FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 25544

FusionGeneSummary for OSBPL3_AOC1

check button Fusion gene summary
Fusion gene informationFusion gene name: OSBPL3_AOC1
Fusion gene ID: 25544
HgeneTgene
Gene symbol

OSBPL3

AOC1

Gene ID

26031

26

Gene nameoxysterol binding protein like 3amine oxidase, copper containing 1
SynonymsORP-3|ORP3|OSBP3ABP|ABP1|DAO|DAO1|KAO
Cytomap

7p15.3

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionoxysterol-binding protein-related protein 3OSBP-related protein 3amiloride-sensitive amine oxidase [copper-containing]amiloride binding protein 1 (amine oxidase (copper-containing))amiloride-binding protein 1amiloride-sensitive amine oxidaseamine oxidase copper domain-containing protein 1diamine oxidasehistaminas
Modification date2018052320180523
UniProtAcc

Q9H4L5

P19801

Ensembl transtripts involved in fusion geneENST00000313367, ENST00000431825, 
ENST00000352860, ENST00000353930, 
ENST00000396431, ENST00000409069, 
ENST00000396429, ENST00000487020, 
ENST00000493429, ENST00000467291, 
ENST00000360937, ENST00000416793, 
ENST00000480582, 
Fusion gene scores* DoF score8 X 3 X 5=1204 X 3 X 3=36
# samples 74
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: OSBPL3 [Title/Abstract] AND AOC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAOC1

GO:0035874

cellular response to copper ion starvation

9399025

TgeneAOC1

GO:0042493

response to drug

8144586

TgeneAOC1

GO:0046677

response to antibiotic

7626074|19764817

TgeneAOC1

GO:0055114

oxidation-reduction process

8144586|16846222

TgeneAOC1

GO:0071280

cellular response to copper ion

9399025

TgeneAOC1

GO:0071420

cellular response to histamine

12072962

TgeneAOC1

GO:0097185

cellular response to azide

16846222


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A8BR-01AOSBPL3chr7

25019505

-AOC1chr7

150553543

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000313367ENST00000493429OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000313367ENST00000467291OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000313367ENST00000360937OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000313367ENST00000416793OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-intronENST00000313367ENST00000480582OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000431825ENST00000493429OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000431825ENST00000467291OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000431825ENST00000360937OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000431825ENST00000416793OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-intronENST00000431825ENST00000480582OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000352860ENST00000493429OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000352860ENST00000467291OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000352860ENST00000360937OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000352860ENST00000416793OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-intronENST00000352860ENST00000480582OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000353930ENST00000493429OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000353930ENST00000467291OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000353930ENST00000360937OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-5UTRENST00000353930ENST00000416793OSBPL3chr7

25019505

-AOC1chr7

150553543

+
5UTR-intronENST00000353930ENST00000480582OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000396431ENST00000493429OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000396431ENST00000467291OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000396431ENST00000360937OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000396431ENST00000416793OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-intronENST00000396431ENST00000480582OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000409069ENST00000493429OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000409069ENST00000467291OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000409069ENST00000360937OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000409069ENST00000416793OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-intronENST00000409069ENST00000480582OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000396429ENST00000493429OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000396429ENST00000467291OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000396429ENST00000360937OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000396429ENST00000416793OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-intronENST00000396429ENST00000480582OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000487020ENST00000493429OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000487020ENST00000467291OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000487020ENST00000360937OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-5UTRENST00000487020ENST00000416793OSBPL3chr7

25019505

-AOC1chr7

150553543

+
intron-intronENST00000487020ENST00000480582OSBPL3chr7

25019505

-AOC1chr7

150553543

+

Top

FusionProtFeatures for OSBPL3_AOC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OSBPL3

Q9H4L5

AOC1

P19801

Catalyzes the degradation of compounds such asputrescine, histamine, spermine, and spermidine, substancesinvolved in allergic and immune responses, cell proliferation,tissue differentiation, tumor formation, and possibly apoptosis.Placental DAO is thought to play a role in the regulation of thefemale reproductive function.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for OSBPL3_AOC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for OSBPL3_AOC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
OSBPL3YWHAG, YWHAB, SFN, ELAVL1, YWHAE, VAPB, ENO1, NXF1, ARRDC1, TTI2, ADCYAP1, AURKA, SMC1A, VAPA, MMGT1, GLTSCR2, ZFPL1, CPNE2, TSPYL1, ACTR3B, HDAC11, ILVBL, JPH4, PRICKLE3, TRAF1, HIF1AN, KCTD3, CBY1AOC1CYB561A3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for OSBPL3_AOC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneAOC1P19801DB00594AmilorideAmiloride-sensitive amine oxidase [copper-containing]small moleculeapproved
TgeneAOC1P19801DB01373CalciumAmiloride-sensitive amine oxidase [copper-containing]small moleculeapproved|nutraceutical

Top

RelatedDiseases for OSBPL3_AOC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAOC1C0018800Cardiomegaly1CTD_human
TgeneAOC1C0020538Hypertensive disease1CTD_human