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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25622

FusionGeneSummary for OTUD4_OTUD4

check button Fusion gene summary
Fusion gene informationFusion gene name: OTUD4_OTUD4
Fusion gene ID: 25622
HgeneTgene
Gene symbol

OTUD4

OTUD4

Gene ID

54726

54726

Gene nameOTU deubiquitinase 4OTU deubiquitinase 4
SynonymsDUBA6|HIN1|HSHIN1DUBA6|HIN1|HSHIN1
Cytomap

4q31.21

4q31.21

Type of geneprotein-codingprotein-coding
DescriptionOTU domain-containing protein 4HIV-1 induced protein HIN-1OTU domain-containing protein 4HIV-1 induced protein HIN-1
Modification date2018052220180522
UniProtAcc

Q01804

Q01804

Ensembl transtripts involved in fusion geneENST00000455611, ENST00000454497, 
ENST00000447906, ENST00000509620, 
ENST00000296579, 
ENST00000455611, 
ENST00000454497, ENST00000447906, 
ENST00000509620, ENST00000296579, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: OTUD4 [Title/Abstract] AND OTUD4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOTUD4

GO:0034122

negative regulation of toll-like receptor signaling pathway

29395066

HgeneOTUD4

GO:0070536

protein K63-linked deubiquitination

29395066

HgeneOTUD4

GO:0071108

protein K48-linked deubiquitination

23827681

HgeneOTUD4

GO:1901537

positive regulation of DNA demethylation

25944111

HgeneOTUD4

GO:1903093

regulation of protein K48-linked deubiquitination

25944111

HgeneOTUD4

GO:2000660

negative regulation of interleukin-1-mediated signaling pathway

29395066

TgeneOTUD4

GO:0034122

negative regulation of toll-like receptor signaling pathway

29395066

TgeneOTUD4

GO:0070536

protein K63-linked deubiquitination

29395066

TgeneOTUD4

GO:0071108

protein K48-linked deubiquitination

23827681

TgeneOTUD4

GO:1901537

positive regulation of DNA demethylation

25944111

TgeneOTUD4

GO:1903093

regulation of protein K48-linked deubiquitination

25944111

TgeneOTUD4

GO:2000660

negative regulation of interleukin-1-mediated signaling pathway

29395066


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DW427746OTUD4chr4

146094939

-OTUD4chr4

146095464

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000455611ENST00000455611OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000455611ENST00000454497OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000455611ENST00000447906OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000455611ENST00000509620OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000455611ENST00000296579OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000454497ENST00000455611OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000454497ENST00000454497OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000454497ENST00000447906OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000454497ENST00000509620OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000454497ENST00000296579OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000447906ENST00000455611OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000447906ENST00000454497OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000447906ENST00000447906OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000447906ENST00000509620OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000447906ENST00000296579OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000509620ENST00000455611OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000509620ENST00000454497OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000509620ENST00000447906OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000509620ENST00000509620OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000509620ENST00000296579OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000296579ENST00000455611OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000296579ENST00000454497OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000296579ENST00000447906OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000296579ENST00000509620OTUD4chr4

146094939

-OTUD4chr4

146095464

-
intron-intronENST00000296579ENST00000296579OTUD4chr4

146094939

-OTUD4chr4

146095464

-

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FusionProtFeatures for OTUD4_OTUD4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OTUD4

Q01804

OTUD4

Q01804

Deubiquitinase which hydrolyzes the isopeptide bondbetween the ubiquitin C-terminus and the lysine epsilon-aminogroup of the target protein (PubMed:23827681, PubMed:25944111,PubMed:29395066). May negatively regulate inflammatory andpathogen recognition signaling in innate immune response. Uponphosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptorand Toll-like receptor signaling pathway, specificallydeubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter proteintriggering down-regulation of NF-kappa-B-dependent transcriptionof inflammatory mediators (PubMed:29395066). Independently of thecatalytic activity, acts as a scaffold for alternativedeubiquitinases to assemble specific deubiquitinase-substratecomplexes. Associates with USP7 and USP9X deubiquitinases tostabilize alkylation repair enzyme ALKBH3, thereby promoting therepair of alkylated DNA lesions (PubMed:25944111).{ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111,ECO:0000269|PubMed:29395066}. Deubiquitinase which hydrolyzes the isopeptide bondbetween the ubiquitin C-terminus and the lysine epsilon-aminogroup of the target protein (PubMed:23827681, PubMed:25944111,PubMed:29395066). May negatively regulate inflammatory andpathogen recognition signaling in innate immune response. Uponphosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptorand Toll-like receptor signaling pathway, specificallydeubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter proteintriggering down-regulation of NF-kappa-B-dependent transcriptionof inflammatory mediators (PubMed:29395066). Independently of thecatalytic activity, acts as a scaffold for alternativedeubiquitinases to assemble specific deubiquitinase-substratecomplexes. Associates with USP7 and USP9X deubiquitinases tostabilize alkylation repair enzyme ALKBH3, thereby promoting therepair of alkylated DNA lesions (PubMed:25944111).{ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111,ECO:0000269|PubMed:29395066}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OTUD4_OTUD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OTUD4_OTUD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OTUD4_OTUD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OTUD4_OTUD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource