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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 25739

FusionGeneSummary for PACS1_STPG1

check button Fusion gene summary
Fusion gene informationFusion gene name: PACS1_STPG1
Fusion gene ID: 25739
HgeneTgene
Gene symbol

PACS1

STPG1

Gene ID

55690

90529

Gene namephosphofurin acidic cluster sorting protein 1sperm tail PG-rich repeat containing 1
SynonymsMRD17|SHMSC1orf201|MAPO2
Cytomap

11q13.1-q13.2

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionphosphofurin acidic cluster sorting protein 1PACS-1cytosolic sorting protein PACS-1O(6)-methylguanine-induced apoptosis 2O6-methylguanine-induced apoptosis 2UPF0490 protein C1orf201sperm-tail PG-rich repeat-containing protein 1
Modification date2018052320180329
UniProtAcc

Q6VY07

Q5TH74

Ensembl transtripts involved in fusion geneENST00000320580, ENST00000529757, 
ENST00000524815, 		ENST00000374409, 
ENST00000440416, ENST00000003583, 
ENST00000468303, ENST00000337248, 
Fusion gene scores* DoF score12 X 5 X 8=4802 X 2 X 2=8
# samples 142
** MAII scorelog2(14/480*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: PACS1 [Title/Abstract] AND STPG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-AA75-01APACS1chr11

65838313

+STPG1chr1

24687531

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000320580ENST00000374409PACS1chr11

65838313

+STPG1chr1

24687531

-
In-frameENST00000320580ENST00000440416PACS1chr11

65838313

+STPG1chr1

24687531

-
In-frameENST00000320580ENST00000003583PACS1chr11

65838313

+STPG1chr1

24687531

-
5CDS-5UTRENST00000320580ENST00000468303PACS1chr11

65838313

+STPG1chr1

24687531

-
5CDS-5UTRENST00000320580ENST00000337248PACS1chr11

65838313

+STPG1chr1

24687531

-
intron-3CDSENST00000529757ENST00000374409PACS1chr11

65838313

+STPG1chr1

24687531

-
intron-3CDSENST00000529757ENST00000440416PACS1chr11

65838313

+STPG1chr1

24687531

-
intron-3CDSENST00000529757ENST00000003583PACS1chr11

65838313

+STPG1chr1

24687531

-
intron-5UTRENST00000529757ENST00000468303PACS1chr11

65838313

+STPG1chr1

24687531

-
intron-5UTRENST00000529757ENST00000337248PACS1chr11

65838313

+STPG1chr1

24687531

-
intron-3CDSENST00000524815ENST00000374409PACS1chr11

65838313

+STPG1chr1

24687531

-
intron-3CDSENST00000524815ENST00000440416PACS1chr11

65838313

+STPG1chr1

24687531

-
intron-3CDSENST00000524815ENST00000003583PACS1chr11

65838313

+STPG1chr1

24687531

-
intron-5UTRENST00000524815ENST00000468303PACS1chr11

65838313

+STPG1chr1

24687531

-
intron-5UTRENST00000524815ENST00000337248PACS1chr11

65838313

+STPG1chr1

24687531

-

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FusionProtFeatures for PACS1_STPG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PACS1

Q6VY07

STPG1

Q5TH74

May positively contribute to the induction of apoptosistriggered by O(6)-methylguanine. {ECO:0000269|PubMed:23028632}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePACS1chr11:65838313chr1:24687531ENST00000320580+124112_115118964Compositional biasNote=Poly-Ser
HgenePACS1chr11:65838313chr1:24687531ENST00000320580+12435_40118964Compositional biasNote=Poly-Gln
HgenePACS1chr11:65838313chr1:24687531ENST00000320580+12455_84118964Compositional biasNote=Ser-rich
HgenePACS1chr11:65838313chr1:24687531ENST00000320580+1245_44118964Compositional biasNote=Gly-rich
HgenePACS1chr11:65838313chr1:24687531ENST00000320580+12462_65118964Compositional biasNote=Poly-Ala
TgeneSTPG1chr11:65838313chr1:24687531ENST00000003583-58225_257198288RepeatNote=STPGR 5
TgeneSTPG1chr11:65838313chr1:24687531ENST00000003583-58267_282198288RepeatNote=STPGR 6
TgeneSTPG1chr11:65838313chr1:24687531ENST00000003583-58306_316198288RepeatNote=STPGR 7
TgeneSTPG1chr11:65838313chr1:24687531ENST00000337248-69267_282245335RepeatNote=STPGR 6
TgeneSTPG1chr11:65838313chr1:24687531ENST00000337248-69306_316245335RepeatNote=STPGR 7
TgeneSTPG1chr11:65838313chr1:24687531ENST00000374409-69267_282245335RepeatNote=STPGR 6
TgeneSTPG1chr11:65838313chr1:24687531ENST00000374409-69306_316245335RepeatNote=STPGR 7
TgeneSTPG1chr11:65838313chr1:24687531ENST00000440416-47225_257198288RepeatNote=STPGR 5
TgeneSTPG1chr11:65838313chr1:24687531ENST00000440416-47267_282198288RepeatNote=STPGR 6
TgeneSTPG1chr11:65838313chr1:24687531ENST00000440416-47306_316198288RepeatNote=STPGR 7

