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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25550

FusionGeneSummary for OSBPL3_TMEM176A

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL3_TMEM176A
Fusion gene ID: 25550
HgeneTgene
Gene symbol

OSBPL3

TMEM176A

Gene ID

26031

55365

Gene nameoxysterol binding protein like 3transmembrane protein 176A
SynonymsORP-3|ORP3|OSBP3GS188|HCA112|MS4B1
Cytomap

7p15.3

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 3OSBP-related protein 3transmembrane protein 176Ahepatocellular carcinoma-associated antigen 112likley ortholog of mouse GS188
Modification date2018052320180519
UniProtAcc

Q9H4L5

Q96HP8

Ensembl transtripts involved in fusion geneENST00000313367, ENST00000431825, 
ENST00000352860, ENST00000353930, 
ENST00000396431, ENST00000409069, 
ENST00000396429, ENST00000487020, 
ENST00000484928, ENST00000004103, 
ENST00000461345, 
Fusion gene scores* DoF score8 X 3 X 5=1201 X 1 X 1=1
# samples 71
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: OSBPL3 [Title/Abstract] AND TMEM176A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A8BR-01AOSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000313367ENST00000484928OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000313367ENST00000004103OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000313367ENST00000461345OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000431825ENST00000484928OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000431825ENST00000004103OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000431825ENST00000461345OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000352860ENST00000484928OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000352860ENST00000004103OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000352860ENST00000461345OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000353930ENST00000484928OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000353930ENST00000004103OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
5UTR-3CDSENST00000353930ENST00000461345OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000396431ENST00000484928OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000396431ENST00000004103OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000396431ENST00000461345OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000409069ENST00000484928OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000409069ENST00000004103OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000409069ENST00000461345OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000396429ENST00000484928OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000396429ENST00000004103OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000396429ENST00000461345OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000487020ENST00000484928OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000487020ENST00000004103OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+
intron-3CDSENST00000487020ENST00000461345OSBPL3chr7

25019505

-TMEM176Achr7

150501915

+

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FusionProtFeatures for OSBPL3_TMEM176A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL3

Q9H4L5

TMEM176A

Q96HP8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSBPL3_TMEM176A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSBPL3_TMEM176A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OSBPL3YWHAG, YWHAB, SFN, ELAVL1, YWHAE, VAPB, ENO1, NXF1, ARRDC1, TTI2, ADCYAP1, AURKA, SMC1A, VAPA, MMGT1, GLTSCR2, ZFPL1, CPNE2, TSPYL1, ACTR3B, HDAC11, ILVBL, JPH4, PRICKLE3, TRAF1, HIF1AN, KCTD3, CBY1TMEM176AVKORC1, TGM2, HIVEP1, HRSP12


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for OSBPL3_TMEM176A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OSBPL3_TMEM176A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource