

>In-frame_PAK1_ENST00000528203_chr11_77090286_-_KCTD14_ENST00000353172_chr11_77728316_-_1936nt
GAGCCCAGCCCAGCTGAATCGAGCGGAGCCGGTGGAGCAGGGGCCTTGTGGGTACCCGGTTGGGCAGGGAGAGGTGCGGCTCTGCGACGG
AAACAATCGCCAGAGATGCCGGGGCTAGCCTTCCCCACCAGCAAATAAAAAGAAAGAGAAAGAGCGGCCAGAGATTTCTCTCCCTTCAGA
TTTTGAACACACAATTCATGTCGGTTTTGATGCTGTCACAGGGGAGTTTACGGGAATGCCAGAGCAGTGGGCCCGCTTGCTTCAGACATC
AAATATCACTAAGTCGGAGCAGAAGAAAAACCCGCAGGCTGTTCTGGATGTGTTGGAGTTTTACAACTCGAAGAAGACATCCAACAGCCA
GAAATACATGAGCTTTACAGATGTCTACTGTTGTGGAGCTGAACGTCGGGGGTGAGTTCCACACCACCACCCTGGGTACCCTGAGGAAGT
TTCCGGGCTCAAAGCTGGCAGAGATGTTCTCTAGCTTAGCCAAGGCCTCCACGGACGCGGAGGGCCGCTTCTTCATCGACCGCCCCAGCA
CCTATTTCAGACCCATCCTGGACTACCTGCGCACTGGGCAAGTGCCCACACAGCACATCCCTGAAGTGTACCGTGAGGCTCAGTTCTACG
AAATCAAGCCTTTGGTCAAGCTGCTGGAGGACATGCCACAGATCTTTGGTGAGCAGGTGTCTCGGAAGCAGTTTTTGCTGCAAGTGCCGG
GCTACAGCGAGAACCTGGAGCTCATGGTGCGCCTGGCACGTGCAGAAGCCATAACAGCACGGAAGTCCAGCGTGCTTGTGTGCCTGGTGG
AAACTGAGGAGCAGGATGCATATTATTCAGAGGTCCTGTGTTTTCTGCAGGATAAGAAGATGTTCAAGTCTGTTGTCAAGTTTGGGCCCT
GGAAGGCGGTCCTAGACAACAGCGACCTCATGCACTGCCTGGAGATGGACATTAAGGCCCAGGGGTACAAGGTATTCTCCAAGTTCTACC
TGACGTACCCCACCAAAAGAAACGAATTCCATTTTAACATTTATTCATTCACCTTCACCTGGTGGTGATCCTCAGGAGCAGAGACTGTTA
TGAATTCTGGCGTGGCTTATGAAATTAAAAGTTGCCATCAAAGCCATTTTCTTTTAATTTCACAAACATCAGGCAATTTCCAGGGTTGGT
CTAGAGTCTTGCCACTAAATATTGATCACTCGTTTAAGGACTTTCCACTCCATTGCAACTGATGCCACTATATTTGCCTAGCAACTTGCA
GCTACTTCCTTTTCAAAGCCTCATGTATCTCCCAGACCCTTCTCTTGAAGTCCAATAACAAGACCAAGTAAGAATGTTTCAACAATGCGT
TGGCAAGAGATGTGAGATGACAACAGGAACATACAAGATACTGTGAATCTAGATGTTCTGACCTAAAGATGTAGTCTACATAGCCCCAGC
TTGGGGTCCAATCCATCTGTCCCTGGCATGTGCCTTCATGTAGTAGGTGCTTTCCTGATCCCCTTTGCGAGATGCTGTGGGTGCTAACAC
CTCAGAGCTGTCCTCTTCTCTAGAGTGGAGGTTTTCAAAGTGCATCATCAGCATTACCTGTGAACTTGCTGGAAATACAAATCCTCAGGC
CCCACCTCAGACCTACTGAATCAGAATCTCTGGGGGTTGGCACAGCATTCTGATTTACCAAACCCTCCAAGTGATTTTGATGTATTCTAA
TTTTGAGACCATCTCTAGAAAAGAATTGCTACCTCTTGTATGGAGGTACAAAAGACTGACCTCTTACATCAAGGAACTTCCTTTCCCAGA
GCTCCTCATGGAATCAAGCTGAAGTCAGTCTTCTTCTGAGAGCACATTCTTACTCAGTTTTTTTCCTCTGTCCTACGCTGCTTCCCTCAC


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FusionGenePPI for PAK1_KCTD14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAK1ARHGEF2, ARPC1B, AKT1, RAC1, CDC42, CDK11A, ERBB2, ABI3, DYNLL1, PKLR, PLCG1, PAK1IP1, LIMK1, CDK5, RAF1, HGS, NCK1, ARHGEF7, MYLK, BAIAP2, NCK2, BMX, RHOJ, PAK1, SH3KBP1, HSP90AA1, YWHAG, YWHAZ, DYRK1B, ZBTB18, ZC3H7A, ZNF823, ZNF83, MYNN, C5orf42, ZNF418, HIST1H4A, TGM2, ARHGEF6, ELF3, GNB1, MAP3K1, MYO6, TGFBR1, TGFBR2, APP, CRIPAK, CHORDC1, ESR1, BAD, HIST1H3A, LYN, DYNLL2, PAK2, FBXO28, GIT1, SORBS3, BRSK1, EGFR, PYCARD, GIT2, H2AFX, SLC25A41, TAS2R41, ILKAP, PPAT, RELA, RHOU, SNW1, ICAM1, LPXN, FSD1, OR2K2, SOX2, SETX, FGB, PPM1A, PPP2CA, PPP1CA, MAPK14KCTD14TCF4, STK16, KCTD14, ACSF3, TUBGCP6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePAK1chr11:77090286chr11:77728316ENST00000278568-416132_270146554CRIPAK
HgenePAK1chr11:77090286chr11:77728316ENST00000356341-415132_270146546CRIPAK


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAK1_KCTD14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAK1_KCTD14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePAK1C0007134Renal Cell Carcinoma1CTD_human
HgenePAK1C0033687Proteinuria1CTD_human
HgenePAK1C1458155Mammary Neoplasms1CTD_human