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePACS1chr11:65838313chr1:24687531ENST00000320580+124353_377118964Coiled coilOntology_term=ECO:0000255
HgenePACS1chr11:65838313chr1:24687531ENST00000320580+124279_283118964Compositional biasNote=Poly-Glu
HgenePACS1chr11:65838313chr1:24687531ENST00000320580+124168_175118964RegionNote=Involved in binding to AP-1
TgeneSTPG1chr11:65838313chr1:24687531ENST00000003583-58109_117198288RepeatNote=STPGR 2
TgeneSTPG1chr11:65838313chr1:24687531ENST00000003583-58148_155198288RepeatNote=STPGR 3
TgeneSTPG1chr11:65838313chr1:24687531ENST00000003583-58187_206198288RepeatNote=STPGR 4
TgeneSTPG1chr11:65838313chr1:24687531ENST00000003583-5867_74198288RepeatNote=STPGR 1
TgeneSTPG1chr11:65838313chr1:24687531ENST00000337248-69109_117245335RepeatNote=STPGR 2
TgeneSTPG1chr11:65838313chr1:24687531ENST00000337248-69148_155245335RepeatNote=STPGR 3
TgeneSTPG1chr11:65838313chr1:24687531ENST00000337248-69187_206245335RepeatNote=STPGR 4
TgeneSTPG1chr11:65838313chr1:24687531ENST00000337248-69225_257245335RepeatNote=STPGR 5
TgeneSTPG1chr11:65838313chr1:24687531ENST00000337248-6967_74245335RepeatNote=STPGR 1
TgeneSTPG1chr11:65838313chr1:24687531ENST00000374409-69109_117245335RepeatNote=STPGR 2
TgeneSTPG1chr11:65838313chr1:24687531ENST00000374409-69148_155245335RepeatNote=STPGR 3
TgeneSTPG1chr11:65838313chr1:24687531ENST00000374409-69187_206245335RepeatNote=STPGR 4
TgeneSTPG1chr11:65838313chr1:24687531ENST00000374409-69225_257245335RepeatNote=STPGR 5
TgeneSTPG1chr11:65838313chr1:24687531ENST00000374409-6967_74245335RepeatNote=STPGR 1
TgeneSTPG1chr11:65838313chr1:24687531ENST00000440416-47109_117198288RepeatNote=STPGR 2
TgeneSTPG1chr11:65838313chr1:24687531ENST00000440416-47148_155198288RepeatNote=STPGR 3
TgeneSTPG1chr11:65838313chr1:24687531ENST00000440416-47187_206198288RepeatNote=STPGR 4
TgeneSTPG1chr11:65838313chr1:24687531ENST00000440416-4767_74198288RepeatNote=STPGR 1


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FusionGeneSequence for PACS1_STPG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PACS1_ENST00000320580_chr11_65838313_+_STPG1_ENST00000374409_chr1_24687531_-_208aa
MAERGGAGGGPGGAGGGSGQRGSGVAQSPQQPPPQQQQQQPPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGP
GPGRTPAPVQMNLYATWEVDRSSSSCVPRKNPILNFSAQPSPLPPKPPFPGPGQYEIVDYLGPRKHFISSASFVSNTSRWTAAPPQPGLP

