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Fusion gene ID: 25599 |
FusionGeneSummary for OSGIN2_DECR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OSGIN2_DECR1 | Fusion gene ID: 25599 | Hgene | Tgene | Gene symbol | OSGIN2 | DECR1 | Gene ID | 734 | 1666 |
| Gene name | oxidative stress induced growth inhibitor family member 2 | 2,4-dienoyl-CoA reductase 1 | |
| Synonyms | C8orf1|hT41 | DECR|NADPH|SDR18C1 | |
| Cytomap | 8q21.3 | 8q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | oxidative stress-induced growth inhibitor 2 | 2,4-dienoyl-CoA reductase, mitochondrial2,4-dienoyl-CoA reductase 1, mitochondrial4-enoyl-CoA reductaseshort chain dehydrogenase/reductase family 18C member 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y236 | Q16698 | |
| Ensembl transtripts involved in fusion gene | ENST00000297438, ENST00000451899, ENST00000520659, | ENST00000220764, ENST00000519007, ENST00000522161, | |
| Fusion gene scores | * DoF score | 2 X 3 X 5=30 | 5 X 5 X 7=175 |
| # samples | 6 | 8 | |
| ** MAII score | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: OSGIN2 [Title/Abstract] AND DECR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DECR1 | GO:0006635 | fatty acid beta-oxidation | 15531764 |
| Tgene | DECR1 | GO:0051289 | protein homotetramerization | 15531764 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-XF-A9T5-01A | OSGIN2 | chr8 | 90933399 | + | DECR1 | chr8 | 91054956 | + |
| TCGA | LD | BRCA | TCGA-GI-A2C9-01A | OSGIN2 | chr8 | 90926974 | + | DECR1 | chr8 | 91029352 | + |
| TCGA | LD | KIRC | TCGA-A3-3335-01A | OSGIN2 | chr8 | 90921949 | + | DECR1 | chr8 | 91029352 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000297438 | ENST00000220764 | OSGIN2 | chr8 | 90933399 | + | DECR1 | chr8 | 91054956 | + |
| 5CDS-intron | ENST00000297438 | ENST00000519007 | OSGIN2 | chr8 | 90933399 | + | DECR1 | chr8 | 91054956 | + |
| 5CDS-intron | ENST00000297438 | ENST00000522161 | OSGIN2 | chr8 | 90933399 | + | DECR1 | chr8 | 91054956 | + |
| In-frame | ENST00000451899 | ENST00000220764 | OSGIN2 | chr8 | 90933399 | + | DECR1 | chr8 | 91054956 | + |
| 5CDS-intron | ENST00000451899 | ENST00000519007 | OSGIN2 | chr8 | 90933399 | + | DECR1 | chr8 | 91054956 | + |
| 5CDS-intron | ENST00000451899 | ENST00000522161 | OSGIN2 | chr8 | 90933399 | + | DECR1 | chr8 | 91054956 | + |
| Frame-shift | ENST00000520659 | ENST00000220764 | OSGIN2 | chr8 | 90933399 | + | DECR1 | chr8 | 91054956 | + |
| 5CDS-intron | ENST00000520659 | ENST00000519007 | OSGIN2 | chr8 | 90933399 | + | DECR1 | chr8 | 91054956 | + |
| 5CDS-intron | ENST00000520659 | ENST00000522161 | OSGIN2 | chr8 | 90933399 | + | DECR1 | chr8 | 91054956 | + |
| In-frame | ENST00000297438 | ENST00000220764 | OSGIN2 | chr8 | 90926974 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000297438 | ENST00000519007 | OSGIN2 | chr8 | 90926974 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000297438 | ENST00000522161 | OSGIN2 | chr8 | 90926974 | + | DECR1 | chr8 | 91029352 | + |
| In-frame | ENST00000451899 | ENST00000220764 | OSGIN2 | chr8 | 90926974 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000451899 | ENST00000519007 | OSGIN2 | chr8 | 90926974 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000451899 | ENST00000522161 | OSGIN2 | chr8 | 90926974 | + | DECR1 | chr8 | 91029352 | + |
