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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25804

FusionGeneSummary for PAIP2_QKI

check button Fusion gene summary
Fusion gene informationFusion gene name: PAIP2_QKI
Fusion gene ID: 25804
HgeneTgene
Gene symbol

PAIP2

QKI

Gene ID

51247

9444

Gene namepoly(A) binding protein interacting protein 2QKI, KH domain containing RNA binding
SynonymsPAIP-2|PAIP2AHqk|QK|QK1|QK3|hqkI
Cytomap

5q31.2

6q26

Type of geneprotein-codingprotein-coding
Descriptionpolyadenylate-binding protein-interacting protein 2PABC1-interacting protein 2PABP-interacting protein 2polyA-binding protein-interacting protein 2protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding
Modification date2018051920180522
UniProtAcc

Q9BPZ3

Q96PU8

Ensembl transtripts involved in fusion geneENST00000265192, ENST00000511381, 
ENST00000511706, ENST00000394795, 
ENST00000510080, 		ENST00000275262, 
ENST00000392127, ENST00000453779, 
ENST00000361752, ENST00000361195, 
ENST00000424802, 
Fusion gene scores* DoF score6 X 4 X 4=9613 X 14 X 6=1092
# samples 618
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1092*10)=-2.60090404459018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PAIP2 [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAIP2

GO:0045947

negative regulation of translational initiation

11172725


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A8BX-01APAIP2chr5

138700432

+QKIchr6

163984452

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265192ENST00000275262PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000265192ENST00000392127PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000265192ENST00000453779PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000265192ENST00000361752PAIP2chr5

138700432

+QKIchr6

163984452

+
5CDS-intronENST00000265192ENST00000361195PAIP2chr5

138700432

+QKIchr6

163984452

+
5CDS-intronENST00000265192ENST00000424802PAIP2chr5

138700432

+QKIchr6

163984452

+
3UTR-3CDSENST00000511381ENST00000275262PAIP2chr5

138700432

+QKIchr6

163984452

+
3UTR-3CDSENST00000511381ENST00000392127PAIP2chr5

138700432

+QKIchr6

163984452

+
3UTR-3CDSENST00000511381ENST00000453779PAIP2chr5

138700432

+QKIchr6

163984452

+
3UTR-3CDSENST00000511381ENST00000361752PAIP2chr5

138700432

+QKIchr6

163984452

+
3UTR-intronENST00000511381ENST00000361195PAIP2chr5

138700432

+QKIchr6

163984452

+
3UTR-intronENST00000511381ENST00000424802PAIP2chr5

138700432

+QKIchr6

163984452

+
intron-3CDSENST00000511706ENST00000275262PAIP2chr5

138700432

+QKIchr6

163984452

+
intron-3CDSENST00000511706ENST00000392127PAIP2chr5

138700432

+QKIchr6

163984452

+
intron-3CDSENST00000511706ENST00000453779PAIP2chr5

138700432

+QKIchr6

163984452

+
intron-3CDSENST00000511706ENST00000361752PAIP2chr5

138700432

+QKIchr6

163984452

+
intron-intronENST00000511706ENST00000361195PAIP2chr5

138700432

+QKIchr6

163984452

+
intron-intronENST00000511706ENST00000424802PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000394795ENST00000275262PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000394795ENST00000392127PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000394795ENST00000453779PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000394795ENST00000361752PAIP2chr5

138700432

+QKIchr6

163984452

+
5CDS-intronENST00000394795ENST00000361195PAIP2chr5

138700432

+QKIchr6

163984452

+
5CDS-intronENST00000394795ENST00000424802PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000510080ENST00000275262PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000510080ENST00000392127PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000510080ENST00000453779PAIP2chr5

138700432

+QKIchr6

163984452

+
Frame-shiftENST00000510080ENST00000361752PAIP2chr5

138700432

+QKIchr6

163984452

+
5CDS-intronENST00000510080ENST00000361195PAIP2chr5

138700432

+QKIchr6

163984452

+
5CDS-intronENST00000510080ENST00000424802PAIP2chr5

138700432

+QKIchr6

163984452

+

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FusionProtFeatures for PAIP2_QKI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PAIP2

Q9BPZ3

QKI

Q96PU8

Acts as a repressor in the regulation of translationinitiation of poly(A)-containing mRNAs. Its inhibitory activity ontranslation is mediated via its action on PABPC1. Displaces theinteraction of PABPC1 with poly(A) RNA and competes with PAIP1 forbinding to PABPC1. Its association with PABPC1 results indisruption of the cytoplasmic poly(A) RNP structure organization.{ECO:0000269|PubMed:11172725}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PAIP2_QKI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PAIP2_QKI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PAIP2PABPC1, UBR5, APP, IGBP1, BAG3, RPL11, NXF1, HNRNPA1, PAIP1, SCCPDH, XPO1, TRIM25QKIHNRNPK, USP30, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED31, MED15, MED14, MED26, MED10, POLR2A, MED27, ELAVL1, PSMF1, C10orf10, FUBP3, HCLS1, PCBP2, PTBP1, PTBP2, RBM14, RBFOX2, RBPMS, RNF138, SERF2, THAP1, USH1C, RBFOX1, PCBP1, PCBP4, APP, NDUFA7, CDV3, ATXN1, FN1, U2AF2, RBM23, RALY, WDR77, HNRNPH2, QKI, DAZ1, IL7R, CARM1, SNRPA, RBM11, NABP1, HNRNPLL, OIP5, RBMX, ZACN, CYP1A1, NTRK1, EWSR1, HYPK, DUSP22, DUSP4, ATE1, RBM42, FBXW11, SLC39A12, VAC14, TRIM11, SYNCRIP, SNRNP27


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PAIP2_QKI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PAIP2_QKI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneQKIC0036341Schizophrenia5PSYGENET
TgeneQKIC0017638Glioma1CTD_human
TgeneQKIC0041696Unipolar Depression1PSYGENET
TgeneQKIC1269683Major Depressive Disorder1PSYGENET