>In-frame_PACS1_ENST00000320580_chr11_65838313_+_STPG1_ENST00000440416_chr1_24687531_-_208aa
MAERGGAGGGPGGAGGGSGQRGSGVAQSPQQPPPQQQQQQPPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGP
GPGRTPAPVQMNLYATWEVDRSSSSCVPRKNPILNFSAQPSPLPPKPPFPGPGQYEIVDYLGPRKHFISSASFVSNTSRWTAAPPQPGLP

>In-frame_PACS1_ENST00000320580_chr11_65838313_+_STPG1_ENST00000003583_chr1_24687531_-_208aa
MAERGGAGGGPGGAGGGSGQRGSGVAQSPQQPPPQQQQQQPPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGP
GPGRTPAPVQMNLYATWEVDRSSSSCVPRKNPILNFSAQPSPLPPKPPFPGPGQYEIVDYLGPRKHFISSASFVSNTSRWTAAPPQPGLP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PACS1_ENST00000320580_chr11_65838313_+_STPG1_ENST00000374409_chr1_24687531_-_624nt
ATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGCCAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAG
CAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAGCTGGCCCAGGCCACCTCGTCGTCCTCGTCCACC
TCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCGGTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCG
GGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTGGACCGGAGCTCGTCCAGCTGCGTGCCTAGGAAA
AACCCCATCCTGAACTTCTCTGCTCAGCCTTCGCCTCTGCCTCCGAAGCCACCTTTCCCAGGTCCTGGTCAGTATGAGATCGTGGACTAC
TTAGGCCCCCGCAAGCATTTCATCTCTAGTGCATCATTCGTGTCCAATACCAGCCGGTGGACAGCGGCGCCGCCTCAGCCAGGCCTGCCT

>In-frame_PACS1_ENST00000320580_chr11_65838313_+_STPG1_ENST00000440416_chr1_24687531_-_624nt
ATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGCCAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAG
CAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAGCTGGCCCAGGCCACCTCGTCGTCCTCGTCCACC
TCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCGGTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCG
GGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTGGACCGGAGCTCGTCCAGCTGCGTGCCTAGGAAA
AACCCCATCCTGAACTTCTCTGCTCAGCCTTCGCCTCTGCCTCCGAAGCCACCTTTCCCAGGTCCTGGTCAGTATGAGATCGTGGACTAC
TTAGGCCCCCGCAAGCATTTCATCTCTAGTGCATCATTCGTGTCCAATACCAGCCGGTGGACAGCGGCGCCGCCTCAGCCAGGCCTGCCT

>In-frame_PACS1_ENST00000320580_chr11_65838313_+_STPG1_ENST00000003583_chr1_24687531_-_624nt
ATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGCCAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAG
CAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAGCTGGCCCAGGCCACCTCGTCGTCCTCGTCCACC
TCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCGGTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCG
GGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTGGACCGGAGCTCGTCCAGCTGCGTGCCTAGGAAA
AACCCCATCCTGAACTTCTCTGCTCAGCCTTCGCCTCTGCCTCCGAAGCCACCTTTCCCAGGTCCTGGTCAGTATGAGATCGTGGACTAC
TTAGGCCCCCGCAAGCATTTCATCTCTAGTGCATCATTCGTGTCCAATACCAGCCGGTGGACAGCGGCGCCGCCTCAGCCAGGCCTGCCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PACS1_ENST00000320580_chr11_65838313_+_STPG1_ENST00000374409_chr1_24687531_-_2201nt
CCTCGGCCTCCGTAACCCCCGCCTAGCCGGGCCATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGC
CAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAGCAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAG
CTGGCCCAGGCCACCTCGTCGTCCTCGTCCACCTCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCG
GTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCGGGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTG
GACCGGAGCTCGTCCAGCTGCGTGCCTAGGAAAAACCCCATCCTGAACTTCTCTGCTCAGCCTTCGCCTCTGCCTCCGAAGCCACCTTTC
CCAGGTCCTGGTCAGTATGAGATCGTGGACTACTTAGGCCCCCGCAAGCATTTCATCTCTAGTGCATCATTCGTGTCCAATACCAGCCGG
TGGACAGCGGCGCCGCCTCAGCCAGGCCTGCCTGGCCCAGCTACGTACAAGCCAGAGCTTCCAGGAAAGCAGTCCTTCCTCTACAACGAG
GACAAGAAATGGATCCCGGTTCTGTAGGGATGTCACACAAGGTCAAGGAGAACTCCAGCCACCAGCCCACCCTGCCCAGCGTCCCCAGGA
CATTCCTCAGGAGGAGACCGATCATGAGTGTGGCAGCTGACAACTTGGGGGGTGGCTCTACCACTCTGGCCTGGCATCCTAGCCGGACTG
CTGCCATTGCCTTTGTCTTGAGCTGGAGACATTGCTCCCTGGAGACTTCACCCCAGCCCCACAGACTCCAGTGGCTTCCTGAGCAGAAGG
GAGGAGTGGACAGAGCCCCCTGGCTGCTTCCCCACGCACCCATCCAGGCTGCCTTCCGGCACGACTCCCTGCCGCAGACTGAAGGGACTC
CTGAAGCGCAGACTTCAAGGAGGATCAGTCCACCCTGAAGGTGGCCAAGCCTGGAAGCCCCACCCTTCCCTGTTTCATTCCTTCATTCAT
TTACACATTCATTCATTCCCTCACTCCTGCCTTTCTCATTTGTCCCTTTCTGACCTCACTCACTTACGGTATGTCTACTGGGCGAAAGCT
ACCTGCAGGCAGGTGATGCTTTTTCCACCAGTCCACAGCTTCCTTTCTAAAGTGACCACCTGTTTGGAAAGACCTCTCTTTACTCCTTTT
AGACCTTTTTCTCTTTGGAGTGGGAGATCATCTTGGAATGGCAGTGGCCGGGCCCGGGGGCTGCGCTTTTCCCTGACTTTCTCTGCTGGC
GGGACTGAATTTTCTCAAGGCTTACAGGCCCTTCCATGGAGTCCACATGGCCTGTCTAGGCCTGATAGCTTTCGTCTCTCTATGTGGAGG
GAAAAAGAAATGTGCCCTAGTGGTTTTGGTGGAGGCTGCACAGATTCGCGGTGGGTGGGGAGCTGCCAGGCTCCTTTTCTGATCTCCCAG
CAGGCTTTGACTGACGCTGTTTAGTCTTTCTGTACATTAACCCCGCCAGATACCGAGAGGTTACAAAGCCTCCAAGGCCTGTACAACTGT
GGCCTCTCCAGAGAAGTGGTTCTCAGCCTTGACTGCACACTGTAATCACCTGGGGACTTTAAAAAGTACTGAGGCCTGGGGCCCACCCAC
AAATGCTGATTTAACTCCTCCAGGGTGGGGTCTGGGCAGTGGGGAGGCAGGAGCCACCCAGGTGATTCCAATGATAGGTGTAGGTTGAGA
AGCGCCACCTTCCAGCTTCCTAACTGGCTCTGGGAGGGGAGCTGGGTGGGAAGTTCAGGAGGTGGGAACTTTGTACACGCAGAGCACCTG
GAGCACCTACAGCATGGCTGTGGTTCCACACTCCTCTGTCATTTAACCTTCACACATCACCTCGTTCTGACATCAAGGGTGCGTCACAGC
CACAGTGAGGCCTCGCCTGGGCAGAGCAACTCTGGGTGCCCCACTGGGTCCCTCCCACAGGGGCAGGCAAGCCTAATGGGAACCCGAGGC
AAAAGGAAACATCAGTAATACGAATCCTGTCTTTAAAACTGTGATGTTTTGTTCACCATGGATTTTTTTTTTGGGGGGGGGGGCCTTAAT

