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Fusion gene ID: 25787 |
FusionGeneSummary for PAFAH2_STMN1 |
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Fusion gene information | Fusion gene name: PAFAH2_STMN1 | Fusion gene ID: 25787 | Hgene | Tgene | Gene symbol | PAFAH2 | STMN1 | Gene ID | 5051 | 3925 |
Gene name | platelet activating factor acetylhydrolase 2 | stathmin 1 | |
Synonyms | HSD-PLA2 | C1orf215|LAP18|Lag|OP18|PP17|PP19|PR22|SMN | |
Cytomap | 1p36.11 | 1p36.11 | |
Type of gene | protein-coding | protein-coding | |
Description | platelet-activating factor acetylhydrolase 2, cytoplasmicSD-PLA2platelet-activating factor acetylhydrolase 2, 40kDaserine-dependent phospholipase A2 | stathminleukemia-associated phosphoprotein p18metablastinoncoprotein 18phosphoprotein 19phosphoprotein p19prosolinstathmin 1/oncoprotein 18testicular tissue protein Li 189transmembrane protein C1orf215 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q99487 | P16949 | |
Ensembl transtripts involved in fusion gene | ENST00000374282, ENST00000374284, ENST00000493892, | ENST00000426559, ENST00000455785, ENST00000399728, ENST00000465604, ENST00000357865, ENST00000374291, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 4=100 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PAFAH2 [Title/Abstract] AND STMN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | STMN1 | GO:0007019 | microtubule depolymerization | 9880330 |
Tgene | STMN1 | GO:0007052 | mitotic spindle organization | 9271428 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | THYM | TCGA-X7-A8D6-01A | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000374282 | ENST00000426559 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374282 | ENST00000455785 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374282 | ENST00000399728 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374282 | ENST00000465604 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374282 | ENST00000357865 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374282 | ENST00000374291 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374284 | ENST00000426559 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374284 | ENST00000455785 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374284 | ENST00000399728 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374284 | ENST00000465604 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374284 | ENST00000357865 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000374284 | ENST00000374291 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000493892 | ENST00000426559 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000493892 | ENST00000455785 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000493892 | ENST00000399728 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000493892 | ENST00000465604 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000493892 | ENST00000357865 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
intron-5UTR | ENST00000493892 | ENST00000374291 | PAFAH2 | chr1 | 26288188 | - | STMN1 | chr1 | 26231230 | - |
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FusionProtFeatures for PAFAH2_STMN1 |
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Hgene | Tgene |
PAFAH2 | STMN1 |
Has a marked selectivity for phospholipids with shortacyl chains at the sn-2 position. May share a common physiologicfunction with the plasma-type enzyme.{ECO:0000269|PubMed:9494101}. | Involved in the regulation of the microtubule (MT)filament system by destabilizing microtubules. Prevents assemblyand promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis.Involved in the control of the learned and innate fear (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PAFAH2_STMN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PAFAH2_STMN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PAFAH2 | STMN1 | TRPC5, HSPA8, SEPT2, CDK2, UBQLN4, NADK2, AHCYL1, TPM2, HPDL, NDUFV1, S100A16, SSSCA1, STIP1, VCP, VCAM1, FN1, ITGA4, PAN2, CDKN1B, BAG3, GLP1R, RLIM, HUWE1, SESTD1, SIVA1, CAMK2G, AHNAK, DUT, HN1, HN1L, IMPA2, MYO1E, NUDCD2, PFDN2, RAB1A, ATP6V1H, CDC42, EEF1D, GDI2, GRPEL1, HSPA9, HSPB1, MYL6, PDCD5, PDLIM1, PPM1G, TPM3, TRIM28, TYMS, UBQLN1, CHEK2, FOSL2, HSPA5, PIWIL1, TUBA1B, TUBB3, STAT3, FANCC, SOD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PAFAH2_STMN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PAFAH2_STMN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | STMN1 | C0011570 | Mental Depression | 3 | PSYGENET |
Tgene | STMN1 | C0011581 | Depressive disorder | 3 | PSYGENET |
Tgene | STMN1 | C0017638 | Glioma | 1 | CTD_human |
Tgene | STMN1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | STMN1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | STMN1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | STMN1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |