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Fusion gene ID: 25634 |
FusionGeneSummary for OTX1_OTX1 |
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Fusion gene information | Fusion gene name: OTX1_OTX1 | Fusion gene ID: 25634 | Hgene | Tgene | Gene symbol | OTX1 | OTX1 | Gene ID | 5013 | 5013 |
Gene name | orthodenticle homeobox 1 | orthodenticle homeobox 1 | |
Synonyms | - | - | |
Cytomap | 2p15 | 2p15 | |
Type of gene | protein-coding | protein-coding | |
Description | homeobox protein OTX1orthodenticle homolog 1 | homeobox protein OTX1orthodenticle homolog 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P32242 | P32242 | |
Ensembl transtripts involved in fusion gene | ENST00000366671, ENST00000282549, | ENST00000366671, ENST00000282549, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 1=4 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/4*10)=3.90689059560852 | |
Context | PubMed: OTX1 [Title/Abstract] AND OTX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | OTX1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18849347 |
Tgene | OTX1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18849347 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ304356 | OTX1 | chr2 | 63283373 | - | OTX1 | chr2 | 63283230 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000366671 | ENST00000366671 | OTX1 | chr2 | 63283373 | - | OTX1 | chr2 | 63283230 | + |
Frame-shift | ENST00000366671 | ENST00000282549 | OTX1 | chr2 | 63283373 | - | OTX1 | chr2 | 63283230 | + |
Frame-shift | ENST00000282549 | ENST00000366671 | OTX1 | chr2 | 63283373 | - | OTX1 | chr2 | 63283230 | + |
Frame-shift | ENST00000282549 | ENST00000282549 | OTX1 | chr2 | 63283373 | - | OTX1 | chr2 | 63283230 | + |
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FusionProtFeatures for OTX1_OTX1 |
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Hgene | Tgene |
OTX1 | OTX1 |
Probably plays a role in the development of the brainand the sense organs. Can bind to the BCD target sequence (BTS):5'-TCTAATCCC-3'. | Probably plays a role in the development of the brainand the sense organs. Can bind to the BCD target sequence (BTS):5'-TCTAATCCC-3'. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OTX1_OTX1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OTX1_OTX1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OTX1_OTX1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OTX1_OTX1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |