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Fusion gene ID: 25551 |
FusionGeneSummary for OSBPL5_CTBP1 |
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Fusion gene information | Fusion gene name: OSBPL5_CTBP1 | Fusion gene ID: 25551 | Hgene | Tgene | Gene symbol | OSBPL5 | CTBP1 | Gene ID | 114879 | 1487 |
Gene name | oxysterol binding protein like 5 | C-terminal binding protein 1 | |
Synonyms | OBPH1|ORP5 | BARS|HADDTS | |
Cytomap | 11p15.4 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | oxysterol-binding protein-related protein 5ORP-5OSBP-related protein 5oxysterol-binding protein homolog 1oxysterol-binding protein homologue 1 | C-terminal-binding protein 1brefeldin A-ribosylated substrate | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9H0X9 | Q13363 | |
Ensembl transtripts involved in fusion gene | ENST00000263650, ENST00000389989, ENST00000525498, ENST00000542243, ENST00000348039, ENST00000478260, ENST00000528124, | ENST00000382952, ENST00000290921, ENST00000510568, ENST00000515690, | |
Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 8 X 7 X 8=448 |
# samples | 9 | 12 | |
** MAII score | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/448*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: OSBPL5 [Title/Abstract] AND CTBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | OSBPL5 | GO:0015914 | phospholipid transport | 26206935 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-D9-A6EA-06A | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000263650 | ENST00000382952 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-intron | ENST00000263650 | ENST00000290921 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-5UTR | ENST00000263650 | ENST00000510568 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-intron | ENST00000263650 | ENST00000515690 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-5UTR | ENST00000389989 | ENST00000382952 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-intron | ENST00000389989 | ENST00000290921 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-5UTR | ENST00000389989 | ENST00000510568 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-intron | ENST00000389989 | ENST00000515690 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
intron-5UTR | ENST00000525498 | ENST00000382952 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
intron-intron | ENST00000525498 | ENST00000290921 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
intron-5UTR | ENST00000525498 | ENST00000510568 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
intron-intron | ENST00000525498 | ENST00000515690 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-5UTR | ENST00000542243 | ENST00000382952 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-intron | ENST00000542243 | ENST00000290921 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-5UTR | ENST00000542243 | ENST00000510568 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-intron | ENST00000542243 | ENST00000515690 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-5UTR | ENST00000348039 | ENST00000382952 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-intron | ENST00000348039 | ENST00000290921 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-5UTR | ENST00000348039 | ENST00000510568 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-intron | ENST00000348039 | ENST00000515690 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
intron-5UTR | ENST00000478260 | ENST00000382952 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
intron-intron | ENST00000478260 | ENST00000290921 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
intron-5UTR | ENST00000478260 | ENST00000510568 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
intron-intron | ENST00000478260 | ENST00000515690 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-5UTR | ENST00000528124 | ENST00000382952 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-intron | ENST00000528124 | ENST00000290921 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-5UTR | ENST00000528124 | ENST00000510568 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
5UTR-intron | ENST00000528124 | ENST00000515690 | OSBPL5 | chr11 | 3186446 | - | CTBP1 | chr4 | 1235307 | - |
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FusionProtFeatures for OSBPL5_CTBP1 |
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Hgene | Tgene |
OSBPL5 | CTBP1 |
Lipid transporter involved in lipid countertransportbetween the endoplasmic reticulum and the plasma membrane:specifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P,which is degraded by the SAC1/SACM1L phosphatase in theendoplasmic reticulum. Binds phosphatidylserine and PI4P in amutually exclusive manner (PubMed:23934110, PubMed:26206935). Maycooperate with NPC1 to mediate the exit of cholesterol fromendosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesteroland cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193,ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110,ECO:0000269|PubMed:26206935}. | Corepressor targeting diverse transcription regulatorssuch as GLIS2 or BCL6. Has dehydrogenase activity. Involved incontrolling the equilibrium between tubular and stacked structuresin the Golgi complex. Functions in brown adipose tissue (BAT)differentiation. {ECO:0000269|PubMed:12419229,ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for OSBPL5_CTBP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for OSBPL5_CTBP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
OSBPL5 | HGS, NPC1, APP, KIFC3, LIMK1, MAGEA1, YWHAH, CDC23, RIOK3, IPO8, ZNF281, LRIF1, KLC4, PRR11, OSBPL8, NAGLU, PLD1, KLHL23 | CTBP1 | PNN, IKZF1, SMAD6, RBBP8, TGIF1, NRIP1, MDM2, HDAC1, HDAC3, HDAC4, HDAC5, HDAC9, BRCA1, HDAC2, KAT2B, GEMIN2, TBP, GTF2B, FOXP1, FOXP2, KMT2A, CBX4, MECOM, IKZF4, CTBP2, ZEB1, ACTL6B, HTT, TBL1X, ZNF217, RCOR1, SATB1, CTBP1, TCF4, LCOR, TP53, HIC1, EHMT2, EHMT1, WIZ, APC, PLK1, TUBG1, HSD11B2, TCF7L2, KDM1A, CREBBP, EP300, KAT2A, SP1, RREB1, CDYL, UBE2I, BCORL1, SERPINH1, BCL3, AKT1, HIST3H3, SPEN, ZBP1, SOBP, ZNF219, LCORL, CHD3, RBBP5, CTNNA1, SOX2, ELAVL1, ZEB2, TERF2IP, TERF2, TFAP4, ATXN1L, BCL6, NCOR2, ECT2, CTNNB1, KLF4, DNMT1, RUNX1, BAG3, THAP11, HEMGN, NME2, ORC4, ARNT2, NOL4L, KLF12, MARCH10, CDC23, FUNDC1, IKZF2, KLF3, LNX1, PIAS2, RAI2, RNF111, ZBTB18, CEP68, NOL4, DGCR6, SNRPN, CRY2, HOXB5, PRKAA1, MAPK9, PLCB1, BCAS3, TSHZ3, DMRTB1, EGFR, HIC2, PRDM2, ZNF516, DYRK1A, TRPS1, C10orf12, BCOR, FBXO11, RCOR2, RCOR3, C2orf44, RBL1, INA, RB1, E2F7, TRMT61B, FOXK1, C15orf39, AMPD2, TOR2A, ADSS, ATIC, CARM1, CTH, ECHS1, FKBP1A, GAPDH, DUT, HYI, SSNA1, WDR1, NTRK1, MED23, OFD1, FBF1, KCNIP3, KLF8, NFATC1, NFATC2, MTMR7, RBM14-RBM4, IGFBP1, CHD4, NISCH, KIAA0430, HELZ, PCGF5, SOWAHA, PAN2, EIF4ENIF1, FANCC, FANCA, FANCF, FANCG, FANCL, FANCE, FANCD2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for OSBPL5_CTBP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OSBPL5_CTBP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | OSBPL5 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | CTBP1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |