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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 25732

FusionGeneSummary for PACS1_FOLH1

check button Fusion gene summary
Fusion gene informationFusion gene name: PACS1_FOLH1
Fusion gene ID: 25732
HgeneTgene
Gene symbol

PACS1

FOLH1

Gene ID

55690

2346

Gene namephosphofurin acidic cluster sorting protein 1folate hydrolase 1
SynonymsMRD17|SHMSFGCP|FOLH|GCP2|GCPII|NAALAD1|NAALAdase|PSM|PSMA|mGCP
Cytomap

11q13.1-q13.2

11p11.12

Type of geneprotein-codingprotein-coding
Descriptionphosphofurin acidic cluster sorting protein 1PACS-1cytosolic sorting protein PACS-1glutamate carboxypeptidase 2N-acetylated alpha-linked acidic dipeptidase 1N-acetylated-alpha-linked acidic dipeptidase INAALADase Icell growth-inhibiting gene 27 proteinfolylpoly-gamma-glutamate carboxypeptidaseglutamate carboxylase IIglutamate car
Modification date2018052320180519
UniProtAcc

Q6VY07

Q04609

Ensembl transtripts involved in fusion geneENST00000320580, ENST00000529757, 
ENST00000524815, 		ENST00000256999, 
ENST00000356696, ENST00000343844, 
ENST00000340334, ENST00000533034, 
ENST00000525629, 
Fusion gene scores* DoF score12 X 5 X 8=4804 X 4 X 3=48
# samples 144
** MAII scorelog2(14/480*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PACS1 [Title/Abstract] AND FOLH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFOLH1

GO:0006508

proteolysis

12949938

TgeneFOLH1

GO:0035609

C-terminal protein deglutamylation

12949938|17241121|24863754


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-UF-A7JV-01APACS1chr11

65961044

+FOLH1chr11

49179595

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000320580ENST00000256999PACS1chr11

65961044

+FOLH1chr11

49179595

-
In-frameENST00000320580ENST00000356696PACS1chr11

65961044

+FOLH1chr11

49179595

-
In-frameENST00000320580ENST00000343844PACS1chr11

65961044

+FOLH1chr11

49179595

-
In-frameENST00000320580ENST00000340334PACS1chr11

65961044

+FOLH1chr11

49179595

-
In-frameENST00000320580ENST00000533034PACS1chr11

65961044

+FOLH1chr11

49179595

-
5CDS-intronENST00000320580ENST00000525629PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-3CDSENST00000529757ENST00000256999PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-3CDSENST00000529757ENST00000356696PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-3CDSENST00000529757ENST00000343844PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-3CDSENST00000529757ENST00000340334PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-3CDSENST00000529757ENST00000533034PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-intronENST00000529757ENST00000525629PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-3CDSENST00000524815ENST00000256999PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-3CDSENST00000524815ENST00000356696PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-3CDSENST00000524815ENST00000343844PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-3CDSENST00000524815ENST00000340334PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-3CDSENST00000524815ENST00000533034PACS1chr11

65961044

+FOLH1chr11

49179595

-
intron-intronENST00000524815ENST00000525629PACS1chr11

65961044

+FOLH1chr11

49179595

-

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FusionProtFeatures for PACS1_FOLH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PACS1

Q6VY07

FOLH1

Q04609


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePACS1chr11:65961044chr11:49179595ENST00000320580+224112_115148964Compositional biasNote=Poly-Ser
HgenePACS1chr11:65961044chr11:49179595ENST00000320580+22435_40148964Compositional biasNote=Poly-Gln
HgenePACS1chr11:65961044chr11:49179595ENST00000320580+22455_84148964Compositional biasNote=Ser-rich
HgenePACS1chr11:65961044chr11:49179595ENST00000320580+2245_44148964Compositional biasNote=Gly-rich
HgenePACS1chr11:65961044chr11:49179595ENST00000320580+22462_65148964Compositional biasNote=Poly-Ala
TgeneFOLH1chr11:65961044chr11:49179595ENST00000256999-1219517_518480751RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000256999-1219534_536480751RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000256999-1219552_553480751RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000256999-1219699_700480751RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000340334-1320517_518465736RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000340334-1320534_536465736RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000340334-1320552_553465736RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000340334-1320699_700465736RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000343844-1017274_587172443RegionNote=NAALADase
TgeneFOLH1chr11:65961044chr11:49179595ENST00000343844-1017517_518172443RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000343844-1017534_536172443RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000343844-1017552_553172443RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000343844-1017699_700172443RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000356696-1218517_518480720RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000356696-1218534_536480720RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000356696-1218552_553480720RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000356696-1218699_700480720RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000533034-1319517_518465705RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000533034-1319534_536465705RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000533034-1319552_553465705RegionSubstrate binding
TgeneFOLH1chr11:65961044chr11:49179595ENST00000533034-1319699_700465705RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePACS1chr11:65961044chr11:49179595ENST00000320580+224353_377148964Coiled coilOntology_term=ECO:0000255
HgenePACS1chr11:65961044chr11:49179595ENST00000320580+224279_283148964Compositional biasNote=Poly-Glu
HgenePACS1chr11:65961044chr11:49179595ENST00000320580+224168_175148964RegionNote=Involved in binding to AP-1
TgeneFOLH1chr11:65961044chr11:49179595ENST00000256999-1219146_149480751Compositional biasPoly-Pro
TgeneFOLH1chr11:65961044chr11:49179595ENST00000340334-1320146_149465736Compositional biasPoly-Pro
TgeneFOLH1chr11:65961044chr11:49179595ENST00000343844-1017146_149172443Compositional biasPoly-Pro
TgeneFOLH1chr11:65961044chr11:49179595ENST00000356696-1218146_149480720Compositional biasPoly-Pro
TgeneFOLH1chr11:65961044chr11:49179595ENST00000533034-1319146_149465705Compositional biasPoly-Pro
TgeneFOLH1chr11:65961044chr11:49179595ENST00000256999-1219274_587480751RegionNote=NAALADase
TgeneFOLH1chr11:65961044chr11:49179595ENST00000340334-1320274_587465736RegionNote=NAALADase
TgeneFOLH1chr11:65961044chr11:49179595ENST00000356696-1218274_587480720RegionNote=NAALADase
TgeneFOLH1chr11:65961044chr11:49179595ENST00000533034-1319274_587465705RegionNote=NAALADase
TgeneFOLH1chr11:65961044chr11:49179595ENST00000256999-12191_19480751Topological domainCytoplasmic
TgeneFOLH1chr11:65961044chr11:49179595ENST00000256999-121944_750480751Topological domainExtracellular
TgeneFOLH1chr11:65961044chr11:49179595ENST00000340334-13201_19465736Topological domainCytoplasmic
TgeneFOLH1chr11:65961044chr11:49179595ENST00000340334-132044_750465736Topological domainExtracellular
TgeneFOLH1chr11:65961044chr11:49179595ENST00000343844-10171_19172443Topological domainCytoplasmic
TgeneFOLH1chr11:65961044chr11:49179595ENST00000343844-101744_750172443Topological domainExtracellular
TgeneFOLH1chr11:65961044chr11:49179595ENST00000356696-12181_19480720Topological domainCytoplasmic
TgeneFOLH1chr11:65961044chr11:49179595ENST00000356696-121844_750480720Topological domainExtracellular
TgeneFOLH1chr11:65961044chr11:49179595ENST00000533034-13191_19465705Topological domainCytoplasmic
TgeneFOLH1chr11:65961044chr11:49179595ENST00000533034-131944_750465705Topological domainExtracellular
TgeneFOLH1chr11:65961044chr11:49179595ENST00000256999-121920_43480751TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFOLH1chr11:65961044chr11:49179595ENST00000340334-132020_43465736TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFOLH1chr11:65961044chr11:49179595ENST00000343844-101720_43172443TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFOLH1chr11:65961044chr11:49179595ENST00000356696-121820_43480720TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFOLH1chr11:65961044chr11:49179595ENST00000533034-131920_43465705TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for PACS1_FOLH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000256999_chr11_49179595_-_419aa
MAERGGAGGGPGGAGGGSGQRGSGVAQSPQQPPPQQQQQQPPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGP
GPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQLKSPDEGFEGKSLYESWTKKSPSPEFSGMPRI
SKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAV
VLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIY

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000356696_chr11_49179595_-_388aa
MAERGGAGGGPGGAGGGSGQRGSGVAQSPQQPPPQQQQQQPPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGP
GPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQLKSPDEGFEGKSLYESWTKKSPSPEFSGMPRI
SKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAV
VLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSKHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSK

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000343844_chr11_49179595_-_419aa
MAERGGAGGGPGGAGGGSGQRGSGVAQSPQQPPPQQQQQQPPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGP
GPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQLKSPDEGFEGKSLYESWTKKSPSPEFSGMPRI
SKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAV
VLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIY

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000340334_chr11_49179595_-_419aa
MAERGGAGGGPGGAGGGSGQRGSGVAQSPQQPPPQQQQQQPPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGP
GPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQLKSPDEGFEGKSLYESWTKKSPSPEFSGMPRI
SKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAV
VLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIY

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000533034_chr11_49179595_-_388aa
MAERGGAGGGPGGAGGGSGQRGSGVAQSPQQPPPQQQQQQPPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGP
GPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQLKSPDEGFEGKSLYESWTKKSPSPEFSGMPRI
SKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAV
VLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSKHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000256999_chr11_49179595_-_1257nt
ATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGCCAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAG
CAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAGCTGGCCCAGGCCACCTCGTCGTCCTCGTCCACC
TCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCGGTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCG
GGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTGGACCGGAGCTCGTCCAGCTGCGTGCCTAGGCTA
TTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAACTCAGTGGTCATCGCTGTGAAGCTGCAGCTGAAA
AGCCCTGATGAAGGCTTTGAAGGCAAATCTCTTTATGAAAGTTGGACTAAAAAAAGTCCTTCCCCAGAGTTCAGTGGCATGCCCAGGATA
AGCAAATTGGGATCTGGAAATGATTTTGAGGTGTTCTTCCAACGACTTGGAATTGCTTCAGGCAGAGCACGGTATACTAAAAATTGGGAA
ACAAACAAATTCAGCGGCTATCCACTGTATCACAGTGTCTATGAAACATATGAGTTGGTGGAAAAGTTTTATGATCCAATGTTTAAATAT
CACCTCACTGTGGCCCAGGTTCGAGGAGGGATGGTGTTTGAGCTAGCCAATTCCATAGTGCTCCCTTTTGATTGTCGAGATTATGCTGTA
GTTTTAAGAAAGTATGCTGACAAAATCTACAGTATTTCTATGAAACATCCACAGGAAATGAAGACATACAGTGTATCATTTGATTCACTT
TTTTCTGCAGTAAAGAATTTTACAGAAATTGCTTCCAAGTTCAGTGAGAGACTCCAGGACTTTGACAAAAGCAACCCAATAGTATTAAGA
ATGATGAATGATCAACTCATGTTTCTGGAAAGAGCATTTATTGATCCATTAGGGTTACCAGACAGGCCTTTTTATAGGCATGTCATCTAT
GCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGATATTGAAAGCAAAGTGGACCCTTCC

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000356696_chr11_49179595_-_1164nt
ATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGCCAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAG
CAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAGCTGGCCCAGGCCACCTCGTCGTCCTCGTCCACC
TCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCGGTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCG
GGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTGGACCGGAGCTCGTCCAGCTGCGTGCCTAGGCTA
TTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAACTCAGTGGTCATCGCTGTGAAGCTGCAGCTGAAA
AGCCCTGATGAAGGCTTTGAAGGCAAATCTCTTTATGAAAGTTGGACTAAAAAAAGTCCTTCCCCAGAGTTCAGTGGCATGCCCAGGATA
AGCAAATTGGGATCTGGAAATGATTTTGAGGTGTTCTTCCAACGACTTGGAATTGCTTCAGGCAGAGCACGGTATACTAAAAATTGGGAA
ACAAACAAATTCAGCGGCTATCCACTGTATCACAGTGTCTATGAAACATATGAGTTGGTGGAAAAGTTTTATGATCCAATGTTTAAATAT
CACCTCACTGTGGCCCAGGTTCGAGGAGGGATGGTGTTTGAGCTAGCCAATTCCATAGTGCTCCCTTTTGATTGTCGAGATTATGCTGTA
GTTTTAAGAAAGTATGCTGACAAAATCTACAGTATTTCTATGAAACATCCACAGGAAATGAAGACATACAGTGTATCATTTGATTCACTT
TTTTCTGCAGTAAAGAATTTTACAGAAATTGCTTCCAAGTTCAGTGAGAGACTCCAGGACTTTGACAAAAGCAAGCATGTCATCTATGCT
CCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGATATTGAAAGCAAAGTGGACCCTTCCAAG

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000343844_chr11_49179595_-_1257nt
ATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGCCAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAG
CAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAGCTGGCCCAGGCCACCTCGTCGTCCTCGTCCACC
TCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCGGTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCG
GGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTGGACCGGAGCTCGTCCAGCTGCGTGCCTAGGCTA
TTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAACTCAGTGGTCATCGCTGTGAAGCTGCAGCTGAAA
AGCCCTGATGAAGGCTTTGAAGGCAAATCTCTTTATGAAAGTTGGACTAAAAAAAGTCCTTCCCCAGAGTTCAGTGGCATGCCCAGGATA
AGCAAATTGGGATCTGGAAATGATTTTGAGGTGTTCTTCCAACGACTTGGAATTGCTTCAGGCAGAGCACGGTATACTAAAAATTGGGAA
ACAAACAAATTCAGCGGCTATCCACTGTATCACAGTGTCTATGAAACATATGAGTTGGTGGAAAAGTTTTATGATCCAATGTTTAAATAT
CACCTCACTGTGGCCCAGGTTCGAGGAGGGATGGTGTTTGAGCTAGCCAATTCCATAGTGCTCCCTTTTGATTGTCGAGATTATGCTGTA
GTTTTAAGAAAGTATGCTGACAAAATCTACAGTATTTCTATGAAACATCCACAGGAAATGAAGACATACAGTGTATCATTTGATTCACTT
TTTTCTGCAGTAAAGAATTTTACAGAAATTGCTTCCAAGTTCAGTGAGAGACTCCAGGACTTTGACAAAAGCAACCCAATAGTATTAAGA
ATGATGAATGATCAACTCATGTTTCTGGAAAGAGCATTTATTGATCCATTAGGGTTACCAGACAGGCCTTTTTATAGGCATGTCATCTAT
GCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGATATTGAAAGCAAAGTGGACCCTTCC

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000340334_chr11_49179595_-_1257nt
ATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGCCAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAG
CAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAGCTGGCCCAGGCCACCTCGTCGTCCTCGTCCACC
TCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCGGTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCG
GGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTGGACCGGAGCTCGTCCAGCTGCGTGCCTAGGCTA
TTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAACTCAGTGGTCATCGCTGTGAAGCTGCAGCTGAAA
AGCCCTGATGAAGGCTTTGAAGGCAAATCTCTTTATGAAAGTTGGACTAAAAAAAGTCCTTCCCCAGAGTTCAGTGGCATGCCCAGGATA
AGCAAATTGGGATCTGGAAATGATTTTGAGGTGTTCTTCCAACGACTTGGAATTGCTTCAGGCAGAGCACGGTATACTAAAAATTGGGAA
ACAAACAAATTCAGCGGCTATCCACTGTATCACAGTGTCTATGAAACATATGAGTTGGTGGAAAAGTTTTATGATCCAATGTTTAAATAT
CACCTCACTGTGGCCCAGGTTCGAGGAGGGATGGTGTTTGAGCTAGCCAATTCCATAGTGCTCCCTTTTGATTGTCGAGATTATGCTGTA
GTTTTAAGAAAGTATGCTGACAAAATCTACAGTATTTCTATGAAACATCCACAGGAAATGAAGACATACAGTGTATCATTTGATTCACTT
TTTTCTGCAGTAAAGAATTTTACAGAAATTGCTTCCAAGTTCAGTGAGAGACTCCAGGACTTTGACAAAAGCAACCCAATAGTATTAAGA
ATGATGAATGATCAACTCATGTTTCTGGAAAGAGCATTTATTGATCCATTAGGGTTACCAGACAGGCCTTTTTATAGGCATGTCATCTAT
GCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGATATTGAAAGCAAAGTGGACCCTTCC

