FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 25551

FusionGeneSummary for OSBPL5_CTBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL5_CTBP1
Fusion gene ID: 25551
HgeneTgene
Gene symbol

OSBPL5

CTBP1

Gene ID

114879

1487

Gene nameoxysterol binding protein like 5C-terminal binding protein 1
SynonymsOBPH1|ORP5BARS|HADDTS
Cytomap

11p15.4

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 5ORP-5OSBP-related protein 5oxysterol-binding protein homolog 1oxysterol-binding protein homologue 1C-terminal-binding protein 1brefeldin A-ribosylated substrate
Modification date2018052320180522
UniProtAcc

Q9H0X9

Q13363

Ensembl transtripts involved in fusion geneENST00000263650, ENST00000389989, 
ENST00000525498, ENST00000542243, 
ENST00000348039, ENST00000478260, 
ENST00000528124, 
ENST00000382952, 
ENST00000290921, ENST00000510568, 
ENST00000515690, 
Fusion gene scores* DoF score8 X 7 X 4=2248 X 7 X 8=448
# samples 912
** MAII scorelog2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/448*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSBPL5 [Title/Abstract] AND CTBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOSBPL5

GO:0015914

phospholipid transport

26206935


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D9-A6EA-06AOSBPL5chr11

3186446

-CTBP1chr4

1235307

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000263650ENST00000382952OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-intronENST00000263650ENST00000290921OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-5UTRENST00000263650ENST00000510568OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-intronENST00000263650ENST00000515690OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-5UTRENST00000389989ENST00000382952OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-intronENST00000389989ENST00000290921OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-5UTRENST00000389989ENST00000510568OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-intronENST00000389989ENST00000515690OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
intron-5UTRENST00000525498ENST00000382952OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
intron-intronENST00000525498ENST00000290921OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
intron-5UTRENST00000525498ENST00000510568OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
intron-intronENST00000525498ENST00000515690OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-5UTRENST00000542243ENST00000382952OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-intronENST00000542243ENST00000290921OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-5UTRENST00000542243ENST00000510568OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-intronENST00000542243ENST00000515690OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-5UTRENST00000348039ENST00000382952OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-intronENST00000348039ENST00000290921OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-5UTRENST00000348039ENST00000510568OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-intronENST00000348039ENST00000515690OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
intron-5UTRENST00000478260ENST00000382952OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
intron-intronENST00000478260ENST00000290921OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
intron-5UTRENST00000478260ENST00000510568OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
intron-intronENST00000478260ENST00000515690OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-5UTRENST00000528124ENST00000382952OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-intronENST00000528124ENST00000290921OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-5UTRENST00000528124ENST00000510568OSBPL5chr11

3186446

-CTBP1chr4

1235307

-
5UTR-intronENST00000528124ENST00000515690OSBPL5chr11

3186446

-CTBP1chr4

1235307

-

Top

FusionProtFeatures for OSBPL5_CTBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL5

Q9H0X9

CTBP1

Q13363

Lipid transporter involved in lipid countertransportbetween the endoplasmic reticulum and the plasma membrane:specifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P,which is degraded by the SAC1/SACM1L phosphatase in theendoplasmic reticulum. Binds phosphatidylserine and PI4P in amutually exclusive manner (PubMed:23934110, PubMed:26206935). Maycooperate with NPC1 to mediate the exit of cholesterol fromendosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesteroland cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193,ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110,ECO:0000269|PubMed:26206935}. Corepressor targeting diverse transcription regulatorssuch as GLIS2 or BCL6. Has dehydrogenase activity. Involved incontrolling the equilibrium between tubular and stacked structuresin the Golgi complex. Functions in brown adipose tissue (BAT)differentiation. {ECO:0000269|PubMed:12419229,ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for OSBPL5_CTBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for OSBPL5_CTBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OSBPL5HGS, NPC1, APP, KIFC3, LIMK1, MAGEA1, YWHAH, CDC23, RIOK3, IPO8, ZNF281, LRIF1, KLC4, PRR11, OSBPL8, NAGLU, PLD1, KLHL23CTBP1PNN, IKZF1, SMAD6, RBBP8, TGIF1, NRIP1, MDM2, HDAC1, HDAC3, HDAC4, HDAC5, HDAC9, BRCA1, HDAC2, KAT2B, GEMIN2, TBP, GTF2B, FOXP1, FOXP2, KMT2A, CBX4, MECOM, IKZF4, CTBP2, ZEB1, ACTL6B, HTT, TBL1X, ZNF217, RCOR1, SATB1, CTBP1, TCF4, LCOR, TP53, HIC1, EHMT2, EHMT1, WIZ, APC, PLK1, TUBG1, HSD11B2, TCF7L2, KDM1A, CREBBP, EP300, KAT2A, SP1, RREB1, CDYL, UBE2I, BCORL1, SERPINH1, BCL3, AKT1, HIST3H3, SPEN, ZBP1, SOBP, ZNF219, LCORL, CHD3, RBBP5, CTNNA1, SOX2, ELAVL1, ZEB2, TERF2IP, TERF2, TFAP4, ATXN1L, BCL6, NCOR2, ECT2, CTNNB1, KLF4, DNMT1, RUNX1, BAG3, THAP11, HEMGN, NME2, ORC4, ARNT2, NOL4L, KLF12, MARCH10, CDC23, FUNDC1, IKZF2, KLF3, LNX1, PIAS2, RAI2, RNF111, ZBTB18, CEP68, NOL4, DGCR6, SNRPN, CRY2, HOXB5, PRKAA1, MAPK9, PLCB1, BCAS3, TSHZ3, DMRTB1, EGFR, HIC2, PRDM2, ZNF516, DYRK1A, TRPS1, C10orf12, BCOR, FBXO11, RCOR2, RCOR3, C2orf44, RBL1, INA, RB1, E2F7, TRMT61B, FOXK1, C15orf39, AMPD2, TOR2A, ADSS, ATIC, CARM1, CTH, ECHS1, FKBP1A, GAPDH, DUT, HYI, SSNA1, WDR1, NTRK1, MED23, OFD1, FBF1, KCNIP3, KLF8, NFATC1, NFATC2, MTMR7, RBM14-RBM4, IGFBP1, CHD4, NISCH, KIAA0430, HELZ, PCGF5, SOWAHA, PAN2, EIF4ENIF1, FANCC, FANCA, FANCF, FANCG, FANCL, FANCE, FANCD2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for OSBPL5_CTBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for OSBPL5_CTBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneOSBPL5C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneCTBP1C0009404Colorectal Neoplasms1CTD_human