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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 25810

FusionGeneSummary for PAK1_CNIH4

check button Fusion gene summary
Fusion gene informationFusion gene name: PAK1_CNIH4
Fusion gene ID: 25810
HgeneTgene
Gene symbol

PAK1

CNIH4

Gene ID

5585

29097

Gene nameprotein kinase N1cornichon family AMPA receptor auxiliary protein 4
SynonymsDBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1CNIH-4|CNIH2|HSPC163
Cytomap

19p13.12

1q42.11

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase Nprotein cornichon homolog 4cornichon homolog 4
Modification date2018052320180519
UniProtAcc

Q13153

Q9P003

Ensembl transtripts involved in fusion geneENST00000356341, ENST00000530617, 
ENST00000278568, ENST00000528203, 
ENST00000525542, 		ENST00000465271, 
ENST00000366858, ENST00000366857, 
ENST00000468318, ENST00000366856, 
Fusion gene scores* DoF score21 X 8 X 8=13444 X 3 X 4=48
# samples 234
** MAII scorelog2(23/1344*10)=-2.54682737183439
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAK1 [Title/Abstract] AND CNIH4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAK1

GO:0006357

regulation of transcription by RNA polymerase II

12514133

HgenePAK1

GO:0006468

protein phosphorylation

17332740

HgenePAK1

GO:0035407

histone H3-T11 phosphorylation

18066052


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-78-7161-01APAK1chr11

77103376

-CNIH4chr1

224553581

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356341ENST00000465271PAK1chr11

77103376

-CNIH4chr1

224553581

+
In-frameENST00000356341ENST00000366858PAK1chr11

77103376

-CNIH4chr1

224553581

+
In-frameENST00000356341ENST00000366857PAK1chr11

77103376

-CNIH4chr1

224553581

+
5CDS-3UTRENST00000356341ENST00000468318PAK1chr11

77103376

-CNIH4chr1

224553581

+
5CDS-3UTRENST00000356341ENST00000366856PAK1chr11

77103376

-CNIH4chr1

224553581

+
Frame-shiftENST00000530617ENST00000465271PAK1chr11

77103376

-CNIH4chr1

224553581

+
Frame-shiftENST00000530617ENST00000366858PAK1chr11

77103376

-CNIH4chr1

224553581

+
Frame-shiftENST00000530617ENST00000366857PAK1chr11

77103376

-CNIH4chr1

224553581

+
5CDS-3UTRENST00000530617ENST00000468318PAK1chr11

77103376

-CNIH4chr1

224553581

+
5CDS-3UTRENST00000530617ENST00000366856PAK1chr11

77103376

-CNIH4chr1

224553581

+
In-frameENST00000278568ENST00000465271PAK1chr11

77103376

-CNIH4chr1

224553581

+
In-frameENST00000278568ENST00000366858PAK1chr11

77103376

-CNIH4chr1

224553581

+
In-frameENST00000278568ENST00000366857PAK1chr11

77103376

-CNIH4chr1

224553581

+
5CDS-3UTRENST00000278568ENST00000468318PAK1chr11

77103376

-CNIH4chr1

224553581

+
5CDS-3UTRENST00000278568ENST00000366856PAK1chr11

77103376

-CNIH4chr1

224553581

+
intron-3CDSENST00000528203ENST00000465271PAK1chr11

77103376

-CNIH4chr1

224553581

+
intron-3CDSENST00000528203ENST00000366858PAK1chr11

77103376

-CNIH4chr1

224553581

+
intron-3CDSENST00000528203ENST00000366857PAK1chr11

77103376

-CNIH4chr1

224553581

+
intron-3UTRENST00000528203ENST00000468318PAK1chr11

77103376

-CNIH4chr1

224553581

+
intron-3UTRENST00000528203ENST00000366856PAK1chr11

77103376

-CNIH4chr1

224553581

+
intron-3CDSENST00000525542ENST00000465271PAK1chr11

77103376

-CNIH4chr1

224553581

+
intron-3CDSENST00000525542ENST00000366858PAK1chr11

77103376

-CNIH4chr1

224553581

+
intron-3CDSENST00000525542ENST00000366857PAK1chr11

77103376

-CNIH4chr1

224553581

+
intron-3UTRENST00000525542ENST00000468318PAK1chr11

77103376

-CNIH4chr1

224553581

+
intron-3UTRENST00000525542ENST00000366856PAK1chr11

77103376

-CNIH4chr1

224553581

+

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FusionProtFeatures for PAK1_CNIH4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAK1

