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Fusion gene ID: 25665 |
FusionGeneSummary for OXSR1_SRP72 |
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Fusion gene information | Fusion gene name: OXSR1_SRP72 | Fusion gene ID: 25665 | Hgene | Tgene | Gene symbol | OXSR1 | SRP72 | Gene ID | 9943 | 6731 |
Gene name | oxidative stress responsive 1 | signal recognition particle 72 | |
Synonyms | OSR1 | BMFF|BMFS1|HEL103 | |
Cytomap | 3p22.2 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase OSR1oxidative stress-responsive 1 protein | signal recognition particle subunit SRP72epididymis luminal protein 103signal recognition particle 72 kDa proteinsignal recognition particle 72kDsignal recognition particle 72kDa | |
Modification date | 20180523 | 20180525 | |
UniProtAcc | O95747 | O76094 | |
Ensembl transtripts involved in fusion gene | ENST00000446845, ENST00000311806, ENST00000492714, | ENST00000342756, ENST00000510663, ENST00000504757, | |
Fusion gene scores | * DoF score | 10 X 9 X 6=540 | 2 X 2 X 1=4 |
# samples | 10 | 2 | |
** MAII score | log2(10/540*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: OXSR1 [Title/Abstract] AND SRP72 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | OXSR1 | GO:0006468 | protein phosphorylation | 14707132 |
Hgene | OXSR1 | GO:0018107 | peptidyl-threonine phosphorylation | 24393035 |
Hgene | OXSR1 | GO:0035556 | intracellular signal transduction | 14707132 |
Tgene | SRP72 | GO:0042493 | response to drug | 18089836 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CV357489 | OXSR1 | chr3 | 38289311 | + | SRP72 | chr4 | 57338968 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000446845 | ENST00000342756 | OXSR1 | chr3 | 38289311 | + | SRP72 | chr4 | 57338968 | + |
intron-intron | ENST00000446845 | ENST00000510663 | OXSR1 | chr3 | 38289311 | + | SRP72 | chr4 | 57338968 | + |
intron-intron | ENST00000446845 | ENST00000504757 | OXSR1 | chr3 | 38289311 | + | SRP72 | chr4 | 57338968 | + |
intron-intron | ENST00000311806 | ENST00000342756 | OXSR1 | chr3 | 38289311 | + | SRP72 | chr4 | 57338968 | + |
intron-intron | ENST00000311806 | ENST00000510663 | OXSR1 | chr3 | 38289311 | + | SRP72 | chr4 | 57338968 | + |
intron-intron | ENST00000311806 | ENST00000504757 | OXSR1 | chr3 | 38289311 | + | SRP72 | chr4 | 57338968 | + |
intron-intron | ENST00000492714 | ENST00000342756 | OXSR1 | chr3 | 38289311 | + | SRP72 | chr4 | 57338968 | + |
intron-intron | ENST00000492714 | ENST00000510663 | OXSR1 | chr3 | 38289311 | + | SRP72 | chr4 | 57338968 | + |
intron-intron | ENST00000492714 | ENST00000504757 | OXSR1 | chr3 | 38289311 | + | SRP72 | chr4 | 57338968 | + |
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FusionProtFeatures for OXSR1_SRP72 |
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Hgene | Tgene |
OXSR1 | SRP72 |
Regulates downstream kinases in response toenvironmental stress. May also have a function in regulating theactin cytoskeleton. {ECO:0000269|PubMed:14707132,ECO:0000303|PubMed:14707132}. | Signal-recognition-particle assembly has a crucial rolein targeting secretory proteins to the rough endoplasmic reticulummembrane. Binds the 7S RNA only in presence of SRP68. Thisribonucleoprotein complex might interact directly with the dockingprotein in the ER membrane and possibly participate in theelongation arrest function. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OXSR1_SRP72 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OXSR1_SRP72 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OXSR1_SRP72 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OXSR1_SRP72 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | OXSR1 | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | OXSR1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | SRP72 | C0008370 | Cholestasis | 1 | CTD_human |
Tgene | SRP72 | C3808553 | BONE MARROW FAILURE SYNDROME 1 | 1 | ORPHANET;UNIPROT |
Tgene | SRP72 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |