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Fusion gene ID: 25602 |
FusionGeneSummary for OSMR_FGG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OSMR_FGG | Fusion gene ID: 25602 | Hgene | Tgene | Gene symbol | OSMR | FGG | Gene ID | 9180 | 2266 |
| Gene name | oncostatin M receptor | fibrinogen gamma chain | |
| Synonyms | IL-31R-beta|IL-31RB|OSMRB|PLCA1 | - | |
| Cytomap | 5p13.1 | 4q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | oncostatin-M-specific receptor subunit betaIL-31 receptor subunit betaIL-31R subunit betainterleukin-31 receptor subunit betaoncostatin-M specific receptor beta subunit | fibrinogen gamma chainfibrinogen, gamma polypeptidetesticular tissue protein Li 70 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q99650 | P02679 | |
| Ensembl transtripts involved in fusion gene | ENST00000274276, ENST00000502536, | ENST00000404648, ENST00000405164, ENST00000336098, ENST00000407946, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 8 X 9 X 3=216 |
| # samples | 3 | 14 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/216*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: OSMR [Title/Abstract] AND FGG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | OSMR | GO:0034097 | response to cytokine | 8999038 |
| Tgene | FGG | GO:0007160 | cell-matrix adhesion | 10903502 |
| Tgene | FGG | GO:0031639 | plasminogen activation | 16846481 |
| Tgene | FGG | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 |
| Tgene | FGG | GO:0034622 | cellular protein-containing complex assembly | 8910396 |
| Tgene | FGG | GO:0042730 | fibrinolysis | 16846481 |
| Tgene | FGG | GO:0045907 | positive regulation of vasoconstriction | 15739255 |
| Tgene | FGG | GO:0045921 | positive regulation of exocytosis | 19193866 |
| Tgene | FGG | GO:0050714 | positive regulation of protein secretion | 19193866 |
| Tgene | FGG | GO:0051592 | response to calcium ion | 6777381 |
| Tgene | FGG | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502|19193866 |
| Tgene | FGG | GO:0070527 | platelet aggregation | 6281794 |
| Tgene | FGG | GO:0072378 | blood coagulation, fibrin clot formation | 16846481 |
| Tgene | FGG | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 |
| Tgene | FGG | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 |
| Tgene | FGG | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI133452 | OSMR | chr5 | 38935546 | - | FGG | chr4 | 155533803 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-5UTR | ENST00000274276 | ENST00000404648 | OSMR | chr5 | 38935546 | - | FGG | chr4 | 155533803 | - |
| 3UTR-intron | ENST00000274276 | ENST00000405164 | OSMR | chr5 | 38935546 | - | FGG | chr4 | 155533803 | - |
| 3UTR-intron | ENST00000274276 | ENST00000336098 | OSMR | chr5 | 38935546 | - | FGG | chr4 | 155533803 | - |
| 3UTR-intron | ENST00000274276 | ENST00000407946 | OSMR | chr5 | 38935546 | - | FGG | chr4 | 155533803 | - |
| intron-5UTR | ENST00000502536 | ENST00000404648 | OSMR | chr5 | 38935546 | - | FGG | chr4 | 155533803 | - |
| intron-intron | ENST00000502536 | ENST00000405164 | OSMR | chr5 | 38935546 | - | FGG | chr4 | 155533803 | - |
| intron-intron | ENST00000502536 | ENST00000336098 | OSMR | chr5 | 38935546 | - | FGG | chr4 | 155533803 | - |
| intron-intron | ENST00000502536 | ENST00000407946 | OSMR | chr5 | 38935546 | - | FGG | chr4 | 155533803 | - |
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FusionProtFeatures for OSMR_FGG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OSMR | FGG |
| Associates with IL31RA to form the IL31 receptor. BindsIL31 to activate STAT3 and possibly STAT1 and STAT5. Capable oftransducing OSM-specific signaling events.{ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OSMR_FGG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OSMR_FGG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OSMR_FGG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | FGG | P02679 | DB00364 | Sucralfate | Fibrinogen gamma chain | small molecule | approved |
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RelatedDiseases for OSMR_FGG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | OSMR | C0268398 | Familial lichen amyloidosis | 2 | CTD_human;ORPHANET;UNIPROT |
| Hgene | OSMR | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Hgene | OSMR | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | FGG | C0272350 | Dysfibrinogenemia, Congenital | 7 | ORPHANET;UNIPROT |
| Tgene | FGG | C0022548 | Keloid | 1 | CTD_human |
| Tgene | FGG | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | FGG | C2584774 | Congenital hypofibrinogenemia | 1 | ORPHANET;UNIPROT |
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