Q13153

CNIH4

Q9P003

Protein kinase involved in intracellular signalingpathways downstream of integrins and receptor-type kinases thatplays an important role in cytoskeleton dynamics, in celladhesion, migration, proliferation, apoptosis, mitosis, and invesicle-mediated transport processes. Can directly phosphorylateBAD and protects cells against apoptosis. Activated by interactionwith CDC42 and RAC1. Functions as GTPase effector that links theRho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway.Phosphorylates and activates MAP2K1, and thereby mediatesactivation of downstream MAP kinases. Involved in thereorganization of the actin cytoskeleton, actin stress fibers andof focal adhesion complexes. Phosphorylates the tubulin chaperoneTBCB and thereby plays a role in the regulation of microtubulebiogenesis and organization of the tubulin cytoskeleton. Plays arole in the regulation of insulin secretion in response toelevated glucose levels. Part of a ternary complex that containsPAK1, DVL1 and MUSK that is important for MUSK-dependentregulation of AChR clustering during the formation of theneuromuscular junction (NMJ). Activity is inhibited in cellsundergoing apoptosis, potentially due to binding of CDC2L1 andCDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338'and 'Ser-339' resulting in: activation of RAF1, stimulation ofRAF1 translocation to mitochondria, phosphorylation of BAD byRAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246'promoting its transcriptional repressor activity by increasing itsaccumulation in the nucleus. In podocytes, promotes NR3C2 nuclearlocalization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for theup-regulation of ACKR2 from endosomal compartment to cellmembrane, increasing its efficiency in chemokine uptake anddegradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1phosphorylation and inactivation. Plays a role in RUFY3-mediatedfacilitating gastric cancer cells migration and invasion(PubMed:25766321). {ECO:0000269|PubMed:10551809,ECO:0000269|PubMed:11733498, ECO:0000269|PubMed:12624090,ECO:0000269|PubMed:12876277, ECO:0000269|PubMed:14585966,ECO:0000269|PubMed:15611088, ECO:0000269|PubMed:15831477,ECO:0000269|PubMed:15833848, ECO:0000269|PubMed:16278681,ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089,ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:23633677,ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:8805275,ECO:0000269|PubMed:9032240, ECO:0000269|PubMed:9395435,ECO:0000269|PubMed:9528787}. Involved in G protein-coupled receptors (GPCRs)trafficking from the endoplasmic reticulum to the cell surface; itpromotes the exit of GPCRs from the early secretory pathway,likely through interaction with the COPII machinery(PubMed:24405750). {ECO:0000269|PubMed:24405750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCNIH4chr11:77103376chr1:224553581ENST00000366857+14118_1384693TransmembraneHelical
TgeneCNIH4chr11:77103376chr1:224553581ENST00000366857+1457_774693TransmembraneHelical
TgeneCNIH4chr11:77103376chr1:224553581ENST00000465271+15118_13846140TransmembraneHelical
TgeneCNIH4chr11:77103376chr1:224553581ENST00000465271+1557_7746140TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAK1chr11:77103376chr1:224553581ENST00000278568-216270_52163554DomainProtein kinase
HgenePAK1chr11:77103376chr1:224553581ENST00000278568-21675_8863554DomainCRIB
HgenePAK1chr11:77103376chr1:224553581ENST00000356341-215270_52163546DomainProtein kinase
HgenePAK1chr11:77103376chr1:224553581ENST00000356341-21575_8863546DomainCRIB
HgenePAK1chr11:77103376chr1:224553581ENST00000278568-216276_28463554Nucleotide bindingNote=ATP
HgenePAK1chr11:77103376chr1:224553581ENST00000278568-216345_34763554Nucleotide bindingNote=ATP
HgenePAK1chr11:77103376chr1:224553581ENST00000356341-215276_28463546Nucleotide bindingNote=ATP
HgenePAK1chr11:77103376chr1:224553581ENST00000356341-215345_34763546Nucleotide bindingNote=ATP
HgenePAK1chr11:77103376chr1:224553581ENST00000278568-21670_14063554RegionNote=Autoregulatory region
HgenePAK1chr11:77103376chr1:224553581ENST00000278568-21675_10563554RegionNote=GTPase-binding
HgenePAK1chr11:77103376chr1:224553581ENST00000356341-21570_14063546RegionNote=Autoregulatory region
HgenePAK1chr11:77103376chr1:224553581ENST00000356341-21575_10563546RegionNote=GTPase-binding
TgeneCNIH4chr11:77103376chr1:224553581ENST00000366857+145_254693TransmembraneHelical
TgeneCNIH4chr11:77103376chr1:224553581ENST00000465271+155_2546140TransmembraneHelical


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FusionGeneSequence for PAK1_CNIH4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PAK1_ENST00000356341_chr11_77103376_-_CNIH4_ENST00000465271_chr1_224553581_+_157aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKMGNSRIDWPYHCHCITAHVIALVHLPS

>In-frame_PAK1_ENST00000356341_chr11_77103376_-_CNIH4_ENST00000366858_chr1_224553581_+_108aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKMGNSRIDWPYHCHCITAHVIALVHLPS

>In-frame_PAK1_ENST00000356341_chr11_77103376_-_CNIH4_ENST00000366857_chr1_224553581_+_110aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKMGNSRIDWPYHCHCITAHVIALVHLPS

>In-frame_PAK1_ENST00000278568_chr11_77103376_-_CNIH4_ENST00000465271_chr1_224553581_+_157aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKMGNSRIDWPYHCHCITAHVIALVHLPS

>In-frame_PAK1_ENST00000278568_chr11_77103376_-_CNIH4_ENST00000366858_chr1_224553581_+_108aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKMGNSRIDWPYHCHCITAHVIALVHLPS

>In-frame_PAK1_ENST00000278568_chr11_77103376_-_CNIH4_ENST00000366857_chr1_224553581_+_110aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKMGNSRIDWPYHCHCITAHVIALVHLPS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PAK1_ENST00000356341_chr11_77103376_-_CNIH4_ENST00000465271_chr1_224553581_+_472nt
ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT
GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT
GGAGATAAAATGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCT
CAACTTACCTGTTGCCACTTGGAATATATATCGATACATTATGGTGCCGAGTGGTAACATGGGAGTGTTTGATCCAACAGAAATACACAA
TCGAGGGCAGCTGAAGTCACACATGAAAGAAGCCATGATCAAGCTTGGTTTCCACTTGCTCTGCTTCTTCATGTATCTTTATAGTATGAT

>In-frame_PAK1_ENST00000356341_chr11_77103376_-_CNIH4_ENST00000366858_chr1_224553581_+_325nt
ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT
GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT
GGAGATAAAATGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCT

>In-frame_PAK1_ENST00000356341_chr11_77103376_-_CNIH4_ENST00000366857_chr1_224553581_+_331nt
ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT
GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT
GGAGATAAAATGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCT

>In-frame_PAK1_ENST00000278568_chr11_77103376_-_CNIH4_ENST00000465271_chr1_224553581_+_472nt
ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT
GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT
GGAGATAAAATGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCT
CAACTTACCTGTTGCCACTTGGAATATATATCGATACATTATGGTGCCGAGTGGTAACATGGGAGTGTTTGATCCAACAGAAATACACAA
TCGAGGGCAGCTGAAGTCACACATGAAAGAAGCCATGATCAAGCTTGGTTTCCACTTGCTCTGCTTCTTCATGTATCTTTATAGTATGAT

>In-frame_PAK1_ENST00000278568_chr11_77103376_-_CNIH4_ENST00000366858_chr1_224553581_+_325nt
ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT
GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT
GGAGATAAAATGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCT

