FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 25605

FusionGeneSummary for OSTC_DDOST

check button Fusion gene summary
Fusion gene informationFusion gene name: OSTC_DDOST
Fusion gene ID: 25605
HgeneTgene
Gene symbol

OSTC

DDOST

Gene ID

58505

1650

Gene nameoligosaccharyltransferase complex non-catalytic subunitdolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
SynonymsDC2AGER1|CDG1R|GATD6|OKSWcl45|OST|OST48|WBP1
Cytomap

4q25

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionoligosaccharyltransferase complex subunit OSTChydrophobic protein HSF-28oligosaccharyltransferase complex subunit (non-catalytic)dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunitadvanced glycation end-product receptor 1advanced glycation endproduct receptor 1dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)dolichy
Modification date2018052320180523
UniProtAcc

Q9NRP0

P39656

Ensembl transtripts involved in fusion geneENST00000361564, ENST00000512478, 
ENST00000505745, 
ENST00000602624, 
ENST00000375048, ENST00000415136, 
ENST00000477229, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 5 X 3=90
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSTC [Title/Abstract] AND DDOST [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDDOST

GO:0006487

protein N-linked glycosylation

9642163

TgeneDDOST

GO:0034097

response to cytokine

9642163

TgeneDDOST

GO:0042110

T cell activation

9642163


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW614804OSTCchr4

109588663

-DDOSTchr1

20978660

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000361564ENST00000602624OSTCchr4

109588663

-DDOSTchr1

20978660

+
3UTR-3UTRENST00000361564ENST00000375048OSTCchr4

109588663

-DDOSTchr1

20978660

+
3UTR-3UTRENST00000361564ENST00000415136OSTCchr4

109588663

-DDOSTchr1

20978660

+
3UTR-intronENST00000361564ENST00000477229OSTCchr4

109588663

-DDOSTchr1

20978660

+
intron-3UTRENST00000512478ENST00000602624OSTCchr4

109588663

-DDOSTchr1

20978660

+
intron-3UTRENST00000512478ENST00000375048OSTCchr4

109588663

-DDOSTchr1

20978660

+
intron-3UTRENST00000512478ENST00000415136OSTCchr4

109588663

-DDOSTchr1

20978660

+
intron-intronENST00000512478ENST00000477229OSTCchr4

109588663

-DDOSTchr1

20978660

+
intron-3UTRENST00000505745ENST00000602624OSTCchr4

109588663

-DDOSTchr1

20978660

+
intron-3UTRENST00000505745ENST00000375048OSTCchr4

109588663

-DDOSTchr1

20978660

+
intron-3UTRENST00000505745ENST00000415136OSTCchr4

109588663

-DDOSTchr1

20978660

+
intron-intronENST00000505745ENST00000477229OSTCchr4

109588663

-DDOSTchr1

20978660

+

Top

FusionProtFeatures for OSTC_DDOST


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSTC

Q9NRP0

DDOST

P39656

May act as substrate-specific component of the N-oligosaccharyl transferase (OST) complex which catalyzes thetransfer of a high mannose oligosaccharide from a lipid-linkedoligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. May beinvolved in N-glycosylation of APP (amyloid-beta precursorprotein). Can modulate gamma-secretase cleavage of APP byenhancing endoprotelysis of PSEN1. {ECO:0000269|PubMed:21768116,ECO:0000305}. Essential subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. Required for the assembly of bothSST3A- and SS3B-containing OST complexes. Required for efficientN-glycosylation. {ECO:0000250|UniProtKB:Q05052,ECO:0000269|PubMed:22467853, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for OSTC_DDOST


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for OSTC_DDOST


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for OSTC_DDOST


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for OSTC_DDOST


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDDOSTC3281084CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ir1ORPHANET;UNIPROT