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000533034_chr11_49179595_-_1164nt
ATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGCCAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAG
CAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAGCTGGCCCAGGCCACCTCGTCGTCCTCGTCCACC
TCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCGGTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCG
GGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTGGACCGGAGCTCGTCCAGCTGCGTGCCTAGGCTA
TTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAACTCAGTGGTCATCGCTGTGAAGCTGCAGCTGAAA
AGCCCTGATGAAGGCTTTGAAGGCAAATCTCTTTATGAAAGTTGGACTAAAAAAAGTCCTTCCCCAGAGTTCAGTGGCATGCCCAGGATA
AGCAAATTGGGATCTGGAAATGATTTTGAGGTGTTCTTCCAACGACTTGGAATTGCTTCAGGCAGAGCACGGTATACTAAAAATTGGGAA
ACAAACAAATTCAGCGGCTATCCACTGTATCACAGTGTCTATGAAACATATGAGTTGGTGGAAAAGTTTTATGATCCAATGTTTAAATAT
CACCTCACTGTGGCCCAGGTTCGAGGAGGGATGGTGTTTGAGCTAGCCAATTCCATAGTGCTCCCTTTTGATTGTCGAGATTATGCTGTA
GTTTTAAGAAAGTATGCTGACAAAATCTACAGTATTTCTATGAAACATCCACAGGAAATGAAGACATACAGTGTATCATTTGATTCACTT
TTTTCTGCAGTAAAGAATTTTACAGAAATTGCTTCCAAGTTCAGTGAGAGACTCCAGGACTTTGACAAAAGCAAGCATGTCATCTATGCT
CCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTGTTTGATATTGAAAGCAAAGTGGACCCTTCCAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000256999_chr11_49179595_-_1411nt
CCTCGGCCTCCGTAACCCCCGCCTAGCCGGGCCATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGC
CAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAGCAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAG
CTGGCCCAGGCCACCTCGTCGTCCTCGTCCACCTCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCG
GTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCGGGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTG
GACCGGAGCTCGTCCAGCTGCGTGCCTAGGCTATTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAAC
TCAGTGGTCATCGCTGTGAAGCTGCAGCTGAAAAGCCCTGATGAAGGCTTTGAAGGCAAATCTCTTTATGAAAGTTGGACTAAAAAAAGT
CCTTCCCCAGAGTTCAGTGGCATGCCCAGGATAAGCAAATTGGGATCTGGAAATGATTTTGAGGTGTTCTTCCAACGACTTGGAATTGCT
TCAGGCAGAGCACGGTATACTAAAAATTGGGAAACAAACAAATTCAGCGGCTATCCACTGTATCACAGTGTCTATGAAACATATGAGTTG
GTGGAAAAGTTTTATGATCCAATGTTTAAATATCACCTCACTGTGGCCCAGGTTCGAGGAGGGATGGTGTTTGAGCTAGCCAATTCCATA
GTGCTCCCTTTTGATTGTCGAGATTATGCTGTAGTTTTAAGAAAGTATGCTGACAAAATCTACAGTATTTCTATGAAACATCCACAGGAA
ATGAAGACATACAGTGTATCATTTGATTCACTTTTTTCTGCAGTAAAGAATTTTACAGAAATTGCTTCCAAGTTCAGTGAGAGACTCCAG
GACTTTGACAAAAGCAACCCAATAGTATTAAGAATGATGAATGATCAACTCATGTTTCTGGAAAGAGCATTTATTGATCCATTAGGGTTA
CCAGACAGGCCTTTTTATAGGCATGTCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCT
CTGTTTGATATTGAAAGCAAAGTGGACCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCA
GCTGCAGAGACTTTGAGTGAAGTAGCCTAAGAGGATTCTTTAGAGAATCCGTATTGAATTTGTGTGGTATGTCACTCAGAAAGAATCGTA

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000356696_chr11_49179595_-_1317nt
CCTCGGCCTCCGTAACCCCCGCCTAGCCGGGCCATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGC
CAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAGCAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAG
CTGGCCCAGGCCACCTCGTCGTCCTCGTCCACCTCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCG
GTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCGGGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTG
GACCGGAGCTCGTCCAGCTGCGTGCCTAGGCTATTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAAC
TCAGTGGTCATCGCTGTGAAGCTGCAGCTGAAAAGCCCTGATGAAGGCTTTGAAGGCAAATCTCTTTATGAAAGTTGGACTAAAAAAAGT
CCTTCCCCAGAGTTCAGTGGCATGCCCAGGATAAGCAAATTGGGATCTGGAAATGATTTTGAGGTGTTCTTCCAACGACTTGGAATTGCT
TCAGGCAGAGCACGGTATACTAAAAATTGGGAAACAAACAAATTCAGCGGCTATCCACTGTATCACAGTGTCTATGAAACATATGAGTTG
GTGGAAAAGTTTTATGATCCAATGTTTAAATATCACCTCACTGTGGCCCAGGTTCGAGGAGGGATGGTGTTTGAGCTAGCCAATTCCATA
GTGCTCCCTTTTGATTGTCGAGATTATGCTGTAGTTTTAAGAAAGTATGCTGACAAAATCTACAGTATTTCTATGAAACATCCACAGGAA
ATGAAGACATACAGTGTATCATTTGATTCACTTTTTTCTGCAGTAAAGAATTTTACAGAAATTGCTTCCAAGTTCAGTGAGAGACTCCAG
GACTTTGACAAAAGCAAGCATGTCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTG
TTTGATATTGAAAGCAAAGTGGACCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCAGCT
GCAGAGACTTTGAGTGAAGTAGCCTAAGAGGATTCTTTAGAGAATCCGTATTGAATTTGTGTGGTATGTCACTCAGAAAGAATCGTAATG