>In-frame_PAK1_ENST00000278568_chr11_77103376_-_CNIH4_ENST00000366857_chr1_224553581_+_331nt
ATGTCAAATAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGAT
GCTGGAACCCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCT
GGAGATAAAATGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PAK1_ENST00000356341_chr11_77103376_-_CNIH4_ENST00000465271_chr1_224553581_+_4634nt
GCCCTCCCGCGGCTGCAGCCGGAGCCGAAGGTGGTGGCTGCACAGTAGACGCCCCCTCACGGCTTCCCCCACACGCTCCCGCCCCCTCGC
TCGCCCATCGCGCTTCCCTCACAGGCTCTGCAGTCCTCCCCCACAGACGCCTTCCCCCTTGGACTCTCATTCCCTTTTCCACGGAGCCCC
GCGCTTTCGTGAGCCCCCTCGAGGAACCTGGTCTCCGCATCCAGTTACCACCTCCTGCCTCAGAGGCCATCTGAGCCCTTCGCACCTCGC
CCCTCAGTCCCCCCTTCCCCCCCCGCCCGCGTCGCCTCGCTCCCTCCCGCCCCCCCATCATCCCTTCCCTCGCAGTTCCCCTGTCCTGAG
GGGAGCCCCGCCACGGGCAGCGCGGCGGCGGCGGCAGGAGGGAGAAAGTGAAGCGGTAGCTCGCGCACACTCGCGCCCTCACTCCCGGCT
AGGCGGCACCCACCGCCGGGAGGAGGAGGAGGAGCCGAGAGGAGCTGAGCGAGCGCGGAAGTAGCTGCTGCTGGTGGTGACAATGTCAAA
TAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAAC
CCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAA
AATGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTAC
CTGTTGCCACTTGGAATATATATCGATACATTATGGTGCCGAGTGGTAACATGGGAGTGTTTGATCCAACAGAAATACACAATCGAGGGC
AGCTGAAGTCACACATGAAAGAAGCCATGATCAAGCTTGGTTTCCACTTGCTCTGCTTCTTCATGTATCTTTATAGTATGATCTTAGCTT
TGATAAATGACTGAAGCTGGAGAAGCCGTGGTTGAAGTCAGCCTACACTACAGTGCACAGTTGAGGAGCCAGAGACTTCTTAAATCATCC
TTAGAACCGTGACCATAGCAGTATATATTTTCCTCTTGGAACAAAAAACTATTTTTGCTGTATTTTTACCATATAAAGTATTTAAAAAAC
ATGAATTGAGTTTCTGTAGATTTCTAGTTCTCAACTTTAGCCTGAACGCCAACACTTGAAGGTGTTTTTCATCCTCTGTATGTTGAAGGT
GGTTATTTGTATGTAGGAACAGGACTGCCATCCCAGCTTTGCATGCCAAAGAAATAAAGAACACACTTTAAAGGGCAAACTGAAGAGATG
AGCGAGCAAAGGTGCCCTTCAGGTCTACTGAAAAGTTAGAGTACAAAACAACACTGTTGATCTGGACAAAAGAAGAAAAATTACCCTTTT
TGCTTGTGTTGTGACAACTTCATTTAATATGGTTTAAAGATTTATGAGACTGTCAGCTAAAAGTCTTTTCACAAGAATGTCAACAGAGAA
TGGCATCTCAAAATATATATATTTCTTTGCACAATTTGTGAAACCTTATAAGCCATTTTCCCCAGGTACAATGTAGTTCCTGCTGATAGA
AAGGAAATATTTTGTCAAGAGCTTTCATTTAAAAGCTACTACCTCCACAATCACCCCCAAACCCAGAAAATCCCCACTGGCTCTTGCCAG
TCTGGTTTTCGTATTGCAGTTATTCCAATTGTATTTGATCTCCCTGATAACGTATTTTCATGGGTTTGGGTAGAAGATGCTAATCAGATT
AGAAGCAGGAATAGTTATTTGCTGTCTGTGAAATTGAGCCTTTTGGTGCGCCACGTGGTGCCAGATCAACACTTCTATCCCTCTGCACTG
ACCACGTTGTGAACTGGGAGACCAAATGCAAGCCATTTCATGGACATAGCAATATACAACCAAACTCTGTTCCTTGGAGTTATATTGTAA
ACTCTTGCAGGTGGGAGAGCAGTTCACCTCCTTAGCTCTGTTTGCCAGCTCTTACAGGGTAAAATAAACCTGGCAATTTATCCTCAGTCC
TAGTTTGTGGTTTAATGTTGCTATCTTAAGCACTGGCATTTGGGCAAAACATGACTGTGTTCTGTGGGAGAATCCAAAGGCATTATTCAC
TCTAGTTGAGATAGAATTGGGTGGCTAAACAGGGTGTGTGGTACCCAAAAGATTAAATGTTACATGTCCTTTTAGTCCTTGACCAGGTCT
AGCCTTGGCAGAAGCAAGGGAGCCACTAAGCCAAACTCCCTGTGCAGACAGACCATGTTTCAAGGCTGGAAGTAGTGCCCTGGCAACACA
CAAAAGGAACGGTGAAATGGTAGGCAAAGTGAACTTGGCTCTGCTGGCCTCTTTGGGGTCACAGAAATTGCTCCTTGTGGTAATCTTATA
TTTCTGTCAGGCACAGGGCCAAGAAGCTGTGTAACAGACATTACTTTGCTTGCATCTCTTTTTCATACCTTTTCCCTCTGAGGCAGCTTT
TGCTTAGAAAACAGTCCCTTCACTCTGCCTTTCCTCCTAACTTCCTGTGCCTCTTCATGTTCTGCTCAAGCTTTTTAAAGCAACGAAGCT
GTTGGAGAACTTAAATCCTTGCAACTGAGAGATAAGCTACTTAAAGGCGGTAGAGATCTTTTTTTTTTTTTTTTTGAGATGGGGTCTTGC
TGTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCTGCTTTCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTC
CCAAGTAGCTGGGATTACGGCTAGCTACTCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCT
CAAACTCCTGACCTCAAACGATCTGCCTGCCTTGGTCTCCCAAAGTGCTGGGATTATAGGTGTGAGCCACTGCGCCTGGCCATGTAGATG
ACTTTTGACCAAAATGTTTCACCTTCTCATTCAGATATTCTTAGTAACCAAAACAGTGACTCATGCAGTTGAGAGAGCCTTTGGGCTGTC
AGTTTACAGTACATCAGGCTTGCTGAGGCTAAGCAAATCAGAAAGGTGCCATGTTTATAACAGAGGTCAAAGCTCCTTACTTCTGAAACA
TTAGCTGTGGTTAAAAACAAAAACTCTTCCTTCTTGTATTGCTTGTCTATCAAAGCCAGGAAAGTGGGGGATCACTGTAGTTAAATTTTT
TTTTTTTTTAATTAGAGACAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCACTGGCGCAATCGTGGTACACTGCAGCCTTGAACTCCTG
GACTCAAGCAGTCCTCCTGCCTCAGCTTCCCAAGTAGTTGGGAGTAGGTGCACACCACCATGCCCAGCGAATTTTTTGTAGAGACAGAGG
TCTTGCTATGTTGCCTAGGCTGGTATCAAAATTACTGGCCTCAAGCGATTCTCCTGCCTCGGCCTCCCAGATGTTGGGATTACTGGTGTG
AGCCACCACGCCCAGCTCAAAAACAATTTTTTTAGGGGCACTTCTACAAATCATGAAAGGGGGATAAAAGCACTGACTTTAAAAAGCCAT
GTTTAAGATGCTATAAATGTTCTCCCCTTTTCATTGATTGGAGAGTTGTAGAGGACCTTAGAGATCATTTTGTCTAACTCCCTCATCCCA
AAGATAAACTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAAC
TGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGT
GTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCG
TTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCT
AGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCTTAGTCCAGTGTTCTCTCTCCCTTACCACTCCTCTTCCCCTTC
CCTCTATAATGGCAGTACCCAGGGCCCGGTCCATAGACTACTATCGAGTGCTCCTATGTGCATCTTAGTACGTATCATTTTCCCTTGCCT
TTTTCCTTCTATCCTTTCAGTGGTAGCAACTGCCCTTGCTAATCACCGTAACCTCGGCTGAGAAAGAAGAGGAAGCGAAATCCAAGATGC
AGCTCAGTTCATCAAAGCCTAGCAGGTCCCCTCAGCTGCCTTTTCATGCCTGCCACAGACTACAGTAGGACAAAACCTGACCTGGTCTTT
GAAGTTAAGAGCTAAGAAAGCTTCCTATAGTAGTATCTCCCATGGCACTTACCACATTCTATCTGGTATTACAGTTATTTGTATGCAATT
AATCACTCTTAGATTGTATGTTCCTGGAGGGCAGAATATGCCCATTCATATTTGTATCTTCTTCCTTCTGCTCTTGGCACCTAACACAGT