| In-frame | ENST00000520659 | ENST00000220764 | OSGIN2 | chr8 | 90926974 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000520659 | ENST00000519007 | OSGIN2 | chr8 | 90926974 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000520659 | ENST00000522161 | OSGIN2 | chr8 | 90926974 | + | DECR1 | chr8 | 91029352 | + |
| Frame-shift | ENST00000297438 | ENST00000220764 | OSGIN2 | chr8 | 90921949 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000297438 | ENST00000519007 | OSGIN2 | chr8 | 90921949 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000297438 | ENST00000522161 | OSGIN2 | chr8 | 90921949 | + | DECR1 | chr8 | 91029352 | + |
| Frame-shift | ENST00000451899 | ENST00000220764 | OSGIN2 | chr8 | 90921949 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000451899 | ENST00000519007 | OSGIN2 | chr8 | 90921949 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000451899 | ENST00000522161 | OSGIN2 | chr8 | 90921949 | + | DECR1 | chr8 | 91029352 | + |
| Frame-shift | ENST00000520659 | ENST00000220764 | OSGIN2 | chr8 | 90921949 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000520659 | ENST00000519007 | OSGIN2 | chr8 | 90921949 | + | DECR1 | chr8 | 91029352 | + |
| 5CDS-3UTR | ENST00000520659 | ENST00000522161 | OSGIN2 | chr8 | 90921949 | + | DECR1 | chr8 | 91029352 | + |
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FusionProtFeatures for OSGIN2_DECR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OSGIN2 | DECR1 |
| May be involved in meiosis or the maturation of germcells. | Auxiliary enzyme of beta-oxidation. It participates inthe metabolism of unsaturated fatty enoyl-CoA esters having doublebonds in both even- and odd-numbered positions. Catalyzes theNADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >DECR1 | chr8:90926974 | chr8:91029352 | ENST00000220764 | + | 0 | 10 | 240_243 | 23 | 336 | Nucleotide binding | NADP |
| Tgene | >DECR1 | chr8:90926974 | chr8:91029352 | ENST00000220764 | + | 0 | 10 | 66_71 | 23 | 336 | Nucleotide binding | NADP |
| Tgene | >DECR1 | chr8:90933399 | chr8:91054956 | ENST00000220764 | + | 5 | 10 | 240_243 | 221 | 336 | Nucleotide binding | NADP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DECR1 | chr8:90933399 | chr8:91054956 | ENST00000220764 | + | 5 | 10 | 66_71 | 221 | 336 | Nucleotide binding | NADP |
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FusionGeneSequence for OSGIN2_DECR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_OSGIN2_ENST00000297438_chr8_90933399_+_DECR1_ENST00000220764_chr8_91054956_+_277aa MPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFD TLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHNMEGSMLTISFGSWMELPGLKFKDWVSSKRRSLAAEWGKYGMRFNVIQ PGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKEQWDTIEELI >In-frame_OSGIN2_ENST00000451899_chr8_90933399_+_DECR1_ENST00000220764_chr8_91054956_+_321aa MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEA IHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHNMEG SMLTISFGSWMELPGLKFKDWVSSKRRSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLC >In-frame_OSGIN2_ENST00000297438_chr8_90926974_+_DECR1_ENST00000220764_chr8_91029352_+_445aa MPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFD TLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGL GKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAW KTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSR >In-frame_OSGIN2_ENST00000451899_chr8_90926974_+_DECR1_ENST00000220764_chr8_91029352_+_489aa MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEA IHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHFFSY GTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCD VRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFV VPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVI >In-frame_OSGIN2_ENST00000520659_chr8_90926974_+_DECR1_ENST00000220764_chr8_91029352_+_489aa MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEA IHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHFFSY GTKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCD VRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFV VPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_OSGIN2_ENST00000297438_chr8_90933399_+_DECR1_ENST00000220764_chr8_91054956_+_831nt ATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGC CTTTCTTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCA AGACATCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGAT ACACTTCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTA GTTCTTGGTAAAGGTCCACCTGGTGGGGCTTGGCATAATATGGAAGGCTCCATGTTGACAATCAGCTTTGGAAGTTGGATGGAACTACCT GGACTTAAATTTAAGGACTGGGTATCAAGTAAACGAAGGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAA CCAGGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAAGAAATGATTGGCAGAATTCCCTGTGGT CGCCTGGGGACTGTAGAAGAACTCGCAAATCTTGCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTT GACGGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAGCAGTGGGACACCATAGAAGAACTCATC >In-frame_OSGIN2_ENST00000451899_chr8_90933399_+_DECR1_ENST00000220764_chr8_91054956_+_963nt ATGCCCGTGTGGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTA GTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACT TTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGCCTTTCTTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCA ATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACATCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGC CTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGATACACTTCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTT TTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTAGTTCTTGGTAAAGGTCCACCTGGTGGGGCTTGGCATAATATGGAAGGC TCCATGTTGACAATCAGCTTTGGAAGTTGGATGGAACTACCTGGACTTAAATTTAAGGACTGGGTATCAAGTAAACGAAGGTCTCTTGCA GCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCAGGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACT GGAACATTTGAGAAAGAAATGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTTGCTGCTTTCCTTTGT AGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGACGGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGA >In-frame_OSGIN2_ENST00000297438_chr8_90926974_+_DECR1_ENST00000220764_chr8_91029352_+_1335nt ATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGC CTTTCTTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCA AGACATCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGAT ACACTTCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTA GTTCTTGGTAAAGGTCCACCTGGTGGGGCTTGGCATTTTTTCAGTTATGGGACAAAAATATTATATCAAAACACTGAAGCTTTGCAATCT AAATTCTTTTCACCTCTTCAAAAAGCGATGCTACCACCTAATAGTTTTCAAGGAAAAGTGGCATTCATTACTGGGGGAGGTACTGGCCTT GGTAAAGGAATGACAACTCTTCTGTCCAGCCTAGGTGCTCAGTGCGTGATAGCCAGCCGGAAGATGGATGTTTTGAAAGCTACCGCAGAA CAAATTTCTTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGATGTGAGGGATCCTGATATGGTTCAAAACACTGTGTCAGAACTG ATCAAAGTTGCAGGACATCCTAATATTGTGATAAACAATGCAGCAGGGAATTTTATTTCTCCTACTGAAAGACTTTCTCCTAATGCTTGG AAAACCATAACTGACATAGTTCTAAATGGCACAGCCTTCGTGACACTAGAAATTGGAAAACAACTAATTAAAGCACAGAAAGGAGCAGCA TTTCTTTCTATTACTACTATCTATGCTGAGACTGGTTCAGGTTTTGTAGTACCAAGTGCTTCTGCCAAAGCAGGTGTGGAAGCCATGAGC AAGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCAGGGCCTATAAAAACCAAAGGTGCCTTTAGCCGT CTGGACCCAACTGGAACATTTGAGAAAGAAATGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTTGCT GCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGACGGTGGAGAGGAAGTACTTATTTCAGGGGAATTC >In-frame_OSGIN2_ENST00000451899_chr8_90926974_+_DECR1_ENST00000220764_chr8_91029352_+_1467nt ATGCCCGTGTGGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTA GTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACT TTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGCCTTTCTTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCA ATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACATCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGC CTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGATACACTTCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTT TTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTAGTTCTTGGTAAAGGTCCACCTGGTGGGGCTTGGCATTTTTTCAGTTAT GGGACAAAAATATTATATCAAAACACTGAAGCTTTGCAATCTAAATTCTTTTCACCTCTTCAAAAAGCGATGCTACCACCTAATAGTTTT CAAGGAAAAGTGGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAAAGGAATGACAACTCTTCTGTCCAGCCTAGGTGCTCAGTGCGTG ATAGCCAGCCGGAAGATGGATGTTTTGAAAGCTACCGCAGAACAAATTTCTTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGAT GTGAGGGATCCTGATATGGTTCAAAACACTGTGTCAGAACTGATCAAAGTTGCAGGACATCCTAATATTGTGATAAACAATGCAGCAGGG AATTTTATTTCTCCTACTGAAAGACTTTCTCCTAATGCTTGGAAAACCATAACTGACATAGTTCTAAATGGCACAGCCTTCGTGACACTA GAAATTGGAAAACAACTAATTAAAGCACAGAAAGGAGCAGCATTTCTTTCTATTACTACTATCTATGCTGAGACTGGTTCAGGTTTTGTA GTACCAAGTGCTTCTGCCAAAGCAGGTGTGGAAGCCATGAGCAAGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTG ATTCAACCAGGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAAGAAATGATTGGCAGAATTCCC TGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTTGCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATT AAATTTGACGGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAGCAGTGGGACACCATAGAAGAA >In-frame_OSGIN2_ENST00000520659_chr8_90926974_+_DECR1_ENST00000220764_chr8_91029352_+_1467nt ATGCCCGTGTGGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTA GTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACT TTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGCCTTTCTTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCA ATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACATCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGC CTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGATACACTTCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTT TTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTAGTTCTTGGTAAAGGTCCACCTGGTGGGGCTTGGCATTTTTTCAGTTAT GGGACAAAAATATTATATCAAAACACTGAAGCTTTGCAATCTAAATTCTTTTCACCTCTTCAAAAAGCGATGCTACCACCTAATAGTTTT CAAGGAAAAGTGGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAAAGGAATGACAACTCTTCTGTCCAGCCTAGGTGCTCAGTGCGTG