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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25627

FusionGeneSummary for OTUD7A_ASCC3

check button Fusion gene summary
Fusion gene informationFusion gene name: OTUD7A_ASCC3
Fusion gene ID: 25627
HgeneTgene
Gene symbol

OTUD7A

ASCC3

Gene ID

161725

10973

Gene nameOTU deubiquitinase 7Aactivating signal cointegrator 1 complex subunit 3
SynonymsC15orf16|C16ORF15|CEZANNE2|OTUD7ASC1p200|HELIC1|RNAH
Cytomap

15q13.3

6q16.3

Type of geneprotein-codingprotein-coding
DescriptionOTU domain-containing protein 7AOTU domain-containing 7Acezanne 2zinc finger protein Cezanne 2activating signal cointegrator 1 complex subunit 3ASC-1 complex subunit P200RNA helicase familyhelicase, ATP binding 1trip4 complex subunit p200
Modification date2018052320180523
UniProtAcc

Q8TE49

Q8N3C0

Ensembl transtripts involved in fusion geneENST00000382902, ENST00000307050, 
ENST00000369162, ENST00000522650, 
ENST00000369143, 
Fusion gene scores* DoF score2 X 2 X 1=410 X 7 X 9=630
# samples 211
** MAII scorelog2(2/4*10)=2.32192809488736log2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OTUD7A [Title/Abstract] AND ASCC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOTUD7A

GO:0035871

protein K11-linked deubiquitination

23827681

TgeneASCC3

GO:0006307

DNA dealkylation involved in DNA repair

22055184

TgeneASCC3

GO:0032508

DNA duplex unwinding

22055184


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-27-2526-01AOTUD7Achr15

31862221

-ASCC3chr6

100988263

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000382902ENST00000369162OTUD7Achr15

31862221

-ASCC3chr6

100988263

-
5CDS-intronENST00000382902ENST00000522650OTUD7Achr15

31862221

-ASCC3chr6

100988263

-
5CDS-intronENST00000382902ENST00000369143OTUD7Achr15

31862221

-ASCC3chr6

100988263

-
Frame-shiftENST00000307050ENST00000369162OTUD7Achr15

31862221

-ASCC3chr6

100988263

-
5CDS-intronENST00000307050ENST00000522650OTUD7Achr15

31862221

-ASCC3chr6

100988263

-
5CDS-intronENST00000307050ENST00000369143OTUD7Achr15

31862221

-ASCC3chr6

100988263

-

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FusionProtFeatures for OTUD7A_ASCC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OTUD7A

Q8TE49

ASCC3

Q8N3C0

Has deubiquitinating activity towards 'Lys-11'-linkedpolyubiquitin chains. {ECO:0000269|PubMed:20622874,ECO:0000269|PubMed:23827681}. 3'-5' DNA helicase involved in repair of alkylated DNA.Promotes DNA unwinding to generate single-stranded substrateneeded for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation.{ECO:0000269|PubMed:22055184}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OTUD7A_ASCC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OTUD7A_ASCC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OTUD7AUBC, TRAF6ASCC3EIF3F, OTUD6B, G3BP1, G3BP2, SIRT7, CAND1, NOTCH1, SKIL, SOX2, HECW2, LGR4, ENO1, MOV10, NXF1, CCDC8, ALKBH3, RPS2, ASCC1, THBS3, ASCC2, NTRK1, IFI16, CC2D2A, CEP170, CEP128, CDK1, IQGAP1, HCCS, ZNF263, UBC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OTUD7A_ASCC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OTUD7A_ASCC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneASCC3C3714756Intellectual Disability1CTD_human