>In-frame_PAK1_ENST00000356341_chr11_77103376_-_CNIH4_ENST00000366858_chr1_224553581_+_1219nt
GCCCTCCCGCGGCTGCAGCCGGAGCCGAAGGTGGTGGCTGCACAGTAGACGCCCCCTCACGGCTTCCCCCACACGCTCCCGCCCCCTCGC
TCGCCCATCGCGCTTCCCTCACAGGCTCTGCAGTCCTCCCCCACAGACGCCTTCCCCCTTGGACTCTCATTCCCTTTTCCACGGAGCCCC
GCGCTTTCGTGAGCCCCCTCGAGGAACCTGGTCTCCGCATCCAGTTACCACCTCCTGCCTCAGAGGCCATCTGAGCCCTTCGCACCTCGC
CCCTCAGTCCCCCCTTCCCCCCCCGCCCGCGTCGCCTCGCTCCCTCCCGCCCCCCCATCATCCCTTCCCTCGCAGTTCCCCTGTCCTGAG
GGGAGCCCCGCCACGGGCAGCGCGGCGGCGGCGGCAGGAGGGAGAAAGTGAAGCGGTAGCTCGCGCACACTCGCGCCCTCACTCCCGGCT
AGGCGGCACCCACCGCCGGGAGGAGGAGGAGGAGCCGAGAGGAGCTGAGCGAGCGCGGAAGTAGCTGCTGCTGGTGGTGACAATGTCAAA
TAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAAC
CCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAA
AATGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTAC
CTGTTGCCACTTGGAATATATATCGTGGTAGCAACTGCCCTTGCTAATCACCGTAACCTCGGCTGAGAAAGAAGAGGAAGCGAAATCCAA
GATGCAGCTCAGTTCATCAAAGCCTAGCAGGTCCCCTCAGCTGCCTTTTCATGCCTGCCACAGACTACAGTAGGACAAAACCTGACCTGG
TCTTTGAAGTTAAGAGCTAAGAAAGCTTCCTATAGTAGTATCTCCCATGGCACTTACCACATTCTATCTGGTATTACAGTTATTTGTATG
CAATTAATCACTCTTAGATTGTATGTTCCTGGAGGGCAGAATATGCCCATTCATATTTGTATCTTCTTCCTTCTGCTCTTGGCACCTAAC