ATAGCCAGCCGGAAGATGGATGTTTTGAAAGCTACCGCAGAACAAATTTCTTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGAT GTGAGGGATCCTGATATGGTTCAAAACACTGTGTCAGAACTGATCAAAGTTGCAGGACATCCTAATATTGTGATAAACAATGCAGCAGGG AATTTTATTTCTCCTACTGAAAGACTTTCTCCTAATGCTTGGAAAACCATAACTGACATAGTTCTAAATGGCACAGCCTTCGTGACACTA GAAATTGGAAAACAACTAATTAAAGCACAGAAAGGAGCAGCATTTCTTTCTATTACTACTATCTATGCTGAGACTGGTTCAGGTTTTGTA GTACCAAGTGCTTCTGCCAAAGCAGGTGTGGAAGCCATGAGCAAGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTG ATTCAACCAGGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAAGAAATGATTGGCAGAATTCCC TGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTTGCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATT AAATTTGACGGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAGCAGTGGGACACCATAGAAGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_OSGIN2_ENST00000297438_chr8_90933399_+_DECR1_ENST00000220764_chr8_91054956_+_1297nt GGTGTGGTCTGGGGCGGGCCTGATGAGCACCTGGATTTTCACCCGGCGTGCTGGTAATTCCTACACTTGTGGGTGTTTGAGAGACATGAA GAGGGGAGGATGACCTCTTCCCGGAAGCGGGACTTCCATAAAAGAAGCGTGGTGGGCGGGTCCCGGGCACCTGTGGTTTGGTGAGTCCTC CAGGTAACTGTGATGCGGGGGTCAGCGGGAGAGGCACCCGGAAGCTCCCGGCGTCTGCACCCCGGCAGCGCGAGGAAATGCCCAAAGAAA CTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCC ATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGCCTTTC TTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACA TCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGATACACT TCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTAGTTCT TGGTAAAGGTCCACCTGGTGGGGCTTGGCATAATATGGAAGGCTCCATGTTGACAATCAGCTTTGGAAGTTGGATGGAACTACCTGGACT TAAATTTAAGGACTGGGTATCAAGTAAACGAAGGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCAGG GCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAAGAAATGATTGGCAGAATTCCCTGTGGTCGCCT GGGGACTGTAGAAGAACTCGCAAATCTTGCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGACGG TGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAGCAGTGGGACACCATAGAAGAACTCATCAGGAA GACAAAAGGTTCCTAAGACCACTTTGGCCTTCATCTTGGTTACAGAAAAGGGAATAGAAATGAAACAAATTATCTCTCATCTTTTGACTA >In-frame_OSGIN2_ENST00000451899_chr8_90933399_+_DECR1_ENST00000220764_chr8_91054956_+_1334nt GCTCCGCCCCTATCGCGGCGCCCCGAGATCACCCGCCTCCGGCGCCTGGCTCCCTGCAGGCGAGGAGCGGAAGCCGCTATCTGGAGGCGG ACTCCGGCGCCACAGAGCCGGGGCAGCCGCGGCAACGGCGAGGCGCGAGGCAGGGGCGCCCGGCAGACCCCGCGACCCCGAGCCAGCGGG CGCCCCGAGCGGGCAGCCTCGCCGGGGGAGGCGGAGGCGGCCACGGCGGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGT GGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACT TTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGG TAATAATAGGAAATGGACCCTCAGGAATATGCCTTTCTTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAA ATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACATCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCC GATCATCCAATCCAGTTGCAGTACTTTTCGATACACTTCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGA AATTAGAGCAACATCATTATATCCCTCACGTAGTTCTTGGTAAAGGTCCACCTGGTGGGGCTTGGCATAATATGGAAGGCTCCATGTTGA CAATCAGCTTTGGAAGTTGGATGGAACTACCTGGACTTAAATTTAAGGACTGGGTATCAAGTAAACGAAGGTCTCTTGCAGCTGAATGGG GTAAATATGGAATGCGATTCAATGTGATTCAACCAGGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTG AGAAAGAAATGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTTGCTGCTTTCCTTTGTAGTGATTATG