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Fusion gene ID: 25627 |
FusionGeneSummary for OTUD7A_ASCC3 |
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Fusion gene information | Fusion gene name: OTUD7A_ASCC3 | Fusion gene ID: 25627 | Hgene | Tgene | Gene symbol | OTUD7A | ASCC3 | Gene ID | 161725 | 10973 |
Gene name | OTU deubiquitinase 7A | activating signal cointegrator 1 complex subunit 3 | |
Synonyms | C15orf16|C16ORF15|CEZANNE2|OTUD7 | ASC1p200|HELIC1|RNAH | |
Cytomap | 15q13.3 | 6q16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | OTU domain-containing protein 7AOTU domain-containing 7Acezanne 2zinc finger protein Cezanne 2 | activating signal cointegrator 1 complex subunit 3ASC-1 complex subunit P200RNA helicase familyhelicase, ATP binding 1trip4 complex subunit p200 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8TE49 | Q8N3C0 | |
Ensembl transtripts involved in fusion gene | ENST00000382902, ENST00000307050, | ENST00000369162, ENST00000522650, ENST00000369143, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 10 X 7 X 9=630 |
# samples | 2 | 11 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: OTUD7A [Title/Abstract] AND ASCC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | OTUD7A | GO:0035871 | protein K11-linked deubiquitination | 23827681 |
Tgene | ASCC3 | GO:0006307 | DNA dealkylation involved in DNA repair | 22055184 |
Tgene | ASCC3 | GO:0032508 | DNA duplex unwinding | 22055184 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | GBM | TCGA-27-2526-01A | OTUD7A | chr15 | 31862221 | - | ASCC3 | chr6 | 100988263 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000382902 | ENST00000369162 | OTUD7A | chr15 | 31862221 | - | ASCC3 | chr6 | 100988263 | - |
5CDS-intron | ENST00000382902 | ENST00000522650 | OTUD7A | chr15 | 31862221 | - | ASCC3 | chr6 | 100988263 | - |
5CDS-intron | ENST00000382902 | ENST00000369143 | OTUD7A | chr15 | 31862221 | - | ASCC3 | chr6 | 100988263 | - |
Frame-shift | ENST00000307050 | ENST00000369162 | OTUD7A | chr15 | 31862221 | - | ASCC3 | chr6 | 100988263 | - |
5CDS-intron | ENST00000307050 | ENST00000522650 | OTUD7A | chr15 | 31862221 | - | ASCC3 | chr6 | 100988263 | - |
5CDS-intron | ENST00000307050 | ENST00000369143 | OTUD7A | chr15 | 31862221 | - | ASCC3 | chr6 | 100988263 | - |
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FusionProtFeatures for OTUD7A_ASCC3 |
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Hgene | Tgene |
OTUD7A | ASCC3 |
Has deubiquitinating activity towards 'Lys-11'-linkedpolyubiquitin chains. {ECO:0000269|PubMed:20622874,ECO:0000269|PubMed:23827681}. | 3'-5' DNA helicase involved in repair of alkylated DNA.Promotes DNA unwinding to generate single-stranded substrateneeded for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation.{ECO:0000269|PubMed:22055184}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OTUD7A_ASCC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OTUD7A_ASCC3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
OTUD7A | UBC, TRAF6 | ASCC3 | EIF3F, OTUD6B, G3BP1, G3BP2, SIRT7, CAND1, NOTCH1, SKIL, SOX2, HECW2, LGR4, ENO1, MOV10, NXF1, CCDC8, ALKBH3, RPS2, ASCC1, THBS3, ASCC2, NTRK1, IFI16, CC2D2A, CEP170, CEP128, CDK1, IQGAP1, HCCS, ZNF263, UBC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OTUD7A_ASCC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OTUD7A_ASCC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ASCC3 | C3714756 | Intellectual Disability | 1 | CTD_human |