>In-frame_PAK1_ENST00000356341_chr11_77103376_-_CNIH4_ENST00000366857_chr1_224553581_+_4493nt
GCCCTCCCGCGGCTGCAGCCGGAGCCGAAGGTGGTGGCTGCACAGTAGACGCCCCCTCACGGCTTCCCCCACACGCTCCCGCCCCCTCGC
TCGCCCATCGCGCTTCCCTCACAGGCTCTGCAGTCCTCCCCCACAGACGCCTTCCCCCTTGGACTCTCATTCCCTTTTCCACGGAGCCCC
GCGCTTTCGTGAGCCCCCTCGAGGAACCTGGTCTCCGCATCCAGTTACCACCTCCTGCCTCAGAGGCCATCTGAGCCCTTCGCACCTCGC
CCCTCAGTCCCCCCTTCCCCCCCCGCCCGCGTCGCCTCGCTCCCTCCCGCCCCCCCATCATCCCTTCCCTCGCAGTTCCCCTGTCCTGAG
GGGAGCCCCGCCACGGGCAGCGCGGCGGCGGCGGCAGGAGGGAGAAAGTGAAGCGGTAGCTCGCGCACACTCGCGCCCTCACTCCCGGCT
AGGCGGCACCCACCGCCGGGAGGAGGAGGAGGAGCCGAGAGGAGCTGAGCGAGCGCGGAAGTAGCTGCTGCTGGTGGTGACAATGTCAAA
TAACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAAC
CCTAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAA
AATGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTAC
CTGTTGCCACTTGGAATATATATCGTATGATCTTAGCTTTGATAAATGACTGAAGCTGGAGAAGCCGTGGTTGAAGTCAGCCTACACTAC
AGTGCACAGTTGAGGAGCCAGAGACTTCTTAAATCATCCTTAGAACCGTGACCATAGCAGTATATATTTTCCTCTTGGAACAAAAAACTA
TTTTTGCTGTATTTTTACCATATAAAGTATTTAAAAAACATGAATTGAGTTTCTGTAGATTTCTAGTTCTCAACTTTAGCCTGAACGCCA
ACACTTGAAGGTGTTTTTCATCCTCTGTATGTTGAAGGTGGTTATTTGTATGTAGGAACAGGACTGCCATCCCAGCTTTGCATGCCAAAG
AAATAAAGAACACACTTTAAAGGGCAAACTGAAGAGATGAGCGAGCAAAGGTGCCCTTCAGGTCTACTGAAAAGTTAGAGTACAAAACAA
CACTGTTGATCTGGACAAAAGAAGAAAAATTACCCTTTTTGCTTGTGTTGTGACAACTTCATTTAATATGGTTTAAAGATTTATGAGACT
GTCAGCTAAAAGTCTTTTCACAAGAATGTCAACAGAGAATGGCATCTCAAAATATATATATTTCTTTGCACAATTTGTGAAACCTTATAA
GCCATTTTCCCCAGGTACAATGTAGTTCCTGCTGATAGAAAGGAAATATTTTGTCAAGAGCTTTCATTTAAAAGCTACTACCTCCACAAT
CACCCCCAAACCCAGAAAATCCCCACTGGCTCTTGCCAGTCTGGTTTTCGTATTGCAGTTATTCCAATTGTATTTGATCTCCCTGATAAC
GTATTTTCATGGGTTTGGGTAGAAGATGCTAATCAGATTAGAAGCAGGAATAGTTATTTGCTGTCTGTGAAATTGAGCCTTTTGGTGCGC
CACGTGGTGCCAGATCAACACTTCTATCCCTCTGCACTGACCACGTTGTGAACTGGGAGACCAAATGCAAGCCATTTCATGGACATAGCA
ATATACAACCAAACTCTGTTCCTTGGAGTTATATTGTAAACTCTTGCAGGTGGGAGAGCAGTTCACCTCCTTAGCTCTGTTTGCCAGCTC
TTACAGGGTAAAATAAACCTGGCAATTTATCCTCAGTCCTAGTTTGTGGTTTAATGTTGCTATCTTAAGCACTGGCATTTGGGCAAAACA
TGACTGTGTTCTGTGGGAGAATCCAAAGGCATTATTCACTCTAGTTGAGATAGAATTGGGTGGCTAAACAGGGTGTGTGGTACCCAAAAG
ATTAAATGTTACATGTCCTTTTAGTCCTTGACCAGGTCTAGCCTTGGCAGAAGCAAGGGAGCCACTAAGCCAAACTCCCTGTGCAGACAG
ACCATGTTTCAAGGCTGGAAGTAGTGCCCTGGCAACACACAAAAGGAACGGTGAAATGGTAGGCAAAGTGAACTTGGCTCTGCTGGCCTC
TTTGGGGTCACAGAAATTGCTCCTTGTGGTAATCTTATATTTCTGTCAGGCACAGGGCCAAGAAGCTGTGTAACAGACATTACTTTGCTT
GCATCTCTTTTTCATACCTTTTCCCTCTGAGGCAGCTTTTGCTTAGAAAACAGTCCCTTCACTCTGCCTTTCCTCCTAACTTCCTGTGCC
TCTTCATGTTCTGCTCAAGCTTTTTAAAGCAACGAAGCTGTTGGAGAACTTAAATCCTTGCAACTGAGAGATAAGCTACTTAAAGGCGGT
AGAGATCTTTTTTTTTTTTTTTTTGAGATGGGGTCTTGCTGTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCT
CTGCTTTCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACGGCTAGCTACTCCTGGCTAATTTTTGTATTTTT
AGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAACGATCTGCCTGCCTTGGTCTCCCAAAGTGCTGG
GATTATAGGTGTGAGCCACTGCGCCTGGCCATGTAGATGACTTTTGACCAAAATGTTTCACCTTCTCATTCAGATATTCTTAGTAACCAA
AACAGTGACTCATGCAGTTGAGAGAGCCTTTGGGCTGTCAGTTTACAGTACATCAGGCTTGCTGAGGCTAAGCAAATCAGAAAGGTGCCA
TGTTTATAACAGAGGTCAAAGCTCCTTACTTCTGAAACATTAGCTGTGGTTAAAAACAAAAACTCTTCCTTCTTGTATTGCTTGTCTATC
AAAGCCAGGAAAGTGGGGGATCACTGTAGTTAAATTTTTTTTTTTTTTAATTAGAGACAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGC
ACTGGCGCAATCGTGGTACACTGCAGCCTTGAACTCCTGGACTCAAGCAGTCCTCCTGCCTCAGCTTCCCAAGTAGTTGGGAGTAGGTGC
ACACCACCATGCCCAGCGAATTTTTTGTAGAGACAGAGGTCTTGCTATGTTGCCTAGGCTGGTATCAAAATTACTGGCCTCAAGCGATTC
TCCTGCCTCGGCCTCCCAGATGTTGGGATTACTGGTGTGAGCCACCACGCCCAGCTCAAAAACAATTTTTTTAGGGGCACTTCTACAAAT
CATGAAAGGGGGATAAAAGCACTGACTTTAAAAAGCCATGTTTAAGATGCTATAAATGTTCTCCCCTTTTCATTGATTGGAGAGTTGTAG
AGGACCTTAGAGATCATTTTGTCTAACTCCCTCATCCCAAAGATAAACTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATC
TGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTG
GGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGT
TGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTT
CAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCTTAG
TCCAGTGTTCTCTCTCCCTTACCACTCCTCTTCCCCTTCCCTCTATAATGGCAGTACCCAGGGCCCGGTCCATAGACTACTATCGAGTGC
TCCTATGTGCATCTTAGTACGTATCATTTTCCCTTGCCTTTTTCCTTCTATCCTTTCAGTGGTAGCAACTGCCCTTGCTAATCACCGTAA
CCTCGGCTGAGAAAGAAGAGGAAGCGAAATCCAAGATGCAGCTCAGTTCATCAAAGCCTAGCAGGTCCCCTCAGCTGCCTTTTCATGCCT
GCCACAGACTACAGTAGGACAAAACCTGACCTGGTCTTTGAAGTTAAGAGCTAAGAAAGCTTCCTATAGTAGTATCTCCCATGGCACTTA
CCACATTCTATCTGGTATTACAGTTATTTGTATGCAATTAATCACTCTTAGATTGTATGTTCCTGGAGGGCAGAATATGCCCATTCATAT