CTTCTTGGATTAATGGAGCAGTCATTAAATTTGACGGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCA AGGAGCAGTGGGACACCATAGAAGAACTCATCAGGAAGACAAAAGGTTCCTAAGACCACTTTGGCCTTCATCTTGGTTACAGAAAAGGGA >In-frame_OSGIN2_ENST00000297438_chr8_90926974_+_DECR1_ENST00000220764_chr8_91029352_+_1801nt GGTGTGGTCTGGGGCGGGCCTGATGAGCACCTGGATTTTCACCCGGCGTGCTGGTAATTCCTACACTTGTGGGTGTTTGAGAGACATGAA GAGGGGAGGATGACCTCTTCCCGGAAGCGGGACTTCCATAAAAGAAGCGTGGTGGGCGGGTCCCGGGCACCTGTGGTTTGGTGAGTCCTC CAGGTAACTGTGATGCGGGGGTCAGCGGGAGAGGCACCCGGAAGCTCCCGGCGTCTGCACCCCGGCAGCGCGAGGAAATGCCCAAAGAAA CTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCC ATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGCCTTTC TTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACA TCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGATACACT TCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTAGTTCT TGGTAAAGGTCCACCTGGTGGGGCTTGGCATTTTTTCAGTTATGGGACAAAAATATTATATCAAAACACTGAAGCTTTGCAATCTAAATT CTTTTCACCTCTTCAAAAAGCGATGCTACCACCTAATAGTTTTCAAGGAAAAGTGGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAA AGGAATGACAACTCTTCTGTCCAGCCTAGGTGCTCAGTGCGTGATAGCCAGCCGGAAGATGGATGTTTTGAAAGCTACCGCAGAACAAAT TTCTTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGATGTGAGGGATCCTGATATGGTTCAAAACACTGTGTCAGAACTGATCAA AGTTGCAGGACATCCTAATATTGTGATAAACAATGCAGCAGGGAATTTTATTTCTCCTACTGAAAGACTTTCTCCTAATGCTTGGAAAAC CATAACTGACATAGTTCTAAATGGCACAGCCTTCGTGACACTAGAAATTGGAAAACAACTAATTAAAGCACAGAAAGGAGCAGCATTTCT TTCTATTACTACTATCTATGCTGAGACTGGTTCAGGTTTTGTAGTACCAAGTGCTTCTGCCAAAGCAGGTGTGGAAGCCATGAGCAAGTC TCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCAGGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGA CCCAACTGGAACATTTGAGAAAGAAATGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTTGCTGCTTT CCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGACGGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGA CCTGAGAAAGGTCACCAAGGAGCAGTGGGACACCATAGAAGAACTCATCAGGAAGACAAAAGGTTCCTAAGACCACTTTGGCCTTCATCT TGGTTACAGAAAAGGGAATAGAAATGAAACAAATTATCTCTCATCTTTTGACTATTTCAAGTCTAATAAATTCTTAATTAACAAACATTC >In-frame_OSGIN2_ENST00000451899_chr8_90926974_+_DECR1_ENST00000220764_chr8_91029352_+_1838nt GCTCCGCCCCTATCGCGGCGCCCCGAGATCACCCGCCTCCGGCGCCTGGCTCCCTGCAGGCGAGGAGCGGAAGCCGCTATCTGGAGGCGG ACTCCGGCGCCACAGAGCCGGGGCAGCCGCGGCAACGGCGAGGCGCGAGGCAGGGGCGCCCGGCAGACCCCGCGACCCCGAGCCAGCGGG CGCCCCGAGCGGGCAGCCTCGCCGGGGGAGGCGGAGGCGGCCACGGCGGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGT GGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGACACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACT TTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAAGAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGG TAATAATAGGAAATGGACCCTCAGGAATATGCCTTTCTTATATGTTATCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAA ATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACATCTTTCCATTGTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCC GATCATCCAATCCAGTTGCAGTACTTTTCGATACACTTCTTCATCCAGATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGA AATTAGAGCAACATCATTATATCCCTCACGTAGTTCTTGGTAAAGGTCCACCTGGTGGGGCTTGGCATTTTTTCAGTTATGGGACAAAAA TATTATATCAAAACACTGAAGCTTTGCAATCTAAATTCTTTTCACCTCTTCAAAAAGCGATGCTACCACCTAATAGTTTTCAAGGAAAAG TGGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAAAGGAATGACAACTCTTCTGTCCAGCCTAGGTGCTCAGTGCGTGATAGCCAGCC