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Fusion gene ID: 25629 |
FusionGeneSummary for OTUD7B_CTSS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OTUD7B_CTSS | Fusion gene ID: 25629 | Hgene | Tgene | Gene symbol | OTUD7B | CTSS | Gene ID | 56957 | 1520 |
| Gene name | OTU deubiquitinase 7B | cathepsin S | |
| Synonyms | CEZANNE|ZA20D1 | - | |
| Cytomap | 1q21.2 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | OTU domain-containing protein 7BOTU domain containing 7Bcellular zinc finger anti-NF-kappa-B proteincellular zinc finger anti-NF-kappaB Cezannezinc finger A20 domain-containing protein 1zinc finger protein Cezannezinc finger, A20 domain containing 1 | cathepsin S | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q6GQQ9 | P25774 | |
| Ensembl transtripts involved in fusion gene | ENST00000369135, ENST00000479905, | ENST00000368985, ENST00000448301, ENST00000480760, | |
| Fusion gene scores | * DoF score | 4 X 2 X 3=24 | 12 X 10 X 8=960 |
| # samples | 3 | 12 | |
| ** MAII score | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/960*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: OTUD7B [Title/Abstract] AND CTSS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | OTUD7B | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21097510 |
| Hgene | OTUD7B | GO:0032717 | negative regulation of interleukin-8 production | 21097510 |
| Hgene | OTUD7B | GO:0035871 | protein K11-linked deubiquitination | 20622874|23827681 |
| Hgene | OTUD7B | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 11463333 |
| Hgene | OTUD7B | GO:0070536 | protein K63-linked deubiquitination | 20622874 |
| Hgene | OTUD7B | GO:0071108 | protein K48-linked deubiquitination | 21097510 |
| Hgene | OTUD7B | GO:1900181 | negative regulation of protein localization to nucleus | 21097510 |
| Tgene | CTSS | GO:0006508 | proteolysis | 12788072|22864553 |
| Tgene | CTSS | GO:0010447 | response to acidic pH | 22864553 |
| Tgene | CTSS | GO:0016485 | protein processing | 22864553 |
| Tgene | CTSS | GO:0030574 | collagen catabolic process | 22952693 |
| Tgene | CTSS | GO:0034769 | basement membrane disassembly | 22952693 |
| Tgene | CTSS | GO:0048002 | antigen processing and presentation of peptide antigen | 8612130 |
| Tgene | CTSS | GO:0051603 | proteolysis involved in cellular protein catabolic process | 22952693 |
| Tgene | CTSS | GO:2001259 | positive regulation of cation channel activity | 22864553 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-68-7755-01A | OTUD7B | chr1 | 149949361 | - | CTSS | chr1 | 150705621 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000369135 | ENST00000368985 | OTUD7B | chr1 | 149949361 | - | CTSS | chr1 | 150705621 | - |
| Frame-shift | ENST00000369135 | ENST00000448301 | OTUD7B | chr1 | 149949361 | - | CTSS | chr1 | 150705621 | - |
| 5CDS-intron | ENST00000369135 | ENST00000480760 | OTUD7B | chr1 | 149949361 | - | CTSS | chr1 | 150705621 | - |
| intron-3CDS | ENST00000479905 | ENST00000368985 | OTUD7B | chr1 | 149949361 | - | CTSS | chr1 | 150705621 | - |
| intron-3CDS | ENST00000479905 | ENST00000448301 | OTUD7B | chr1 | 149949361 | - | CTSS | chr1 | 150705621 | - |
| intron-intron | ENST00000479905 | ENST00000480760 | OTUD7B | chr1 | 149949361 | - | CTSS | chr1 | 150705621 | - |
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FusionProtFeatures for OTUD7B_CTSS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OTUD7B | CTSS |
| Negative regulator of the non-canonical NF-kappa-Bpathway that acts by mediating deubiquitination of TRAF3, aninhibitor of the NF-kappa-B pathway, thereby acting as a negativeregulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitinchains of TRAF3, preventing TRAF3 proteolysis and over-activationof non-canonical NF-kappa-B. Negatively regulates mucosal immunityagainst infections (By similarity). Deubiquitinates ZAP70, andthereby regulates T cell receptor (TCR) signaling that leads tothe activation of NF-kappa-B (PubMed:26903241). Plays a role in Tcell homeostasis and is required for normal T cell responses,including production of IFNG and IL2 (By similarity). Mediatesdeubiquitination of EGFR (PubMed:22179831). Has deubiquitinatingactivity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linkedpolyubiquitin chains (PubMed:27732584). Has a much highercatalytic rate with 'Lys-11'-linked polyubiquitin chains (invitro); however the physiological significance of these data areunsure (PubMed:27732584). Hydrolyzes both linear and branchedforms of polyubiquitin. {ECO:0000250|UniProtKB:B2RUR8,ECO:0000269|PubMed:11463333, ECO:0000269|PubMed:12682062,ECO:0000269|PubMed:18178551, ECO:0000269|PubMed:20622874,ECO:0000269|PubMed:22179831, ECO:0000269|PubMed:23827681,ECO:0000269|PubMed:27732584}. | Thiol protease. Key protease responsible for the removalof the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to thespecificities of cathepsin L. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OTUD7B_CTSS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OTUD7B_CTSS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| OTUD7B | TRAF6, SLC9A3R2, NUP155, ACAD9, HIF1AN, PARK7, EGFR, UBC, UBE2S, XPO1, MSH3, WWOX, LGR4, ZDHHC17, PIK3R3, HIF1A, AGO1, AURKA, WWP2 | CTSS | SERPINB3, CST5, IRF2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OTUD7B_CTSS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OTUD7B_CTSS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CTSS | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Tgene | CTSS | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | CTSS | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | CTSS | C0028754 | Obesity | 1 | CTD_human |
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