>In-frame_PAK1_ENST00000278568_chr11_77103376_-_CNIH4_ENST00000465271_chr1_224553581_+_4632nt
CCTCCCGCGGCTGCAGCCGGAGCCGAAGGTGGTGGCTGCACAGTAGACGCCCCCTCACGGCTTCCCCCACACGCTCCCGCCCCCTCGCTC
GCCCATCGCGCTTCCCTCACAGGCTCTGCAGTCCTCCCCCACAGACGCCTTCCCCCTTGGACTCTCATTCCCTTTTCCACGGAGCCCCGC
GCTTTCGTGAGCCCCCTCGAGGAACCTGGTCTCCGCATCCAGTTACCACCTCCTGCCTCAGAGGCCATCTGAGCCCTTCGCACCTCGCCC
CTCAGTCCCCCCTTCCCCCCCCGCCCGCGTCGCCTCGCTCCCTCCCGCCCCCCCATCATCCCTTCCCTCGCAGTTCCCCTGTCCTGAGGG
GAGCCCCGCCACGGGCAGCGCGGCGGCGGCGGCAGGAGGGAGAAAGTGAAGCGGTAGCTCGCGCACACTCGCGCCCTCACTCCCGGCTAG
GCGGCACCCACCGCCGGGAGGAGGAGGAGGAGCCGAGAGGAGCTGAGCGAGCGCGGAAGTAGCTGCTGCTGGTGGTGACAATGTCAAATA
ACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAACCC
TAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAAAA
TGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTACCT
GTTGCCACTTGGAATATATATCGATACATTATGGTGCCGAGTGGTAACATGGGAGTGTTTGATCCAACAGAAATACACAATCGAGGGCAG
CTGAAGTCACACATGAAAGAAGCCATGATCAAGCTTGGTTTCCACTTGCTCTGCTTCTTCATGTATCTTTATAGTATGATCTTAGCTTTG
ATAAATGACTGAAGCTGGAGAAGCCGTGGTTGAAGTCAGCCTACACTACAGTGCACAGTTGAGGAGCCAGAGACTTCTTAAATCATCCTT
AGAACCGTGACCATAGCAGTATATATTTTCCTCTTGGAACAAAAAACTATTTTTGCTGTATTTTTACCATATAAAGTATTTAAAAAACAT
GAATTGAGTTTCTGTAGATTTCTAGTTCTCAACTTTAGCCTGAACGCCAACACTTGAAGGTGTTTTTCATCCTCTGTATGTTGAAGGTGG
TTATTTGTATGTAGGAACAGGACTGCCATCCCAGCTTTGCATGCCAAAGAAATAAAGAACACACTTTAAAGGGCAAACTGAAGAGATGAG
CGAGCAAAGGTGCCCTTCAGGTCTACTGAAAAGTTAGAGTACAAAACAACACTGTTGATCTGGACAAAAGAAGAAAAATTACCCTTTTTG
CTTGTGTTGTGACAACTTCATTTAATATGGTTTAAAGATTTATGAGACTGTCAGCTAAAAGTCTTTTCACAAGAATGTCAACAGAGAATG
GCATCTCAAAATATATATATTTCTTTGCACAATTTGTGAAACCTTATAAGCCATTTTCCCCAGGTACAATGTAGTTCCTGCTGATAGAAA
GGAAATATTTTGTCAAGAGCTTTCATTTAAAAGCTACTACCTCCACAATCACCCCCAAACCCAGAAAATCCCCACTGGCTCTTGCCAGTC
TGGTTTTCGTATTGCAGTTATTCCAATTGTATTTGATCTCCCTGATAACGTATTTTCATGGGTTTGGGTAGAAGATGCTAATCAGATTAG
AAGCAGGAATAGTTATTTGCTGTCTGTGAAATTGAGCCTTTTGGTGCGCCACGTGGTGCCAGATCAACACTTCTATCCCTCTGCACTGAC
CACGTTGTGAACTGGGAGACCAAATGCAAGCCATTTCATGGACATAGCAATATACAACCAAACTCTGTTCCTTGGAGTTATATTGTAAAC
TCTTGCAGGTGGGAGAGCAGTTCACCTCCTTAGCTCTGTTTGCCAGCTCTTACAGGGTAAAATAAACCTGGCAATTTATCCTCAGTCCTA
GTTTGTGGTTTAATGTTGCTATCTTAAGCACTGGCATTTGGGCAAAACATGACTGTGTTCTGTGGGAGAATCCAAAGGCATTATTCACTC
TAGTTGAGATAGAATTGGGTGGCTAAACAGGGTGTGTGGTACCCAAAAGATTAAATGTTACATGTCCTTTTAGTCCTTGACCAGGTCTAG
CCTTGGCAGAAGCAAGGGAGCCACTAAGCCAAACTCCCTGTGCAGACAGACCATGTTTCAAGGCTGGAAGTAGTGCCCTGGCAACACACA
AAAGGAACGGTGAAATGGTAGGCAAAGTGAACTTGGCTCTGCTGGCCTCTTTGGGGTCACAGAAATTGCTCCTTGTGGTAATCTTATATT
TCTGTCAGGCACAGGGCCAAGAAGCTGTGTAACAGACATTACTTTGCTTGCATCTCTTTTTCATACCTTTTCCCTCTGAGGCAGCTTTTG
CTTAGAAAACAGTCCCTTCACTCTGCCTTTCCTCCTAACTTCCTGTGCCTCTTCATGTTCTGCTCAAGCTTTTTAAAGCAACGAAGCTGT
TGGAGAACTTAAATCCTTGCAACTGAGAGATAAGCTACTTAAAGGCGGTAGAGATCTTTTTTTTTTTTTTTTTGAGATGGGGTCTTGCTG
TGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCTGCTTTCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCC
AAGTAGCTGGGATTACGGCTAGCTACTCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCA
AACTCCTGACCTCAAACGATCTGCCTGCCTTGGTCTCCCAAAGTGCTGGGATTATAGGTGTGAGCCACTGCGCCTGGCCATGTAGATGAC
TTTTGACCAAAATGTTTCACCTTCTCATTCAGATATTCTTAGTAACCAAAACAGTGACTCATGCAGTTGAGAGAGCCTTTGGGCTGTCAG
TTTACAGTACATCAGGCTTGCTGAGGCTAAGCAAATCAGAAAGGTGCCATGTTTATAACAGAGGTCAAAGCTCCTTACTTCTGAAACATT
AGCTGTGGTTAAAAACAAAAACTCTTCCTTCTTGTATTGCTTGTCTATCAAAGCCAGGAAAGTGGGGGATCACTGTAGTTAAATTTTTTT
TTTTTTTAATTAGAGACAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCACTGGCGCAATCGTGGTACACTGCAGCCTTGAACTCCTGGA
CTCAAGCAGTCCTCCTGCCTCAGCTTCCCAAGTAGTTGGGAGTAGGTGCACACCACCATGCCCAGCGAATTTTTTGTAGAGACAGAGGTC
TTGCTATGTTGCCTAGGCTGGTATCAAAATTACTGGCCTCAAGCGATTCTCCTGCCTCGGCCTCCCAGATGTTGGGATTACTGGTGTGAG
CCACCACGCCCAGCTCAAAAACAATTTTTTTAGGGGCACTTCTACAAATCATGAAAGGGGGATAAAAGCACTGACTTTAAAAAGCCATGT
TTAAGATGCTATAAATGTTCTCCCCTTTTCATTGATTGGAGAGTTGTAGAGGACCTTAGAGATCATTTTGTCTAACTCCCTCATCCCAAA
GATAAACTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTG
GGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGT
TGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTT
CAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAG
AGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCTTAGTCCAGTGTTCTCTCTCCCTTACCACTCCTCTTCCCCTTCCC
TCTATAATGGCAGTACCCAGGGCCCGGTCCATAGACTACTATCGAGTGCTCCTATGTGCATCTTAGTACGTATCATTTTCCCTTGCCTTT
TTCCTTCTATCCTTTCAGTGGTAGCAACTGCCCTTGCTAATCACCGTAACCTCGGCTGAGAAAGAAGAGGAAGCGAAATCCAAGATGCAG
CTCAGTTCATCAAAGCCTAGCAGGTCCCCTCAGCTGCCTTTTCATGCCTGCCACAGACTACAGTAGGACAAAACCTGACCTGGTCTTTGA
AGTTAAGAGCTAAGAAAGCTTCCTATAGTAGTATCTCCCATGGCACTTACCACATTCTATCTGGTATTACAGTTATTTGTATGCAATTAA
TCACTCTTAGATTGTATGTTCCTGGAGGGCAGAATATGCCCATTCATATTTGTATCTTCTTCCTTCTGCTCTTGGCACCTAACACAGTGC

>In-frame_PAK1_ENST00000278568_chr11_77103376_-_CNIH4_ENST00000366858_chr1_224553581_+_1217nt
CCTCCCGCGGCTGCAGCCGGAGCCGAAGGTGGTGGCTGCACAGTAGACGCCCCCTCACGGCTTCCCCCACACGCTCCCGCCCCCTCGCTC
GCCCATCGCGCTTCCCTCACAGGCTCTGCAGTCCTCCCCCACAGACGCCTTCCCCCTTGGACTCTCATTCCCTTTTCCACGGAGCCCCGC
GCTTTCGTGAGCCCCCTCGAGGAACCTGGTCTCCGCATCCAGTTACCACCTCCTGCCTCAGAGGCCATCTGAGCCCTTCGCACCTCGCCC
CTCAGTCCCCCCTTCCCCCCCCGCCCGCGTCGCCTCGCTCCCTCCCGCCCCCCCATCATCCCTTCCCTCGCAGTTCCCCTGTCCTGAGGG
GAGCCCCGCCACGGGCAGCGCGGCGGCGGCGGCAGGAGGGAGAAAGTGAAGCGGTAGCTCGCGCACACTCGCGCCCTCACTCCCGGCTAG
GCGGCACCCACCGCCGGGAGGAGGAGGAGGAGCCGAGAGGAGCTGAGCGAGCGCGGAAGTAGCTGCTGCTGGTGGTGACAATGTCAAATA
ACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAACCC
TAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAAAA
TGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTACCT
GTTGCCACTTGGAATATATATCGTGGTAGCAACTGCCCTTGCTAATCACCGTAACCTCGGCTGAGAAAGAAGAGGAAGCGAAATCCAAGA
TGCAGCTCAGTTCATCAAAGCCTAGCAGGTCCCCTCAGCTGCCTTTTCATGCCTGCCACAGACTACAGTAGGACAAAACCTGACCTGGTC
TTTGAAGTTAAGAGCTAAGAAAGCTTCCTATAGTAGTATCTCCCATGGCACTTACCACATTCTATCTGGTATTACAGTTATTTGTATGCA
ATTAATCACTCTTAGATTGTATGTTCCTGGAGGGCAGAATATGCCCATTCATATTTGTATCTTCTTCCTTCTGCTCTTGGCACCTAACAC

>In-frame_PAK1_ENST00000278568_chr11_77103376_-_CNIH4_ENST00000366857_chr1_224553581_+_4491nt
CCTCCCGCGGCTGCAGCCGGAGCCGAAGGTGGTGGCTGCACAGTAGACGCCCCCTCACGGCTTCCCCCACACGCTCCCGCCCCCTCGCTC
GCCCATCGCGCTTCCCTCACAGGCTCTGCAGTCCTCCCCCACAGACGCCTTCCCCCTTGGACTCTCATTCCCTTTTCCACGGAGCCCCGC
GCTTTCGTGAGCCCCCTCGAGGAACCTGGTCTCCGCATCCAGTTACCACCTCCTGCCTCAGAGGCCATCTGAGCCCTTCGCACCTCGCCC
CTCAGTCCCCCCTTCCCCCCCCGCCCGCGTCGCCTCGCTCCCTCCCGCCCCCCCATCATCCCTTCCCTCGCAGTTCCCCTGTCCTGAGGG
GAGCCCCGCCACGGGCAGCGCGGCGGCGGCGGCAGGAGGGAGAAAGTGAAGCGGTAGCTCGCGCACACTCGCGCCCTCACTCCCGGCTAG
GCGGCACCCACCGCCGGGAGGAGGAGGAGGAGCCGAGAGGAGCTGAGCGAGCGCGGAAGTAGCTGCTGCTGGTGGTGACAATGTCAAATA
ACGGCCTAGACATTCAAGACAAACCCCCAGCCCCTCCGATGAGAAATACCAGCACTATGATTGGAGCCGGCAGCAAAGATGCTGGAACCC
TAAACCATGGTTCTAAACCTCTGCCTCCAAACCCAGAGGAGAAGAAAAAGAAGGACCGATTTTACCGATCCATTTTACCTGGAGATAAAA
TGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTACCT
GTTGCCACTTGGAATATATATCGTATGATCTTAGCTTTGATAAATGACTGAAGCTGGAGAAGCCGTGGTTGAAGTCAGCCTACACTACAG
TGCACAGTTGAGGAGCCAGAGACTTCTTAAATCATCCTTAGAACCGTGACCATAGCAGTATATATTTTCCTCTTGGAACAAAAAACTATT
TTTGCTGTATTTTTACCATATAAAGTATTTAAAAAACATGAATTGAGTTTCTGTAGATTTCTAGTTCTCAACTTTAGCCTGAACGCCAAC
ACTTGAAGGTGTTTTTCATCCTCTGTATGTTGAAGGTGGTTATTTGTATGTAGGAACAGGACTGCCATCCCAGCTTTGCATGCCAAAGAA
ATAAAGAACACACTTTAAAGGGCAAACTGAAGAGATGAGCGAGCAAAGGTGCCCTTCAGGTCTACTGAAAAGTTAGAGTACAAAACAACA
CTGTTGATCTGGACAAAAGAAGAAAAATTACCCTTTTTGCTTGTGTTGTGACAACTTCATTTAATATGGTTTAAAGATTTATGAGACTGT
CAGCTAAAAGTCTTTTCACAAGAATGTCAACAGAGAATGGCATCTCAAAATATATATATTTCTTTGCACAATTTGTGAAACCTTATAAGC
CATTTTCCCCAGGTACAATGTAGTTCCTGCTGATAGAAAGGAAATATTTTGTCAAGAGCTTTCATTTAAAAGCTACTACCTCCACAATCA
CCCCCAAACCCAGAAAATCCCCACTGGCTCTTGCCAGTCTGGTTTTCGTATTGCAGTTATTCCAATTGTATTTGATCTCCCTGATAACGT
ATTTTCATGGGTTTGGGTAGAAGATGCTAATCAGATTAGAAGCAGGAATAGTTATTTGCTGTCTGTGAAATTGAGCCTTTTGGTGCGCCA
CGTGGTGCCAGATCAACACTTCTATCCCTCTGCACTGACCACGTTGTGAACTGGGAGACCAAATGCAAGCCATTTCATGGACATAGCAAT
ATACAACCAAACTCTGTTCCTTGGAGTTATATTGTAAACTCTTGCAGGTGGGAGAGCAGTTCACCTCCTTAGCTCTGTTTGCCAGCTCTT
ACAGGGTAAAATAAACCTGGCAATTTATCCTCAGTCCTAGTTTGTGGTTTAATGTTGCTATCTTAAGCACTGGCATTTGGGCAAAACATG
ACTGTGTTCTGTGGGAGAATCCAAAGGCATTATTCACTCTAGTTGAGATAGAATTGGGTGGCTAAACAGGGTGTGTGGTACCCAAAAGAT
TAAATGTTACATGTCCTTTTAGTCCTTGACCAGGTCTAGCCTTGGCAGAAGCAAGGGAGCCACTAAGCCAAACTCCCTGTGCAGACAGAC
CATGTTTCAAGGCTGGAAGTAGTGCCCTGGCAACACACAAAAGGAACGGTGAAATGGTAGGCAAAGTGAACTTGGCTCTGCTGGCCTCTT
TGGGGTCACAGAAATTGCTCCTTGTGGTAATCTTATATTTCTGTCAGGCACAGGGCCAAGAAGCTGTGTAACAGACATTACTTTGCTTGC
ATCTCTTTTTCATACCTTTTCCCTCTGAGGCAGCTTTTGCTTAGAAAACAGTCCCTTCACTCTGCCTTTCCTCCTAACTTCCTGTGCCTC
TTCATGTTCTGCTCAAGCTTTTTAAAGCAACGAAGCTGTTGGAGAACTTAAATCCTTGCAACTGAGAGATAAGCTACTTAAAGGCGGTAG
AGATCTTTTTTTTTTTTTTTTTGAGATGGGGTCTTGCTGTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCT
GCTTTCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACGGCTAGCTACTCCTGGCTAATTTTTGTATTTTTAG
TAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAACGATCTGCCTGCCTTGGTCTCCCAAAGTGCTGGGA
TTATAGGTGTGAGCCACTGCGCCTGGCCATGTAGATGACTTTTGACCAAAATGTTTCACCTTCTCATTCAGATATTCTTAGTAACCAAAA
CAGTGACTCATGCAGTTGAGAGAGCCTTTGGGCTGTCAGTTTACAGTACATCAGGCTTGCTGAGGCTAAGCAAATCAGAAAGGTGCCATG
TTTATAACAGAGGTCAAAGCTCCTTACTTCTGAAACATTAGCTGTGGTTAAAAACAAAAACTCTTCCTTCTTGTATTGCTTGTCTATCAA
AGCCAGGAAAGTGGGGGATCACTGTAGTTAAATTTTTTTTTTTTTTAATTAGAGACAGAGTCTTGCCCTGTCGCCCAAGCTGGAGTGCAC
TGGCGCAATCGTGGTACACTGCAGCCTTGAACTCCTGGACTCAAGCAGTCCTCCTGCCTCAGCTTCCCAAGTAGTTGGGAGTAGGTGCAC
ACCACCATGCCCAGCGAATTTTTTGTAGAGACAGAGGTCTTGCTATGTTGCCTAGGCTGGTATCAAAATTACTGGCCTCAAGCGATTCTC
CTGCCTCGGCCTCCCAGATGTTGGGATTACTGGTGTGAGCCACCACGCCCAGCTCAAAAACAATTTTTTTAGGGGCACTTCTACAAATCA
TGAAAGGGGGATAAAAGCACTGACTTTAAAAAGCCATGTTTAAGATGCTATAAATGTTCTCCCCTTTTCATTGATTGGAGAGTTGTAGAG
GACCTTAGAGATCATTTTGTCTAACTCCCTCATCCCAAAGATAAACTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTG
AATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGG
AACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTG
TAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCA
GGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCCTAGAGATCGTTCAGGGTGTTGTAACTGGGAACATCTGAATGCTGAGGCTTAGTC
CAGTGTTCTCTCTCCCTTACCACTCCTCTTCCCCTTCCCTCTATAATGGCAGTACCCAGGGCCCGGTCCATAGACTACTATCGAGTGCTC
CTATGTGCATCTTAGTACGTATCATTTTCCCTTGCCTTTTTCCTTCTATCCTTTCAGTGGTAGCAACTGCCCTTGCTAATCACCGTAACC
TCGGCTGAGAAAGAAGAGGAAGCGAAATCCAAGATGCAGCTCAGTTCATCAAAGCCTAGCAGGTCCCCTCAGCTGCCTTTTCATGCCTGC
CACAGACTACAGTAGGACAAAACCTGACCTGGTCTTTGAAGTTAAGAGCTAAGAAAGCTTCCTATAGTAGTATCTCCCATGGCACTTACC
ACATTCTATCTGGTATTACAGTTATTTGTATGCAATTAATCACTCTTAGATTGTATGTTCCTGGAGGGCAGAATATGCCCATTCATATTT


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FusionGenePPI for PAK1_CNIH4


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAK1ARHGEF2, ARPC1B, AKT1, RAC1, CDC42, CDK11A, ERBB2, ABI3, DYNLL1, PKLR, PLCG1, PAK1IP1, LIMK1, CDK5, RAF1, HGS, NCK1, ARHGEF7, MYLK, BAIAP2, NCK2, BMX, RHOJ, PAK1, SH3KBP1, HSP90AA1, YWHAG, YWHAZ, DYRK1B, ZBTB18, ZC3H7A, ZNF823, ZNF83, MYNN, C5orf42, ZNF418, HIST1H4A, TGM2, ARHGEF6, ELF3, GNB1, MAP3K1, MYO6, TGFBR1, TGFBR2, APP, CRIPAK, CHORDC1, ESR1, BAD, HIST1H3A, LYN, DYNLL2, PAK2, FBXO28, GIT1, SORBS3, BRSK1, EGFR, PYCARD, GIT2, H2AFX, SLC25A41, TAS2R41, ILKAP, PPAT, RELA, RHOU, SNW1, ICAM1, LPXN, FSD1, OR2K2, SOX2, SETX, FGB, PPM1A, PPP2CA, PPP1CA, MAPK14CNIH4TOR1A, ABCE1, UNK, TCTN2, TCTN3, GLP1R, PTPRN, PTPRO


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePAK1chr11:77103376chr1:224553581ENST00000278568-216132_27063554CRIPAK
HgenePAK1chr11:77103376chr1:224553581ENST00000356341-215132_27063546CRIPAK


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAK1_CNIH4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAK1_CNIH4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePAK1C0007134Renal Cell Carcinoma1CTD_human
HgenePAK1C0033687Proteinuria1CTD_human
HgenePAK1C1458155Mammary Neoplasms1CTD_human
TgeneCNIH4C0036341Schizophrenia1PSYGENET