>In-frame_PACS1_ENST00000320580_chr11_65838313_+_STPG1_ENST00000440416_chr1_24687531_-_2200nt
CCTCGGCCTCCGTAACCCCCGCCTAGCCGGGCCATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGC
CAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAGCAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAG
CTGGCCCAGGCCACCTCGTCGTCCTCGTCCACCTCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCG
GTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCGGGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTG
GACCGGAGCTCGTCCAGCTGCGTGCCTAGGAAAAACCCCATCCTGAACTTCTCTGCTCAGCCTTCGCCTCTGCCTCCGAAGCCACCTTTC
CCAGGTCCTGGTCAGTATGAGATCGTGGACTACTTAGGCCCCCGCAAGCATTTCATCTCTAGTGCATCATTCGTGTCCAATACCAGCCGG
TGGACAGCGGCGCCGCCTCAGCCAGGCCTGCCTGGCCCAGCTACGTACAAGCCAGAGCTTCCAGGAAAGCAGTCCTTCCTCTACAACGAG
GACAAGAAATGGATCCCGGTTCTGTAGGGATGTCACACAAGGTCAAGGAGAACTCCAGCCACCAGCCCACCCTGCCCAGCGTCCCCAGGA
CATTCCTCAGGAGGAGACCGATCATGAGTGTGGCAGCTGACAACTTGGGGGGTGGCTCTACCACTCTGGCCTGGCATCCTAGCCGGACTG
CTGCCATTGCCTTTGTCTTGAGCTGGAGACATTGCTCCCTGGAGACTTCACCCCAGCCCCACAGACTCCAGTGGCTTCCTGAGCAGAAGG
GAGGAGTGGACAGAGCCCCCTGGCTGCTTCCCCACGCACCCATCCAGGCTGCCTTCCGGCACGACTCCCTGCCGCAGACTGAAGGGACTC
CTGAAGCGCAGACTTCAAGGAGGATCAGTCCACCCTGAAGGTGGCCAAGCCTGGAAGCCCCACCCTTCCCTGTTTCATTCCTTCATTCAT
TTACACATTCATTCATTCCCTCACTCCTGCCTTTCTCATTTGTCCCTTTCTGACCTCACTCACTTACGGTATGTCTACTGGGCGAAAGCT
ACCTGCAGGCAGGTGATGCTTTTTCCACCAGTCCACAGCTTCCTTTCTAAAGTGACCACCTGTTTGGAAAGACCTCTCTTTACTCCTTTT
AGACCTTTTTCTCTTTGGAGTGGGAGATCATCTTGGAATGGCAGTGGCCGGGCCCGGGGGCTGCGCTTTTCCCTGACTTTCTCTGCTGGC
GGGACTGAATTTTCTCAAGGCTTACAGGCCCTTCCATGGAGTCCACATGGCCTGTCTAGGCCTGATAGCTTTCGTCTCTCTATGTGGAGG
GAAAAAGAAATGTGCCCTAGTGGTTTTGGTGGAGGCTGCACAGATTCGCGGTGGGTGGGGAGCTGCCAGGCTCCTTTTCTGATCTCCCAG
CAGGCTTTGACTGACGCTGTTTAGTCTTTCTGTACATTAACCCCGCCAGATACCGAGAGGTTACAAAGCCTCCAAGGCCTGTACAACTGT
GGCCTCTCCAGAGAAGTGGTTCTCAGCCTTGACTGCACACTGTAATCACCTGGGGACTTTAAAAAGTACTGAGGCCTGGGGCCCACCCAC
AAATGCTGATTTAACTCCTCCAGGGTGGGGTCTGGGCAGTGGGGAGGCAGGAGCCACCCAGGTGATTCCAATGATAGGTGTAGGTTGAGA
AGCGCCACCTTCCAGCTTCCTAACTGGCTCTGGGAGGGGAGCTGGGTGGGAAGTTCAGGAGGTGGGAACTTTGTACACGCAGAGCACCTG
GAGCACCTACAGCATGGCTGTGGTTCCACACTCCTCTGTCATTTAACCTTCACACATCACCTCGTTCTGACATCAAGGGTGCGTCACAGC
CACAGTGAGGCCTCGCCTGGGCAGAGCAACTCTGGGTGCCCCACTGGGTCCCTCCCACAGGGGCAGGCAAGCCTAATGGGAACCCGAGGC
AAAAGGAAACATCAGTAATACGAATCCTGTCTTTAAAACTGTGATGTTTTGTTCACCATGGATTTTTTTTTTGGGGGGGGGGGCCTTAAT

>In-frame_PACS1_ENST00000320580_chr11_65838313_+_STPG1_ENST00000003583_chr1_24687531_-_2195nt
CCTCGGCCTCCGTAACCCCCGCCTAGCCGGGCCATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGC
CAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAGCAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAG
CTGGCCCAGGCCACCTCGTCGTCCTCGTCCACCTCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCG
GTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCGGGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTG
GACCGGAGCTCGTCCAGCTGCGTGCCTAGGAAAAACCCCATCCTGAACTTCTCTGCTCAGCCTTCGCCTCTGCCTCCGAAGCCACCTTTC
CCAGGTCCTGGTCAGTATGAGATCGTGGACTACTTAGGCCCCCGCAAGCATTTCATCTCTAGTGCATCATTCGTGTCCAATACCAGCCGG
TGGACAGCGGCGCCGCCTCAGCCAGGCCTGCCTGGCCCAGCTACGTACAAGCCAGAGCTTCCAGGAAAGCAGTCCTTCCTCTACAACGAG
GACAAGAAATGGATCCCGGTTCTGTAGGGATGTCACACAAGGTCAAGGAGAACTCCAGCCACCAGCCCACCCTGCCCAGCGTCCCCAGGA
CATTCCTCAGGAGGAGACCGATCATGAGTGTGGCAGCTGACAACTTGGGGGGTGGCTCTACCACTCTGGCCTGGCATCCTAGCCGGACTG
CTGCCATTGCCTTTGTCTTGAGCTGGAGACATTGCTCCCTGGAGACTTCACCCCAGCCCCACAGACTCCAGTGGCTTCCTGAGCAGAAGG
GAGGAGTGGACAGAGCCCCCTGGCTGCTTCCCCACGCACCCATCCAGGCTGCCTTCCGGCACGACTCCCTGCCGCAGACTGAAGGGACTC
CTGAAGCGCAGACTTCAAGGAGGATCAGTCCACCCTGAAGGTGGCCAAGCCTGGAAGCCCCACCCTTCCCTGTTTCATTCCTTCATTCAT
TTACACATTCATTCATTCCCTCACTCCTGCCTTTCTCATTTGTCCCTTTCTGACCTCACTCACTTACGGTATGTCTACTGGGCGAAAGCT
ACCTGCAGGCAGGTGATGCTTTTTCCACCAGTCCACAGCTTCCTTTCTAAAGTGACCACCTGTTTGGAAAGACCTCTCTTTACTCCTTTT
AGACCTTTTTCTCTTTGGAGTGGGAGATCATCTTGGAATGGCAGTGGCCGGGCCCGGGGGCTGCGCTTTTCCCTGACTTTCTCTGCTGGC
GGGACTGAATTTTCTCAAGGCTTACAGGCCCTTCCATGGAGTCCACATGGCCTGTCTAGGCCTGATAGCTTTCGTCTCTCTATGTGGAGG
GAAAAAGAAATGTGCCCTAGTGGTTTTGGTGGAGGCTGCACAGATTCGCGGTGGGTGGGGAGCTGCCAGGCTCCTTTTCTGATCTCCCAG
CAGGCTTTGACTGACGCTGTTTAGTCTTTCTGTACATTAACCCCGCCAGATACCGAGAGGTTACAAAGCCTCCAAGGCCTGTACAACTGT
GGCCTCTCCAGAGAAGTGGTTCTCAGCCTTGACTGCACACTGTAATCACCTGGGGACTTTAAAAAGTACTGAGGCCTGGGGCCCACCCAC
AAATGCTGATTTAACTCCTCCAGGGTGGGGTCTGGGCAGTGGGGAGGCAGGAGCCACCCAGGTGATTCCAATGATAGGTGTAGGTTGAGA
AGCGCCACCTTCCAGCTTCCTAACTGGCTCTGGGAGGGGAGCTGGGTGGGAAGTTCAGGAGGTGGGAACTTTGTACACGCAGAGCACCTG
GAGCACCTACAGCATGGCTGTGGTTCCACACTCCTCTGTCATTTAACCTTCACACATCACCTCGTTCTGACATCAAGGGTGCGTCACAGC
CACAGTGAGGCCTCGCCTGGGCAGAGCAACTCTGGGTGCCCCACTGGGTCCCTCCCACAGGGGCAGGCAAGCCTAATGGGAACCCGAGGC
AAAAGGAAACATCAGTAATACGAATCCTGTCTTTAAAACTGTGATGTTTTGTTCACCATGGATTTTTTTTTTGGGGGGGGGGGCCTTAAT


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FusionGenePPI for PACS1_STPG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PACS1VAMP4, FURIN, FGFR1OP, GGA3, CSNK2A1, SORL1, WDR37, NTRK1, CTDSPL, IQCF1, SNX24, PTPRG, PPP1R7, C17orf70, PPP1CB, PPP1CASTPG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PACS1_STPG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PACS1_STPG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePACS1C0028754Obesity1CTD_human
HgenePACS1C0236969Substance-Related Disorders1CTD_human
HgenePACS1C3554343MENTAL RETARDATION, AUTOSOMAL DOMINANT 171ORPHANET;UNIPROT