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000343844_chr11_49179595_-_1410nt
CCTCGGCCTCCGTAACCCCCGCCTAGCCGGGCCATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGC
CAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAGCAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAG
CTGGCCCAGGCCACCTCGTCGTCCTCGTCCACCTCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCG
GTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCGGGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTG
GACCGGAGCTCGTCCAGCTGCGTGCCTAGGCTATTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAAC
TCAGTGGTCATCGCTGTGAAGCTGCAGCTGAAAAGCCCTGATGAAGGCTTTGAAGGCAAATCTCTTTATGAAAGTTGGACTAAAAAAAGT
CCTTCCCCAGAGTTCAGTGGCATGCCCAGGATAAGCAAATTGGGATCTGGAAATGATTTTGAGGTGTTCTTCCAACGACTTGGAATTGCT
TCAGGCAGAGCACGGTATACTAAAAATTGGGAAACAAACAAATTCAGCGGCTATCCACTGTATCACAGTGTCTATGAAACATATGAGTTG
GTGGAAAAGTTTTATGATCCAATGTTTAAATATCACCTCACTGTGGCCCAGGTTCGAGGAGGGATGGTGTTTGAGCTAGCCAATTCCATA
GTGCTCCCTTTTGATTGTCGAGATTATGCTGTAGTTTTAAGAAAGTATGCTGACAAAATCTACAGTATTTCTATGAAACATCCACAGGAA
ATGAAGACATACAGTGTATCATTTGATTCACTTTTTTCTGCAGTAAAGAATTTTACAGAAATTGCTTCCAAGTTCAGTGAGAGACTCCAG
GACTTTGACAAAAGCAACCCAATAGTATTAAGAATGATGAATGATCAACTCATGTTTCTGGAAAGAGCATTTATTGATCCATTAGGGTTA
CCAGACAGGCCTTTTTATAGGCATGTCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCT
CTGTTTGATATTGAAAGCAAAGTGGACCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCA
GCTGCAGAGACTTTGAGTGAAGTAGCCTAAGAGGATTCTTTAGAGAATCCGTATTGAATTTGTGTGGTATGTCACTCAGAAAGAATCGTA

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000340334_chr11_49179595_-_1410nt
CCTCGGCCTCCGTAACCCCCGCCTAGCCGGGCCATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGC
CAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAGCAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAG
CTGGCCCAGGCCACCTCGTCGTCCTCGTCCACCTCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCG
GTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCGGGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTG
GACCGGAGCTCGTCCAGCTGCGTGCCTAGGCTATTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAAC
TCAGTGGTCATCGCTGTGAAGCTGCAGCTGAAAAGCCCTGATGAAGGCTTTGAAGGCAAATCTCTTTATGAAAGTTGGACTAAAAAAAGT
CCTTCCCCAGAGTTCAGTGGCATGCCCAGGATAAGCAAATTGGGATCTGGAAATGATTTTGAGGTGTTCTTCCAACGACTTGGAATTGCT
TCAGGCAGAGCACGGTATACTAAAAATTGGGAAACAAACAAATTCAGCGGCTATCCACTGTATCACAGTGTCTATGAAACATATGAGTTG
GTGGAAAAGTTTTATGATCCAATGTTTAAATATCACCTCACTGTGGCCCAGGTTCGAGGAGGGATGGTGTTTGAGCTAGCCAATTCCATA
GTGCTCCCTTTTGATTGTCGAGATTATGCTGTAGTTTTAAGAAAGTATGCTGACAAAATCTACAGTATTTCTATGAAACATCCACAGGAA
ATGAAGACATACAGTGTATCATTTGATTCACTTTTTTCTGCAGTAAAGAATTTTACAGAAATTGCTTCCAAGTTCAGTGAGAGACTCCAG
GACTTTGACAAAAGCAACCCAATAGTATTAAGAATGATGAATGATCAACTCATGTTTCTGGAAAGAGCATTTATTGATCCATTAGGGTTA
CCAGACAGGCCTTTTTATAGGCATGTCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCT
CTGTTTGATATTGAAAGCAAAGTGGACCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCA
GCTGCAGAGACTTTGAGTGAAGTAGCCTAAGAGGATTCTTTAGAGAATCCGTATTGAATTTGTGTGGTATGTCACTCAGAAAGAATCGTA

>In-frame_PACS1_ENST00000320580_chr11_65961044_+_FOLH1_ENST00000533034_chr11_49179595_-_1202nt
CCTCGGCCTCCGTAACCCCCGCCTAGCCGGGCCATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGC
CAGCGGGGATCCGGGGTCGCCCAGTCCCCTCAGCAGCCGCCGCCGCAGCAGCAGCAGCAGCAGCCGCCGCAGCAGCCGACGCCCCCCAAG
CTGGCCCAGGCCACCTCGTCGTCCTCGTCCACCTCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCG
GTGGCCTCGGGCTCCGCGCCTCCCGGTGGCCCGGGGCCAGGCCGCACCCCCGCCCCGGTGCAGATGAACCTGTACGCCACCTGGGAGGTG
GACCGGAGCTCGTCCAGCTGCGTGCCTAGGCTATTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAAC
TCAGTGGTCATCGCTGTGAAGCTGCAGCTGAAAAGCCCTGATGAAGGCTTTGAAGGCAAATCTCTTTATGAAAGTTGGACTAAAAAAAGT
CCTTCCCCAGAGTTCAGTGGCATGCCCAGGATAAGCAAATTGGGATCTGGAAATGATTTTGAGGTGTTCTTCCAACGACTTGGAATTGCT
TCAGGCAGAGCACGGTATACTAAAAATTGGGAAACAAACAAATTCAGCGGCTATCCACTGTATCACAGTGTCTATGAAACATATGAGTTG
GTGGAAAAGTTTTATGATCCAATGTTTAAATATCACCTCACTGTGGCCCAGGTTCGAGGAGGGATGGTGTTTGAGCTAGCCAATTCCATA
GTGCTCCCTTTTGATTGTCGAGATTATGCTGTAGTTTTAAGAAAGTATGCTGACAAAATCTACAGTATTTCTATGAAACATCCACAGGAA
ATGAAGACATACAGTGTATCATTTGATTCACTTTTTTCTGCAGTAAAGAATTTTACAGAAATTGCTTCCAAGTTCAGTGAGAGACTCCAG
GACTTTGACAAAAGCAAGCATGTCATCTATGCTCCAAGCAGCCACAACAAGTATGCAGGGGAGTCATTCCCAGGAATTTATGATGCTCTG
TTTGATATTGAAAGCAAAGTGGACCCTTCCAAGGCCTGGGGAGAAGTGAAGAGACAGATTTATGTTGCAGCCTTCACAGTGCAGGCAGCT


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FusionGenePPI for PACS1_FOLH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PACS1VAMP4, FURIN, FGFR1OP, GGA3, CSNK2A1, SORL1, WDR37, NTRK1, CTDSPL, IQCF1, SNX24, PTPRG, PPP1R7, C17orf70, PPP1CB, PPP1CAFOLH1MME, RPS3, MTAP, CTH


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PACS1_FOLH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFOLH1Q04609DB00089Capromab pendetideGlutamate carboxypeptidase 2biotechapproved
TgeneFOLH1Q04609DB08835Spaglumic AcidGlutamate carboxypeptidase 2small moleculeapproved
TgeneFOLH1Q04609DB00142Glutamic AcidGlutamate carboxypeptidase 2small moleculeapproved|nutraceutical

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RelatedDiseases for PACS1_FOLH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePACS1C0028754Obesity1CTD_human
HgenePACS1C0236969Substance-Related Disorders1CTD_human
HgenePACS1C3554343MENTAL RETARDATION, AUTOSOMAL DOMINANT 171ORPHANET;UNIPROT
TgeneFOLH1C0033578Prostatic Neoplasms2CTD_human
TgeneFOLH1C0036341Schizophrenia2PSYGENET
TgeneFOLH1C0011570Mental Depression1PSYGENET
TgeneFOLH1C0011581Depressive disorder1PSYGENET