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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 25545

FusionGeneSummary for OSBPL3_CORIN

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL3_CORIN
Fusion gene ID: 25545
HgeneTgene
Gene symbol

OSBPL3

CORIN

Gene ID

26031

10699

Gene nameoxysterol binding protein like 3corin, serine peptidase
SynonymsORP-3|ORP3|OSBP3ATC2|CRN|Lrp4|PEE5|TMPRSS10
Cytomap

7p15.3

4p12

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 3OSBP-related protein 3atrial natriuretic peptide-converting enzymeheart-specific serine proteinase ATC2pro-ANP-convertasepro-ANP-converting enzymetransmembrane protease serine 10
Modification date2018052320180506
UniProtAcc

Q9H4L5

Q9Y5Q5

Ensembl transtripts involved in fusion geneENST00000313367, ENST00000431825, 
ENST00000352860, ENST00000353930, 
ENST00000396431, ENST00000409069, 
ENST00000396429, ENST00000487020, 
ENST00000273857, ENST00000508498, 
ENST00000502252, ENST00000505909, 
ENST00000504584, ENST00000515827, 
Fusion gene scores* DoF score8 X 3 X 5=1205 X 6 X 5=150
# samples 75
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: OSBPL3 [Title/Abstract] AND CORIN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCORIN

GO:0016486

peptide hormone processing

10880574


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AQ-A04L-01BOSBPL3chr7

24931996

-CORINchr4

47746600

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000313367ENST00000273857OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000313367ENST00000508498OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000313367ENST00000502252OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000313367ENST00000505909OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000313367ENST00000504584OSBPL3chr7

24931996

-CORINchr4

47746600

-
5CDS-intronENST00000313367ENST00000515827OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000431825ENST00000273857OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000431825ENST00000508498OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000431825ENST00000502252OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000431825ENST00000505909OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000431825ENST00000504584OSBPL3chr7

24931996

-CORINchr4

47746600

-
5CDS-intronENST00000431825ENST00000515827OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000352860ENST00000273857OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000352860ENST00000508498OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000352860ENST00000502252OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000352860ENST00000505909OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000352860ENST00000504584OSBPL3chr7

24931996

-CORINchr4

47746600

-
5CDS-intronENST00000352860ENST00000515827OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000353930ENST00000273857OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000353930ENST00000508498OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000353930ENST00000502252OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000353930ENST00000505909OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000353930ENST00000504584OSBPL3chr7

24931996

-CORINchr4

47746600

-
5CDS-intronENST00000353930ENST00000515827OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000396431ENST00000273857OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000396431ENST00000508498OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000396431ENST00000502252OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000396431ENST00000505909OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000396431ENST00000504584OSBPL3chr7

24931996

-CORINchr4

47746600

-
5CDS-intronENST00000396431ENST00000515827OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000409069ENST00000273857OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000409069ENST00000508498OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000409069ENST00000502252OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000409069ENST00000505909OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000409069ENST00000504584OSBPL3chr7

24931996

-CORINchr4

47746600

-
5CDS-intronENST00000409069ENST00000515827OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000396429ENST00000273857OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000396429ENST00000508498OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000396429ENST00000502252OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000396429ENST00000505909OSBPL3chr7

24931996

-CORINchr4

47746600

-
Frame-shitENST00000396429ENST00000504584OSBPL3chr7

24931996

-CORINchr4

47746600

-
5CDS-intronENST00000396429ENST00000515827OSBPL3chr7

24931996

-CORINchr4

47746600

-
intron-3CDSENST00000487020ENST00000273857OSBPL3chr7

24931996

-CORINchr4

47746600

-
intron-3CDSENST00000487020ENST00000508498OSBPL3chr7

24931996

-CORINchr4

47746600

-
intron-3CDSENST00000487020ENST00000502252OSBPL3chr7

24931996

-CORINchr4

47746600

-
intron-3CDSENST00000487020ENST00000505909OSBPL3chr7

24931996

-CORINchr4

47746600

-
intron-3CDSENST00000487020ENST00000504584OSBPL3chr7

24931996

-CORINchr4

47746600

-
intron-intronENST00000487020ENST00000515827OSBPL3chr7

24931996

-CORINchr4

47746600

-

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FusionProtFeatures for OSBPL3_CORIN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL3

Q9H4L5

CORIN

Q9Y5Q5

Serine-type endopeptidase involved in atrial natriureticpeptide hormone (NPPA) processing. Converts through proteolyticcleavage the non-functional propeptide NPPA into the activehormone, thereby regulating blood pressure in heart and promotingnatriuresis, diuresis and vasodilation. Proteolytic cleavage ofpro-NPPA also plays a role in female pregnancy by promotingtrophoblast invasion and spiral artery remodeling in uterus. Alsoacts as a regulator of sodium reabsorption in kidney. May alsoprocess pro-NPPB the B-type natriuretic peptide. Isoform 2: has weaker endopeptidase activity compared toisoform 1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for OSBPL3_CORIN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for OSBPL3_CORIN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OSBPL3YWHAG, YWHAB, SFN, ELAVL1, YWHAE, VAPB, ENO1, NXF1, ARRDC1, TTI2, ADCYAP1, AURKA, SMC1A, VAPA, MMGT1, GLTSCR2, ZFPL1, CPNE2, TSPYL1, ACTR3B, HDAC11, ILVBL, JPH4, PRICKLE3, TRAF1, HIF1AN, KCTD3, CBY1CORIN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for OSBPL3_CORIN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for OSBPL3_CORIN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCORINC3281288PREECLAMPSIA/ECLAMPSIA 51UNIPROT