GGAAGATGGATGTTTTGAAAGCTACCGCAGAACAAATTTCTTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGATGTGAGGGATC CTGATATGGTTCAAAACACTGTGTCAGAACTGATCAAAGTTGCAGGACATCCTAATATTGTGATAAACAATGCAGCAGGGAATTTTATTT CTCCTACTGAAAGACTTTCTCCTAATGCTTGGAAAACCATAACTGACATAGTTCTAAATGGCACAGCCTTCGTGACACTAGAAATTGGAA AACAACTAATTAAAGCACAGAAAGGAGCAGCATTTCTTTCTATTACTACTATCTATGCTGAGACTGGTTCAGGTTTTGTAGTACCAAGTG CTTCTGCCAAAGCAGGTGTGGAAGCCATGAGCAAGTCTCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCAG GGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGAACATTTGAGAAAGAAATGATTGGCAGAATTCCCTGTGGTCGCC TGGGGACTGTAGAAGAACTCGCAAATCTTGCTGCTTTCCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGACG GTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAGGTCACCAAGGAGCAGTGGGACACCATAGAAGAACTCATCAGGA AGACAAAAGGTTCCTAAGACCACTTTGGCCTTCATCTTGGTTACAGAAAAGGGAATAGAAATGAAACAAATTATCTCTCATCTTTTGACT >In-frame_OSGIN2_ENST00000520659_chr8_90926974_+_DECR1_ENST00000220764_chr8_91029352_+_1611nt GGCCGCGCTCGGGCGCCCCTCGCGCAGCGCTCCATGCCCGTGTGGTGCTGCCGCTGCTCCCTGGCCGGTCATTTCAGAAACTATAGTGAC ACTGAAACTGAAGGAGAGATTTTTAATTCCTTAGTGCAATACTTTGGTGACAACTTGGGGCGAAAAGTTAAAGCGATGCCATTAGTTGAA GAAACTTCTTTACTGGAAGATTCGTCAGTGACTTTTCCTGTGGTAATAATAGGAAATGGACCCTCAGGAATATGCCTTTCTTATATGTTA TCAGGCTACAGACCGTATTTATCATCAGAAGCAATACACCCAAATACAATCTTAAATAGTAAATTAGAAGAAGCAAGACATCTTTCCATT GTTGATCAGGACTTAGAATACTTGTCTGAGGGCCTTGAGGGCCGATCATCCAATCCAGTTGCAGTACTTTTCGATACACTTCTTCATCCA GATGCTGACTTTGGGTATGATTATCCATCCGTTTTGCATTGGAAATTAGAGCAACATCATTATATCCCTCACGTAGTTCTTGGTAAAGGT CCACCTGGTGGGGCTTGGCATTTTTTCAGTTATGGGACAAAAATATTATATCAAAACACTGAAGCTTTGCAATCTAAATTCTTTTCACCT CTTCAAAAAGCGATGCTACCACCTAATAGTTTTCAAGGAAAAGTGGCATTCATTACTGGGGGAGGTACTGGCCTTGGTAAAGGAATGACA ACTCTTCTGTCCAGCCTAGGTGCTCAGTGCGTGATAGCCAGCCGGAAGATGGATGTTTTGAAAGCTACCGCAGAACAAATTTCTTCTCAA ACTGGAAATAAGGTTCATGCAATTCAGTGTGATGTGAGGGATCCTGATATGGTTCAAAACACTGTGTCAGAACTGATCAAAGTTGCAGGA CATCCTAATATTGTGATAAACAATGCAGCAGGGAATTTTATTTCTCCTACTGAAAGACTTTCTCCTAATGCTTGGAAAACCATAACTGAC ATAGTTCTAAATGGCACAGCCTTCGTGACACTAGAAATTGGAAAACAACTAATTAAAGCACAGAAAGGAGCAGCATTTCTTTCTATTACT ACTATCTATGCTGAGACTGGTTCAGGTTTTGTAGTACCAAGTGCTTCTGCCAAAGCAGGTGTGGAAGCCATGAGCAAGTCTCTTGCAGCT GAATGGGGTAAATATGGAATGCGATTCAATGTGATTCAACCAGGGCCTATAAAAACCAAAGGTGCCTTTAGCCGTCTGGACCCAACTGGA ACATTTGAGAAAGAAATGATTGGCAGAATTCCCTGTGGTCGCCTGGGGACTGTAGAAGAACTCGCAAATCTTGCTGCTTTCCTTTGTAGT GATTATGCTTCTTGGATTAATGGAGCAGTCATTAAATTTGACGGTGGAGAGGAAGTACTTATTTCAGGGGAATTCAACGACCTGAGAAAG GTCACCAAGGAGCAGTGGGACACCATAGAAGAACTCATCAGGAAGACAAAAGGTTCCTAAGACCACTTTGGCCTTCATCTTGGTTACAGA |
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FusionGenePPI for OSGIN2_DECR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| OSGIN2 | ELAVL1, FBXW7 | DECR1 | HGS, PTTG1, APP, ESR1, FN1, VCAM1, ITGA4, SHMT2, NXF1, NDUFA10, CREB3, ECSIT, NTRK1, HSD17B4, AK1, MSH6, JAK3, KIF11, NPM1, RPL10, BAIAP2, NOP56, GEMIN5, C10orf12, CCDC22, EXOSC5, NLRP5, NF2, FAM118B, CHMP2A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OSGIN2_DECR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OSGIN2_DECR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DECR1 | C0009171 | Cocaine Abuse | 1 | PSYGENET |
| Tgene | DECR1 | C0023772 | Lipid Metabolism, Inborn Errors | 1 | CTD_human |
| Tgene | DECR1 | C1857252 | 2,4-Dienoyl-CoA Reductase Deficiency | 1 | CTD_human |
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