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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25602

FusionGeneSummary for OSMR_FGG

check button Fusion gene summary
Fusion gene informationFusion gene name: OSMR_FGG
Fusion gene ID: 25602
HgeneTgene
Gene symbol

OSMR

FGG

Gene ID

9180

2266

Gene nameoncostatin M receptorfibrinogen gamma chain
SynonymsIL-31R-beta|IL-31RB|OSMRB|PLCA1-
Cytomap

5p13.1

4q32.1

Type of geneprotein-codingprotein-coding
Descriptiononcostatin-M-specific receptor subunit betaIL-31 receptor subunit betaIL-31R subunit betainterleukin-31 receptor subunit betaoncostatin-M specific receptor beta subunitfibrinogen gamma chainfibrinogen, gamma polypeptidetesticular tissue protein Li 70
Modification date2018052320180519
UniProtAcc

Q99650

P02679

Ensembl transtripts involved in fusion geneENST00000274276, ENST00000502536, 
ENST00000404648, ENST00000405164, 
ENST00000336098, ENST00000407946, 
Fusion gene scores* DoF score3 X 3 X 3=278 X 9 X 3=216
# samples 314
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(14/216*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSMR [Title/Abstract] AND FGG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOSMR

GO:0034097

response to cytokine

8999038

TgeneFGG

GO:0007160

cell-matrix adhesion

10903502

TgeneFGG

GO:0031639

plasminogen activation

16846481

TgeneFGG

GO:0034116

positive regulation of heterotypic cell-cell adhesion

8100742

TgeneFGG

GO:0034622

cellular protein-containing complex assembly

8910396

TgeneFGG

GO:0042730

fibrinolysis

16846481

TgeneFGG

GO:0045907

positive regulation of vasoconstriction

15739255

TgeneFGG

GO:0045921

positive regulation of exocytosis

19193866

TgeneFGG

GO:0050714

positive regulation of protein secretion

19193866

TgeneFGG

GO:0051592

response to calcium ion

6777381

TgeneFGG

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10903502|19193866

TgeneFGG

GO:0070527

platelet aggregation

6281794

TgeneFGG

GO:0072378

blood coagulation, fibrin clot formation

16846481

TgeneFGG

GO:0090277

positive regulation of peptide hormone secretion

19193866

TgeneFGG

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

TgeneFGG

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI133452OSMRchr5

38935546

-FGGchr4

155533803

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000274276ENST00000404648OSMRchr5

38935546

-FGGchr4

155533803

-
3UTR-intronENST00000274276ENST00000405164OSMRchr5

38935546

-FGGchr4

155533803

-
3UTR-intronENST00000274276ENST00000336098OSMRchr5

38935546

-FGGchr4

155533803

-
3UTR-intronENST00000274276ENST00000407946OSMRchr5

38935546

-FGGchr4

155533803

-
intron-5UTRENST00000502536ENST00000404648OSMRchr5

38935546

-FGGchr4

155533803

-
intron-intronENST00000502536ENST00000405164OSMRchr5

38935546

-FGGchr4

155533803

-
intron-intronENST00000502536ENST00000336098OSMRchr5

38935546

-FGGchr4

155533803

-
intron-intronENST00000502536ENST00000407946OSMRchr5

38935546

-FGGchr4

155533803

-

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FusionProtFeatures for OSMR_FGG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSMR

Q99650

FGG

P02679

Associates with IL31RA to form the IL31 receptor. BindsIL31 to activate STAT3 and possibly STAT1 and STAT5. Capable oftransducing OSM-specific signaling events.{ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSMR_FGG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSMR_FGG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OSMR_FGG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGGP02679DB00364SucralfateFibrinogen gamma chainsmall moleculeapproved

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RelatedDiseases for OSMR_FGG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOSMRC0268398Familial lichen amyloidosis2CTD_human;ORPHANET;UNIPROT
HgeneOSMRC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneOSMRC0345967Malignant mesothelioma1CTD_human
TgeneFGGC0272350Dysfibrinogenemia, Congenital7ORPHANET;UNIPROT
TgeneFGGC0022548Keloid1CTD_human
TgeneFGGC0038356Stomach Neoplasms1CTD_human
TgeneFGGC2584774Congenital hypofibrinogenemia1ORPHANET;UNIPROT