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Fusion gene ID: 25605 |
FusionGeneSummary for OSTC_DDOST |
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Fusion gene information | Fusion gene name: OSTC_DDOST | Fusion gene ID: 25605 | Hgene | Tgene | Gene symbol | OSTC | DDOST | Gene ID | 58505 | 1650 |
Gene name | oligosaccharyltransferase complex non-catalytic subunit | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | |
Synonyms | DC2 | AGER1|CDG1R|GATD6|OKSWcl45|OST|OST48|WBP1 | |
Cytomap | 4q25 | 1p36.12 | |
Type of gene | protein-coding | protein-coding | |
Description | oligosaccharyltransferase complex subunit OSTChydrophobic protein HSF-28oligosaccharyltransferase complex subunit (non-catalytic) | dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunitadvanced glycation end-product receptor 1advanced glycation endproduct receptor 1dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)dolichy | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NRP0 | P39656 | |
Ensembl transtripts involved in fusion gene | ENST00000361564, ENST00000512478, ENST00000505745, | ENST00000602624, ENST00000375048, ENST00000415136, ENST00000477229, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 5 X 3=90 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: OSTC [Title/Abstract] AND DDOST [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | DDOST | GO:0006487 | protein N-linked glycosylation | 9642163 |
Tgene | DDOST | GO:0034097 | response to cytokine | 9642163 |
Tgene | DDOST | GO:0042110 | T cell activation | 9642163 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW614804 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000361564 | ENST00000602624 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
3UTR-3UTR | ENST00000361564 | ENST00000375048 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
3UTR-3UTR | ENST00000361564 | ENST00000415136 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
3UTR-intron | ENST00000361564 | ENST00000477229 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
intron-3UTR | ENST00000512478 | ENST00000602624 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
intron-3UTR | ENST00000512478 | ENST00000375048 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
intron-3UTR | ENST00000512478 | ENST00000415136 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
intron-intron | ENST00000512478 | ENST00000477229 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
intron-3UTR | ENST00000505745 | ENST00000602624 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
intron-3UTR | ENST00000505745 | ENST00000375048 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
intron-3UTR | ENST00000505745 | ENST00000415136 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
intron-intron | ENST00000505745 | ENST00000477229 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
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FusionProtFeatures for OSTC_DDOST |
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Hgene | Tgene |
OSTC | DDOST |
May act as substrate-specific component of the N-oligosaccharyl transferase (OST) complex which catalyzes thetransfer of a high mannose oligosaccharide from a lipid-linkedoligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. May beinvolved in N-glycosylation of APP (amyloid-beta precursorprotein). Can modulate gamma-secretase cleavage of APP byenhancing endoprotelysis of PSEN1. {ECO:0000269|PubMed:21768116,ECO:0000305}. | Essential subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to anasparagine residue within an Asn-X-Ser/Thr consensus motif innascent polypeptide chains. Required for the assembly of bothSST3A- and SS3B-containing OST complexes. Required for efficientN-glycosylation. {ECO:0000250|UniProtKB:Q05052,ECO:0000269|PubMed:22467853, ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OSTC_DDOST |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OSTC_DDOST |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OSTC_DDOST |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OSTC_DDOST |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DDOST | C3281084 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ir | 1 | ORPHANET;UNIPROT |