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Fusion gene ID: 25614 |
FusionGeneSummary for OTP_PACRG |
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Fusion gene information | Fusion gene name: OTP_PACRG | Fusion gene ID: 25614 | Hgene | Tgene | Gene symbol | OTP | PACRG | Gene ID | 23440 | 135138 |
Gene name | orthopedia homeobox | parkin coregulated | |
Synonyms | - | GLUP|HAK005771|PARK2CRG | |
Cytomap | 5q14.1 | 6q26 | |
Type of gene | protein-coding | protein-coding | |
Description | homeobox protein orthopediaorthopedia homolog | parkin coregulated gene proteinPARK2 co-regulatedPARK2 coregulatedmolecular chaperone/chaperonin-binding proteinparkin co-regulated gene protein | |
Modification date | 20180403 | 20180523 | |
UniProtAcc | Q5XKR4 | Q96M98 | |
Ensembl transtripts involved in fusion gene | ENST00000306422, ENST00000515716, | ENST00000337019, ENST00000366889, ENST00000366888, ENST00000542669, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 6 X 11=528 |
# samples | 1 | 12 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(12/528*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: OTP [Title/Abstract] AND PACRG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI690188 | OTP | chr5 | 76931867 | + | PACRG | chr6 | 163536744 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000306422 | ENST00000337019 | OTP | chr5 | 76931867 | + | PACRG | chr6 | 163536744 | - |
intron-intron | ENST00000306422 | ENST00000366889 | OTP | chr5 | 76931867 | + | PACRG | chr6 | 163536744 | - |
intron-intron | ENST00000306422 | ENST00000366888 | OTP | chr5 | 76931867 | + | PACRG | chr6 | 163536744 | - |
intron-intron | ENST00000306422 | ENST00000542669 | OTP | chr5 | 76931867 | + | PACRG | chr6 | 163536744 | - |
intron-intron | ENST00000515716 | ENST00000337019 | OTP | chr5 | 76931867 | + | PACRG | chr6 | 163536744 | - |
intron-intron | ENST00000515716 | ENST00000366889 | OTP | chr5 | 76931867 | + | PACRG | chr6 | 163536744 | - |
intron-intron | ENST00000515716 | ENST00000366888 | OTP | chr5 | 76931867 | + | PACRG | chr6 | 163536744 | - |
intron-intron | ENST00000515716 | ENST00000542669 | OTP | chr5 | 76931867 | + | PACRG | chr6 | 163536744 | - |
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FusionProtFeatures for OTP_PACRG |
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Hgene | Tgene |
OTP | PACRG |
Probably involved in the differentiation of hypothalamicneuroendocrine cells. | Suppresses cell death induced by accumulation ofunfolded Pael receptor (Pael-R, a substrate of Parkin).Facilitates the formation of inclusions consisting of Pael-R,molecular chaperones, protein degradation molecules and itselfwhen proteasome is inhibited. May play an important role in theformation of Lewy bodies and protection of dopaminergic neuronsagainst Parkinson disease. {ECO:0000269|PubMed:14532270}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OTP_PACRG |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OTP_PACRG |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OTP_PACRG |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OTP_PACRG |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |